PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33815123-0 2021 High Expression of Lysophosphatidic Acid Induces Nerve Injury in LSS Patients via AKT Mediated NF-kappaB p65 Pathway. lysophosphatidic acid 19-40 AKT serine/threonine kinase 1 Homo sapiens 82-85 33815123-17 2021 The high levels of LPA induced nerve injury by reducing the viability of RN-SC cells and promoted cell apoptosis through Akt mediated NF-kappaB p65 signaling pathway. lysophosphatidic acid 19-22 AKT serine/threonine kinase 1 Homo sapiens 121-124 32920014-5 2020 We found that LPA stimulates ROS and Akt signalling in VSMCs, however they are not associated in LPAR5 mediated transactivation of the TGFBR1. lysophosphatidic acid 14-17 AKT serine/threonine kinase 1 Homo sapiens 37-40 34886812-15 2021 CONCLUSIONS: Acacetin may not only engender direct inhibition of ovarian cancer cell malignancy, but also antagonize mesothelial cell-evoked malignancy by blocking LPA release-activated RAGE-PI3K/AKT signaling. lysophosphatidic acid 164-167 AKT serine/threonine kinase 1 Homo sapiens 196-199 34639115-8 2021 LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression. lysophosphatidic acid 174-177 AKT serine/threonine kinase 1 Homo sapiens 74-77 34639115-8 2021 LPA increased Rho-associated protein kinase 2 (ROCK2) expression and PI3K/AKT activation; moreover, the pharmacological inhibition of ROCK2 and PI3K/AKT signaling suppressed LPA-induced cell cycle progression. lysophosphatidic acid 174-177 AKT serine/threonine kinase 1 Homo sapiens 149-152 34065317-6 2021 In addition, treatment of the cells with pharmacological inhibitors of phosphoinositide 3-kinase (PI3K), Akt, and mTOR abrogated LPA-induced DDR2 expression. lysophosphatidic acid 129-132 AKT serine/threonine kinase 1 Homo sapiens 105-108 33367557-0 2021 Lysophosphatidic acid mediated PI3K/AKT activation contributed to esophageal squamous cell cancer progression. lysophosphatidic acid 0-21 AKT serine/threonine kinase 1 Homo sapiens 36-39 33367557-7 2021 Mechanistic studies revealed that LPA promoted ESCC cell lines proliferation and migration through PI3K/AKT pathway. lysophosphatidic acid 34-37 AKT serine/threonine kinase 1 Homo sapiens 104-107 31636669-5 2019 Here we show that three LPA receptors are involved in tumor progression by activation of both the AKT and ERK signaling pathways. lysophosphatidic acid 24-27 AKT serine/threonine kinase 1 Homo sapiens 98-101 32297350-8 2020 Lycopene also inhibited activation of Akt in response to LPA and EGF as assessed by immunoblotting. lysophosphatidic acid 57-60 AKT serine/threonine kinase 1 Homo sapiens 38-41 32774171-8 2020 LPA may mediate TAM formation by activating the PI3K/AKT/mTOR signaling pathway through LPAR on the cell surface, which may also affect the function of PPAR gamma, leading to increased LPA production by TAMs. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 53-56 32774171-8 2020 LPA may mediate TAM formation by activating the PI3K/AKT/mTOR signaling pathway through LPAR on the cell surface, which may also affect the function of PPAR gamma, leading to increased LPA production by TAMs. lysophosphatidic acid 88-91 AKT serine/threonine kinase 1 Homo sapiens 53-56 29046393-8 2017 Cells expressing CA-Rac1 exhibited a robust induction of macropinocytosis, and inhibitors of macropinocytosis blocked the activation of Akt by CA-Rac1 or lysophosphatidic acid. lysophosphatidic acid 154-175 AKT serine/threonine kinase 1 Homo sapiens 136-139 29466791-0 2018 Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway. lysophosphatidic acid 0-21 AKT serine/threonine kinase 1 Homo sapiens 78-81 29466791-11 2018 Our in vitro findings were supported by our in vivo evidence that lyophilized LPA significantly induced LF hypertrophy via the LPAR1-Akt signaling pathway. lysophosphatidic acid 78-81 AKT serine/threonine kinase 1 Homo sapiens 133-136 29466791-13 2018 Taken together, these data indicate that LPA binds to the receptor LPAR1 to induce LF cell proliferation and inhibit apoptosis by activating AKT signaling cascades. lysophosphatidic acid 41-44 AKT serine/threonine kinase 1 Homo sapiens 141-144 28232483-11 2017 In a signaling pathway screen, lysophosphatidic acid increased phosphorylation of AKT, EGF receptor, ERK1/2, JNK1/2/3, and c-Jun. lysophosphatidic acid 31-52 AKT serine/threonine kinase 1 Homo sapiens 82-85 28359316-10 2017 Phosphorylation of Akt (Thr308 and Ser473) and p42/44MAPK in BxPC3 and PANC-1 cells was observed after LPA stimulation, which was clearly inhibited by pre-treatment with a compound Ki16425. lysophosphatidic acid 103-106 AKT serine/threonine kinase 1 Homo sapiens 19-22 26800320-10 2016 In addition, we further identified that AKT1 activity was upregulated in ovarian CSCs through an LPA-dependent mechanism and silencing of AKT1 expression led to suppression of CSC characteristics. lysophosphatidic acid 97-100 AKT serine/threonine kinase 1 Homo sapiens 40-44 27994056-5 2017 PM-recruited GRK2ct-KERE inhibits lysophosphatidic acid-induced phosphorylation of Akt, whereas Golgi-recruited GRK2ct-KERE inhibits cargo transport from the TGN to the PM. lysophosphatidic acid 34-55 AKT serine/threonine kinase 1 Homo sapiens 83-86 26861299-4 2016 LPA moieties efficiently activate AKT phosphorylation and activation in a multitude of cell types. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 34-37 26171059-14 2015 PKG II also inhibited the activation of PI3K/Akt and MEK/ERK mediated signaling, which is important for LPA-induced Rac1 activation. lysophosphatidic acid 104-107 AKT serine/threonine kinase 1 Homo sapiens 45-48 26386720-5 2016 In five of the six cell lines, LPA induced phosphorylation of the EGFR, and the effects on EGFR and Akt, and in some of the cells also ERK, were sensitive to the EGFR tyrosine kinase inhibitor gefitinib, strongly suggesting LPA-induced EGFR transactivation in these cells. lysophosphatidic acid 31-34 AKT serine/threonine kinase 1 Homo sapiens 100-103 26171059-8 2015 Phosphorylation of phosphatidylinositol 4,5 bisphosphate 3 kinase (PI3K) and its downstream effecter protein kinase B (Akt) are associated with lysophosphatidic acid (LPA)-induced motility/migration of cancer cells. lysophosphatidic acid 144-165 AKT serine/threonine kinase 1 Homo sapiens 119-122 25783839-6 2015 LPA was able to diminish LPS-induced phosphorylation of p38 and Akt, as well as NF-kappaB p65 nuclear translocation. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 64-67 25783839-8 2015 Our findings demonstrate a clear anti-inflammatory role of LPA acting via Galpha(i) in LPS-mediated inflammatory response in macrophages, owing, at least in part, to its suppressive effect on LPS-induced activation of p38, Akt and NF-kappaB. lysophosphatidic acid 59-62 AKT serine/threonine kinase 1 Homo sapiens 223-226 26171059-15 2015 These results suggest that PKG II affects LPA-stimulated migration of AGS cells by blocking Rac1 activation, via inhibition of PI3K/Akt and MEK/ERK mediated signaling. lysophosphatidic acid 42-45 AKT serine/threonine kinase 1 Homo sapiens 132-135 26171059-8 2015 Phosphorylation of phosphatidylinositol 4,5 bisphosphate 3 kinase (PI3K) and its downstream effecter protein kinase B (Akt) are associated with lysophosphatidic acid (LPA)-induced motility/migration of cancer cells. lysophosphatidic acid 167-170 AKT serine/threonine kinase 1 Homo sapiens 119-122 25975684-0 2015 [Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation]. lysophosphatidic acid 1-22 AKT serine/threonine kinase 1 Homo sapiens 109-112 25633408-10 2015 Taken together, our data suggest that LPA rescues H2O2-induced apoptosis mainly by interacting with Gi-coupled LPA3, resulting activation of the ERK1/2- and PI3 K/AKT-pathways and inhibition caspase-3 cleavage, and LPA protection of BMSCs against the apoptosis is independent of it induced autophagy. lysophosphatidic acid 38-41 AKT serine/threonine kinase 1 Homo sapiens 163-166 25975684-0 2015 [Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation]. lysophosphatidic acid 24-27 AKT serine/threonine kinase 1 Homo sapiens 109-112 25975684-10 2015 Rac(-) blocked the LPA response of invasive SK-OV3 and HEY cells (LPA-induced fold increase of cell migration: SK-OV3 cells: 2.988+-0.095 vs. 0.997+-0.100,P=0.01; HEY cells: 2.404+-0.059 vs. 0.901+-0.072, P=0.01). lysophosphatidic acid 19-22 AKT serine/threonine kinase 1 Homo sapiens 0-3 25975684-10 2015 Rac(-) blocked the LPA response of invasive SK-OV3 and HEY cells (LPA-induced fold increase of cell migration: SK-OV3 cells: 2.988+-0.095 vs. 0.997+-0.100,P=0.01; HEY cells: 2.404+-0.059 vs. 0.901+-0.072, P=0.01). lysophosphatidic acid 66-69 AKT serine/threonine kinase 1 Homo sapiens 0-3 25975684-11 2015 But Rac(+) confered the non-invasive cells with LPA response and invasion capability (LPA-induced fold increase of cell migration: OVCAR3 cells: 1.072+-0.080 vs. 1.898+-0.078, P<0.01; IGROV1 cells: 1.002+-0.044 vs. 2.141+-0.057, P<0.05). lysophosphatidic acid 48-51 AKT serine/threonine kinase 1 Homo sapiens 4-7 25975684-11 2015 But Rac(+) confered the non-invasive cells with LPA response and invasion capability (LPA-induced fold increase of cell migration: OVCAR3 cells: 1.072+-0.080 vs. 1.898+-0.078, P<0.01; IGROV1 cells: 1.002+-0.044 vs. 2.141+-0.057, P<0.05). lysophosphatidic acid 86-89 AKT serine/threonine kinase 1 Homo sapiens 4-7 25975684-12 2015 Among Rho GTPases, only Rac activation was different between ovarian cancer cell lines with different metastatic capability after LPA stimulation: Cdc42 could not be activated in both the invasive and non-invasive cell lines. lysophosphatidic acid 130-133 AKT serine/threonine kinase 1 Homo sapiens 24-27 25975684-14 2015 Rac could be activated by LPA in the invasive ovarian cancer cell lines. lysophosphatidic acid 26-29 AKT serine/threonine kinase 1 Homo sapiens 0-3 25975684-16 2015 CONCLUSION: Lysophosphatidic acid stimulates invasion and metastasis of ovarian cancer cells through Rac activation. lysophosphatidic acid 12-33 AKT serine/threonine kinase 1 Homo sapiens 101-104 26366416-7 2015 Moreover, PI3K/AKT pathway was found to be important for the LPA antiapoptosis effect, and administration of PI3K/AKT partially reversed the LPA-mediated protection against cisplatin-induced apoptosis (p < 0.05). lysophosphatidic acid 61-64 AKT serine/threonine kinase 1 Homo sapiens 15-18 26366416-7 2015 Moreover, PI3K/AKT pathway was found to be important for the LPA antiapoptosis effect, and administration of PI3K/AKT partially reversed the LPA-mediated protection against cisplatin-induced apoptosis (p < 0.05). lysophosphatidic acid 141-144 AKT serine/threonine kinase 1 Homo sapiens 15-18 26366416-7 2015 Moreover, PI3K/AKT pathway was found to be important for the LPA antiapoptosis effect, and administration of PI3K/AKT partially reversed the LPA-mediated protection against cisplatin-induced apoptosis (p < 0.05). lysophosphatidic acid 141-144 AKT serine/threonine kinase 1 Homo sapiens 114-117 23808384-8 2013 In human lung fibroblasts, the knockdown of LPA2 attenuated the LPA-induced expression of TGF-beta1 and the differentiation of lung fibroblasts to myofibroblasts, resulting in the decreased expression of FN, alpha-SMA, and collagen, as well as decreased activation of extracellular regulated kinase 1/2, Akt, Smad3, and p38 mitogen-activated protein kinase. lysophosphatidic acid 44-47 AKT serine/threonine kinase 1 Homo sapiens 304-307 25424429-0 2014 Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. lysophosphatidic acid 110-131 AKT serine/threonine kinase 1 Homo sapiens 62-65 23618389-7 2013 We demonstrated that G13, but not or to a lesser extent G12, Gi or Gq, was necessary for LPA-induced dpYAP and its nuclear translocation and that RhoA-ROCK, but not RhoB, RhoC, Rac1, cdc42, PI3K, ERK, or AKT, were required for the LPA-dpYAP effect. lysophosphatidic acid 89-92 AKT serine/threonine kinase 1 Homo sapiens 204-207 23919615-6 2013 Furthermore, Akt and GSK3beta phosphorylation levels were markedly enhanced in serum- or LPA-stimulated HIEC but not by EGF. lysophosphatidic acid 89-92 AKT serine/threonine kinase 1 Homo sapiens 13-16 23137199-5 2012 Conversely, in response to the G-protein-coupled receptor agonist lysophosphatidic acid, Akt phosphorylation was attenuated in p110beta-deficient myoblasts. lysophosphatidic acid 66-87 AKT serine/threonine kinase 1 Homo sapiens 89-92 22627809-3 2012 Lysophosphatidic acid (LPA)- induced migration was higher than that of epidermal growth factor (EGF)-induced migration; however, LPA-induced activation of Akt was lower than that stimulated by EGF. lysophosphatidic acid 129-132 AKT serine/threonine kinase 1 Homo sapiens 155-158 22159277-0 2012 LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 73-76 22049212-0 2012 Integrin alpha6beta4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. lysophosphatidic acid 37-40 AKT serine/threonine kinase 1 Homo sapiens 64-67 22049212-2 2012 In this study, we explore how the alpha(6)beta(4) integrin cooperates with lysophosphatidic acid (LPA) to activate Rho and Rac small GTPases. lysophosphatidic acid 75-96 AKT serine/threonine kinase 1 Homo sapiens 123-126 22049212-2 2012 In this study, we explore how the alpha(6)beta(4) integrin cooperates with lysophosphatidic acid (LPA) to activate Rho and Rac small GTPases. lysophosphatidic acid 98-101 AKT serine/threonine kinase 1 Homo sapiens 123-126 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 88-91 AKT serine/threonine kinase 1 Homo sapiens 263-266 21915944-10 2011 Furthermore, the enhancement of LPA on erythropoiesis was diminished by blocking c-Jun-activated kinase/signal transducer and activator of transcription and phosphatidylinositol 3-kinase/AKT activation, the downstream signaling pathways of EPO receptor, suggested that LPA might play a synergistic role with EPO to regulate erythropoietic process. lysophosphatidic acid 32-35 AKT serine/threonine kinase 1 Homo sapiens 187-190 20934509-3 2010 Exogenous LPA further stimulated ERK and Akt phosphorylation and NF-kappaB activity. lysophosphatidic acid 10-13 AKT serine/threonine kinase 1 Homo sapiens 41-44 21925926-8 2012 ERK1/2 and Akt-mediated NF-kappaB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion. lysophosphatidic acid 68-71 AKT serine/threonine kinase 1 Homo sapiens 11-14 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 AKT serine/threonine kinase 1 Homo sapiens 263-266 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 AKT serine/threonine kinase 1 Homo sapiens 263-266 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 AKT serine/threonine kinase 1 Homo sapiens 263-266 20576526-8 2010 In the brown pre-adipocytes, LPA instead induced Erk1/2 activation via two distinct non-transactivational pathways, one G(i)-protein dependent, involving PKC and Src activation, the other, a PTX-insensitive pathway, involving PI3K (but not Akt) activation. lysophosphatidic acid 29-32 AKT serine/threonine kinase 1 Homo sapiens 240-243 20861350-8 2010 Pertussis toxin, the inhibitors for PI3K and Akt also attenuated the inhibitory effect of LPA on CCL5/RANTES secretion. lysophosphatidic acid 90-93 AKT serine/threonine kinase 1 Homo sapiens 45-48 18779657-0 2008 Lysophosphatidic acid induces cell migration through the selective activation of Akt1. lysophosphatidic acid 0-21 AKT serine/threonine kinase 1 Homo sapiens 81-85 19864456-5 2009 The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is required for the inhibitory ISO-induced and Rap1B-mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA. lysophosphatidic acid 237-240 AKT serine/threonine kinase 1 Homo sapiens 207-210 19461126-4 2009 Analysis of signal transduction showed that LPA induces common signaling pathways of chemotaxins such as G(i) protein-dependent actin re-organization, activation of the mitogen-activated protein kinase p38 as well as phosphatidylinositol-3-kinase-dependent signal molecules [protein kinase B/Akt and glycogen synthase kinase-3beta (GSK-3beta)]. lysophosphatidic acid 44-47 AKT serine/threonine kinase 1 Homo sapiens 292-295 19910524-10 2010 LPA-mediated stimulation of Cl(-)/OH(-) exchange activity was dependent on activation of phosphatidylinositol 3-kinase/Akt signaling pathway. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 119-122 19906815-11 2010 Mechanistic dissection disclosed that LPA functioned mainly via the LPA1 receptor, Gi protein, various signal mediators of ERK, protein kinase C, p38, Akt, and c-Jun N-terminal kinase, and nuclear factor-kappaB pathways to secrete these chemokines. lysophosphatidic acid 38-41 AKT serine/threonine kinase 1 Homo sapiens 151-154 18779657-7 2008 Furthermore, cells lacking Akt1 displayed defect in LPA-induced cell migration. lysophosphatidic acid 52-55 AKT serine/threonine kinase 1 Homo sapiens 27-31 18779657-8 2008 Re-expression of Akt1 in DKO (Akt1-/-Akt2-/-) cells restored LPA-induced cell migration, whereas re-expression of Akt2 in DKO cells could not restore the LPA-induced cell migration. lysophosphatidic acid 61-64 AKT serine/threonine kinase 1 Homo sapiens 17-21 18779657-10 2008 These results suggest that LPA is a major factor responsible for AOCP-induced cell migration and signaling specificity of Akt1 may dictate LPA-induced cell migration. lysophosphatidic acid 27-30 AKT serine/threonine kinase 1 Homo sapiens 122-126 17251460-8 2007 Consistent with the effects on epithelial migration, these inhibitors, as well as the Src kinase inhibitor (PP2), retarded LPA-induced activation of EGFR and its downstream effectors ERK and AKT in THCE cells. lysophosphatidic acid 123-126 AKT serine/threonine kinase 1 Homo sapiens 191-194 17236191-6 2007 Furthermore, LPA induced a higher level of Ras-GTP and Akt phosphorylation in Nf1-/- SCs as compared to WT cells. lysophosphatidic acid 13-16 AKT serine/threonine kinase 1 Homo sapiens 55-58 16882668-7 2006 Lysophosphatidic acid activates Akt that in turn acts in a feedback loop to block the cleavage of poly-(ADP-ribose) polymerase and DNA fragmentation factor as well as prevent apoptosis. lysophosphatidic acid 0-21 AKT serine/threonine kinase 1 Homo sapiens 32-35 16760261-6 2006 Pertussis toxin (PTX) blocks LPA-induced activation of p38 and ERK but only slightly inhibits LPA-induced activation of Akt. lysophosphatidic acid 94-97 AKT serine/threonine kinase 1 Homo sapiens 120-123 16760261-8 2006 In these cells, both Akt and ERK pathways are important for LPA-induced proliferation. lysophosphatidic acid 60-63 AKT serine/threonine kinase 1 Homo sapiens 21-24 16760261-12 2006 LPA-induced activations of p38, ERK, and Akt kinases, as well as proliferation, are inhibited by Ki16425. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 41-44 17085645-7 2006 In OVCAR-3 and PC-3 cells, the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin/p70S6K and p42/p44 mitogen-activated protein kinase pathways were required for LPA-induced HIF-1alpha and VEGF expressions, whereas only the phosphoinositide 3-kinase/mammalian target of rapamycin/p70S6K pathway was important in SK-Hep1 cells. lysophosphatidic acid 170-173 AKT serine/threonine kinase 1 Homo sapiens 57-60 16301320-10 2006 LPA increased the amount of GTP-bound Rac in the cells and isoproterenol reduced basal levels of GTP-bound Rac and blunted the effect of LPA. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 38-41 16301320-10 2006 LPA increased the amount of GTP-bound Rac in the cells and isoproterenol reduced basal levels of GTP-bound Rac and blunted the effect of LPA. lysophosphatidic acid 137-140 AKT serine/threonine kinase 1 Homo sapiens 38-41 15857137-11 2005 Analogue 15 was also more effective than 1-oleoyl-LPA in activating MAPK and AKT in cells expressing high levels of LPA(3). lysophosphatidic acid 41-53 AKT serine/threonine kinase 1 Homo sapiens 77-80 15920762-6 2006 In C9 hepatocytes, agonist activation of AT1 angiotensin II (AT1-R), lysophosphatidic acid (LPA), and EGF receptors caused phosphorylation of Akt through activation of the EGF-R in a PI3K-dependent manner. lysophosphatidic acid 69-90 AKT serine/threonine kinase 1 Homo sapiens 142-145 15920762-6 2006 In C9 hepatocytes, agonist activation of AT1 angiotensin II (AT1-R), lysophosphatidic acid (LPA), and EGF receptors caused phosphorylation of Akt through activation of the EGF-R in a PI3K-dependent manner. lysophosphatidic acid 92-95 AKT serine/threonine kinase 1 Homo sapiens 142-145 15890344-2 2005 LPA also induced the activation/phosphorylation of Src, Akt and p44/42 MAPK, and the translocation of PKC-delta from cytosol to membrane coupled to its tyrosine phosphorylation. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 56-59 16230405-2 2005 LPAAT-beta converts lysophosphatidic acid to phosphatidic acid, which functions as a cofactor in Akt/mTOR and Ras/Raf/Erk pathways. lysophosphatidic acid 20-41 AKT serine/threonine kinase 1 Homo sapiens 97-100 15728708-4 2005 LPA2 activated Akt and Erk1/2 in response to LPA. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 15-18 15297884-5 2004 LPA increased phosphatidylinositol 3-kinase (PI3K)-dependent Akt activation, cellular FLICE-inhibitory protein (cFLIP) expression, and Bad phosphorylation, resulting in inhibition of caspase-8 activation and Bad translocation to mitochondria. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 61-64 15618220-0 2005 Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB. lysophosphatidic acid 0-21 AKT serine/threonine kinase 1 Homo sapiens 157-164 15618220-0 2005 Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB. lysophosphatidic acid 23-26 AKT serine/threonine kinase 1 Homo sapiens 157-164 15618220-10 2005 The protective effect of LPA was inhibited by blocking activation of the phosphatidylinositol 3-kinase/AKT signaling pathway. lysophosphatidic acid 25-28 AKT serine/threonine kinase 1 Homo sapiens 103-106 15657067-9 2005 The functional interactions between IGF-1 receptor, lysophosphatidic acid (LPA) signaling, and EGF receptor were observed, both direct and/or indirectly on phospho-Akt, phospho-Erk1/2, and phospho-ribosomal S6. lysophosphatidic acid 52-73 AKT serine/threonine kinase 1 Homo sapiens 164-167 15297884-6 2004 The antiapoptotic effect of LPA was abrogated by PI3K inhibitor, transfection with dominant-negative Akt, and specific downregulation of cFLIP expression using siRNA and further increased by siRNA-mediated suppression of Bad expression. lysophosphatidic acid 28-31 AKT serine/threonine kinase 1 Homo sapiens 101-104 14769825-6 2004 LPA caused much less phosphorylation of Akt and this was dependent on PLD activity. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 40-43 15471896-0 2005 Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. lysophosphatidic acid 99-120 AKT serine/threonine kinase 1 Homo sapiens 74-77 15471896-7 2005 Pharmacological and genetic inhibition assays revealed that Gi-mediated PI3K activation phosphorylated downstream Akt and subsequently induced NF-kappaB activation causes the induction of IL-6 by LPA in SK-OV-3 cells. lysophosphatidic acid 196-199 AKT serine/threonine kinase 1 Homo sapiens 114-117 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 49-52 AKT serine/threonine kinase 1 Homo sapiens 133-136 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 89-92 AKT serine/threonine kinase 1 Homo sapiens 133-136 15305333-7 2004 RESULTS: Molecular dissection of the LPA-regulated PC3 cell survival revealed the sequential phosphorylation of Akt, IkappaB, and transcriptional activation of NF-kappaB. lysophosphatidic acid 37-40 AKT serine/threonine kinase 1 Homo sapiens 112-115 15305333-8 2004 Both Akt and NF-kappaB were required to escape serum deprivation-induced cell death since their inhibition abrogated the LPA-mediated PC3 cell survival. lysophosphatidic acid 121-124 AKT serine/threonine kinase 1 Homo sapiens 5-8 14769825-7 2004 Toxin B, which inactivates Rho GTPases, markedly impaired PLD1 activation and phosphorylation of Akt, p70(S6K), and 4E-BP1 induced by LPA but had a minimal or no effect on the actions of PDGF. lysophosphatidic acid 134-137 AKT serine/threonine kinase 1 Homo sapiens 97-100 14769825-8 2004 These results support the hypothesis that LPA activates protein translation through the action of PLD1-generated PA on mTOR and the PI3K/Akt pathway whereas PDGF acts through P13K/Akt independent of PLD1. lysophosphatidic acid 42-45 AKT serine/threonine kinase 1 Homo sapiens 137-140 14723340-4 2003 We first examined the regulation of the three major subfamilies of mitogen-activated protein (MAP) kinases and of the Akt pathway by LPA. lysophosphatidic acid 133-136 AKT serine/threonine kinase 1 Homo sapiens 118-121 12902401-5 2003 LPA-induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins, on activation of the small GTPases Ras, Rac and RhoA, and on GTPase-dependent activation of ERK. lysophosphatidic acid 0-3 AKT serine/threonine kinase 1 Homo sapiens 143-146 12181443-0 2002 Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. lysophosphatidic acid 26-47 AKT serine/threonine kinase 1 Homo sapiens 0-3 12181443-1 2002 The signaling pathways that lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) use to activate Akt in ovarian cancer cells are investigated here. lysophosphatidic acid 28-49 AKT serine/threonine kinase 1 Homo sapiens 106-109 12181443-1 2002 The signaling pathways that lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) use to activate Akt in ovarian cancer cells are investigated here. lysophosphatidic acid 51-54 AKT serine/threonine kinase 1 Homo sapiens 106-109 12181443-2 2002 We show for the first time, with the use of both pharmacological and genetic inhibitors, that the kinase activity and S473 phosphorylation of Akt induced by LPA and S1P requires both mitogen-activated protein (MAP) kinase kinase (MEK) and p38 MAP kinase, and MEK is likely to be upstream of p38, in HEY ovarian cancer cells. lysophosphatidic acid 157-160 AKT serine/threonine kinase 1 Homo sapiens 142-145 12181443-10 2002 In contrast to S1P and PDGF, LPA requires Rho for Akt S473 phosphorylation, and Rho is upstream of phosphatidylinositol 3-kinase (PI3-K). lysophosphatidic acid 29-32 AKT serine/threonine kinase 1 Homo sapiens 50-53 11099498-0 2001 Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading. lysophosphatidic acid 52-73 AKT serine/threonine kinase 1 Homo sapiens 14-17 11099498-8 2001 These findings indicate that both G alpha(i) and G beta gamma stimulate Rac and Cdc42 pathways with lysophosphatidic acid-induced cell spreading on fibronectin. lysophosphatidic acid 100-121 AKT serine/threonine kinase 1 Homo sapiens 72-75 11230322-0 2001 Src and Rac mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter. lysophosphatidic acid 37-58 AKT serine/threonine kinase 1 Homo sapiens 8-11 11230322-12 2001 The nonreceptor tyrosine kinase Src and the small GTPase Rac mediate the effects of both ET and LPA in stimulation of the hBNP promoter. lysophosphatidic acid 96-99 AKT serine/threonine kinase 1 Homo sapiens 57-60 10220449-6 1999 Moreover, LPA"s effect depends on Akt, a downstream kinase that can mediate phosphoinositide 3-kinase-dependent survival, as demonstrated by both Western blot and transfection analyses. lysophosphatidic acid 10-13 AKT serine/threonine kinase 1 Homo sapiens 34-37 12393875-2 2003 In addition to stimulating cell proliferation, LPA also induces cytoskeletal changes and promotes cell migration in a RhoA- and Rac-dependent manner. lysophosphatidic acid 47-50 AKT serine/threonine kinase 1 Homo sapiens 128-131 12393875-7 2003 Tiam1-deficient cells show enhanced RhoA activation, stress fiber formation, and cell rounding in response to LPA, consistent with Tiam1/Rac counteracting RhoA. lysophosphatidic acid 110-113 AKT serine/threonine kinase 1 Homo sapiens 137-140 11061948-6 2000 Treatment of the PC-3 cells with lysophosphatidic acid, EGF or serum induced an 8-fold increase in the phosphorylation levels of the mitogen activated protein kinases Erk 1 and 2, and a 3-fold increase in the phosphorylation level of Akt. lysophosphatidic acid 33-54 AKT serine/threonine kinase 1 Homo sapiens 234-237 11061948-7 2000 Erk 1/2 and Akt phosphorylation by lysophosphatidic acid and serum was inhibited by pertussis toxin, suggesting a Gi/o subunit dependent mechanism. lysophosphatidic acid 35-56 AKT serine/threonine kinase 1 Homo sapiens 12-15 11061948-9 2000 Expression of the G beta gamma sequestrant peptide G protein coupled receptor kinase 2 carboxy terminus inhibited the lysophosphatidic acid and serum mediated activation of Erk 1/2 and Akt but showed no effect on the IGF-1 or EGF mediated response. lysophosphatidic acid 118-139 AKT serine/threonine kinase 1 Homo sapiens 185-188 11062066-5 2000 In addition to activation of mitogen-activated protein kinase (MAPK), LPA stimulates a modest PTX-sensitive phosphorylation/activation of the serine/threonine kinase Akt, a survival mediator downstream of phosphoinositide 3-kinase (PI3K). lysophosphatidic acid 70-73 AKT serine/threonine kinase 1 Homo sapiens 166-169 11062066-6 2000 Inhibition of PI3K with LY 294002 or wortmannin resulted in a marked inhibition of LPA-induced DNA synthesis, and yet the survival activity of LPA decreased by only 20-30%, suggesting a limited input of the PI3K-Akt cascade in LPA-induced cell survival. lysophosphatidic acid 143-146 AKT serine/threonine kinase 1 Homo sapiens 212-215 11062066-6 2000 Inhibition of PI3K with LY 294002 or wortmannin resulted in a marked inhibition of LPA-induced DNA synthesis, and yet the survival activity of LPA decreased by only 20-30%, suggesting a limited input of the PI3K-Akt cascade in LPA-induced cell survival. lysophosphatidic acid 143-146 AKT serine/threonine kinase 1 Homo sapiens 212-215