PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26609804-11 2017 mDia1 silencing and ROCK inhibition suppressed the LPA-induced formation of the cytoskeleton, FA and phosphorylation of FAK and paxillin. lysophosphatidic acid 51-54 protein tyrosine kinase 2 Homo sapiens 120-123 26786295-6 2016 Furthermore, the KLF5/FYN/p-FAK axis is necessary for lysophosphatidic acid (LPA) to promote cell migration. lysophosphatidic acid 54-75 protein tyrosine kinase 2 Homo sapiens 28-31 26786295-6 2016 Furthermore, the KLF5/FYN/p-FAK axis is necessary for lysophosphatidic acid (LPA) to promote cell migration. lysophosphatidic acid 77-80 protein tyrosine kinase 2 Homo sapiens 28-31 25491146-7 2015 However, when added 15 minutes prior to LPA, EPA suppresses LPA-induced activating phosphorylations of ERK, FAK, and p70S6K, and expression of the matricellular protein CCN1. lysophosphatidic acid 60-63 protein tyrosine kinase 2 Homo sapiens 108-111 24461407-8 2014 LPA functioned as an antiapoptotic cytokine by activation of the phosphorylation of FAK and ERK. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 84-87 24461407-11 2014 LPA could effectively rescue HDPCs from ischemia-induced apoptosis via regulation of Bax and Bcl-2 and the activation of phosphorylated FAK and phosphorylated ERK. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 136-139 24061591-0 2013 Lysophosphatidic acid stimulates activation of focal adhesion kinase and paxillin and promotes cell motility, via LPA1-3, in human pancreatic cancer. lysophosphatidic acid 0-21 protein tyrosine kinase 2 Homo sapiens 47-68 24061591-4 2013 OBJECTIVES: This study examined the involvement of LPA1-3 in LPA-induced activation of FAK and paxillin, and in cell motility, in pancreatic cancer PANC-1 cells. lysophosphatidic acid 51-54 protein tyrosine kinase 2 Homo sapiens 87-90 24061591-10 2013 Treatment with LPA induced both time and dose-dependent tyrosine phosphorylation of FAK and paxillin. lysophosphatidic acid 15-18 protein tyrosine kinase 2 Homo sapiens 84-87 24061591-13 2013 CONCLUSIONS: These results suggest LPA induces activation of FAK and paxillin via LPA1-3, which may contribute to the increased cell motility in human pancreatic cancer PANC-1 cells. lysophosphatidic acid 35-38 protein tyrosine kinase 2 Homo sapiens 61-64 21968138-0 2011 Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells. lysophosphatidic acid 0-21 protein tyrosine kinase 2 Homo sapiens 98-101 22473839-0 2012 Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells. lysophosphatidic acid 11-32 protein tyrosine kinase 2 Homo sapiens 68-89 22473839-9 2012 LPA causes minor FAK proteolysis when added alone, but protects against ionomycin-induced proteolysis in a time-dependent manner. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 17-20 22473839-14 2012 CONCLUSIONS: The complex effects of LPA on calpain-mediated proteolysis of FAK and other adhesion proteins are likely to play a role in the ability of LPA to promote attachment, migration, and survival of prostate cancer cells. lysophosphatidic acid 36-39 protein tyrosine kinase 2 Homo sapiens 75-78 22473839-14 2012 CONCLUSIONS: The complex effects of LPA on calpain-mediated proteolysis of FAK and other adhesion proteins are likely to play a role in the ability of LPA to promote attachment, migration, and survival of prostate cancer cells. lysophosphatidic acid 151-154 protein tyrosine kinase 2 Homo sapiens 75-78 21968138-10 2011 Moreover, we showed that Src acts upstream of RhoA in this signalling cascade and that LPA induces focal adhesion formation and FAK redistribution and activation in confluent monolayers. lysophosphatidic acid 87-90 protein tyrosine kinase 2 Homo sapiens 128-131 18757408-2 2008 Here, we show that simultaneous signaling by lysophosphatidic acid (LPA) and platelet-derived growth factor (PDGF) initiates glioma cell spreading and migration through syndecan-4-independent activation of paxillin and FAK and by stabilizing expression of RhoA, TM1, TM2, and TM3. lysophosphatidic acid 45-66 protein tyrosine kinase 2 Homo sapiens 219-222 21073482-8 2011 LPA also increased the level of tyrosine phosphorylation of paxillin at 30min (P<0.05) and FAK at 5 and 30min (P<0.05). lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 94-97 21073482-10 2011 Y-27632 also suppressed the effects of LPA on p-paxillin and p-FAK at 5 and 30min (P<0.05). lysophosphatidic acid 39-42 protein tyrosine kinase 2 Homo sapiens 63-66 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 13-16 protein tyrosine kinase 2 Homo sapiens 53-74 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 13-16 protein tyrosine kinase 2 Homo sapiens 76-79 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 13-16 protein tyrosine kinase 2 Homo sapiens 107-110 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 13-16 protein tyrosine kinase 2 Homo sapiens 107-110 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 160-163 protein tyrosine kinase 2 Homo sapiens 107-110 19586906-6 2009 Furthermore, LPA induced tyrosine phosphorylation of focal adhesion kinase (FAK) and overexpression of the FAK inhibitor, and FAK-related non-kinase-attenuated LPA induced increases in TER and E-cadherin accumulation at cell-cell junctions. lysophosphatidic acid 160-163 protein tyrosine kinase 2 Homo sapiens 107-110 19586906-7 2009 Overexpression of dominant negative protein kinase delta and zeta attenuated LPA-induced phosphorylation of FAK, accumulation of E-cadherin at cell-cell junctions, and an increase in TER. lysophosphatidic acid 77-80 protein tyrosine kinase 2 Homo sapiens 108-111 18757408-2 2008 Here, we show that simultaneous signaling by lysophosphatidic acid (LPA) and platelet-derived growth factor (PDGF) initiates glioma cell spreading and migration through syndecan-4-independent activation of paxillin and FAK and by stabilizing expression of RhoA, TM1, TM2, and TM3. lysophosphatidic acid 68-71 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 26-47 protein tyrosine kinase 2 Homo sapiens 62-65 18303050-9 2008 These studies support a model in which FAK and PDZ-RhoGEF cooperate to induce Rho/ROCKII-dependent focal adhesion movement and trailing-edge retraction in response to LPA. lysophosphatidic acid 167-170 protein tyrosine kinase 2 Homo sapiens 39-42 17012251-1 2006 We have previously reported that both hypotonic stress (HTS) and lysophosphatidic acid (LPA) induce ATP release and a transient reorganization of actin through sequential activation of RhoA/Rho-kinase and focal adhesion kinase F-actin (FAK)/paxillin in human umbilical cord vein endothelial cells (HUVECs). lysophosphatidic acid 65-86 protein tyrosine kinase 2 Homo sapiens 205-234 17012251-1 2006 We have previously reported that both hypotonic stress (HTS) and lysophosphatidic acid (LPA) induce ATP release and a transient reorganization of actin through sequential activation of RhoA/Rho-kinase and focal adhesion kinase F-actin (FAK)/paxillin in human umbilical cord vein endothelial cells (HUVECs). lysophosphatidic acid 65-86 protein tyrosine kinase 2 Homo sapiens 236-239 17012251-1 2006 We have previously reported that both hypotonic stress (HTS) and lysophosphatidic acid (LPA) induce ATP release and a transient reorganization of actin through sequential activation of RhoA/Rho-kinase and focal adhesion kinase F-actin (FAK)/paxillin in human umbilical cord vein endothelial cells (HUVECs). lysophosphatidic acid 88-91 protein tyrosine kinase 2 Homo sapiens 205-234 17012251-1 2006 We have previously reported that both hypotonic stress (HTS) and lysophosphatidic acid (LPA) induce ATP release and a transient reorganization of actin through sequential activation of RhoA/Rho-kinase and focal adhesion kinase F-actin (FAK)/paxillin in human umbilical cord vein endothelial cells (HUVECs). lysophosphatidic acid 88-91 protein tyrosine kinase 2 Homo sapiens 236-239 16301993-6 2006 However, Gi inhibitor pertussis toxin or dominant-negative H-Ras still significantly inhibited LPA-stimulated cell migration in cells expressing the membrane anchored FAK containing a mutation in the autophosphorylation site [CD2-FAK(Y397A)]. lysophosphatidic acid 95-98 protein tyrosine kinase 2 Homo sapiens 167-170 16301993-6 2006 However, Gi inhibitor pertussis toxin or dominant-negative H-Ras still significantly inhibited LPA-stimulated cell migration in cells expressing the membrane anchored FAK containing a mutation in the autophosphorylation site [CD2-FAK(Y397A)]. lysophosphatidic acid 95-98 protein tyrosine kinase 2 Homo sapiens 230-233 16301993-7 2006 These results suggest that FAK autophosphorylation plays a role in LPA-stimulated cell migration. lysophosphatidic acid 67-70 protein tyrosine kinase 2 Homo sapiens 27-30 16301993-8 2006 With the aid of p115RhoGEF-RGS, G12 and G13 minigenes to inhibit G12/13, we found that the G12/13 pathway was required for LPA-induced FAK autophosphorylation and efficient cell migration. lysophosphatidic acid 123-126 protein tyrosine kinase 2 Homo sapiens 135-138 16301993-9 2006 Moreover, LPA activated RhoA and Rho kinase (ROCK) in a G12/13-dependent manner and their activities were required for LPA-induced FAK autophosphorylation. lysophosphatidic acid 10-13 protein tyrosine kinase 2 Homo sapiens 131-134 16301993-11 2006 Our studies show that the G12/13-RhoA-ROCK signaling pathway mediates LPA-induced FAK autophosphorylation and contributes to LPA-stimulated cell migration. lysophosphatidic acid 70-73 protein tyrosine kinase 2 Homo sapiens 82-85 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 26-47 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 26-47 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 49-52 protein tyrosine kinase 2 Homo sapiens 62-65 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 49-52 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 49-52 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 207-210 protein tyrosine kinase 2 Homo sapiens 62-65 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 207-210 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-2 2006 We previously showed that Lysophosphatidic acid (LPA) induced FAK membrane redistribution and autophosphorylation in ovarian cancer SK-OV3 cells and the signaling pathway consisting of Gi-Ras-MEKK1 mediated LPA-induced FAK membrane redistribution but not FAK autophosphorylation. lysophosphatidic acid 207-210 protein tyrosine kinase 2 Homo sapiens 219-222 16301993-4 2006 These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. lysophosphatidic acid 46-49 protein tyrosine kinase 2 Homo sapiens 58-61 16301993-4 2006 These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. lysophosphatidic acid 99-102 protein tyrosine kinase 2 Homo sapiens 58-61 16301993-4 2006 These findings raised the question of whether LPA-induced FAK autophosphorylation was required for LPA-stimulated cell migration and what signaling mechanism was involved in LPA-induced FAK autophosphorylation. lysophosphatidic acid 99-102 protein tyrosine kinase 2 Homo sapiens 58-61 15155793-5 2004 HTS and LPA induced membrane translocation of RhoA, which occurs when RhoA is activated, and tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin. lysophosphatidic acid 8-11 protein tyrosine kinase 2 Homo sapiens 121-142 15155793-5 2004 HTS and LPA induced membrane translocation of RhoA, which occurs when RhoA is activated, and tyrosine phosphorylation of focal adhesion kinase (FAK) and paxillin. lysophosphatidic acid 8-11 protein tyrosine kinase 2 Homo sapiens 144-147 15066181-0 2004 Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells. lysophosphatidic acid 53-74 protein tyrosine kinase 2 Homo sapiens 83-104 15175910-6 2004 RESULTS: Incubation of cells with LPA (10 micro M) for 2 min resulted in marked activation of Rho, and this effect was blocked by pretreatment with the Rho inhibitor exoenzyme C3 (2 micro g/ml) for 24 h. Tyrosine phosphorylation of both paxillin and FAK was detected in HCE cells under basal conditions by immunofluorescence staining, immunoprecipitation, and immunoblot analyses. lysophosphatidic acid 34-37 protein tyrosine kinase 2 Homo sapiens 250-253 15066181-2 2004 In the present study, we investigated the roles of p21-activated kinase 1 (PAK1) on LPA-induced focal adhesion kinase (FAK) phosphorylation and cell motility. lysophosphatidic acid 84-87 protein tyrosine kinase 2 Homo sapiens 96-117 15066181-2 2004 In the present study, we investigated the roles of p21-activated kinase 1 (PAK1) on LPA-induced focal adhesion kinase (FAK) phosphorylation and cell motility. lysophosphatidic acid 84-87 protein tyrosine kinase 2 Homo sapiens 119-122 15066181-6 2004 Furthermore, PAK1 was necessary for FAK phosphorylation by LPA, which might cause cell migration, as transfection of the kinase deficient mutant of PAK1 or PAK auto-inhibitory domain significantly abrogated LPA-induced FAK phosphorylation. lysophosphatidic acid 59-62 protein tyrosine kinase 2 Homo sapiens 36-39 15066181-6 2004 Furthermore, PAK1 was necessary for FAK phosphorylation by LPA, which might cause cell migration, as transfection of the kinase deficient mutant of PAK1 or PAK auto-inhibitory domain significantly abrogated LPA-induced FAK phosphorylation. lysophosphatidic acid 59-62 protein tyrosine kinase 2 Homo sapiens 219-222 15066181-6 2004 Furthermore, PAK1 was necessary for FAK phosphorylation by LPA, which might cause cell migration, as transfection of the kinase deficient mutant of PAK1 or PAK auto-inhibitory domain significantly abrogated LPA-induced FAK phosphorylation. lysophosphatidic acid 207-210 protein tyrosine kinase 2 Homo sapiens 36-39 15066181-6 2004 Furthermore, PAK1 was necessary for FAK phosphorylation by LPA, which might cause cell migration, as transfection of the kinase deficient mutant of PAK1 or PAK auto-inhibitory domain significantly abrogated LPA-induced FAK phosphorylation. lysophosphatidic acid 207-210 protein tyrosine kinase 2 Homo sapiens 219-222 12738990-5 2003 Tyrosine-phosphorylation of FAK especially at Tyr-397 was obviously persistent after stimulation with LPA + FN compared to after stimulation with LPA alone. lysophosphatidic acid 102-105 protein tyrosine kinase 2 Homo sapiens 28-31 12738990-9 2003 Moreover, we demonstrated that autophosphorylation of FAK at Tyr-397, downstream of RhoA, contributed to formation of focal adhesions and was critical in LPA-induced MM1 cell migration by developing autophosphorylation-deficient (Y397F) FAK-transfectants. lysophosphatidic acid 154-157 protein tyrosine kinase 2 Homo sapiens 54-57 12738990-9 2003 Moreover, we demonstrated that autophosphorylation of FAK at Tyr-397, downstream of RhoA, contributed to formation of focal adhesions and was critical in LPA-induced MM1 cell migration by developing autophosphorylation-deficient (Y397F) FAK-transfectants. lysophosphatidic acid 154-157 protein tyrosine kinase 2 Homo sapiens 237-240 12738990-10 2003 Collectively, Pal-cPA hampered LPA-induced morphological changes and transcellular migration of MM1 cells through downregulating active RhoA and inhibiting its downstream events including autophosphorylation of FAK. lysophosphatidic acid 31-34 protein tyrosine kinase 2 Homo sapiens 211-214 12441137-3 2002 LPA (0.4-100 microM) stimulated migration, FAK tyrosine phosphorylation, and stress fiber assembly with a sigmoidal dose response. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 43-46 12441137-6 2002 A dose of 1-10 ng/ml PDGF acted synergistically with LPA (10 microM) to stimulate FAK tyrosine phosphorylation and migration, whereas higher concentrations of PDGF (100-250 ng/ml) inhibited FAK tyrosine phosphorylation and migration in response to LPA (10 microM). lysophosphatidic acid 53-56 protein tyrosine kinase 2 Homo sapiens 82-85 12441137-7 2002 These data indicate that PDGF and LPA coordinately govern the migration of HMFs by differentially regulating FAK and suggest a novel model in which PDGF, acting as an amplifier/attenuator of LPA-induced signaling, facilitates HMF accumulation within injured areas of the liver. lysophosphatidic acid 34-37 protein tyrosine kinase 2 Homo sapiens 109-112 11346466-13 2001 Low LPA enhanced the tyrosine phosphorylation of FAK whereas high LPA reduced it. lysophosphatidic acid 4-7 protein tyrosine kinase 2 Homo sapiens 49-52 10800944-5 2000 In contrast, preincubation with selective inhibitors of either Rho (C3 exoenzyme) or Rho kinase (HA-1 077) resulted in 80-90% reductions in LPA-induced FAK phosphorylation but only 40-50% decreases in mAChR-stimulated phosphorylation. lysophosphatidic acid 140-143 protein tyrosine kinase 2 Homo sapiens 152-155 9182707-6 1997 Similarly, PMA also decreased LPA-induced tyrosine phosphorylation of p125(FAK) and paxillin without abrogating the response to SPP. lysophosphatidic acid 30-33 protein tyrosine kinase 2 Homo sapiens 70-79 9354853-11 1997 We observed a profound effect of LPA on the structure of the cytoskeleton and on the phosphorylation of Focal Adhesion Kinase (p125FAK), indicating that 3T3-L1 adipocytes respond to LPA and that Rho was activated by LPA. lysophosphatidic acid 33-36 protein tyrosine kinase 2 Homo sapiens 127-134 9354853-11 1997 We observed a profound effect of LPA on the structure of the cytoskeleton and on the phosphorylation of Focal Adhesion Kinase (p125FAK), indicating that 3T3-L1 adipocytes respond to LPA and that Rho was activated by LPA. lysophosphatidic acid 182-185 protein tyrosine kinase 2 Homo sapiens 127-134 9354853-11 1997 We observed a profound effect of LPA on the structure of the cytoskeleton and on the phosphorylation of Focal Adhesion Kinase (p125FAK), indicating that 3T3-L1 adipocytes respond to LPA and that Rho was activated by LPA. lysophosphatidic acid 182-185 protein tyrosine kinase 2 Homo sapiens 127-134 8809054-4 1996 For this, cells were grown on poly(L-lysine) plates, and the tyrosine phosphorylation of pp125FAK and paxillin was increased by addition of lysophosphatidic acid. lysophosphatidic acid 140-161 protein tyrosine kinase 2 Homo sapiens 89-97 7741705-8 1995 LPA stimulated an increase in the tyrosine phosphorylation of focal adhesion kinase pp125 (pp125FAK) in EAhy 926 cells which was both protein kinase C- and pertussis toxin-independent. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 91-99 7639713-6 1995 LPA, SPC and LPS also induced rapid increases in tyrosine phosphorylation of specific cellular proteins, including p125FAK. lysophosphatidic acid 0-3 protein tyrosine kinase 2 Homo sapiens 115-122 7741705-9 1995 These results are discussed in terms of the pathways regulating both MAP kinase and pp125FAK in response to LPA in the EAhy 926 endothelial cells line. lysophosphatidic acid 108-111 protein tyrosine kinase 2 Homo sapiens 84-92 7706413-2 1994 We have investigated the possible involvement of tyrosine phosphorylation and the focal adhesion kinase (FAK) in the cytoskeletal changes induced by serum or lysophosphatidic acid (LPA) in quiescent Swiss 3T3 fibroblasts. lysophosphatidic acid 181-184 protein tyrosine kinase 2 Homo sapiens 82-103 7706413-2 1994 We have investigated the possible involvement of tyrosine phosphorylation and the focal adhesion kinase (FAK) in the cytoskeletal changes induced by serum or lysophosphatidic acid (LPA) in quiescent Swiss 3T3 fibroblasts. lysophosphatidic acid 181-184 protein tyrosine kinase 2 Homo sapiens 105-108 7706413-9 1994 However, these inhibitors did prevent FAK phosphorylation and cytoskeletal assembly in response to lysophosphatidic acid (LPA), one component of serum previously shown to stimulate assembly of focal adhesions and stress fibers. lysophosphatidic acid 99-120 protein tyrosine kinase 2 Homo sapiens 38-41 7706413-9 1994 However, these inhibitors did prevent FAK phosphorylation and cytoskeletal assembly in response to lysophosphatidic acid (LPA), one component of serum previously shown to stimulate assembly of focal adhesions and stress fibers. lysophosphatidic acid 122-125 protein tyrosine kinase 2 Homo sapiens 38-41 7929215-8 1994 Since tyrosine phosphorylation of FAK is essential to its activity as a transduction component of integrin-, peptide-, and lysophosphatidic acid-mediated signaling, the data establish a link between A beta aggregates and signal transduction pathways implicated in diverse cell functions including neurite outgrowth, control of the cell cycle, and apoptosis. lysophosphatidic acid 123-144 protein tyrosine kinase 2 Homo sapiens 34-37