PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32409422-1 2020 Lysophosphatidic acid (LPA) is the natural ligand for two phylogenetically distinct families of receptors (LPA1-3, LPA4-6) whose pathways control a variety of physiologic and pathophysiological responses. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 115-121 32409422-1 2020 Lysophosphatidic acid (LPA) is the natural ligand for two phylogenetically distinct families of receptors (LPA1-3, LPA4-6) whose pathways control a variety of physiologic and pathophysiological responses. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 4 Homo sapiens 115-121 27993681-0 2017 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 42-46 27993681-0 2017 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 4 Homo sapiens 42-46 27993681-4 2017 LPA treatment increased the cell growth activities of LPA4 and LPA6 knockdown cells, compared with control cells. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 4 Homo sapiens 54-58 21746769-2 2011 Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth subtype, LPA4. lysophosphatidic acid 12-15 lysophosphatidic acid receptor 4 Homo sapiens 230-234 23467751-12 2013 Finally, LPA-induced cell motility was suppressed by ectopic LPA4 expression as well as by Ki16425, Rac1 inhibitor or Y-27632. lysophosphatidic acid 9-12 lysophosphatidic acid receptor 4 Homo sapiens 61-65 23084965-8 2013 The LPA-mediated loss of barrier function in HPAECs appears to be independent of the LPA1 receptor and likely to be mediated via the LPA6 receptor although we cannot exclude an additional role for the LPA2 and LPA4 receptors in mediating these effects. lysophosphatidic acid 4-7 lysophosphatidic acid receptor 4 Homo sapiens 210-214 26084470-7 2015 LPA1 is responsible for LPA-driven cell motility, which is attenuated by LPA4. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 4 Homo sapiens 73-77 19423373-0 2009 Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study. lysophosphatidic acid 43-64 lysophosphatidic acid receptor 4 Homo sapiens 96-102 20482379-3 2010 In Chinese hamster ovary cells expressing the human GPR23, LPA induced an increase in cellular cyclic adenosine monophosphate (cAMP) and calcium levels. lysophosphatidic acid 59-62 lysophosphatidic acid receptor 4 Homo sapiens 52-57 20482379-6 2010 Here we report the identification of novel GPR23 agonists, inverse agonists, and a negative modulator from 2 high-throughput screens, a beta-lactamase reporter screen, and a [3H]LPA-binding screen. lysophosphatidic acid 178-181 lysophosphatidic acid receptor 4 Homo sapiens 43-48 19423373-0 2009 Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study. lysophosphatidic acid 43-64 lysophosphatidic acid receptor 4 Homo sapiens 103-109 19423373-0 2009 Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study. lysophosphatidic acid 43-64 lysophosphatidic acid receptor 4 Homo sapiens 110-115 19423373-11 2009 Based on these analyses, LPA is predicted to bind to LPA(4) in an orientation similar to that reported for LPA(1-3), but through a different network of hydrogen bonds. lysophosphatidic acid 25-28 lysophosphatidic acid receptor 4 Homo sapiens 53-59 19366702-1 2009 Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 133-140 15461590-1 2005 LPA (lysophosphatidic acid), a potent bioactive phospholipid, elicits diverse cellular responses through activation of the G-protein-coupled receptors LPA1-LPA4. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 4 Homo sapiens 156-160 18337445-6 2008 This elevated LPA, acting through LPA(4), modulates VEGF responsiveness by inducing VEGF receptor (VEGFR)-2 expression. lysophosphatidic acid 14-17 lysophosphatidic acid receptor 4 Homo sapiens 34-39 17166850-5 2007 Importantly, we further demonstrate new LPA-dependent activities of LPA(4) that include the following: receptor internalization; G(12/13)- and Rho-mediated neurite retraction and stress fiber formation; G(q) protein and pertussis toxin-sensitive calcium mobilization and activation of a nonselective cation conductance; and cAMP increases mediated by G(s). lysophosphatidic acid 40-43 lysophosphatidic acid receptor 4 Homo sapiens 68-73 15461590-1 2005 LPA (lysophosphatidic acid), a potent bioactive phospholipid, elicits diverse cellular responses through activation of the G-protein-coupled receptors LPA1-LPA4. lysophosphatidic acid 5-26 lysophosphatidic acid receptor 4 Homo sapiens 156-160 15280372-1 2004 Lysophosphatidic acid (LPA), a potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled receptors LPA1, LPA2, LPA3, and LPA4. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 161-165 15280372-1 2004 Lysophosphatidic acid (LPA), a potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled receptors LPA1, LPA2, LPA3, and LPA4. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 4 Homo sapiens 161-165 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 225-229 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 4 Homo sapiens 230-235 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 4 Homo sapiens 225-229 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 4 Homo sapiens 230-235