PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22079467-3 2012 In cell motility and invasion assay, lpa2-2 and lpa3-3-2 cells showed significant higher intrinsic activity without LPA treatment than LPA receptor-unexpressing AB2-1bf cells. lysophosphatidic acid 116-119 lysophosphatidic acid receptor 2 Mus musculus 37-43 22427635-5 2012 In this article, we show that DC from lpa2(-/-) mice are hyperactive compared with their wild-type counterparts and are less susceptible to inhibition by different LPA species. lysophosphatidic acid 164-167 lysophosphatidic acid receptor 2 Mus musculus 38-42 22427635-9 2012 Taken together, these findings identify LPA acting via lpa2 as a novel negative regulatory pathway that inhibits DC activation and allergic airway inflammation. lysophosphatidic acid 40-43 lysophosphatidic acid receptor 2 Mus musculus 55-59 22968304-6 2012 The antiapoptotic cellular signaling responses were present selectively in mouse embryonic fibroblast cells derived from LPA(1&2) double-knockout mice reconstituted with the LPA2 receptor and were absent in vector-transduced control cells. lysophosphatidic acid 121-124 lysophosphatidic acid receptor 2 Mus musculus 178-182 16203867-4 2005 LPA inhibited CFTR-dependent iodide efflux through LPA2-mediated Gi pathway, and LPA inhibited CFTR-mediated short-circuit currents in a compartmentalized fashion. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 2 Mus musculus 51-55 20230855-3 2010 So far, six GPCRs for LPA have been identified: LPA(1)/Edg2, LPA(2)/Edg4, LPA(3)/Edg7, LPA(4)/GPR23/P2Y9, LPA(5)/GPR92 and LPA(6)/P2Y5. lysophosphatidic acid 22-25 lysophosphatidic acid receptor 2 Mus musculus 61-66 20230855-3 2010 So far, six GPCRs for LPA have been identified: LPA(1)/Edg2, LPA(2)/Edg4, LPA(3)/Edg7, LPA(4)/GPR23/P2Y9, LPA(5)/GPR92 and LPA(6)/P2Y5. lysophosphatidic acid 22-25 lysophosphatidic acid receptor 2 Mus musculus 68-72 19930563-11 2009 The PGE2 production by LPA was reduced in isolated tracheal epithelial cells from LPA2+/- mice. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 2 Mus musculus 82-86 18198181-7 2008 At least two LPA receptor subtypes are involved in LPA priming, since the priming effect was lost in astrocytes derived from LPA receptor double-null mice (LPA(1)((-/-))/LPA(2)((-/-))). lysophosphatidic acid 13-16 lysophosphatidic acid receptor 2 Mus musculus 170-175 16263766-1 2005 Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA(1), LPA(2) and LPA(3). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 2 Mus musculus 136-142 16263766-1 2005 Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed LPA(1), LPA(2) and LPA(3). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 2 Mus musculus 136-142 16203867-5 2005 CFTR-dependent intestinal fluid secretion induced by CTX in mice was reduced substantially by LPA administration; disruption of this complex using a cell-permeant LPA2-specific peptide reversed LPA2-mediated inhibition. lysophosphatidic acid 94-97 lysophosphatidic acid receptor 2 Mus musculus 163-167 16203867-5 2005 CFTR-dependent intestinal fluid secretion induced by CTX in mice was reduced substantially by LPA administration; disruption of this complex using a cell-permeant LPA2-specific peptide reversed LPA2-mediated inhibition. lysophosphatidic acid 94-97 lysophosphatidic acid receptor 2 Mus musculus 194-198 12770838-1 2003 Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1, LPA2, and LPA3 (formerly Edg-2, -4, and -7). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 2 Mus musculus 130-134 15988003-2 2005 Previously we have shown that TRIP6 binds to the LPA2 receptor and associates with several components of focal complexes in an agonist-dependent manner and, thus, enhances lysophosphatidic acid (LPA)-induced cell migration. lysophosphatidic acid 172-193 lysophosphatidic acid receptor 2 Mus musculus 49-53 15716590-4 2005 The LPA-induced attenuation of steroid production occurs only in the mid-cycle corpus luteum and is associated with a transient endogenous expression of mRNA for the lysophosphatidic acid A2 (LPA2) receptor (with no concomitant changes in the expression of LPA1 receptor). lysophosphatidic acid 4-7 lysophosphatidic acid receptor 2 Mus musculus 192-196 12770838-1 2003 Lysophosphatidic acid (LPA) released during ischemia has diverse physiological effects via its G protein-coupled receptors, LPA1, LPA2, and LPA3 (formerly Edg-2, -4, and -7). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 2 Mus musculus 130-134 30550929-6 2019 We also found that the demyelinating lesion triggered by intraspinal injection of LPA into the undamaged spinal cord was markedly reduced in the lack of LPA2. lysophosphatidic acid 82-85 lysophosphatidic acid receptor 2 Mus musculus 153-157 33035680-2 2021 We previously demonstrated that lysophosphatidic acid (LPA), a lipid growth factor, has opposing regulatory effects on erythrocyte differentiation through activation of LPA receptors 2 and 3; yet the mechanisms underlying this process remain unclear. lysophosphatidic acid 32-53 lysophosphatidic acid receptor 2 Mus musculus 169-190 33035680-2 2021 We previously demonstrated that lysophosphatidic acid (LPA), a lipid growth factor, has opposing regulatory effects on erythrocyte differentiation through activation of LPA receptors 2 and 3; yet the mechanisms underlying this process remain unclear. lysophosphatidic acid 55-58 lysophosphatidic acid receptor 2 Mus musculus 169-190 12215548-8 2002 However, many LPA-induced responses, including phospholipase C activation, Ca(2+) mobilization, adenylyl cyclase activation, proliferation, JNK activation, Akt activation, and stress fiber formation, were absent or severely reduced in embryonic fibroblasts derived from lpa(1)((-/-)) lpa(2)((-/-)) mice. lysophosphatidic acid 14-17 lysophosphatidic acid receptor 2 Mus musculus 284-290 32846422-11 2021 CONCLUSION: These findings suggest that LPA plays an important role in allergic airway inflammation and that the blockade of LPA2 might have therapeutic potential for bronchial asthma. lysophosphatidic acid 40-43 lysophosphatidic acid receptor 2 Mus musculus 125-129 30550929-11 2019 Overall, this study provides new mechanistic insights into how LPA contributes to SCI physiopathology, and suggest that targeting LPA2 could be a novel therapeutic approach for the treatment of acute SCI. lysophosphatidic acid 63-66 lysophosphatidic acid receptor 2 Mus musculus 130-134 27124742-1 2016 Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 2 Mus musculus 36-40 28578681-8 2017 Further, treatment with an LPAR2 agonist reduced clinical signs of relapsing-remitting EAE suggesting that the LPAR2 agonist partially compensated the endogenous loss of LPAs and implicating LPA signaling as a novel treatment approach. lysophosphatidic acid 27-30 lysophosphatidic acid receptor 2 Mus musculus 111-116 27124742-1 2016 Lysophosphatidic acid (LPA) acts on LPA2 receptor to mediate multiple pathological effects that are associated with tumorigenesis. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 2 Mus musculus 36-40 26101324-4 2015 Downstream signaling pathway analysis revealed the p38 MAPK-mediated activation of a calcium independent phospholipase A2 with resultant synthesis of lysophosphatidic acid (LPA) driving chemotaxis through LPA receptor 2 and actin cytoskeletal mobilization. lysophosphatidic acid 150-171 lysophosphatidic acid receptor 2 Mus musculus 205-219 26101324-4 2015 Downstream signaling pathway analysis revealed the p38 MAPK-mediated activation of a calcium independent phospholipase A2 with resultant synthesis of lysophosphatidic acid (LPA) driving chemotaxis through LPA receptor 2 and actin cytoskeletal mobilization. lysophosphatidic acid 173-176 lysophosphatidic acid receptor 2 Mus musculus 205-219 26005700-5 2015 First, our in vitro findings demonstrate that LPA receptors, specifically LPA2 and LPA5 expressed in B16F10 cells appear to have opposing roles in cell invasion; the former seems to be responsible for the high basal invasion rate of B16F10 cells while the latter is anti-invasive upon exogenous LPA stimulation. lysophosphatidic acid 46-49 lysophosphatidic acid receptor 2 Mus musculus 74-78