PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34884486-11 2021 Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8. lysophosphatidic acid 63-84 C-X-C motif chemokine ligand 8 Homo sapiens 154-158 34884486-11 2021 Preincubation with heparin, autotaxin (ATX) inhibitor HA130 or lysophosphatidic acid (LPA) receptor antagonist Ki16425 reduced PLA1A-induced-secretion of IL-8. lysophosphatidic acid 86-89 C-X-C motif chemokine ligand 8 Homo sapiens 154-158 35365723-6 2022 IL-8, IL-6 and TNF-alpha secretion was induced by LPA in MDA-MB-468 cells. lysophosphatidic acid 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 35216080-8 2022 Moreover, IL-8 production was involved in the LPA response via the activation of the Ca2+-dependent transcriptional factor nuclear factor of activated T cells. lysophosphatidic acid 46-49 C-X-C motif chemokine ligand 8 Homo sapiens 10-14 22465753-0 2012 Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 31429784-15 2019 Expression of CXCL1 and IL-8 in human endothelial cells was enhanced by LPA, but was inhibited by LA-01. lysophosphatidic acid 72-75 C-X-C motif chemokine ligand 8 Homo sapiens 24-28 29178922-12 2017 LPA induced the release of IL-8 from ESCs but did not affect cell proliferation and VEGF production. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 27680872-9 2016 Furthermore, the expression of IL-6 and IL-8 increased in LPA-stimulated human primary granulosa cells (P < .01). lysophosphatidic acid 58-61 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 27680872-10 2016 Co-stimulation with rPEDF decreased the expression of LPA-induced IL-6 and IL-8 mRNA and protein by 4- and 2- to 5-fold, respectively. lysophosphatidic acid 54-57 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 24792438-0 2014 Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 30-34 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 144-157 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 159-163 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 23-26 C-X-C motif chemokine ligand 8 Homo sapiens 144-157 24792438-1 2014 Lysophosphatidic acid (LPA) is a pleiotropic lipid mediator that promotes motility, survival, and the synthesis of chemokines/cytokines such as interleukin-8 (IL-8) and interleukin-6 by human fibroblast-like synoviocytes from patients with rheumatoid arthritis (RAFLS). lysophosphatidic acid 23-26 C-X-C motif chemokine ligand 8 Homo sapiens 159-163 24792438-2 2014 In those cells LPA was reported to induce IL-8 secretion through activation of various signaling pathways including p38 mitogen-activated protein kinase (p38 MAPK), p42/44 MAPK, and Rho kinase. lysophosphatidic acid 15-18 C-X-C motif chemokine ligand 8 Homo sapiens 42-46 24792438-4 2014 The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1. lysophosphatidic acid 141-144 C-X-C motif chemokine ligand 8 Homo sapiens 206-210 24792438-5 2014 Whereas CREB inhibitors have off target effects and increased LPA-mediated IL-8 secretion, the silencing of CREB1 with short hairpin RNA significantly reduced LPA-induced chemokine production in RAFLS. lysophosphatidic acid 62-65 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 21964883-8 2012 Finally, we evaluated the regulation pathways involved in LPA-induced IL-8 expression. lysophosphatidic acid 58-61 C-X-C motif chemokine ligand 8 Homo sapiens 70-74 31233937-6 2019 In this study, we report that LPA markedly enhanced IL-6 and CXCL15 (mouse homologue of human IL-8) production in MLO-Y4 cells and that this enhancement was suppressed by the LPA1/3-selective antagonist Ki16425, the Gi/o protein inhibitor PTX or the protein kinase C (PKC) inhibitor sotrastaurin. lysophosphatidic acid 30-33 C-X-C motif chemokine ligand 8 Homo sapiens 94-98 30181697-4 2018 Result demonstrated that IL-8 and IL-11 expression were upregulated in LPA-treated MDA-MB-231 cells. lysophosphatidic acid 71-74 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 30181697-7 2018 In the case of PKC activation, it was observed that PKCdelta and PKCmu might regulate LPA-induced expression of IL-11 and IL-8, respectively, by using specific PKC subtype inhibitors. lysophosphatidic acid 86-89 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 30181697-9 2018 In conclusion, LPA induced the expression of osteolytic cytokines (IL-8 and IL-11) in breast cancer cells by involving different LPA receptors. lysophosphatidic acid 15-18 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 30181697-10 2018 Enhanced expression of IL-8 by LPA may be via ROCK, PKCu, PI3K, and NFkB signaling pathways, while enhanced expression of IL-11 might involve PKCdelta signaling pathway. lysophosphatidic acid 31-34 C-X-C motif chemokine ligand 8 Homo sapiens 23-27 29209219-2 2017 Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. lysophosphatidic acid 72-75 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 29209219-12 2017 In TNFalpha-primed RAFLS the super-production of IL-8 and IL-6 induced by LPA occurs mainly via MSK-independent pathways, and simultaneous inhibition of at least two MAPK signaling pathways was required to block their synthesis. lysophosphatidic acid 74-77 C-X-C motif chemokine ligand 8 Homo sapiens 49-53 29209219-13 2017 Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis. lysophosphatidic acid 113-116 C-X-C motif chemokine ligand 8 Homo sapiens 126-130 26553339-5 2015 In hypoxia and serum-deprived culture conditions, LPA induces CD34(+) cell proliferation without maintaining the their undifferentiating state, and enhances IL-8, IL-6 and G-CSF secretion during the first 12 h compared to non-treated cells. lysophosphatidic acid 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 157-161 24879414-11 2014 Angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF mRNA and protein expressions were significantly enhanced in LPA-treated chondrocytes. lysophosphatidic acid 110-113 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 24879414-13 2014 Pretreatment with the Gi/o type G protein inhibitor, pertussis toxin (PTX), and the NF-kB inhibitor, PDTC, significantly inhibited LPA-induced angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF expressions in chondrocytes. lysophosphatidic acid 131-134 C-X-C motif chemokine ligand 8 Homo sapiens 164-168 22465753-5 2012 In addition, LPA induces IL-8 expression by enhancing IL-8 promoter activity via activation of the NF-kappaB pathway in LECs. lysophosphatidic acid 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 22465753-5 2012 In addition, LPA induces IL-8 expression by enhancing IL-8 promoter activity via activation of the NF-kappaB pathway in LECs. lysophosphatidic acid 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 54-58 22465753-6 2012 Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro. lysophosphatidic acid 98-101 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 22465753-6 2012 Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro. lysophosphatidic acid 98-101 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 22465753-6 2012 Using IL-8 siRNA and IL-8 neutralizing antibody, we revealed that IL-8 plays an important role in LPA-induced lymphangiogenesis in vitro. lysophosphatidic acid 98-101 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 22465753-7 2012 Moreover, using siRNA inhibition, we discovered that LPA-induced lymphangiogenesis in vitro and IL-8 production are mediated via the LPA(2) receptor in LECs. lysophosphatidic acid 53-56 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 22465753-8 2012 Finally, using human sentinel afferent lymphatic vessel explants, we demonstrated that LPA up-regulates IL-8 production in the LECs of lymphatic endothelia. lysophosphatidic acid 87-90 C-X-C motif chemokine ligand 8 Homo sapiens 104-108 22465753-9 2012 These studies provide the first evidence that LPA promotes lymphangiogenesis and induces IL-8 production in LECs; we also reveal a possible new role of LPA in the promotion of tumor progression, as well as metastasis, in different cancer types. lysophosphatidic acid 46-49 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 20434448-0 2010 Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells. lysophosphatidic acid 20-41 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 21925926-0 2012 Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. lysophosphatidic acid 32-53 C-X-C motif chemokine ligand 8 Homo sapiens 22-26 21925926-6 2012 LPA induced the secretion of IL-6 and IL-8 in oral squamous cell carcinoma (OSCC). lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 21925926-7 2012 LPA-stimulated secretion of IL-6 and IL-8 is partly dependent on the LPA and EGF receptor (EGFR) pathways. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 37-41 21925926-8 2012 ERK1/2 and Akt-mediated NF-kappaB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion. lysophosphatidic acid 68-71 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 21925926-10 2012 Neutralization against both human IL-6 and IL-8 suppressed osteoclast formation induced by CM derived from the LPA-stimulated OSCC. lysophosphatidic acid 111-114 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 21925926-11 2012 Direct treatment with recombinant IL-6 (rIL-6) and/or soluble IL-6 receptor (sIL-6R), or IL-8 (rIL-8) reproduced the effect of the CM derived from the LPA-stimulated OSCC on osteoclast formation. lysophosphatidic acid 151-154 C-X-C motif chemokine ligand 8 Homo sapiens 89-93 21925926-13 2012 Taken together, LPA may be a potent inducer of osteolytic factor IL-6 and IL-8 in OSCC. lysophosphatidic acid 16-19 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 21925926-14 2012 LPA-induced IL-6 and IL-8 exerted propound effects on RANKL expression in osteoblast and thereby promoted osteoclast formation from osteoclast precursors. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 21-25 19906815-0 2010 Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 82-95 19647363-7 2010 Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility. lysophosphatidic acid 47-50 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 19906815-12 2010 LPA-induced IL-8 protein secretion of trophoblasts enhanced permeability, migration, proliferation, and capillary tube formation of human endometrial microvascular endothelial cells. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 12-16 16687414-8 2006 These results demonstrate that LPA-induced IL-8 secretion is partly dependent on EGFR transactivation regulated by PKCdelta-dependent activation of Lyn kinase and MMPs and proHB-EGF shedding, suggesting a novel mechanism of cross-talk and interaction between G-protein-coupled receptors and receptor-tyrosine kinases in HBEpCs. lysophosphatidic acid 31-34 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 18294142-1 2008 We have demonstrated that LPA (lysophosphatidic acid)-induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial primary cells). lysophosphatidic acid 26-29 C-X-C motif chemokine ligand 8 Homo sapiens 62-80 18294142-1 2008 We have demonstrated that LPA (lysophosphatidic acid)-induced IL (interleukin)-8 secretion was partly mediated via transactivation of EGFR [EGF (epidermal growth factor) receptor] in HBEpCs (human bronchial epithelial primary cells). lysophosphatidic acid 31-52 C-X-C motif chemokine ligand 8 Homo sapiens 62-80 18171700-0 2008 Lysophosphatidic acid up-regulates expression of interleukin-8 and -6 in granulosa-lutein cells through its receptors and nuclear factor-kappaB dependent pathways: implications for angiogenesis of corpus luteum and ovarian hyperstimulation syndrome. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 49-69 18171700-14 2008 LPA induced IL-8 and IL-6 through different pathways. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 12-16 18171700-15 2008 LPA-induced IL-8 and IL-6 increased permeability of human umbilical vein endothelial cell monolayer. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 12-16 18171700-16 2008 CONCLUSIONS: LPA induces IL-8 and IL-6 expressions through LPA receptors and nuclear factor-kappaB dependent pathways in granulosa-lutein cells. lysophosphatidic acid 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 25-29 18171700-18 2008 Large amounts of LPA-induced IL-8 and IL-6 from multiple corpora luteae of stimulated ovaries may be one of the pathophysiological causes of ovarian hyperstimulation syndrome. lysophosphatidic acid 17-20 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 18006645-5 2008 Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6, whereas the LPA(3) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate (2S-OMPT) stimulates cytokine synthesis but not cell motility. lysophosphatidic acid 30-33 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 17923111-5 2007 Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media. lysophosphatidic acid 10-13 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 17923111-5 2007 Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media. lysophosphatidic acid 19-22 C-X-C motif chemokine ligand 8 Homo sapiens 83-87 16687414-0 2006 Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases. lysophosphatidic acid 14-35 C-X-C motif chemokine ligand 8 Homo sapiens 97-110 16687414-1 2006 We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs). lysophosphatidic acid 34-55 C-X-C motif chemokine ligand 8 Homo sapiens 70-83 16687414-1 2006 We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs). lysophosphatidic acid 34-55 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 16687414-1 2006 We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs). lysophosphatidic acid 57-60 C-X-C motif chemokine ligand 8 Homo sapiens 70-83 16687414-1 2006 We have demonstrated earlier that lysophosphatidic acid (LPA)-induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta)-dependent NF-kappaB activation in human bronchial epithelial cells (HBEpCs). lysophosphatidic acid 57-60 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 16687414-2 2006 Here we provide evidence for signaling pathways that regulate LPA-mediated transactivation of epidermal growth factor receptor (EGFR) and the role of cross-talk between G-protein-coupled receptors and receptor-tyrosine kinases in IL-8 secretion in HBEpCs. lysophosphatidic acid 62-65 C-X-C motif chemokine ligand 8 Homo sapiens 230-234 19112101-0 2009 Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells. lysophosphatidic acid 31-34 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 19112101-5 2009 Overexpression of lentiviral AGK wild type increased intracellular LPA production ( approximately 1.8-fold), enhanced LPA-mediated IL-8 secretion, and stimulated tyrosine phosphorylation epidermal growth factor-receptor (EGF-R). lysophosphatidic acid 118-121 C-X-C motif chemokine ligand 8 Homo sapiens 131-135 19112101-6 2009 Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold) and attenuated LPA-induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion. lysophosphatidic acid 145-148 C-X-C motif chemokine ligand 8 Homo sapiens 237-241 19112101-7 2009 These results suggest that native AGK regulates LPA-mediated IL-8 secretion involving MAPKs, NF-kappaB, and transactivation of EGF-R. lysophosphatidic acid 48-51 C-X-C motif chemokine ligand 8 Homo sapiens 61-65 18617617-0 2008 Lysophosphatidic acid mediates interleukin-8 expression in human endometrial stromal cells through its receptor and nuclear factor-kappaB-dependent pathway: a possible role in angiogenesis of endometrium and placenta. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 31-44 18617617-11 2008 LPA enhanced IL-8 expression in a dose- and time-dependent manner, whereas vascular endothelial growth factor or IL-6 expression was not affected by LPA treatment. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 13-17 18617617-15 2008 Through the LPA1 receptor, LPA induces IL-8 expression via a nuclear factor-kappaB-dependent signal pathway. lysophosphatidic acid 12-15 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 17915188-1 2008 Using human osteoblastic SaM-1 cells, we investigated the effects of lysophosphatidic acid (LPA) on the production of interleukin (IL)-6 and IL-8, molecules which are capable of stimulating the development of osteoclasts from their haematopoietic precursors, and examined the signal transduction systems involved in their effect on these cells. lysophosphatidic acid 69-90 C-X-C motif chemokine ligand 8 Homo sapiens 141-145 17915188-1 2008 Using human osteoblastic SaM-1 cells, we investigated the effects of lysophosphatidic acid (LPA) on the production of interleukin (IL)-6 and IL-8, molecules which are capable of stimulating the development of osteoclasts from their haematopoietic precursors, and examined the signal transduction systems involved in their effect on these cells. lysophosphatidic acid 92-95 C-X-C motif chemokine ligand 8 Homo sapiens 141-145 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 C-X-C motif chemokine ligand 8 Homo sapiens 88-92 17915188-7 2008 The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA. lysophosphatidic acid 161-164 C-X-C motif chemokine ligand 8 Homo sapiens 131-135 17915188-8 2008 These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells. lysophosphatidic acid 42-45 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 16928771-0 2007 Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB. lysophosphatidic acid 27-48 C-X-C motif chemokine ligand 8 Homo sapiens 57-70 16928771-1 2007 The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined. lysophosphatidic acid 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 157-170 16928771-1 2007 The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined. lysophosphatidic acid 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 172-176 16928771-1 2007 The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined. lysophosphatidic acid 145-148 C-X-C motif chemokine ligand 8 Homo sapiens 157-170 16928771-1 2007 The signaling pathways mediating lysophosphatidic acid (LPA)-stimulated PKD(2) activation and the potential contribution of PKD(2) in regulating LPA-induced interleukin 8 (IL-8) secretion in nontransformed, human colonic epithelial NCM460 cells were examined. lysophosphatidic acid 145-148 C-X-C motif chemokine ligand 8 Homo sapiens 172-176 16928771-5 2007 LPA induced a striking increase in IL-8 production and stimulated NF-kappaB activation, as measured by NF-kappaB-DNA binding, NF-kappaB-driven luciferase reporter activity, and IkappaBalpha phosphorylation. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 35-39 16928771-7 2007 PKD(2) activation is a novel early event in the biological action of LPA and mediates LPA-stimulated IL-8 secretion in NCM460 cells through a NF-kappaB-dependent pathway. lysophosphatidic acid 86-89 C-X-C motif chemokine ligand 8 Homo sapiens 101-105 16197369-0 2006 Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. lysophosphatidic acid 30-51 C-X-C motif chemokine ligand 8 Homo sapiens 60-73 16289596-10 2006 LPA induced significant migration and IL-8 secretion in DLD1, both of which were significantly inhibited by AG1478 or GM6001. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 16197369-9 2006 Furthermore, SB203580 attenuated LPA-dependent phosphorylation of IkappaB (inhibitory kappaB), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter-mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription. lysophosphatidic acid 33-36 C-X-C motif chemokine ligand 8 Homo sapiens 179-183 16197369-3 2006 We have recently demonstrated that LPA (lysophosphatidic acid) stimulated IL-8 production in HBEpCs via protein kinase C delta dependent signal transduction. lysophosphatidic acid 35-38 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 16197369-10 2006 Similarly, JNK(i) II only blocked LPA-mediated phosphorylation of JNK and c-Jun, AP-1 transcription and IL-8 promoter-mediated luciferase reporter activity, without blocking p38 MAPK-dependent NF-kappaB transcription. lysophosphatidic acid 34-37 C-X-C motif chemokine ligand 8 Homo sapiens 104-108 16197369-11 2006 Additionally, siRNA for LPA(1-3) receptors partially blocked LPA-induced IL-8 production and activation of MAPKs. lysophosphatidic acid 24-27 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 16197369-3 2006 We have recently demonstrated that LPA (lysophosphatidic acid) stimulated IL-8 production in HBEpCs via protein kinase C delta dependent signal transduction. lysophosphatidic acid 40-61 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 16197369-12 2006 The LPA1 and LPA3 receptors, as compared with LPA2, were most efficient in transducing LPA-mediated IL-8 production. lysophosphatidic acid 4-7 C-X-C motif chemokine ligand 8 Homo sapiens 100-104 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 C-X-C motif chemokine ligand 8 Homo sapiens 74-78 16197369-13 2006 These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs. lysophosphatidic acid 63-66 C-X-C motif chemokine ligand 8 Homo sapiens 75-79 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 C-X-C motif chemokine ligand 8 Homo sapiens 29-33 16210650-3 2005 We now report that LPA potently induces the generation of proinflammatory chemokines (MIP-1beta, IL-8, and MCP-1) by hMCs by a mechanism that absolutely requires IL-4. lysophosphatidic acid 19-22 C-X-C motif chemokine ligand 8 Homo sapiens 97-101 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 C-X-C motif chemokine ligand 8 Homo sapiens 95-108 15461590-7 2005 Furthermore, overexpression of LPP-1 partially attenuated LPA-induced increases in the intracellular Ca2+ concentration, phosphorylation of IkappaB (inhibitory kappaB) and translocation of NF-kappaB (nuclear factor-kappaB) to the nucleus, and almost completely prevented IL-8 secretion. lysophosphatidic acid 58-61 C-X-C motif chemokine ligand 8 Homo sapiens 271-275 15491751-0 2004 Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8. lysophosphatidic acid 0-21 C-X-C motif chemokine ligand 8 Homo sapiens 105-118 15728708-6 2005 LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily activating LPA2 receptor. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 17-30 15728708-6 2005 LPA also induced interleukin-8 (IL-8) synthesis in the colon cancer cells by primarily activating LPA2 receptor. lysophosphatidic acid 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 32-36 15491751-2 2004 Here, we investigate a second mechanism in which LPA enhances cellular invasion through the increased expression of IL-8, independent of the expression or activation of MMP2. lysophosphatidic acid 49-52 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 15491751-3 2004 METHODS: Epithelial ovarian carcinoma cells (DOV 13) were exposed to LPA (80 microM) and IL-8 (100 ng/ml) for 24 h. IL-8 expression was quantified by enzyme-linked immunosorbent assay (ELISA). lysophosphatidic acid 69-72 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 15491751-7 2004 RESULTS: Our results found LPA to increase IL-8 expression threefold. lysophosphatidic acid 27-30 C-X-C motif chemokine ligand 8 Homo sapiens 43-47 15280372-6 2004 Treatment of HBEpCs with LPA increased both IL-8 gene and protein expression, which was coupled to Gi and G(12/13) proteins. lysophosphatidic acid 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 44-48 15280372-8 2004 Furthermore, LPA-activated PKCdelta and the LPA-mediated activation of NF-kappaB and IL-8 production were attenuated by overexpression of dominant-negative PKCdelta and rottlerin. lysophosphatidic acid 13-16 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 15280372-10 2004 These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCdelta/NF-kappaB signaling pathways. lysophosphatidic acid 50-53 C-X-C motif chemokine ligand 8 Homo sapiens 80-84 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 C-X-C motif chemokine ligand 8 Homo sapiens 162-166 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 C-X-C motif chemokine ligand 8 Homo sapiens 162-166 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 C-X-C motif chemokine ligand 8 Homo sapiens 39-43 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 C-X-C motif chemokine ligand 8 Homo sapiens 162-166 14670967-10 2004 These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA-induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer. lysophosphatidic acid 66-69 C-X-C motif chemokine ligand 8 Homo sapiens 113-117 7592725-8 1995 Thus, phosphatidic acid and lysophosphatidic acid, similarly to other physiological chemoattractants (e.g. C5a and interleukin-8), induce cell migration by an haptotactic mechanism. lysophosphatidic acid 28-49 C-X-C motif chemokine ligand 8 Homo sapiens 115-128 15041999-8 2004 Pretreatment of the ovarian cancer cells with the pertussis toxin completely inhibited lysophosphatidic acid-stimulated production of interleukin-6, interleukin-8 and tumor necrosis factor-alpha. lysophosphatidic acid 87-108 C-X-C motif chemokine ligand 8 Homo sapiens 149-194