PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21632882-9 2011 CONCLUSION: LPA induced disruption and protection of VE-cadherin integrity through LPA(1)-G(i) protein-Rac1-JNK/p38MAPK and LPA(6)-G(12/13) protein-Src-C3G-Rap1 pathways, respectively. lysophosphatidic acid 12-15 Rac family small GTPase 1 Homo sapiens 103-107 16007180-4 2005 The LPA-induced action was also suppressed, although incompletely, by several specific inhibitors for intracellular signaling pathways including Rac1, Cdc42, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun terminal kinase (JNK), but not extracellular signal-regulated kinase. lysophosphatidic acid 4-7 Rac family small GTPase 1 Homo sapiens 145-149 17178255-8 2007 LPA induced Rac-1 activation in SMCs, which was suppressed by pitavastatin or LPA receptor antagonist. lysophosphatidic acid 0-3 Rac family small GTPase 1 Homo sapiens 12-17 17178255-10 2007 These results suggest that pitavastatin could block the LPA-induced proliferation and MCP-1 expression in SMCs by suppressing Rac-1-mediated NADPH oxidase-dependent ROS generation. lysophosphatidic acid 56-59 Rac family small GTPase 1 Homo sapiens 126-131 19864456-5 2009 The expression of tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is required for the inhibitory ISO-induced and Rap1B-mediated actions on the migration, Rac1 activation, and Akt activation in response to LPA. lysophosphatidic acid 237-240 Rac family small GTPase 1 Homo sapiens 186-190 17178255-0 2007 Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation. lysophosphatidic acid 22-43 Rac family small GTPase 1 Homo sapiens 161-166 17178255-7 2007 Furthermore, overexpression of dominant negative Rac-1 mutant was found to inhibit the LPA-induced ROS generation in SMCs. lysophosphatidic acid 87-90 Rac family small GTPase 1 Homo sapiens 49-54 15447683-0 2004 Rho-mediated cytoskeletal rearrangement in response to LPA is functionally antagonized by Rac1 and PIP2. lysophosphatidic acid 55-58 Rac family small GTPase 1 Homo sapiens 90-94 15755723-2 2005 LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42. lysophosphatidic acid 0-3 Rac family small GTPase 1 Homo sapiens 89-93 15591411-9 2005 This effect is a result of Rac1-mediated inhibition of RhoA and can be prevented by activators of RhoA, L63RhoA, and lysophosphatidic acid. lysophosphatidic acid 117-138 Rac family small GTPase 1 Homo sapiens 27-31 15447683-6 2004 Blocking Gi with pertussis toxin enabled LPA to induce cell rounding and to decrease activated Rac1. lysophosphatidic acid 41-44 Rac family small GTPase 1 Homo sapiens 95-99 15066181-4 2004 In addition, we demonstrated that Rac1/Cdc42 signals acted as upstream effector molecules of LPA-induced PAK activation. lysophosphatidic acid 93-96 Rac family small GTPase 1 Homo sapiens 34-38 15066181-7 2004 Taken together, these findings strongly indicated that PAK1 activation was necessary for LPA-induced cell motility and FAK phosphorylation that might be mediated by sequential activation of Gi protein, PI3Kgamma and Rac1/Cdc42. lysophosphatidic acid 89-92 Rac family small GTPase 1 Homo sapiens 216-220 12902401-8 2003 Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA-induced activation of Ras, Rac1 and RhoA. lysophosphatidic acid 53-56 Rac family small GTPase 1 Homo sapiens 167-171 12902401-8 2003 Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA-induced activation of Ras, Rac1 and RhoA. lysophosphatidic acid 136-139 Rac family small GTPase 1 Homo sapiens 167-171 11286990-5 2001 Translocation to the plasma membrane of small GTPases, such as RhoA and Rac1, could not be detected within 15 min of stimulation with PDGF or lysophosphatidic acid (LPA) (early G1 phase), but occurred after 24 hr of PDGF stimulation (late G1/S phase). lysophosphatidic acid 142-163 Rac family small GTPase 1 Homo sapiens 72-76 9032247-7 1997 Lysophosphatidic acid (LPA)-induced neurite retraction, which is mediated by RhoA, was inhibited by ACh, while C3 exoenzyme-mediated neurite outgrowth was inhibited by injection with Cdc42Hs(T17N) or Rac1(T17N). lysophosphatidic acid 0-21 Rac family small GTPase 1 Homo sapiens 200-204 10212259-2 1999 We have recently demonstrated that lysophosphatidic acid and several other agonists stimulate phosphorylation of the Rac1-specific exchange factor Tiam1 in Swiss 3T3 fibroblasts, and that protein kinase C is involved in Tiam1 phosphorylation (Fleming, I. N., Elliott, C. M., Collard, J. G., and Exton, J. H. (1997) J. Biol. lysophosphatidic acid 35-56 Rac family small GTPase 1 Homo sapiens 117-121 9407095-3 1997 In this study, we demonstrate that lysophosphatidic acid (LPA) induces a rapid, sustainable phosphorylation of the Rac1-specific nucleotide exchange factor Tiam1 in Swiss 3T3 fibroblasts. lysophosphatidic acid 35-56 Rac family small GTPase 1 Homo sapiens 115-119 9407095-3 1997 In this study, we demonstrate that lysophosphatidic acid (LPA) induces a rapid, sustainable phosphorylation of the Rac1-specific nucleotide exchange factor Tiam1 in Swiss 3T3 fibroblasts. lysophosphatidic acid 58-61 Rac family small GTPase 1 Homo sapiens 115-119 10734127-0 2000 Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid. lysophosphatidic acid 113-134 Rac family small GTPase 1 Homo sapiens 21-25 9032247-7 1997 Lysophosphatidic acid (LPA)-induced neurite retraction, which is mediated by RhoA, was inhibited by ACh, while C3 exoenzyme-mediated neurite outgrowth was inhibited by injection with Cdc42Hs(T17N) or Rac1(T17N). lysophosphatidic acid 23-26 Rac family small GTPase 1 Homo sapiens 200-204 9032247-8 1997 Together these results suggest that there is competition between the ACh- and LPA-induced morphological pathways mediated by Cdc42Hs and/or Rac1 and by RhoA, leading to either neurite development or collapse. lysophosphatidic acid 78-81 Rac family small GTPase 1 Homo sapiens 140-144 26171059-12 2015 The results revealed that blocking the activation of Rac1 by ectopically expressing an inactive Rac1 mutant (T17N) impeded LPA-induced cell migration. lysophosphatidic acid 123-126 Rac family small GTPase 1 Homo sapiens 53-57 34110567-3 2021 Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. lysophosphatidic acid 72-75 Rac family small GTPase 1 Homo sapiens 29-33 34110567-3 2021 Among the Rho GTPases, RhoA, Rac1, and Cdc42 are best characterized and LPA-induced activation of the GTPases RhoA, Rac1, and Cdc42 influences a wide range of cellular processes and functions such as cell differentiation, contractile movements, cellular migration, or infiltration. lysophosphatidic acid 72-75 Rac family small GTPase 1 Homo sapiens 116-120 29046393-8 2017 Cells expressing CA-Rac1 exhibited a robust induction of macropinocytosis, and inhibitors of macropinocytosis blocked the activation of Akt by CA-Rac1 or lysophosphatidic acid. lysophosphatidic acid 154-175 Rac family small GTPase 1 Homo sapiens 20-24 26792863-7 2016 Pak-CRIB pulldown assays demonstrated that Norbin promotes the P-Rex1-mediated activation of endogenous Rac1 upon stimulation of HEK-293 cells with lysophosphatidic acid. lysophosphatidic acid 148-169 Rac family small GTPase 1 Homo sapiens 104-108 26171059-13 2015 Increased PKG II activity inhibited LPA-induced migration and LPA-induced activation of Rac1; however, it had no effect on the phosphorylation of Rac1. lysophosphatidic acid 62-65 Rac family small GTPase 1 Homo sapiens 88-92 26171059-14 2015 PKG II also inhibited the activation of PI3K/Akt and MEK/ERK mediated signaling, which is important for LPA-induced Rac1 activation. lysophosphatidic acid 104-107 Rac family small GTPase 1 Homo sapiens 116-120 26171059-15 2015 These results suggest that PKG II affects LPA-stimulated migration of AGS cells by blocking Rac1 activation, via inhibition of PI3K/Akt and MEK/ERK mediated signaling. lysophosphatidic acid 42-45 Rac family small GTPase 1 Homo sapiens 92-96 26171059-12 2015 The results revealed that blocking the activation of Rac1 by ectopically expressing an inactive Rac1 mutant (T17N) impeded LPA-induced cell migration. lysophosphatidic acid 123-126 Rac family small GTPase 1 Homo sapiens 96-100 23467751-11 2013 Ectopic LPA4 induction also downregulated proliferation of Rac1 inhibitor-treated SQ-20B cells, however, LPA no longer recovered it. lysophosphatidic acid 8-11 Rac family small GTPase 1 Homo sapiens 59-63 24469268-0 2014 RhoA and Rac1 play independent roles in lysophosphatidic acid-induced ovarian cancer chemotaxis. lysophosphatidic acid 40-61 Rac family small GTPase 1 Homo sapiens 9-13 24469268-3 2014 In this research, we first investigated roles of RhoA and Rac1 in the LPA-induced chemotaxis of SKOV3 human ovarian cancer cells using a multilevel microfluidic platform. lysophosphatidic acid 70-73 Rac family small GTPase 1 Homo sapiens 58-62 24469268-8 2014 These results suggest that RhoA and Rac1 signaling pathways potentially play independent roles in the chemotactic migration of SKOV3 ovarian cancer cells in the linear and stable LPA concentration gradient. lysophosphatidic acid 179-182 Rac family small GTPase 1 Homo sapiens 36-40 25376707-11 2015 LPA-induced PKC phosphorylation is also involved in Rac1 and CDC42 activation, and Rac1 and CDC42 knockdown abolished LPA-induced F-actin reorganization. lysophosphatidic acid 0-3 Rac family small GTPase 1 Homo sapiens 52-56 25376707-11 2015 LPA-induced PKC phosphorylation is also involved in Rac1 and CDC42 activation, and Rac1 and CDC42 knockdown abolished LPA-induced F-actin reorganization. lysophosphatidic acid 118-121 Rac family small GTPase 1 Homo sapiens 83-87 23467751-12 2013 Finally, LPA-induced cell motility was suppressed by ectopic LPA4 expression as well as by Ki16425, Rac1 inhibitor or Y-27632. lysophosphatidic acid 9-12 Rac family small GTPase 1 Homo sapiens 100-104 22049212-8 2012 Finally, we find that the regulation of Rac1 and RhoA in response to LPA is differentially regulated by phosphodiesterases, PKA, and phosphatidylinositol 3-kinase, thus supporting their spatially distinct compartmentalization. lysophosphatidic acid 69-72 Rac family small GTPase 1 Homo sapiens 40-44 22049212-9 2012 In summary, signaling from integrin alpha(6)beta(4) facilitates LPA-stimulated chemotaxis through preferential activation of RhoA, which, in turn, facilitates activation of Rac1. lysophosphatidic acid 64-67 Rac family small GTPase 1 Homo sapiens 173-177 23618389-7 2013 We demonstrated that G13, but not or to a lesser extent G12, Gi or Gq, was necessary for LPA-induced dpYAP and its nuclear translocation and that RhoA-ROCK, but not RhoB, RhoC, Rac1, cdc42, PI3K, ERK, or AKT, were required for the LPA-dpYAP effect. lysophosphatidic acid 89-92 Rac family small GTPase 1 Homo sapiens 177-181