PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16197369-0 2006 Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. lysophosphatidic acid 30-51 mitogen-activated protein kinase 1 Homo sapiens 102-105 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 1 Homo sapiens 57-61 16760261-6 2006 Pertussis toxin (PTX) blocks LPA-induced activation of p38 and ERK but only slightly inhibits LPA-induced activation of Akt. lysophosphatidic acid 29-32 mitogen-activated protein kinase 1 Homo sapiens 63-66 16760261-8 2006 In these cells, both Akt and ERK pathways are important for LPA-induced proliferation. lysophosphatidic acid 60-63 mitogen-activated protein kinase 1 Homo sapiens 29-32 16760261-12 2006 LPA-induced activations of p38, ERK, and Akt kinases, as well as proliferation, are inhibited by Ki16425. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 32-35 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 1 Homo sapiens 186-189 16197369-0 2006 Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. lysophosphatidic acid 30-51 mitogen-activated protein kinase 1 Homo sapiens 106-110 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 1 Homo sapiens 144-147 16197369-9 2006 Furthermore, SB203580 attenuated LPA-dependent phosphorylation of IkappaB (inhibitory kappaB), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter-mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription. lysophosphatidic acid 33-36 mitogen-activated protein kinase 1 Homo sapiens 117-120 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 1 Homo sapiens 149-186 16197369-13 2006 These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs. lysophosphatidic acid 63-66 mitogen-activated protein kinase 1 Homo sapiens 43-46 16197369-13 2006 These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs. lysophosphatidic acid 63-66 mitogen-activated protein kinase 1 Homo sapiens 47-51 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 1 Homo sapiens 189-192 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 1 Homo sapiens 193-197 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 1 Homo sapiens 53-56 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 1 Homo sapiens 85-88 15194005-3 2004 We also found that LPA stimulated two kinds of mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and p38 kinase via PLD-dependent signaling pathways in WISH cells. lysophosphatidic acid 19-22 mitogen-activated protein kinase 1 Homo sapiens 81-85 16230405-2 2005 LPAAT-beta converts lysophosphatidic acid to phosphatidic acid, which functions as a cofactor in Akt/mTOR and Ras/Raf/Erk pathways. lysophosphatidic acid 20-41 mitogen-activated protein kinase 1 Homo sapiens 118-121 15533756-0 2004 Lysophosphatidic acid inhibits TGF-beta-mediated stimulation of type I collagen mRNA stability via an ERK-dependent pathway in dermal fibroblasts. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 102-105 15533756-5 2004 Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-beta-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production. lysophosphatidic acid 290-293 mitogen-activated protein kinase 1 Homo sapiens 105-142 15533756-5 2004 Furthermore, using the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059, we show that the extracellular signal-regulated kinase (ERK) pathway is a negative regulator of the TGF-beta-induced stabilization of type I collagen mRNA, and that the activation of the ERK pathway by LPA mediates their inhibitory effects on collagen production. lysophosphatidic acid 290-293 mitogen-activated protein kinase 1 Homo sapiens 144-147 16210650-5 2005 ERK phosphorylation and chemokine production in response to LPA require IL-4-dependent up-regulation of MEK-1 expression by a pathway involving PI3K. lysophosphatidic acid 60-63 mitogen-activated protein kinase 1 Homo sapiens 0-3 15653692-5 2005 Surprisingly, dominant negative MEK1 or Erk2 displays only marginal inhibitory effect on LPA-induced uPA up-regulation, suggesting that a signaling pathway distinct from Raf-MEK1/2-Erk is the prominent pathway responsible for this process. lysophosphatidic acid 89-92 mitogen-activated protein kinase 1 Homo sapiens 40-44 15653692-5 2005 Surprisingly, dominant negative MEK1 or Erk2 displays only marginal inhibitory effect on LPA-induced uPA up-regulation, suggesting that a signaling pathway distinct from Raf-MEK1/2-Erk is the prominent pathway responsible for this process. lysophosphatidic acid 89-92 mitogen-activated protein kinase 1 Homo sapiens 40-43 15710431-9 2005 Phosphorylation of ERK and Bad112 by LPA may play a role in preventing caspase-3 activation through mitochondrial pathway induced by Cyto D. Our investigation found that LPA inhibited anti-Fas-induced apoptosis enhanced by actin depolymerization, and LPA may protect epithelial ovarian cancer from immune cell attack and cytoskeleton disrupting reagents induced apoptosis through multiple pathways. lysophosphatidic acid 37-40 mitogen-activated protein kinase 1 Homo sapiens 19-22 15710431-9 2005 Phosphorylation of ERK and Bad112 by LPA may play a role in preventing caspase-3 activation through mitochondrial pathway induced by Cyto D. Our investigation found that LPA inhibited anti-Fas-induced apoptosis enhanced by actin depolymerization, and LPA may protect epithelial ovarian cancer from immune cell attack and cytoskeleton disrupting reagents induced apoptosis through multiple pathways. lysophosphatidic acid 170-173 mitogen-activated protein kinase 1 Homo sapiens 19-22 15710431-9 2005 Phosphorylation of ERK and Bad112 by LPA may play a role in preventing caspase-3 activation through mitochondrial pathway induced by Cyto D. Our investigation found that LPA inhibited anti-Fas-induced apoptosis enhanced by actin depolymerization, and LPA may protect epithelial ovarian cancer from immune cell attack and cytoskeleton disrupting reagents induced apoptosis through multiple pathways. lysophosphatidic acid 170-173 mitogen-activated protein kinase 1 Homo sapiens 19-22 15194005-3 2004 We also found that LPA stimulated two kinds of mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and p38 kinase via PLD-dependent signaling pathways in WISH cells. lysophosphatidic acid 19-22 mitogen-activated protein kinase 1 Homo sapiens 88-125 15194005-3 2004 We also found that LPA stimulated two kinds of mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and p38 kinase via PLD-dependent signaling pathways in WISH cells. lysophosphatidic acid 19-22 mitogen-activated protein kinase 1 Homo sapiens 127-130 15118098-5 2004 MORG1 facilitates ERK activation when cells are stimulated with lysophosphatidic acid, phorbol 12-myristate 13-acetate, or serum, but not in response to epidermal growth factor. lysophosphatidic acid 64-85 mitogen-activated protein kinase 1 Homo sapiens 18-21 15024019-3 2004 Stimulation with lysophosphatidic acid (LPA) activates the mitogenic ERK signaling pathway in PS30, but not LNCaP, cells. lysophosphatidic acid 17-38 mitogen-activated protein kinase 1 Homo sapiens 69-72 15024019-3 2004 Stimulation with lysophosphatidic acid (LPA) activates the mitogenic ERK signaling pathway in PS30, but not LNCaP, cells. lysophosphatidic acid 40-43 mitogen-activated protein kinase 1 Homo sapiens 69-72 15024019-4 2004 The co-culture of PS30 and LNCaP cells results in the activation of ERK in LNCaP cells and that is further increased in response to stimulation with LPA. lysophosphatidic acid 149-152 mitogen-activated protein kinase 1 Homo sapiens 68-71 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 181-184 mitogen-activated protein kinase 1 Homo sapiens 19-64 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 181-184 mitogen-activated protein kinase 1 Homo sapiens 66-69 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 240-243 mitogen-activated protein kinase 1 Homo sapiens 66-69 14504178-7 2003 The 18:1 LPA-induced neointimal formation in vivo was also dependent on the coordinated activation of ERK and p38MAPK. lysophosphatidic acid 9-12 mitogen-activated protein kinase 1 Homo sapiens 102-105 12447997-0 2002 Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 42-45 12902401-0 2003 Mechanisms in LPA-induced tumor cell migration: critical role of phosphorylated ERK. lysophosphatidic acid 14-17 mitogen-activated protein kinase 1 Homo sapiens 80-83 12902401-5 2003 LPA-induced chemotaxis is markedly dependent on activation of PTX-sensitive heterotrimeric G-proteins, on activation of the small GTPases Ras, Rac and RhoA, and on GTPase-dependent activation of ERK. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 195-198 12902401-6 2003 LPA-induced ERK activation results in a transient translocation of the phosphorylated ERK to newly forming focal contact sites at the leading edge of the migrating cells. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 12-15 12902401-6 2003 LPA-induced ERK activation results in a transient translocation of the phosphorylated ERK to newly forming focal contact sites at the leading edge of the migrating cells. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 86-89 12902401-7 2003 Inhibition of ERK activation and its subsequent translocation impaired LPA-induced chemotaxis and LPA-induced actin reorganization. lysophosphatidic acid 71-74 mitogen-activated protein kinase 1 Homo sapiens 14-17 12902401-7 2003 Inhibition of ERK activation and its subsequent translocation impaired LPA-induced chemotaxis and LPA-induced actin reorganization. lysophosphatidic acid 98-101 mitogen-activated protein kinase 1 Homo sapiens 14-17 12902401-8 2003 Thus, pancreatic tumor cell migration in response to LPA is essentially controlled by activation of a Gi/o-ERK pathway and requires the LPA-induced activation of Ras, Rac1 and RhoA. lysophosphatidic acid 53-56 mitogen-activated protein kinase 1 Homo sapiens 107-110 12730329-7 2003 The findings indicate that LPA transiently stimulates MAPK ERK in LPA1/edg2-expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway. lysophosphatidic acid 27-30 mitogen-activated protein kinase 1 Homo sapiens 59-62 12765417-7 2003 Activation of the inhibitory guanine nucleotide-binding protein and of ERK signalling pathways were required for most transcription factor responses to LPA. lysophosphatidic acid 152-155 mitogen-activated protein kinase 1 Homo sapiens 71-74 12765417-11 2003 In summary, extracellular signal-regulated kinase activation is required for many transcription factor responses to lysophosphatidic acid and epidermal growth factor, however it is not synergistic. lysophosphatidic acid 116-137 mitogen-activated protein kinase 1 Homo sapiens 12-49 12447997-5 2002 Furthermore, treatment with LPA alone induces the rapid (maximal signal within 2 min) tyrosine phosphorylation of EGFR, and subsequent (maximal signal after 5 min) activation of ERK, suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK. lysophosphatidic acid 28-31 mitogen-activated protein kinase 1 Homo sapiens 178-181 12730329-5 2003 Surprisingly, functional inhibition of Rho-GTPase, in C3-exotoxin-lipofected cells, markedly reduced LPA-stimulated phosphorylation of ERK, without affecting the EGF-induced stimulation of MAPK. lysophosphatidic acid 101-104 mitogen-activated protein kinase 1 Homo sapiens 135-138 11832770-8 2002 Specifically stimulation of GPCRs for lysophosphatidic acid and bradykinin induces proliferation of androgen independent prostate cancer cells via the activation of the extracellular signal regulated kinase (ERK) pathway. lysophosphatidic acid 38-59 mitogen-activated protein kinase 1 Homo sapiens 169-206 12139919-7 2002 Phosphorylation of the ERK1/ERK2 MAP kinases was the only response elicited by LPA in oligodendrocytes. lysophosphatidic acid 79-82 mitogen-activated protein kinase 1 Homo sapiens 28-32 12447997-5 2002 Furthermore, treatment with LPA alone induces the rapid (maximal signal within 2 min) tyrosine phosphorylation of EGFR, and subsequent (maximal signal after 5 min) activation of ERK, suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK. lysophosphatidic acid 28-31 mitogen-activated protein kinase 1 Homo sapiens 224-227 12447997-5 2002 Furthermore, treatment with LPA alone induces the rapid (maximal signal within 2 min) tyrosine phosphorylation of EGFR, and subsequent (maximal signal after 5 min) activation of ERK, suggesting that EGFR activation precedes ERK phosphorylation and may constitute a required component for signal relay from the LPA receptor to ERK. lysophosphatidic acid 28-31 mitogen-activated protein kinase 1 Homo sapiens 224-227 12447997-6 2002 Accordingly, we show that inhibition of EGFR kinase activity attenuates the LPA-regulated ERK activation. lysophosphatidic acid 76-79 mitogen-activated protein kinase 1 Homo sapiens 90-93 12447997-7 2002 In addition, we find that the LPA-regulated tyrosine phosphorylation of EGFR and activation of ERK are attenuated by batimastat, a generic inhibitor of matrix metalloproteinases (MMP). lysophosphatidic acid 30-33 mitogen-activated protein kinase 1 Homo sapiens 95-98 12069837-5 2002 Induction of ERK by LPA proceeds via Gbetagamma-dependent activation of tyrosine kinases, including the epidermal growth factor (EGF) receptor and c-Src. lysophosphatidic acid 20-23 mitogen-activated protein kinase 1 Homo sapiens 13-16 12069837-6 2002 Further, LPA-induced ERK activation involves matrix metalloproteinases (MMPs), which cause the release of active EGFR ligands. lysophosphatidic acid 9-12 mitogen-activated protein kinase 1 Homo sapiens 21-24 11832770-8 2002 Specifically stimulation of GPCRs for lysophosphatidic acid and bradykinin induces proliferation of androgen independent prostate cancer cells via the activation of the extracellular signal regulated kinase (ERK) pathway. lysophosphatidic acid 38-59 mitogen-activated protein kinase 1 Homo sapiens 208-211 11832770-9 2002 Induction of ERK by the bradykinin and lysophosphatidic acid in prostate cells proceeds via distinct pathways and involves Galphaq and Gbetagamma subunits, respectively. lysophosphatidic acid 39-60 mitogen-activated protein kinase 1 Homo sapiens 13-16 11160627-5 2001 In contrast, activation of ERK by lysophosphatidic acid, a Gi-coupled receptor activator, was inhibited by PTX, PP1, and AG1478, but not by calphostin C. lysophosphatidic acid 34-55 mitogen-activated protein kinase 1 Homo sapiens 27-30 11062066-8 2000 These results indicate that LPA promotes cell survival largely via G(i)-protein-mediated activation of ERK1/ERK2, or other PD 98059-sensitive member(s) of the MAPK family. lysophosphatidic acid 28-31 mitogen-activated protein kinase 1 Homo sapiens 108-112 10688043-7 2000 In the androgen-insensitive cell line, PC-3, EGF- and LPA-induced ERK phosphorylation and cell proliferation. lysophosphatidic acid 54-57 mitogen-activated protein kinase 1 Homo sapiens 66-69 10788507-7 2000 Expression of Gab1Y627F blocked the extracellular signal-regulated kinase-2 (ERK2) activation by lysophosphatidic acid (LPA) and EGF. lysophosphatidic acid 97-118 mitogen-activated protein kinase 1 Homo sapiens 36-75 10788507-7 2000 Expression of Gab1Y627F blocked the extracellular signal-regulated kinase-2 (ERK2) activation by lysophosphatidic acid (LPA) and EGF. lysophosphatidic acid 97-118 mitogen-activated protein kinase 1 Homo sapiens 77-81 10788507-7 2000 Expression of Gab1Y627F blocked the extracellular signal-regulated kinase-2 (ERK2) activation by lysophosphatidic acid (LPA) and EGF. lysophosphatidic acid 120-123 mitogen-activated protein kinase 1 Homo sapiens 36-75 10788507-7 2000 Expression of Gab1Y627F blocked the extracellular signal-regulated kinase-2 (ERK2) activation by lysophosphatidic acid (LPA) and EGF. lysophosphatidic acid 120-123 mitogen-activated protein kinase 1 Homo sapiens 77-81 10788507-9 2000 Whereas the PH domain was required for Gab1 mediation of ERK2 activation by LPA, it was not essential for EGF-induced ERK2 activation. lysophosphatidic acid 76-79 mitogen-activated protein kinase 1 Homo sapiens 57-61 10788507-11 2000 These results establish a role for Gab1 in the LPA-induced MAP kinase pathway and clearly demonstrate that Gab1-SHP2 interaction is essential for ERK2 activation by LPA and EGF. lysophosphatidic acid 47-50 mitogen-activated protein kinase 1 Homo sapiens 146-150 10788507-11 2000 These results establish a role for Gab1 in the LPA-induced MAP kinase pathway and clearly demonstrate that Gab1-SHP2 interaction is essential for ERK2 activation by LPA and EGF. lysophosphatidic acid 165-168 mitogen-activated protein kinase 1 Homo sapiens 146-150 10688043-8 2000 Inhibition of EGF- and LPA- induced ERK activation with the EGF receptor inhibitor, AG1478, or the MEK inhibitor, PD98059, attenuated their proliferative effects. lysophosphatidic acid 23-26 mitogen-activated protein kinase 1 Homo sapiens 36-39 30403494-6 2019 Using Western blotting and ELISA, we determined that LPA stimulates the ERK and mTOR pathways in complete and serum-free medium. lysophosphatidic acid 53-56 mitogen-activated protein kinase 1 Homo sapiens 72-75 9792916-4 1998 The kinetics and concentration-dependency of LPA-induced JNK activation were in sharp contrast with those of LPA-induced extracellular signal-regulated kinase (ERK) activation, which reached the maximum within 3 min and occurred with an EC50 of 0.1 microg/ml. lysophosphatidic acid 109-112 mitogen-activated protein kinase 1 Homo sapiens 121-158 9792916-4 1998 The kinetics and concentration-dependency of LPA-induced JNK activation were in sharp contrast with those of LPA-induced extracellular signal-regulated kinase (ERK) activation, which reached the maximum within 3 min and occurred with an EC50 of 0.1 microg/ml. lysophosphatidic acid 109-112 mitogen-activated protein kinase 1 Homo sapiens 160-163 9792916-6 1998 These results indicate that the signal transduction pathways of LPA-induced JNK and ERK activations are distinct. lysophosphatidic acid 64-67 mitogen-activated protein kinase 1 Homo sapiens 84-87 9792916-7 1998 Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. lysophosphatidic acid 44-47 mitogen-activated protein kinase 1 Homo sapiens 65-68 9792916-7 1998 Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. lysophosphatidic acid 168-171 mitogen-activated protein kinase 1 Homo sapiens 65-68 35391830-3 2022 This action of LPA was mediated by the RHO/ROCK-SRF signaling downstream of LPA1 and LPA5 receptors and required ERK activity. lysophosphatidic acid 15-18 mitogen-activated protein kinase 1 Homo sapiens 113-116 32007501-4 2020 In both cell types amitriptyline, clomipramine and mianserin mimicked the ability of LPA to induce the phosphorylation/activation of extracellular signal -regulated kinases 1 and 2 (ERK1/2), which was blocked by the selective LPA1 receptor antagonist AM966 and the LPA1/3 antagonist Ki16425. lysophosphatidic acid 85-88 mitogen-activated protein kinase 1 Homo sapiens 133-180 31781264-0 2019 Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1. lysophosphatidic acid 20-23 mitogen-activated protein kinase 1 Homo sapiens 97-100 31781264-0 2019 Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1. lysophosphatidic acid 20-23 mitogen-activated protein kinase 1 Homo sapiens 101-105 31781264-8 2019 In addition, berberine inhibited the LPA-induced p-38/ERK-phosphorylation through binding to LPA1. lysophosphatidic acid 37-40 mitogen-activated protein kinase 1 Homo sapiens 54-57 31781264-10 2019 Berberine potentially modulates LPA function to suppress the proliferation and inflammation of FLS-RA through blocking the p38/ERK MAPK pathway mediated by LPA1. lysophosphatidic acid 32-35 mitogen-activated protein kinase 1 Homo sapiens 127-130 31781264-10 2019 Berberine potentially modulates LPA function to suppress the proliferation and inflammation of FLS-RA through blocking the p38/ERK MAPK pathway mediated by LPA1. lysophosphatidic acid 32-35 mitogen-activated protein kinase 1 Homo sapiens 131-135 29328374-10 2018 ATX downregulation moderately decreased estrogen- and LPA-induced phosphorylation of ERK. lysophosphatidic acid 54-57 mitogen-activated protein kinase 1 Homo sapiens 85-88 29328374-11 2018 In addition, the ERK inhibitor, PD98059, reduced cell proliferation with estrogen, ATX and LPA treatment. lysophosphatidic acid 91-94 mitogen-activated protein kinase 1 Homo sapiens 17-20 29328374-9 2018 High LPA levels markedly elevated the phosphorylation levels of extracellular signal-regulated kinase (ERK). lysophosphatidic acid 5-8 mitogen-activated protein kinase 1 Homo sapiens 64-101 26171059-14 2015 PKG II also inhibited the activation of PI3K/Akt and MEK/ERK mediated signaling, which is important for LPA-induced Rac1 activation. lysophosphatidic acid 104-107 mitogen-activated protein kinase 1 Homo sapiens 57-60 29328374-9 2018 High LPA levels markedly elevated the phosphorylation levels of extracellular signal-regulated kinase (ERK). lysophosphatidic acid 5-8 mitogen-activated protein kinase 1 Homo sapiens 103-106 29209219-7 2017 LPA induced MSK activation by signaling through ERK whereas p38MAPK, Rho kinase, NF-kappaB or PI3K contribute to IL-8 synthesis mainly via MSK-independent pathways. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 48-51 29209219-13 2017 Since simultaneous inhibition of both the p38MAPK and ERK-MSK-CREB pathways are required to significantly reduce LPA-mediated IL-8 and IL-6 production in TNFalpha-preconditioned RAFLS, drug combinations targeting these two pathways are potential new strategies to treat rheumatoid arthritis. lysophosphatidic acid 113-116 mitogen-activated protein kinase 1 Homo sapiens 54-57 28943105-3 2017 Here we show that these cells expressed messenger RNA coding for LPA1-3 receptors with the following order of abundance: LPA1 > LPA2 > LPA3 and that LPA was able to increase intracellular calcium, extracellular signal-regulated kinases 1/2 phosphorylation, and cell contraction. lysophosphatidic acid 65-68 mitogen-activated protein kinase 1 Homo sapiens 203-245 28348459-8 2017 LPA-induced DR6 expression was also dramatically inhibited by knockdown of ERK or CREB. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 75-78 28348459-9 2017 These results suggest that activation of the MEK/ERK pathway and the transcription factor CREB mediate LPA-induced DR6 expression. lysophosphatidic acid 103-106 mitogen-activated protein kinase 1 Homo sapiens 49-52 26553339-4 2015 The pro-survival effect of LPA is concentration- and time-dependent and it is mediated by the activation of peroxisome proliferator-activator receptor gamma (PPARgamma) and downstream, by the activation of pro-survival ERK and Akt signaling pathways and the inhibition of mitochondrial apoptotic pathway. lysophosphatidic acid 27-30 mitogen-activated protein kinase 1 Homo sapiens 219-222 26171059-10 2015 ERK and its upstream activator MAPK kinase (MEK) are also involved in LPA-induced motility/migration of cancer cells. lysophosphatidic acid 70-73 mitogen-activated protein kinase 1 Homo sapiens 0-3 26171059-10 2015 ERK and its upstream activator MAPK kinase (MEK) are also involved in LPA-induced motility/migration of cancer cells. lysophosphatidic acid 70-73 mitogen-activated protein kinase 1 Homo sapiens 31-35 29209219-2 2017 Signaling through p38MAPK, ERK, Rho kinase, and MSK-CREB contributes to LPA-mediated IL-8 production in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients. lysophosphatidic acid 72-75 mitogen-activated protein kinase 1 Homo sapiens 27-30 26171059-15 2015 These results suggest that PKG II affects LPA-stimulated migration of AGS cells by blocking Rac1 activation, via inhibition of PI3K/Akt and MEK/ERK mediated signaling. lysophosphatidic acid 42-45 mitogen-activated protein kinase 1 Homo sapiens 144-147 25491146-7 2015 However, when added 15 minutes prior to LPA, EPA suppresses LPA-induced activating phosphorylations of ERK, FAK, and p70S6K, and expression of the matricellular protein CCN1. lysophosphatidic acid 60-63 mitogen-activated protein kinase 1 Homo sapiens 103-106 24461407-8 2014 LPA functioned as an antiapoptotic cytokine by activation of the phosphorylation of FAK and ERK. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 92-95 24845645-9 2014 Pharmacological inhibition and reporter gene assays revealed that the activation of the LPA receptor LPAR1, Gi/o protein, phosphatidylinositol-3 kinase (PI3K), extracellular-signal-regulated kinase (ERK), and cyclic adenosine monophosphate response element-binding protein (CREB) but not nuclear factor kappaB induced hyaluronic acid synthesis by the treatment with cPA and LPA in NB1RGB cells. lysophosphatidic acid 88-91 mitogen-activated protein kinase 1 Homo sapiens 199-202 25424429-0 2014 Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. lysophosphatidic acid 110-131 mitogen-activated protein kinase 1 Homo sapiens 54-57 24845645-10 2014 These results demonstrate for the first time that cPA and LPA induce hyaluronic acid synthesis in human skin fibroblasts mainly through the activation of LPAR1-Gi/o followed by the PI3K, ERK, and CREB signaling pathway. lysophosphatidic acid 58-61 mitogen-activated protein kinase 1 Homo sapiens 187-190 24461407-11 2014 LPA could effectively rescue HDPCs from ischemia-induced apoptosis via regulation of Bax and Bcl-2 and the activation of phosphorylated FAK and phosphorylated ERK. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 159-162 22847216-4 2012 Immunoblot experiments with P19 cells revealed that the mitogen activated protein kinases, including p-ERK, p38, pAKT, glycogen synthase kinase 3beta, and CREB were phosphorylated by treatment with 10 muM LPA. lysophosphatidic acid 205-208 mitogen-activated protein kinase 1 Homo sapiens 108-111 23747852-4 2013 Intriguingly, the angiogenic signaling mechanisms mediated by LPA have been linked to specific G-protein coupled receptors and down stream MAPK including Erk1/2, p38 and JNK, protein kinase D (PKD-1), Rho kinase (ROCK), and the NF-kappa B signaling pathways. lysophosphatidic acid 62-65 mitogen-activated protein kinase 1 Homo sapiens 162-165 23618389-7 2013 We demonstrated that G13, but not or to a lesser extent G12, Gi or Gq, was necessary for LPA-induced dpYAP and its nuclear translocation and that RhoA-ROCK, but not RhoB, RhoC, Rac1, cdc42, PI3K, ERK, or AKT, were required for the LPA-dpYAP effect. lysophosphatidic acid 89-92 mitogen-activated protein kinase 1 Homo sapiens 196-199 23319595-11 2013 We also present evidence that both RhoC and MRK are required for LPA-induced stimulation of the p38 and ERK MAP kinases. lysophosphatidic acid 65-68 mitogen-activated protein kinase 1 Homo sapiens 104-107 23319595-12 2013 In conclusion, we have identified MRK as a novel RhoC effector that controls LPA-stimulated cell invasion at least in part by regulating myosin dynamics, ERK and p38. lysophosphatidic acid 77-80 mitogen-activated protein kinase 1 Homo sapiens 154-157 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 31-34 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 107-110 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 203-206 mitogen-activated protein kinase 1 Homo sapiens 31-34 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 203-206 mitogen-activated protein kinase 1 Homo sapiens 107-110 23942151-9 2013 These results suggest that MEK-ERK pathway plays a key role in LPA-induced cell migration and mRNA expression of TAZ in R182 cells, without affecting stability of TAZ protein. lysophosphatidic acid 63-66 mitogen-activated protein kinase 1 Homo sapiens 31-34 21209852-7 2010 Furthermore, LPA increased PI3K activity, and the PI3K inhibitor LY294002 inhibited both LPA-induced PAK1/ERK activation and cell migration. lysophosphatidic acid 89-92 mitogen-activated protein kinase 1 Homo sapiens 106-109 22577133-0 2012 Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 117-154 22577133-0 2012 Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 156-159 22577133-8 2012 Examining the upstream kinases that mediate ERK and JNK activation, leading to Egr-1 expression, we found that LPA-induced activation of MAPKs and expression of Egr-1 are dependent on PKC activation. lysophosphatidic acid 111-114 mitogen-activated protein kinase 1 Homo sapiens 44-47 22577133-12 2012 Our data reveal an intracellular regulatory mechanism: LPA induction of Egr-1 expression is via LPA cognate receptor (LPA receptor 1)-dependent and PKCdelta-mediated ERK and JNK activation. lysophosphatidic acid 55-58 mitogen-activated protein kinase 1 Homo sapiens 166-169 22577133-13 2012 This study provides the first evidence that PKCdelta mediates ERK and JNK activation in the LPA signaling pathway and that this pathway is required for LPA-induced gene regulation as evidenced by Egr-1 expression. lysophosphatidic acid 92-95 mitogen-activated protein kinase 1 Homo sapiens 62-65 22024689-2 2011 Lysophosphatidic acid (LPA) is a mitogenic lipid present within the ovarian tumor microenvironment and induces LPA receptor activation and intracellular signaling cascades like ERK/MAPK, leading to enhanced cellular proliferation. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 177-180 22024689-2 2011 Lysophosphatidic acid (LPA) is a mitogenic lipid present within the ovarian tumor microenvironment and induces LPA receptor activation and intracellular signaling cascades like ERK/MAPK, leading to enhanced cellular proliferation. lysophosphatidic acid 23-26 mitogen-activated protein kinase 1 Homo sapiens 177-180 21209852-0 2010 Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling. lysophosphatidic acid 0-21 mitogen-activated protein kinase 1 Homo sapiens 103-106 21209852-5 2010 LPA also increased ERK activity and the MEK inhibitor U0126 could block LPA-induced ERK activity and cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 19-22 21209852-8 2010 Moreover, in the breast cancer cell, LPA treatment resulted in remarkable production of reactive oxygen species (ROS), while LPA-induced ROS generation, PI3K/PAK1/ERK activation and cell migration could be inhibited by N-acetyl-L-Cysteine, a scavenger of ROS. lysophosphatidic acid 37-40 mitogen-activated protein kinase 1 Homo sapiens 163-166 21209852-5 2010 LPA also increased ERK activity and the MEK inhibitor U0126 could block LPA-induced ERK activity and cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 84-87 21209852-8 2010 Moreover, in the breast cancer cell, LPA treatment resulted in remarkable production of reactive oxygen species (ROS), while LPA-induced ROS generation, PI3K/PAK1/ERK activation and cell migration could be inhibited by N-acetyl-L-Cysteine, a scavenger of ROS. lysophosphatidic acid 125-128 mitogen-activated protein kinase 1 Homo sapiens 163-166 21209852-5 2010 LPA also increased ERK activity and the MEK inhibitor U0126 could block LPA-induced ERK activity and cell migration. lysophosphatidic acid 72-75 mitogen-activated protein kinase 1 Homo sapiens 19-22 21209852-5 2010 LPA also increased ERK activity and the MEK inhibitor U0126 could block LPA-induced ERK activity and cell migration. lysophosphatidic acid 72-75 mitogen-activated protein kinase 1 Homo sapiens 84-87 21209852-9 2010 CONCLUSIONS/SIGNIFICANCE: Taken together, this study identifies a PI3K/PAK1/ERK signaling pathway for LPA-stimulated breast cancer cell migration. lysophosphatidic acid 102-105 mitogen-activated protein kinase 1 Homo sapiens 76-79 21209852-10 2010 These data also suggest that ROS generation plays an essential role in the activation of LPA-stimulated PI3K/PAK1/ERK signaling and breast cancer cell migration. lysophosphatidic acid 89-92 mitogen-activated protein kinase 1 Homo sapiens 114-117 20934509-3 2010 Exogenous LPA further stimulated ERK and Akt phosphorylation and NF-kappaB activity. lysophosphatidic acid 10-13 mitogen-activated protein kinase 1 Homo sapiens 33-36 18658095-9 2009 Wounding-, LPA-, and ATP-induced HB-EGF shedding and EGFR activation were attenuated by the MAPK/ERK kinase (MEK) inhibitors PD98059 and U0126, as well as by ADAM10 and -17 inhibitors. lysophosphatidic acid 11-14 mitogen-activated protein kinase 1 Homo sapiens 97-100 20177148-9 2010 Moreover, LPA-induced alpha-SMA expression was abrogated by treatment with the ERK inhibitor U0126 or the phosphoinositide-3-kinase inhibitor LY294002, but not the PLC inhibitor U73122. lysophosphatidic acid 10-13 mitogen-activated protein kinase 1 Homo sapiens 79-82 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 88-91 mitogen-activated protein kinase 1 Homo sapiens 15-18 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 88-91 mitogen-activated protein kinase 1 Homo sapiens 151-154 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 15-18 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 151-154 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 15-18 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 151-154 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 15-18 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 1 Homo sapiens 151-154 20177148-11 2010 These results suggest that cancer-secreted LPA induces differentiation of hASCs to cancer-associated fibroblasts through multiple signaling pathways involving Rho kinase, ERK, PLC, and phosphoinositide-3-kinase. lysophosphatidic acid 43-46 mitogen-activated protein kinase 1 Homo sapiens 171-174 19116446-3 2008 LPA induced COX-2 expression in a dose-dependent manner, and pretreatment of the cells with pharmacological inhibitors of Gi (pertussis toxin), Src (PP2), EGF receptor (EGFR) (AG1478), ERK (PD98059) significantly inhibited LPA- induced COX-2 expression. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 185-188 18309089-9 2008 Together, the data presented here indicate that LPA mediates the rapid decrease in EGFR binding via EGFR transactivation, MEK/ERK, and PKC, whereas the sustained decrease is regulated primarily by PKC. lysophosphatidic acid 48-51 mitogen-activated protein kinase 1 Homo sapiens 126-129 18762583-2 2008 We show that stimulation of interphase cells with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal-regulated kinase (ERK), which phosphorylates the Golgi structural protein GRASP65 at serine 277. lysophosphatidic acid 90-111 mitogen-activated protein kinase 1 Homo sapiens 126-163 18762583-2 2008 We show that stimulation of interphase cells with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal-regulated kinase (ERK), which phosphorylates the Golgi structural protein GRASP65 at serine 277. lysophosphatidic acid 90-111 mitogen-activated protein kinase 1 Homo sapiens 165-168 18268018-5 2008 This effect of calcium was apparent upon lysophosphatidic acid stimulation, where ERKs translocation was delayed compared with that induced by EGF in a calcium-dependent manner. lysophosphatidic acid 41-62 mitogen-activated protein kinase 1 Homo sapiens 82-86 18027882-5 2008 LPA induced activation of ERK through pertussis toxin-sensitive manner, and pretreatment of MSCs with U0126, a MEK inhibitor, or pertussis toxin attenuated the LPA-induced migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 1 Homo sapiens 26-29 18027882-5 2008 LPA induced activation of ERK through pertussis toxin-sensitive manner, and pretreatment of MSCs with U0126, a MEK inhibitor, or pertussis toxin attenuated the LPA-induced migration. lysophosphatidic acid 160-163 mitogen-activated protein kinase 1 Homo sapiens 26-29 17251460-1 2007 PURPOSE: To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3"-kinase (PI3K) during corneal epithelial wound healing. lysophosphatidic acid 71-92 mitogen-activated protein kinase 1 Homo sapiens 138-175 17937769-5 2007 Furthermore, LPA-induced ERK activation was found to be independent of matrix metalloproteinases; thus, c-Src acted as the scaffold-transactivating epidermal growth factor receptor. lysophosphatidic acid 13-16 mitogen-activated protein kinase 1 Homo sapiens 25-28 17531530-3 2007 Our results demonstrate that parallel activation of ERK1/2 and p38, but not JNK, is responsible for LPA-stimulated PC3 cell migration. lysophosphatidic acid 100-103 mitogen-activated protein kinase 1 Homo sapiens 63-66 17531530-4 2007 Furthermore, using small interfering RNA (siRNA) technology, and overexpressing dominant-negative mutants of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration. lysophosphatidic acid 295-298 mitogen-activated protein kinase 1 Homo sapiens 109-112 17531530-4 2007 Furthermore, using small interfering RNA (siRNA) technology, and overexpressing dominant-negative mutants of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration. lysophosphatidic acid 295-298 mitogen-activated protein kinase 1 Homo sapiens 202-206 17531530-4 2007 Furthermore, using small interfering RNA (siRNA) technology, and overexpressing dominant-negative mutants of p38 MAPK isotypes of alpha, beta, gamma and delta, we have identified that the activation of ERK2 (p42) and p38alpha, but not of ERK1 and the other isoforms of p38 MAPK, is required for LPA-induced migration. lysophosphatidic acid 295-298 mitogen-activated protein kinase 1 Homo sapiens 217-220 17531530-6 2007 The results of the present study suggest that LPA, the receptor LPA(1), ERK2 and p38alpha are important regulators for prostate cancer cell invasion and thus could play a significant role in the development of metastasis. lysophosphatidic acid 46-49 mitogen-activated protein kinase 1 Homo sapiens 72-76 17251460-1 2007 PURPOSE: To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3"-kinase (PI3K) during corneal epithelial wound healing. lysophosphatidic acid 71-92 mitogen-activated protein kinase 1 Homo sapiens 177-180 17251460-1 2007 PURPOSE: To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3"-kinase (PI3K) during corneal epithelial wound healing. lysophosphatidic acid 94-97 mitogen-activated protein kinase 1 Homo sapiens 138-175 17251460-1 2007 PURPOSE: To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3"-kinase (PI3K) during corneal epithelial wound healing. lysophosphatidic acid 94-97 mitogen-activated protein kinase 1 Homo sapiens 177-180 17251460-8 2007 Consistent with the effects on epithelial migration, these inhibitors, as well as the Src kinase inhibitor (PP2), retarded LPA-induced activation of EGFR and its downstream effectors ERK and AKT in THCE cells. lysophosphatidic acid 123-126 mitogen-activated protein kinase 1 Homo sapiens 183-186