PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21900174-0 2011 The salt stress-induced LPA response in Chlamydomonas is produced via PLA2 hydrolysis of DGK-generated phosphatidic acid. lysophosphatidic acid 24-27 phospholipase A2 group IB Homo sapiens 70-74 22867755-2 2013 Enzymes that participate in LPC and LPA metabolism, such as the phospholipase A(2) superfamily (PLA(2)) and autotaxin (ATX, ENPP2), play central roles in regulating LPC and LPA levels and consequently their actions. lysophosphatidic acid 36-39 phospholipase A2 group IB Homo sapiens 64-82 22867755-2 2013 Enzymes that participate in LPC and LPA metabolism, such as the phospholipase A(2) superfamily (PLA(2)) and autotaxin (ATX, ENPP2), play central roles in regulating LPC and LPA levels and consequently their actions. lysophosphatidic acid 36-39 phospholipase A2 group IB Homo sapiens 96-102 22767227-2 2012 Lysophosphatidic acid (LPA), a major tumor-promoting factor in EOC ascites, is an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes. lysophosphatidic acid 0-21 phospholipase A2 group IB Homo sapiens 123-141 22767227-2 2012 Lysophosphatidic acid (LPA), a major tumor-promoting factor in EOC ascites, is an enzymatic product of autotaxin (ATX) and phospholipase A(2) (PLA(2))enzymes. lysophosphatidic acid 23-26 phospholipase A2 group IB Homo sapiens 123-141 21900174-3 2011 Lysophosphatidic acid (LPA) was also increased and was suggested to reflect a phospholipase A2 (PLA2) activity based on pharmacological evidence. lysophosphatidic acid 0-21 phospholipase A2 group IB Homo sapiens 78-94 21900174-3 2011 Lysophosphatidic acid (LPA) was also increased and was suggested to reflect a phospholipase A2 (PLA2) activity based on pharmacological evidence. lysophosphatidic acid 0-21 phospholipase A2 group IB Homo sapiens 96-100 21900174-3 2011 Lysophosphatidic acid (LPA) was also increased and was suggested to reflect a phospholipase A2 (PLA2) activity based on pharmacological evidence. lysophosphatidic acid 23-26 phospholipase A2 group IB Homo sapiens 78-94 21900174-3 2011 Lysophosphatidic acid (LPA) was also increased and was suggested to reflect a phospholipase A2 (PLA2) activity based on pharmacological evidence. lysophosphatidic acid 23-26 phospholipase A2 group IB Homo sapiens 96-100 21900174-8 2011 Together with differential 32P-radiolabeling studies and earlier PLD-transphosphatidylation and PLA2-inhibitor assays, the data were consistent with the hypothesis that the salt-induced LPA response is primarily generated through PLA2-mediated hydrolysis of DGK-generated PA and that PLD or de novo synthesis [via endoplasmic reticulum - or plastid-localized routes] is not a major contributor. lysophosphatidic acid 186-189 phospholipase A2 group IB Homo sapiens 96-100 21900174-8 2011 Together with differential 32P-radiolabeling studies and earlier PLD-transphosphatidylation and PLA2-inhibitor assays, the data were consistent with the hypothesis that the salt-induced LPA response is primarily generated through PLA2-mediated hydrolysis of DGK-generated PA and that PLD or de novo synthesis [via endoplasmic reticulum - or plastid-localized routes] is not a major contributor. lysophosphatidic acid 186-189 phospholipase A2 group IB Homo sapiens 230-234 11230322-10 2001 The PLA(2) metabolite lysophosphatidic acid (LPA) also activated the hBNP promoter, but arachidonic acid itself did not. lysophosphatidic acid 22-43 phospholipase A2 group IB Homo sapiens 4-10 19864325-11 2010 A phospholipase A2 (PLA2) inhibitor also blocks LPA- and EGF-induced LPA production. lysophosphatidic acid 48-51 phospholipase A2 group IB Homo sapiens 2-18 19864325-11 2010 A phospholipase A2 (PLA2) inhibitor also blocks LPA- and EGF-induced LPA production. lysophosphatidic acid 48-51 phospholipase A2 group IB Homo sapiens 20-24 19864325-11 2010 A phospholipase A2 (PLA2) inhibitor also blocks LPA- and EGF-induced LPA production. lysophosphatidic acid 69-72 phospholipase A2 group IB Homo sapiens 2-18 19864325-11 2010 A phospholipase A2 (PLA2) inhibitor also blocks LPA- and EGF-induced LPA production. lysophosphatidic acid 69-72 phospholipase A2 group IB Homo sapiens 20-24 15465041-4 2004 LPA-induced Ca(2+) influx was not affected by pertussis toxin and phospholipase C inhibitor (U73122), ruling out the involvement of pertussis toxin-sensitive G-proteins, and phospholipase C. Stimulation of U937 cells with Trp-Lys-Tyr-Met-Val-D-Met (WKYMVm), which binds to formyl peptide receptor like 1, enhanced phospholipase A(2) and phospholipase D activation, indicating LPA formation. lysophosphatidic acid 0-3 phospholipase A2 group IB Homo sapiens 314-332 15465041-5 2004 The inhibition of LPA synthesis by phospholipase A(2)-specific inhibitor (MAFP) or n-butanol significantly inhibited WKYMVm-induced Ca(2+) influx, suggesting a crucial role for LPA in the process. lysophosphatidic acid 18-21 phospholipase A2 group IB Homo sapiens 35-53 15465041-5 2004 The inhibition of LPA synthesis by phospholipase A(2)-specific inhibitor (MAFP) or n-butanol significantly inhibited WKYMVm-induced Ca(2+) influx, suggesting a crucial role for LPA in the process. lysophosphatidic acid 177-180 phospholipase A2 group IB Homo sapiens 35-53 14760444-3 2003 Because platelet function and phospholipase A2 activity are upregulated in hypertensive and coronary heart disease patients, respectively, plasma and cytosolic LPA levels are expected to be higher in these pathological conditions. lysophosphatidic acid 160-163 phospholipase A2 group IB Homo sapiens 30-46 12837850-8 2003 SK-OV-3 cells express and secrete a phospholipase A2 activity that can generate LPA from the lipid product of PLD, phosphatidic acid. lysophosphatidic acid 80-83 phospholipase A2 group IB Homo sapiens 36-52 11982483-1 2002 Lysophosphatidic acid (LPA) is a physiological agonist that is produced by lysophospholipase D, phospholipase A(1) and phospholipase A(2) in the blood of animals. lysophosphatidic acid 0-21 phospholipase A2 group IB Homo sapiens 119-137 11982483-1 2002 Lysophosphatidic acid (LPA) is a physiological agonist that is produced by lysophospholipase D, phospholipase A(1) and phospholipase A(2) in the blood of animals. lysophosphatidic acid 23-26 phospholipase A2 group IB Homo sapiens 119-137 11230322-10 2001 The PLA(2) metabolite lysophosphatidic acid (LPA) also activated the hBNP promoter, but arachidonic acid itself did not. lysophosphatidic acid 45-48 phospholipase A2 group IB Homo sapiens 4-10 10873103-0 2000 Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. lysophosphatidic acid 17-38 phospholipase A2 group IB Homo sapiens 97-113 21340821-2 2001 An elevation in [Ca(2+)](i) activates enzymes (phospholipase A(2), phospho- lipase D and some isoforms of protein kinase C) associated with the liberation of bioactive lipids such as arachidonic acid (AA) and lysophosphatidic acid (LPA) (1,2). lysophosphatidic acid 209-230 phospholipase A2 group IB Homo sapiens 47-84 21340821-2 2001 An elevation in [Ca(2+)](i) activates enzymes (phospholipase A(2), phospho- lipase D and some isoforms of protein kinase C) associated with the liberation of bioactive lipids such as arachidonic acid (AA) and lysophosphatidic acid (LPA) (1,2). lysophosphatidic acid 232-235 phospholipase A2 group IB Homo sapiens 47-84 10873103-0 2000 Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. lysophosphatidic acid 40-43 phospholipase A2 group IB Homo sapiens 97-113 10873103-5 2000 Constitutive and LPA-induced LPA synthesis by ovarian cancer cells is differentially regulated with respect to the requirement of specific phospholipase A2 (PLA2) subgroups. lysophosphatidic acid 17-20 phospholipase A2 group IB Homo sapiens 139-155 10873103-5 2000 Constitutive and LPA-induced LPA synthesis by ovarian cancer cells is differentially regulated with respect to the requirement of specific phospholipase A2 (PLA2) subgroups. lysophosphatidic acid 17-20 phospholipase A2 group IB Homo sapiens 157-161 10873103-5 2000 Constitutive and LPA-induced LPA synthesis by ovarian cancer cells is differentially regulated with respect to the requirement of specific phospholipase A2 (PLA2) subgroups. lysophosphatidic acid 29-32 phospholipase A2 group IB Homo sapiens 139-155 10873103-5 2000 Constitutive and LPA-induced LPA synthesis by ovarian cancer cells is differentially regulated with respect to the requirement of specific phospholipase A2 (PLA2) subgroups. lysophosphatidic acid 29-32 phospholipase A2 group IB Homo sapiens 157-161 10873103-6 2000 Group IB (pancreatic) secretory PLA2 plays a critical role in both constitutive and LPA-induced LPA formation, whereas group IIA (synovial) secretory PLA2 contributes to LPA-induced LPA production only. lysophosphatidic acid 84-87 phospholipase A2 group IB Homo sapiens 32-36 10873103-6 2000 Group IB (pancreatic) secretory PLA2 plays a critical role in both constitutive and LPA-induced LPA formation, whereas group IIA (synovial) secretory PLA2 contributes to LPA-induced LPA production only. lysophosphatidic acid 96-99 phospholipase A2 group IB Homo sapiens 32-36 10873103-6 2000 Group IB (pancreatic) secretory PLA2 plays a critical role in both constitutive and LPA-induced LPA formation, whereas group IIA (synovial) secretory PLA2 contributes to LPA-induced LPA production only. lysophosphatidic acid 96-99 phospholipase A2 group IB Homo sapiens 32-36 10873103-6 2000 Group IB (pancreatic) secretory PLA2 plays a critical role in both constitutive and LPA-induced LPA formation, whereas group IIA (synovial) secretory PLA2 contributes to LPA-induced LPA production only. lysophosphatidic acid 96-99 phospholipase A2 group IB Homo sapiens 32-36 9282910-2 1997 The products of the PLA2-catalyzed reaction can potentially act as second messengers themselves, or be further metabolized to eicosanoids, platelet-activating factor, and lysophosphatidic acid. lysophosphatidic acid 171-192 phospholipase A2 group IB Homo sapiens 20-24 9611122-3 1998 LPA is also generated by a secretory, cytokine-inducible phospholipase A2 present in high concentrations in inflammatory exudates and septic states. lysophosphatidic acid 0-3 phospholipase A2 group IB Homo sapiens 57-73 10595650-7 1999 LPA induces a proinflammatory activation of endothelial cells that (i) involves Gi proteins; (ii) depends on phospholipase A2 activity; (iii) is associated with the activation of NF-kappaB and (iv) results in increased expression of proinflammatory genes. lysophosphatidic acid 0-3 phospholipase A2 group IB Homo sapiens 109-125 9202883-2 1997 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). lysophosphatidic acid 319-340 phospholipase A2 group IB Homo sapiens 0-4 9032461-2 1997 The phospholipase A2 (PLA2)-catalysed hydrolysis of phosphatidic acid (PA) is thought to be a primary synthetic route for LPA. lysophosphatidic acid 122-125 phospholipase A2 group IB Homo sapiens 4-20 9032461-2 1997 The phospholipase A2 (PLA2)-catalysed hydrolysis of phosphatidic acid (PA) is thought to be a primary synthetic route for LPA. lysophosphatidic acid 122-125 phospholipase A2 group IB Homo sapiens 22-26 9032461-3 1997 Of the multiple forms of PLA2 present in human tissues, human secretory class-II PLA2 (hs-PLA2) has been implicated in the production of LPA from platelets and whole blood cells challenged with inflammatory stimuli. lysophosphatidic acid 137-140 phospholipase A2 group IB Homo sapiens 25-29 9032461-3 1997 Of the multiple forms of PLA2 present in human tissues, human secretory class-II PLA2 (hs-PLA2) has been implicated in the production of LPA from platelets and whole blood cells challenged with inflammatory stimuli. lysophosphatidic acid 137-140 phospholipase A2 group IB Homo sapiens 81-85 9032461-3 1997 Of the multiple forms of PLA2 present in human tissues, human secretory class-II PLA2 (hs-PLA2) has been implicated in the production of LPA from platelets and whole blood cells challenged with inflammatory stimuli. lysophosphatidic acid 137-140 phospholipase A2 group IB Homo sapiens 87-94 9032461-4 1997 To explore further the possibility that hs-PLA2 is involved in the production of LPA, we rigorously measured the phospholipid head group specificity of hs-PLA2 by a novel PLA2 kinetic system using polymerized mixed liposomes. lysophosphatidic acid 81-84 phospholipase A2 group IB Homo sapiens 40-47 9032461-4 1997 To explore further the possibility that hs-PLA2 is involved in the production of LPA, we rigorously measured the phospholipid head group specificity of hs-PLA2 by a novel PLA2 kinetic system using polymerized mixed liposomes. lysophosphatidic acid 81-84 phospholipase A2 group IB Homo sapiens 43-47 9032461-10 1997 In conjunction with a recent cell study [Fourcade, Simon, Viode, Rugani, Leballe, Ragab, Fournie, Sarda and Chap (1995) Cell 80, 919-927], these studies suggest that hs-PLA2 can rapidly hydrolyse PA molecules exposed to the outer layer of cell-derived microvesicles and thereby produce LPA. lysophosphatidic acid 286-289 phospholipase A2 group IB Homo sapiens 166-173 9114816-9 1997 Another important function of phosphatidic acid is to act as a substrate for a specific phospholipase A2 to generate lysophosphatidic acid, which is becoming increasingly recognized as a major intercellular messenger. lysophosphatidic acid 117-138 phospholipase A2 group IB Homo sapiens 88-104 9202883-2 1997 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGa) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). lysophosphatidic acid 342-348 phospholipase A2 group IB Homo sapiens 0-4 33794877-1 2021 BACKGROUND: Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower respiratory tract of patients with idiopathic pulmonary fibrosis (IPF). lysophosphatidic acid 12-33 phospholipase A2 group IB Homo sapiens 98-114 3931692-2 1985 Such synthesis of lysophosphatidic acid can be inhibited by mepacrine, an inhibitor of the phospholipase A2 which attacks phosphatidic acid to give lysophosphatidic acid. lysophosphatidic acid 148-169 phospholipase A2 group IB Homo sapiens 91-107 3931692-6 1985 The results suggest that lysophosphatidic acid primarily acts distal to mepacrine inhibition of phospholipase A2 and phospholipase C and are consistent with the possibility that lysophosphatidic acid might be a mediator of part of the effects of low-dose thrombin on human platelets. lysophosphatidic acid 25-46 phospholipase A2 group IB Homo sapiens 96-112 6795196-3 1981 The effect of 1-oleoyl-lysophosphatidic acid (10 microM) plus thrombin (0.2 unit/ml) on the formation of phosphatidic acid temporally precedes the production of arachidonate metabolites consistent with a sequential activation of phosphatidylinositol-specific phospholipase C and phospholipase A2 activities. lysophosphatidic acid 14-44 phospholipase A2 group IB Homo sapiens 279-295 2393400-6 1990 Pancreatic phospholipase A2 hydrolyzes it to the lysophosphatidic acid conjugate. lysophosphatidic acid 49-70 phospholipase A2 group IB Homo sapiens 11-27 3931692-2 1985 Such synthesis of lysophosphatidic acid can be inhibited by mepacrine, an inhibitor of the phospholipase A2 which attacks phosphatidic acid to give lysophosphatidic acid. lysophosphatidic acid 18-39 phospholipase A2 group IB Homo sapiens 91-107 33794877-1 2021 BACKGROUND: Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the lower respiratory tract of patients with idiopathic pulmonary fibrosis (IPF). lysophosphatidic acid 35-38 phospholipase A2 group IB Homo sapiens 98-114 24778183-6 2014 In addition, incubating cells with the two products of PLA2 (lysophosphatidic acid and arachidonic acid) mimicked treatment with gossypol. lysophosphatidic acid 61-82 phospholipase A2 group IB Homo sapiens 55-59 30353652-4 2019 Data derived from transcriptome and secretome analyses of primary ascite-derived cells indicate that (a) the major route of LPA synthesis is the consecutive action of a secretory phospholipase A2 (PLA2 ) and autotaxin, (b) that the components of this pathway are coordinately upregulated in ascites, and (c) that CD163+CD206+ tumor-associated macrophages play an essential role as main producers of PLA2 G7 and autotaxin. lysophosphatidic acid 124-127 phospholipase A2 group IB Homo sapiens 197-201 29773019-2 2017 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). lysophosphatidic acid 319-340 phospholipase A2 group IB Homo sapiens 0-4 29773019-2 2017 PLA2 provides precursors for generation of eicosanoids, such as prostaglandins (PGs) and leukotrienes (LTs), when the cleaved fatty acid is arachidonic acid, platelet-activating factor (PAF) when the sn-1 position of the phosphatidylcholine contains an alkyl ether linkage and some bioactive lysophospholipids, such as lysophosphatidic acid (lysoPA). lysophosphatidic acid 342-348 phospholipase A2 group IB Homo sapiens 0-4