PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31359502-4 2019 Besides these changes, a variation of the spacer length (C3 -C5 ) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. dicyandiamido 101-115 ADAM metallopeptidase with thrombospondin type 1 motif 1 Homo sapiens 57-63 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 251-255 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 176-180 20044439-10 2010 The present study profiles the regulatory relationship between LPA and multiple cytokines in vascular SMCs for the first time, provides the first evidence that LPA upregulates IL-6 in vascular SMCs, and reveals the regulatory mechanism of LPA-induced IL-6 production in HASMCs. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 251-255 17915188-0 2008 Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts. lysophosphatidic acid 0-21 interleukin 6 Homo sapiens 33-53 19647363-7 2010 Treatment of the cells with curcumin inhibited LPA-induced IL-6 and IL-8 secretion and STAT3 phosphorylation, leading to blocked ovarian cancer cell motility. lysophosphatidic acid 47-50 interleukin 6 Homo sapiens 59-63 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 interleukin 6 Homo sapiens 18-22 17915188-4 2008 The expression of IL-6 and IL-8 mRNAs was maximal at 1-3h, and the increase in IL-6 and IL-8 synthesis in response to lysophosphatidic acid (1-10 microM) occurred in a concentration-dependent manner. lysophosphatidic acid 118-139 interleukin 6 Homo sapiens 79-83 17915188-7 2008 The pretreatment of SaM-1 cells with U-73122, a phospholipase C (PLC) inhibitor, and 2-APB also inhibited the increase in IL-6 and IL-8 synthesis in response to LPA. lysophosphatidic acid 161-164 interleukin 6 Homo sapiens 122-126 17915188-8 2008 These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells. lysophosphatidic acid 42-45 interleukin 6 Homo sapiens 54-58 17325741-6 2007 Our results strongly suggest that SPARC exerts a dual inhibitory effect on LPA-induced mesothelial-ovarian cancer cell crosstalk through the regulation of both LPA-induced IL-6 production and function. lysophosphatidic acid 75-78 interleukin 6 Homo sapiens 172-176 18006645-5 2008 Moreover, exogenously applied LPA induces FLS migration and secretion of IL-8/IL-6, whereas the LPA(3) agonist l-sn-1-O-oleoyl-2-methyl-glyceryl-3-phosphothionate (2S-OMPT) stimulates cytokine synthesis but not cell motility. lysophosphatidic acid 30-33 interleukin 6 Homo sapiens 78-82 18171700-8 2008 The effects of LPA on the expression of IL-6, IL-8, and vascular endothelial growth factor were examined. lysophosphatidic acid 15-18 interleukin 6 Homo sapiens 40-44 18171700-14 2008 LPA induced IL-8 and IL-6 through different pathways. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 21-25 18171700-15 2008 LPA-induced IL-8 and IL-6 increased permeability of human umbilical vein endothelial cell monolayer. lysophosphatidic acid 0-3 interleukin 6 Homo sapiens 21-25 18171700-16 2008 CONCLUSIONS: LPA induces IL-8 and IL-6 expressions through LPA receptors and nuclear factor-kappaB dependent pathways in granulosa-lutein cells. lysophosphatidic acid 13-16 interleukin 6 Homo sapiens 34-38 18171700-18 2008 Large amounts of LPA-induced IL-8 and IL-6 from multiple corpora luteae of stimulated ovaries may be one of the pathophysiological causes of ovarian hyperstimulation syndrome. lysophosphatidic acid 17-20 interleukin 6 Homo sapiens 38-42 17325741-6 2007 Our results strongly suggest that SPARC exerts a dual inhibitory effect on LPA-induced mesothelial-ovarian cancer cell crosstalk through the regulation of both LPA-induced IL-6 production and function. lysophosphatidic acid 160-163 interleukin 6 Homo sapiens 172-176 15024019-0 2004 Interleukin 6 mediates the lysophosphatidic acid-regulated cross-talk between stromal and epithelial prostate cancer cells. lysophosphatidic acid 27-48 interleukin 6 Homo sapiens 0-13 17253943-7 2006 Co-incubation with LPA attenuated the LPS-induced production of IL-6, without significantly affecting IL-10 secretion or the ability of DC to promote T cell proliferation. lysophosphatidic acid 19-22 interleukin 6 Homo sapiens 64-68 15471896-0 2005 Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. lysophosphatidic acid 99-120 interleukin 6 Homo sapiens 17-30 15471896-4 2005 To elucidate the pathogenesis of ovarian cancer, this study investigated how LPA affects IL-6 production in ovarian cancer cells. lysophosphatidic acid 77-80 interleukin 6 Homo sapiens 89-93 15471896-5 2005 Experimental results indicated that LPA stimulates IL-6 expression in all ovarian cancer cell lines tested, but not in normal ovarian surface epithelial (NOSE) cells, owing to the lack of LPA-specific Edg4 and/or Edg7 receptors in NOSE cells. lysophosphatidic acid 36-39 interleukin 6 Homo sapiens 51-55 15471896-6 2005 This work demonstrated that LPA transcriptionally activates IL-6 expression, which can be totally blocked by the pertussis toxin, indicating that Gi-mediated signaling is critically involved in inducing IL-6 by LPA. lysophosphatidic acid 28-31 interleukin 6 Homo sapiens 60-64 15471896-6 2005 This work demonstrated that LPA transcriptionally activates IL-6 expression, which can be totally blocked by the pertussis toxin, indicating that Gi-mediated signaling is critically involved in inducing IL-6 by LPA. lysophosphatidic acid 28-31 interleukin 6 Homo sapiens 203-207 15471896-7 2005 Pharmacological and genetic inhibition assays revealed that Gi-mediated PI3K activation phosphorylated downstream Akt and subsequently induced NF-kappaB activation causes the induction of IL-6 by LPA in SK-OV-3 cells. lysophosphatidic acid 196-199 interleukin 6 Homo sapiens 188-192 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 49-52 interleukin 6 Homo sapiens 80-84 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 49-52 interleukin 6 Homo sapiens 103-107 15471896-8 2005 In summary, data presented here demonstrate that LPA is an important inducer of IL-6 and LPA-regulated IL-6 expression via a Gi/PI3K-Akt/NF-kappaB pathway in ovarian cancer cells, providing molecular therapeutic targets for treating ovarian cancer. lysophosphatidic acid 89-92 interleukin 6 Homo sapiens 103-107 15024019-9 2004 Antibody neutralization experiments reveal that IL-6 is responsible for the LPA-induced mitogenic signaling and growth of the LNCaP cells. lysophosphatidic acid 76-79 interleukin 6 Homo sapiens 48-52 15024019-8 2004 Protein analysis demonstrates that treatment of the PS30 cells with LPA induces synthesis of interleukin 6 (IL-6). lysophosphatidic acid 68-71 interleukin 6 Homo sapiens 93-106 15024019-8 2004 Protein analysis demonstrates that treatment of the PS30 cells with LPA induces synthesis of interleukin 6 (IL-6). lysophosphatidic acid 68-71 interleukin 6 Homo sapiens 108-112 15041999-8 2004 Pretreatment of the ovarian cancer cells with the pertussis toxin completely inhibited lysophosphatidic acid-stimulated production of interleukin-6, interleukin-8 and tumor necrosis factor-alpha. lysophosphatidic acid 87-108 interleukin 6 Homo sapiens 134-147 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 interleukin 6 Homo sapiens 70-83 14670967-2 2004 In the current study, we demonstrated that LPA is a potent inducer of interleukin-6 (IL-6) and interleukin-8 (IL-8) production in ovarian cancer cells. lysophosphatidic acid 43-46 interleukin 6 Homo sapiens 85-89 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 23-26 interleukin 6 Homo sapiens 153-157 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 153-157 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 30-34 14670967-8 2004 Further, the effect of LPA on IL-6 and IL-8 generation is mediated by the Edg LPA receptors as enforced expression of LPA receptors restored LPA-induced IL-6 and IL-8 production in non-responsive cells and enhanced the sensitivity to LPA in responsive cell lines. lysophosphatidic acid 78-81 interleukin 6 Homo sapiens 153-157 14670967-10 2004 These studies elucidate the transcriptional mechanism and the Edg LPA receptors involved in LPA-induced IL-6 and IL-8 production and suggest potential strategies to restrain the expression of these cytokines in ovarian cancer. lysophosphatidic acid 66-69 interleukin 6 Homo sapiens 104-108