PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32392404-9 2020 This effect of calcium was also apparent upon the physiological lysophosphatidic acid stimulation, where ERKs translocation was delayed compared to that induced by EGF in a calcium-dependent manner. lysophosphatidic acid 64-85 mitogen-activated protein kinase 3 Homo sapiens 105-109 33794877-7 2021 RESULTS: LPA treatment induced signaling by cAMP response element-binding protein (CREB), extracellular signal-related kinases 1 and 2 (Erk1/2), and epithelial growth factor receptor (EGFR) resulting in elevated expression of connective tissue growth factor (CTGF), endothelin-1 (EDN1/ET-1 protein), and platelet derived growth factor B (PDGFB) at the mRNA and protein levels. lysophosphatidic acid 9-12 mitogen-activated protein kinase 3 Homo sapiens 90-134 33794877-7 2021 RESULTS: LPA treatment induced signaling by cAMP response element-binding protein (CREB), extracellular signal-related kinases 1 and 2 (Erk1/2), and epithelial growth factor receptor (EGFR) resulting in elevated expression of connective tissue growth factor (CTGF), endothelin-1 (EDN1/ET-1 protein), and platelet derived growth factor B (PDGFB) at the mRNA and protein levels. lysophosphatidic acid 9-12 mitogen-activated protein kinase 3 Homo sapiens 136-142 32007501-4 2020 In both cell types amitriptyline, clomipramine and mianserin mimicked the ability of LPA to induce the phosphorylation/activation of extracellular signal -regulated kinases 1 and 2 (ERK1/2), which was blocked by the selective LPA1 receptor antagonist AM966 and the LPA1/3 antagonist Ki16425. lysophosphatidic acid 85-88 mitogen-activated protein kinase 3 Homo sapiens 182-188 31906413-8 2020 More interestingly, we discovered that LPA induced RON expression via the MAPK (ERK1/2, JNK1/2), Egr-1, AP-1, and NF-kappaB signaling axes. lysophosphatidic acid 39-42 mitogen-activated protein kinase 3 Homo sapiens 74-78 31906413-8 2020 More interestingly, we discovered that LPA induced RON expression via the MAPK (ERK1/2, JNK1/2), Egr-1, AP-1, and NF-kappaB signaling axes. lysophosphatidic acid 39-42 mitogen-activated protein kinase 3 Homo sapiens 80-86 28943105-10 2017 Furthermore, the LPA agonist, 1-oleoyl-2-O-methyl-rac-glycerophosphothionate, OMPT, induced a weak increase in intracellular calcium, but was able to induce full ERK 1/2 phosphorylation and cell contraction. lysophosphatidic acid 17-20 mitogen-activated protein kinase 3 Homo sapiens 162-169 30403494-4 2019 The purpose of this study is to elucidate whether LPA affects autophagy through the ERK1/2 and (or) the Akt-mTOR signaling pathways. lysophosphatidic acid 50-53 mitogen-activated protein kinase 3 Homo sapiens 84-90 25888927-7 2015 ERK1/2 stimulation by antidepressants and LPA was suppressed by pertussis toxin and inhibition of Src, phosphatidylinositol-3 kinase and insulin-like growth factor-I receptor (IGF-IR) activities. lysophosphatidic acid 42-45 mitogen-activated protein kinase 3 Homo sapiens 0-6 28232483-11 2017 In a signaling pathway screen, lysophosphatidic acid increased phosphorylation of AKT, EGF receptor, ERK1/2, JNK1/2/3, and c-Jun. lysophosphatidic acid 31-52 mitogen-activated protein kinase 3 Homo sapiens 101-107 26134517-3 2015 The results of the present study demonstrated that LPA increased the proliferation and migration of ASCs, and acted as a mitogenic signal via extracellular signal-regulated kinases 1/2 and the phosphoinositide 3-kinase/Akt signaling pathways. lysophosphatidic acid 51-54 mitogen-activated protein kinase 3 Homo sapiens 142-184 28766061-9 2017 LPA stimulated cell proliferation was associated with LPAR1 mediated Gi/o-proteins/ERK1/2 pathway. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 83-89 25633408-6 2015 Furthermore, we found that membrane G protein Gi2 and Gi3 are involved in LPA-elicited anti-apoptotic effects through activation of ERK1/2- and PI3 K-pathways. lysophosphatidic acid 74-77 mitogen-activated protein kinase 3 Homo sapiens 132-138 24792438-2 2014 In those cells LPA was reported to induce IL-8 secretion through activation of various signaling pathways including p38 mitogen-activated protein kinase (p38 MAPK), p42/44 MAPK, and Rho kinase. lysophosphatidic acid 15-18 mitogen-activated protein kinase 3 Homo sapiens 158-162 25564987-5 2015 When present during oocyte maturation, LPA significantly increased the abundance of phosphorylated ERK1/2 in MI and MII oocytes, showing that LPA enhanced nuclear maturation via activation of the mitogen-activated protein kinase (MAPK) pathway. lysophosphatidic acid 39-42 mitogen-activated protein kinase 3 Homo sapiens 99-105 25564987-5 2015 When present during oocyte maturation, LPA significantly increased the abundance of phosphorylated ERK1/2 in MI and MII oocytes, showing that LPA enhanced nuclear maturation via activation of the mitogen-activated protein kinase (MAPK) pathway. lysophosphatidic acid 39-42 mitogen-activated protein kinase 3 Homo sapiens 230-234 25564987-5 2015 When present during oocyte maturation, LPA significantly increased the abundance of phosphorylated ERK1/2 in MI and MII oocytes, showing that LPA enhanced nuclear maturation via activation of the mitogen-activated protein kinase (MAPK) pathway. lysophosphatidic acid 142-145 mitogen-activated protein kinase 3 Homo sapiens 99-105 25564987-5 2015 When present during oocyte maturation, LPA significantly increased the abundance of phosphorylated ERK1/2 in MI and MII oocytes, showing that LPA enhanced nuclear maturation via activation of the mitogen-activated protein kinase (MAPK) pathway. lysophosphatidic acid 142-145 mitogen-activated protein kinase 3 Homo sapiens 230-234 24792438-3 2014 In addition to those pathways we report that mitogen- and stress-activated protein kinases (MSKs) known to be activated downstream of the ERK1/2 and p38 MAPK cascades and CREB are phosphorylated in response to LPA. lysophosphatidic acid 210-213 mitogen-activated protein kinase 3 Homo sapiens 138-144 22847216-4 2012 Immunoblot experiments with P19 cells revealed that the mitogen activated protein kinases, including p-ERK, p38, pAKT, glycogen synthase kinase 3beta, and CREB were phosphorylated by treatment with 10 muM LPA. lysophosphatidic acid 205-208 mitogen-activated protein kinase 3 Homo sapiens 103-106 23747852-4 2013 Intriguingly, the angiogenic signaling mechanisms mediated by LPA have been linked to specific G-protein coupled receptors and down stream MAPK including Erk1/2, p38 and JNK, protein kinase D (PKD-1), Rho kinase (ROCK), and the NF-kappa B signaling pathways. lysophosphatidic acid 62-65 mitogen-activated protein kinase 3 Homo sapiens 154-160 22820196-3 2012 LPA and DGPP 8:0 stimulation of ERK(1/2) occurred through different pathways. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 32-39 22847216-5 2012 LPA-induced phosphorylation of CREB was efficiently blocked by U0126 and H89, inhibitors of the MAP kinases ERK1/2 and mitogen- and stress-activated protein kinase 1, respectively. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 108-114 21925926-8 2012 ERK1/2 and Akt-mediated NF-kappaB and AP-1 were responsible for the LPA-induced IL-6 and IL-8 secretion. lysophosphatidic acid 68-71 mitogen-activated protein kinase 3 Homo sapiens 0-6 22577133-5 2012 Our data demonstrate that activation of ERK1/2 and JNK, but not p38 MAPK, is required for LPA-induced Egr-1 expression in smooth muscle cells. lysophosphatidic acid 90-93 mitogen-activated protein kinase 3 Homo sapiens 40-46 19940066-5 2010 RhoAV14, lysophosphatidic acid, and TGF-beta(2) stimulated significant increases in Erk1/2 phosphorylation, paralleled by profound increases in fibronectin, serum response factor (SRF), and alpha-SMA expression. lysophosphatidic acid 9-30 mitogen-activated protein kinase 3 Homo sapiens 84-90 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 88-91 mitogen-activated protein kinase 3 Homo sapiens 199-205 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 3 Homo sapiens 199-205 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 3 Homo sapiens 199-205 20533299-7 2010 Interestingly, p38 activation, a common process mediating various biological effects of LPA, was inhibited by LPA in this study, and the regulation of p38 pathway by LPA was dependent on LPA(1/3)/Gi/ERK1/2 pathway-mediated MKP-1 induction but independent of PI3K/Akt pathway. lysophosphatidic acid 110-113 mitogen-activated protein kinase 3 Homo sapiens 199-205 20576526-0 2010 Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes. lysophosphatidic acid 41-44 mitogen-activated protein kinase 3 Homo sapiens 53-59 20576526-3 2010 The mechanism by which LPA activates the Erk1/2 MAP kinase is generally accepted to be via EGF receptor transactivation. lysophosphatidic acid 23-26 mitogen-activated protein kinase 3 Homo sapiens 41-47 20576526-5 2010 Therefore, we have here examined whether LPA, via EGF transactivation, can activate Erk1/2 in brown pre-adipocytes. lysophosphatidic acid 41-44 mitogen-activated protein kinase 3 Homo sapiens 84-90 20576526-6 2010 We found that LPA could induce Erk1/2 activation. lysophosphatidic acid 14-17 mitogen-activated protein kinase 3 Homo sapiens 31-37 20576526-7 2010 However, the LPA-induced Erk1/2 activation was independent of transactivation of EGF receptors (or PDGF receptors) in these cells (whereas in transformed HIB-1B brown adipocytes, the LPA-induced Erk1/2 activation indeed proceeded via EGF receptor transactivation). lysophosphatidic acid 13-16 mitogen-activated protein kinase 3 Homo sapiens 25-31 20576526-7 2010 However, the LPA-induced Erk1/2 activation was independent of transactivation of EGF receptors (or PDGF receptors) in these cells (whereas in transformed HIB-1B brown adipocytes, the LPA-induced Erk1/2 activation indeed proceeded via EGF receptor transactivation). lysophosphatidic acid 13-16 mitogen-activated protein kinase 3 Homo sapiens 195-201 20576526-7 2010 However, the LPA-induced Erk1/2 activation was independent of transactivation of EGF receptors (or PDGF receptors) in these cells (whereas in transformed HIB-1B brown adipocytes, the LPA-induced Erk1/2 activation indeed proceeded via EGF receptor transactivation). lysophosphatidic acid 183-186 mitogen-activated protein kinase 3 Homo sapiens 25-31 20576526-7 2010 However, the LPA-induced Erk1/2 activation was independent of transactivation of EGF receptors (or PDGF receptors) in these cells (whereas in transformed HIB-1B brown adipocytes, the LPA-induced Erk1/2 activation indeed proceeded via EGF receptor transactivation). lysophosphatidic acid 183-186 mitogen-activated protein kinase 3 Homo sapiens 195-201 20576526-8 2010 In the brown pre-adipocytes, LPA instead induced Erk1/2 activation via two distinct non-transactivational pathways, one G(i)-protein dependent, involving PKC and Src activation, the other, a PTX-insensitive pathway, involving PI3K (but not Akt) activation. lysophosphatidic acid 29-32 mitogen-activated protein kinase 3 Homo sapiens 49-55 20576526-9 2010 Earlier studies showing LPA-induced Erk1/2 activation being fully dependent on RTK transactivation have all been performed in cell lines and transfected cells. lysophosphatidic acid 24-27 mitogen-activated protein kinase 3 Homo sapiens 36-42 20804754-0 2010 Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription. lysophosphatidic acid 0-21 mitogen-activated protein kinase 3 Homo sapiens 71-75 20804754-3 2010 Our data implicate ERK1 as an important mediator of LPA signaling leading to upregulation of SphK1 and point to SphK1 and sphingosine-1-phosphate production as potential therapeutic targets in gastric cancer. lysophosphatidic acid 52-55 mitogen-activated protein kinase 3 Homo sapiens 19-23 17937769-4 2007 ERK1/2 phosphorylation mediated by LPA proceeds via activation of the type 2 LPA receptor, activation of the nonreceptor tyrosine kinase c-Src, and subsequent transactivation of the epidermal growth factor receptor. lysophosphatidic acid 35-38 mitogen-activated protein kinase 3 Homo sapiens 0-6 18658095-8 2009 RESULTS: Early, but not late, ERK1/2 phosphorylation in response to wounding, LPA, and ATP was EGFR independent, but sensitive to the inhibitors of calcium influx, protein kinase C and Src kinase. lysophosphatidic acid 78-81 mitogen-activated protein kinase 3 Homo sapiens 30-36 18658095-9 2009 Wounding-, LPA-, and ATP-induced HB-EGF shedding and EGFR activation were attenuated by the MAPK/ERK kinase (MEK) inhibitors PD98059 and U0126, as well as by ADAM10 and -17 inhibitors. lysophosphatidic acid 11-14 mitogen-activated protein kinase 3 Homo sapiens 92-96 18762810-9 2008 The transforming ability of LPA1, LPA2 and LPA4 was confirmed by tumor formation assays in vivo and correlated with prolonged ERK1/2 activation in response to LPA. lysophosphatidic acid 28-31 mitogen-activated protein kinase 3 Homo sapiens 126-132 18958425-0 2008 Regulation of lysophosphatidic acid-induced COX-2 expression by ERK1/2 activation in cultured feline esophageal epithelial cells. lysophosphatidic acid 14-35 mitogen-activated protein kinase 3 Homo sapiens 64-70 18958425-5 2008 Of the three major MAPKs, only ERK1/2 was activated by LPA in a time-dependent manner. lysophosphatidic acid 55-58 mitogen-activated protein kinase 3 Homo sapiens 31-37 19656035-6 2009 RESULTS: LPA stimulated ERK1/2 phosphorylation via LPA(1)(-3). lysophosphatidic acid 9-12 mitogen-activated protein kinase 3 Homo sapiens 24-30 17531530-2 2007 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid 20-41 mitogen-activated protein kinase 3 Homo sapiens 266-270 17531530-2 2007 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid 43-46 mitogen-activated protein kinase 3 Homo sapiens 266-270 17531530-3 2007 Our results demonstrate that parallel activation of ERK1/2 and p38, but not JNK, is responsible for LPA-stimulated PC3 cell migration. lysophosphatidic acid 100-103 mitogen-activated protein kinase 3 Homo sapiens 52-58 15657067-9 2005 The functional interactions between IGF-1 receptor, lysophosphatidic acid (LPA) signaling, and EGF receptor were observed, both direct and/or indirectly on phospho-Akt, phospho-Erk1/2, and phospho-ribosomal S6. lysophosphatidic acid 75-78 mitogen-activated protein kinase 3 Homo sapiens 177-183 15728708-4 2005 LPA2 activated Akt and Erk1/2 in response to LPA. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 23-29 15107593-7 2004 Inhibition of ERK1/2 by PD 98059 completely abolished LDL- and LPA-induced activation of SAPK, whereas the activation of p38 MAP kinase was not affected. lysophosphatidic acid 63-66 mitogen-activated protein kinase 3 Homo sapiens 14-20 15581951-7 2004 The MEK/ERK1/2 kinase cascade is required for FasL upregulation, since the MEK inhibitor PD98059 significantly inhibited FasL upregulation induced by LPA (P < 0.01). lysophosphatidic acid 150-153 mitogen-activated protein kinase 3 Homo sapiens 8-14 15364923-1 2004 Lysophosphatidic acid (LPA)-elicited transphosphorylation of receptor tyrosine kinases has been implicated in mediating extracellular signal-regulated kinase (ERK) 1/2 activation, which is necessary for LPA-induced cell proliferation, migration, and survival. lysophosphatidic acid 0-21 mitogen-activated protein kinase 3 Homo sapiens 120-167 15364923-1 2004 Lysophosphatidic acid (LPA)-elicited transphosphorylation of receptor tyrosine kinases has been implicated in mediating extracellular signal-regulated kinase (ERK) 1/2 activation, which is necessary for LPA-induced cell proliferation, migration, and survival. lysophosphatidic acid 23-26 mitogen-activated protein kinase 3 Homo sapiens 120-167 15364923-1 2004 Lysophosphatidic acid (LPA)-elicited transphosphorylation of receptor tyrosine kinases has been implicated in mediating extracellular signal-regulated kinase (ERK) 1/2 activation, which is necessary for LPA-induced cell proliferation, migration, and survival. lysophosphatidic acid 203-206 mitogen-activated protein kinase 3 Homo sapiens 120-167 15364923-8 2004 In EGFR(Y5F)-expressing cells, LPA failed to elicit tyrosine phosphorylation of Src homologous and collagen protein (SHC) and caused only a modest increase in ERK1/2 phosphorylation similar to that in wild-type B82L cells. lysophosphatidic acid 31-34 mitogen-activated protein kinase 3 Homo sapiens 159-165 15364923-9 2004 The present data pinpoint the lack of importance of the intrinsic kinase activity in contrast to the importance of autophosphorylation sites of the EGFR for SHC phosphorylation in the enhancement of select ERK1/2-dependent LPA responses. lysophosphatidic acid 223-226 mitogen-activated protein kinase 3 Homo sapiens 206-212 12730329-5 2003 Surprisingly, functional inhibition of Rho-GTPase, in C3-exotoxin-lipofected cells, markedly reduced LPA-stimulated phosphorylation of ERK, without affecting the EGF-induced stimulation of MAPK. lysophosphatidic acid 101-104 mitogen-activated protein kinase 3 Homo sapiens 189-193 12730329-1 2003 We investigated the mechanism of lysophosphatidic acid (LPA) signaling in ovarian theca cells and observed that stimulation with this bioactive lipid markedly enhanced Thr/Tyr phosphorylation of the MAPK ERK1/2. lysophosphatidic acid 33-54 mitogen-activated protein kinase 3 Homo sapiens 199-203 12730329-1 2003 We investigated the mechanism of lysophosphatidic acid (LPA) signaling in ovarian theca cells and observed that stimulation with this bioactive lipid markedly enhanced Thr/Tyr phosphorylation of the MAPK ERK1/2. lysophosphatidic acid 33-54 mitogen-activated protein kinase 3 Homo sapiens 204-210 12730329-1 2003 We investigated the mechanism of lysophosphatidic acid (LPA) signaling in ovarian theca cells and observed that stimulation with this bioactive lipid markedly enhanced Thr/Tyr phosphorylation of the MAPK ERK1/2. lysophosphatidic acid 56-59 mitogen-activated protein kinase 3 Homo sapiens 199-203 12730329-1 2003 We investigated the mechanism of lysophosphatidic acid (LPA) signaling in ovarian theca cells and observed that stimulation with this bioactive lipid markedly enhanced Thr/Tyr phosphorylation of the MAPK ERK1/2. lysophosphatidic acid 56-59 mitogen-activated protein kinase 3 Homo sapiens 204-210 12730329-7 2003 The findings indicate that LPA transiently stimulates MAPK ERK in LPA1/edg2-expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway. lysophosphatidic acid 27-30 mitogen-activated protein kinase 3 Homo sapiens 54-58 12812976-7 2003 Immunoblot assays of ERK1/2 phosphorylation by the cell- and pathway-specific stimulant lysophosphatidic acid (LPA) showed activation of this pathway in a time- and concentration-dependent manner that was prevented by a specific inhibitor. lysophosphatidic acid 88-109 mitogen-activated protein kinase 3 Homo sapiens 21-27 12812976-7 2003 Immunoblot assays of ERK1/2 phosphorylation by the cell- and pathway-specific stimulant lysophosphatidic acid (LPA) showed activation of this pathway in a time- and concentration-dependent manner that was prevented by a specific inhibitor. lysophosphatidic acid 111-114 mitogen-activated protein kinase 3 Homo sapiens 21-27 12812976-8 2003 There was a greater rate of growth in mutant cells; forskolin and isoproterenol inhibited LPA-induced ERK1/2 phosphorylation in normal but not in mutant cells. lysophosphatidic acid 90-93 mitogen-activated protein kinase 3 Homo sapiens 102-108 12812976-11 2003 We conclude that PKA activity in CNC cells is increased and that its stimulation by forskolin or isoproterenol increases LPA-induced ERK1/2 phosphorylation, cell metabolism and proliferation. lysophosphatidic acid 121-124 mitogen-activated protein kinase 3 Homo sapiens 133-139 12588763-6 2003 Phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signaling-regulated kinases (ERK1/2) was rapidly and markedly induced by LPA. lysophosphatidic acid 156-159 mitogen-activated protein kinase 3 Homo sapiens 112-118 12588763-9 2003 The Galpha(i) protein inhibitor, pertussis toxin, abolished LPA-induced phosphorylation of MEKs and ERKs, as well as the induction of TF mRNA. lysophosphatidic acid 60-63 mitogen-activated protein kinase 3 Homo sapiens 100-104 12588763-10 2003 CONCLUSIONS: Our data demonstrate that a Galpha(i) protein and activation of MEKs and ERKs mediate LPA-induced TF expression. lysophosphatidic acid 99-102 mitogen-activated protein kinase 3 Homo sapiens 86-90 11061948-6 2000 Treatment of the PC-3 cells with lysophosphatidic acid, EGF or serum induced an 8-fold increase in the phosphorylation levels of the mitogen activated protein kinases Erk 1 and 2, and a 3-fold increase in the phosphorylation level of Akt. lysophosphatidic acid 33-54 mitogen-activated protein kinase 3 Homo sapiens 167-178 11061948-7 2000 Erk 1/2 and Akt phosphorylation by lysophosphatidic acid and serum was inhibited by pertussis toxin, suggesting a Gi/o subunit dependent mechanism. lysophosphatidic acid 35-56 mitogen-activated protein kinase 3 Homo sapiens 0-7 11061948-9 2000 Expression of the G beta gamma sequestrant peptide G protein coupled receptor kinase 2 carboxy terminus inhibited the lysophosphatidic acid and serum mediated activation of Erk 1/2 and Akt but showed no effect on the IGF-1 or EGF mediated response. lysophosphatidic acid 118-139 mitogen-activated protein kinase 3 Homo sapiens 173-180 11062066-8 2000 These results indicate that LPA promotes cell survival largely via G(i)-protein-mediated activation of ERK1/ERK2, or other PD 98059-sensitive member(s) of the MAPK family. lysophosphatidic acid 28-31 mitogen-activated protein kinase 3 Homo sapiens 103-107 11062066-8 2000 These results indicate that LPA promotes cell survival largely via G(i)-protein-mediated activation of ERK1/ERK2, or other PD 98059-sensitive member(s) of the MAPK family. lysophosphatidic acid 28-31 mitogen-activated protein kinase 3 Homo sapiens 159-163 10706774-7 2000 LPA also stimulated Ca(2+) fluctuations and activation of extracellular signal-regulated kinases (ERKS) 1 and 2, although blocking either pathway had little effect on glioma cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 58-111 33944929-0 2021 Lysophosphatidic acid improves oocyte quality during IVM by activating the ERK1/2 pathway in cumulus cells and oocytes. lysophosphatidic acid 0-21 mitogen-activated protein kinase 3 Homo sapiens 75-81 33944929-9 2021 We observed that LPA promotes the activation of ERK1/2, although this was not statistically significant in DOs. lysophosphatidic acid 17-20 mitogen-activated protein kinase 3 Homo sapiens 48-54 33944929-12 2021 This study demonstrates that LPA improves oocyte quality during IVM through the activation of ERK1/2 pathway CCs and oocytes, which provides evidence for the potential addition of LPA to IVM medium. lysophosphatidic acid 29-32 mitogen-activated protein kinase 3 Homo sapiens 94-100 33944929-12 2021 This study demonstrates that LPA improves oocyte quality during IVM through the activation of ERK1/2 pathway CCs and oocytes, which provides evidence for the potential addition of LPA to IVM medium. lysophosphatidic acid 180-183 mitogen-activated protein kinase 3 Homo sapiens 94-100 35526043-4 2022 LPA bound to its receptor LPAR2 activated its downstream MEK1/2-ERK1/2 signaling pathway and enhanced oxidative phosphorylation (OXPHOS) in mitochondria in MM cells. lysophosphatidic acid 0-3 mitogen-activated protein kinase 3 Homo sapiens 64-70 12139919-7 2002 Phosphorylation of the ERK1/ERK2 MAP kinases was the only response elicited by LPA in oligodendrocytes. lysophosphatidic acid 79-82 mitogen-activated protein kinase 3 Homo sapiens 23-27 11850124-2 2002 Pyk2 can be activated by canonic stimuli such as tumor necrosis factoralpha and lysophosphatidic acid (LPA) in PC3 cells, in addition, LPA stimulated Pyk2 phosphorylation also induced extracellular signal-regulated kinase 1 and 2 activation in these cells. lysophosphatidic acid 80-101 mitogen-activated protein kinase 3 Homo sapiens 184-229 11850124-2 2002 Pyk2 can be activated by canonic stimuli such as tumor necrosis factoralpha and lysophosphatidic acid (LPA) in PC3 cells, in addition, LPA stimulated Pyk2 phosphorylation also induced extracellular signal-regulated kinase 1 and 2 activation in these cells. lysophosphatidic acid 103-106 mitogen-activated protein kinase 3 Homo sapiens 184-229 11850124-2 2002 Pyk2 can be activated by canonic stimuli such as tumor necrosis factoralpha and lysophosphatidic acid (LPA) in PC3 cells, in addition, LPA stimulated Pyk2 phosphorylation also induced extracellular signal-regulated kinase 1 and 2 activation in these cells. lysophosphatidic acid 135-138 mitogen-activated protein kinase 3 Homo sapiens 184-229 11522591-3 2001 The de-acylated product of PA, lysophosphatidic acid (LPA), which binds to members of the endothelial differentiation gene (EDG) family of receptors also stimulated p42/p44 MAPK in a pertussis toxin sensitive manner, but with an approximately 100 - 1000 fold lower potency compared with the different molecular species of PA. lysophosphatidic acid 31-52 mitogen-activated protein kinase 3 Homo sapiens 169-177 11522591-3 2001 The de-acylated product of PA, lysophosphatidic acid (LPA), which binds to members of the endothelial differentiation gene (EDG) family of receptors also stimulated p42/p44 MAPK in a pertussis toxin sensitive manner, but with an approximately 100 - 1000 fold lower potency compared with the different molecular species of PA. lysophosphatidic acid 54-57 mitogen-activated protein kinase 3 Homo sapiens 169-177 11061948-10 2000 Finally, we showed that activation of the Erk 1/2 pathway in the prostate cancer cells by lysophosphatidic acid and serum is dependent on the EGF receptor and c-Src protein tyrosine kinases. lysophosphatidic acid 90-111 mitogen-activated protein kinase 3 Homo sapiens 42-49 11062066-7 2000 In contrast, inhibition of MAPK activation by the MEK-1 inhibitor, PD 98059, blocked both the proliferative and survival effects of LPA. lysophosphatidic acid 132-135 mitogen-activated protein kinase 3 Homo sapiens 27-31