PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19112101-6 2009 Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold) and attenuated LPA-induced p38 MAPK, JNK, and NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion. lysophosphatidic acid 145-148 mitogen-activated protein kinase 8 Homo sapiens 167-170 18396013-7 2008 The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression. lysophosphatidic acid 35-38 mitogen-activated protein kinase 8 Homo sapiens 72-95 18396013-9 2008 Knocking down expression of VEGFR1 and inhibiting activation of NFkappaB and JNK also blocked LPA induced protection against apoptosis. lysophosphatidic acid 94-97 mitogen-activated protein kinase 8 Homo sapiens 77-80 18396013-7 2008 The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression. lysophosphatidic acid 35-38 mitogen-activated protein kinase 8 Homo sapiens 97-100 18396013-7 2008 The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression. lysophosphatidic acid 35-38 mitogen-activated protein kinase 8 Homo sapiens 151-154 18396013-7 2008 The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression. lysophosphatidic acid 188-191 mitogen-activated protein kinase 8 Homo sapiens 72-95 18396013-7 2008 The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or NFkappaB activation inhibited LPA induced VEGF expression. lysophosphatidic acid 188-191 mitogen-activated protein kinase 8 Homo sapiens 151-154 18247343-6 2008 In addition, AGS cells treated with LPA showed enhanced invasion, which was partially abrogated by the uPAR-neutralizing antibodies and inhibitors of Rho kinase, JNK, and NF-kappaB. lysophosphatidic acid 36-39 mitogen-activated protein kinase 8 Homo sapiens 162-165 18247343-7 2008 This suggests that LPA induces uPAR expression through the LPA receptors, Rho-family GTPase, JNK, AP-1 and NF-kappaB signaling pathways, which in turn stimulates the cell invasiveness of human gastric cancer AGS cells. lysophosphatidic acid 19-22 mitogen-activated protein kinase 8 Homo sapiens 93-96 18294142-5 2008 Downregulation of EGFR by siRNA or pretreatment with the EGFR tyrosine kinase inhibitor, AG1478, partly attenuated LPA-induced COX-2 expression and phosphorylation of C/EBPbeta; however, neither of these factors had an effect on the NF-kappaB and JNK pathways. lysophosphatidic acid 115-118 mitogen-activated protein kinase 8 Homo sapiens 247-250 17122328-6 2007 LPA decreased intracellular GSH levels and induced a p38 MAPK/JNK-dependent inducible nitric oxide synthase (NOS) expression. lysophosphatidic acid 0-3 mitogen-activated protein kinase 8 Homo sapiens 62-65 17287216-5 2007 Pretreatment with pertussis toxin (100 ng/ml, 4 h) or transfection of c-Jun small interference RNA or an inhibitor of JNK attenuated LPA-induced IL-13Ralpha2 gene expression and secretion of soluble IL-13Ralpha2. lysophosphatidic acid 133-136 mitogen-activated protein kinase 8 Homo sapiens 118-121 17287216-6 2007 Overexpression of catalytically inactive mutants of phospholipase D (PLD) 1 or 2 attenuated LPA-induced IL-13Ralpha2 gene expression and protein secretion as well as phosphorylation of JNK. lysophosphatidic acid 92-95 mitogen-activated protein kinase 8 Homo sapiens 185-188 17287216-10 2007 These results demonstrate that LPA induces IL-13Ralpha2 expression and release via PLD and JNK/AP-1 signal transduction and that pretreatment with LPA down-regulates IL-13 signaling in HBEpCs. lysophosphatidic acid 31-34 mitogen-activated protein kinase 8 Homo sapiens 91-94 17493936-0 2007 Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization. lysophosphatidic acid 0-21 mitogen-activated protein kinase 8 Homo sapiens 99-102 16007180-0 2005 Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. lysophosphatidic acid 88-109 mitogen-activated protein kinase 8 Homo sapiens 41-62 16197369-9 2006 Furthermore, SB203580 attenuated LPA-dependent phosphorylation of IkappaB (inhibitory kappaB), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter-mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription. lysophosphatidic acid 33-36 mitogen-activated protein kinase 8 Homo sapiens 254-257 16197369-10 2006 Similarly, JNK(i) II only blocked LPA-mediated phosphorylation of JNK and c-Jun, AP-1 transcription and IL-8 promoter-mediated luciferase reporter activity, without blocking p38 MAPK-dependent NF-kappaB transcription. lysophosphatidic acid 34-37 mitogen-activated protein kinase 8 Homo sapiens 11-14 16197369-10 2006 Similarly, JNK(i) II only blocked LPA-mediated phosphorylation of JNK and c-Jun, AP-1 transcription and IL-8 promoter-mediated luciferase reporter activity, without blocking p38 MAPK-dependent NF-kappaB transcription. lysophosphatidic acid 34-37 mitogen-activated protein kinase 8 Homo sapiens 66-69 16197369-13 2006 These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs. lysophosphatidic acid 63-66 mitogen-activated protein kinase 8 Homo sapiens 56-59 16197369-0 2006 Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. lysophosphatidic acid 30-51 mitogen-activated protein kinase 8 Homo sapiens 115-118 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 8 Homo sapiens 202-205 16197369-6 2006 Exposure of HBEpCs to LPA (1 microM) enhanced expression and secretion of IL-8 by 5-8-fold and stimulated threonine/tyrosine phosphorylation of ERK (extracellular-signal-regulated kinase), p38 MAPK and JNK (c-Jun N-terminal kinase). lysophosphatidic acid 22-25 mitogen-activated protein kinase 8 Homo sapiens 207-230 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 8 Homo sapiens 136-139 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase 8 Homo sapiens 150-153 16007180-4 2005 The LPA-induced action was also suppressed, although incompletely, by several specific inhibitors for intracellular signaling pathways including Rac1, Cdc42, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun terminal kinase (JNK), but not extracellular signal-regulated kinase. lysophosphatidic acid 4-7 mitogen-activated protein kinase 8 Homo sapiens 209-230 16007180-4 2005 The LPA-induced action was also suppressed, although incompletely, by several specific inhibitors for intracellular signaling pathways including Rac1, Cdc42, p38 mitogen-activated protein kinase (p38MAPK) and c-Jun terminal kinase (JNK), but not extracellular signal-regulated kinase. lysophosphatidic acid 4-7 mitogen-activated protein kinase 8 Homo sapiens 232-235 16007180-5 2005 Nearly complete inhibition of migration response to LPA, however, required simultaneous inhibition of both the p38MAPK and JNK pathways. lysophosphatidic acid 52-55 mitogen-activated protein kinase 8 Homo sapiens 123-126 28232483-11 2017 In a signaling pathway screen, lysophosphatidic acid increased phosphorylation of AKT, EGF receptor, ERK1/2, JNK1/2/3, and c-Jun. lysophosphatidic acid 31-52 mitogen-activated protein kinase 8 Homo sapiens 109-117 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 181-184 mitogen-activated protein kinase 8 Homo sapiens 75-98 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 181-184 mitogen-activated protein kinase 8 Homo sapiens 100-103 14723340-5 2003 The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. lysophosphatidic acid 240-243 mitogen-activated protein kinase 8 Homo sapiens 100-103 9792916-0 1998 Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. lysophosphatidic acid 47-68 mitogen-activated protein kinase 8 Homo sapiens 14-37 9792916-0 1998 Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts. lysophosphatidic acid 47-68 mitogen-activated protein kinase 8 Homo sapiens 39-42 9792916-1 1998 Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. lysophosphatidic acid 0-21 mitogen-activated protein kinase 8 Homo sapiens 50-73 9792916-1 1998 Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. lysophosphatidic acid 0-21 mitogen-activated protein kinase 8 Homo sapiens 75-78 9792916-1 1998 Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. lysophosphatidic acid 23-26 mitogen-activated protein kinase 8 Homo sapiens 50-73 9792916-1 1998 Lysophosphatidic acid (LPA) induced activation of c-Jun N-terminal kinase (JNK) in Swiss 3T3 fibroblasts. lysophosphatidic acid 23-26 mitogen-activated protein kinase 8 Homo sapiens 75-78 9792916-3 1998 LPA-induced activation of JNK was not suppressed by prior treatment of the cells with pertussis toxin, whereas it was completely blocked by suramin, a non-selective inhibitor of ligand-receptor interactions. lysophosphatidic acid 0-3 mitogen-activated protein kinase 8 Homo sapiens 26-29 9792916-4 1998 The kinetics and concentration-dependency of LPA-induced JNK activation were in sharp contrast with those of LPA-induced extracellular signal-regulated kinase (ERK) activation, which reached the maximum within 3 min and occurred with an EC50 of 0.1 microg/ml. lysophosphatidic acid 45-48 mitogen-activated protein kinase 8 Homo sapiens 57-60 9792916-6 1998 These results indicate that the signal transduction pathways of LPA-induced JNK and ERK activations are distinct. lysophosphatidic acid 64-67 mitogen-activated protein kinase 8 Homo sapiens 76-79 9792916-7 1998 Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. lysophosphatidic acid 44-47 mitogen-activated protein kinase 8 Homo sapiens 89-92 9792916-7 1998 Thus, this is the first report showing that LPA induces not only ERK activation but also JNK activation, which may be responsible for the induction of DNA synthesis in LPA-stimulated Swiss 3T3 fibroblasts. lysophosphatidic acid 168-171 mitogen-activated protein kinase 8 Homo sapiens 89-92 31906413-8 2020 More interestingly, we discovered that LPA induced RON expression via the MAPK (ERK1/2, JNK1/2), Egr-1, AP-1, and NF-kappaB signaling axes. lysophosphatidic acid 39-42 mitogen-activated protein kinase 8 Homo sapiens 88-94 30217824-6 2018 We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. lysophosphatidic acid 190-193 mitogen-activated protein kinase 8 Homo sapiens 14-37 30217824-6 2018 We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. lysophosphatidic acid 190-193 mitogen-activated protein kinase 8 Homo sapiens 39-42 30217824-6 2018 We identified c-Jun N-terminal kinase (JNK) as a key intermediary in mSin1 up-regulation by the pro-fibrotic mediators, as pharmacological and siRNA-mediated inhibition of JNK prevented the LPA-induced mSin1 increase. lysophosphatidic acid 190-193 mitogen-activated protein kinase 8 Homo sapiens 172-175 30217824-7 2018 Proteasomal inhibition rescued mSin1 levels after JNK inhibition in LPA-treated MCs, and the decrease in mSin1 ubiquitination in response to LPA was counteracted by JNK inhibitors. lysophosphatidic acid 141-144 mitogen-activated protein kinase 8 Homo sapiens 165-168 27134758-4 2016 Upon lysophosphatidic acid stimulation, TRIP6 recruits TRAF6 to the LPA2 receptor and promotes lysophosphatidic acid-induced JNK and nuclear factor-kappaB activation in a TRAF6-dependent manner. lysophosphatidic acid 5-26 mitogen-activated protein kinase 8 Homo sapiens 125-128 23747852-4 2013 Intriguingly, the angiogenic signaling mechanisms mediated by LPA have been linked to specific G-protein coupled receptors and down stream MAPK including Erk1/2, p38 and JNK, protein kinase D (PKD-1), Rho kinase (ROCK), and the NF-kappa B signaling pathways. lysophosphatidic acid 62-65 mitogen-activated protein kinase 8 Homo sapiens 170-173 22577133-0 2012 Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. lysophosphatidic acid 0-21 mitogen-activated protein kinase 8 Homo sapiens 165-188 22577133-0 2012 Lysophosphatidic acid induces early growth response-1 (Egr-1) protein expression via protein kinase Cdelta-regulated extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) activation in vascular smooth muscle cells. lysophosphatidic acid 0-21 mitogen-activated protein kinase 8 Homo sapiens 190-193 22577133-5 2012 Our data demonstrate that activation of ERK1/2 and JNK, but not p38 MAPK, is required for LPA-induced Egr-1 expression in smooth muscle cells. lysophosphatidic acid 90-93 mitogen-activated protein kinase 8 Homo sapiens 51-54 22577133-6 2012 We provide the first evidence that MEK-mediated JNK activation leads to LPA-induced gene expression. lysophosphatidic acid 72-75 mitogen-activated protein kinase 8 Homo sapiens 48-51 22577133-8 2012 Examining the upstream kinases that mediate ERK and JNK activation, leading to Egr-1 expression, we found that LPA-induced activation of MAPKs and expression of Egr-1 are dependent on PKC activation. lysophosphatidic acid 111-114 mitogen-activated protein kinase 8 Homo sapiens 52-55 22577133-12 2012 Our data reveal an intracellular regulatory mechanism: LPA induction of Egr-1 expression is via LPA cognate receptor (LPA receptor 1)-dependent and PKCdelta-mediated ERK and JNK activation. lysophosphatidic acid 55-58 mitogen-activated protein kinase 8 Homo sapiens 174-177 22577133-13 2012 This study provides the first evidence that PKCdelta mediates ERK and JNK activation in the LPA signaling pathway and that this pathway is required for LPA-induced gene regulation as evidenced by Egr-1 expression. lysophosphatidic acid 92-95 mitogen-activated protein kinase 8 Homo sapiens 70-73 22374302-11 2012 Finally, we demonstrate that LPA-mediated TGFBIp induction requires JNK activation, but not ERK signaling pathways. lysophosphatidic acid 29-32 mitogen-activated protein kinase 8 Homo sapiens 68-71 21871564-5 2012 Inhibition of NF-kappaB or JNK pathway reduced LPA-induced sST2 release. lysophosphatidic acid 47-50 mitogen-activated protein kinase 8 Homo sapiens 27-30 21632882-9 2011 CONCLUSION: LPA induced disruption and protection of VE-cadherin integrity through LPA(1)-G(i) protein-Rac1-JNK/p38MAPK and LPA(6)-G(12/13) protein-Src-C3G-Rap1 pathways, respectively. lysophosphatidic acid 12-15 mitogen-activated protein kinase 8 Homo sapiens 108-111 20434448-0 2010 Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells. lysophosphatidic acid 20-41 mitogen-activated protein kinase 8 Homo sapiens 88-91 27134758-4 2016 Upon lysophosphatidic acid stimulation, TRIP6 recruits TRAF6 to the LPA2 receptor and promotes lysophosphatidic acid-induced JNK and nuclear factor-kappaB activation in a TRAF6-dependent manner. lysophosphatidic acid 95-116 mitogen-activated protein kinase 8 Homo sapiens 125-128 27134758-6 2016 In contrast, depletion of TRIP6 by TRIP6-specific shRNA or Cas9/sgRNA greatly enhances the association of TRAF6 with A20 and CYLD, and attenuates lysophosphatidic acid-induced muclear factor-kappaB and JNK/p38 activation in ovarian cancer cells. lysophosphatidic acid 146-167 mitogen-activated protein kinase 8 Homo sapiens 202-205 24445011-0 2014 Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts. lysophosphatidic acid 36-57 mitogen-activated protein kinase 8 Homo sapiens 105-108 24445011-7 2014 EGCG completely inhibited LPA-induced CCN2 expression through attenuating the LPA-induced JNK and Smad3 phosphorylation in human GFs. lysophosphatidic acid 26-29 mitogen-activated protein kinase 8 Homo sapiens 90-93 24445011-7 2014 EGCG completely inhibited LPA-induced CCN2 expression through attenuating the LPA-induced JNK and Smad3 phosphorylation in human GFs. lysophosphatidic acid 78-81 mitogen-activated protein kinase 8 Homo sapiens 90-93 20965247-0 2011 Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type beta receptors and the JNK pathway. lysophosphatidic acid 45-66 mitogen-activated protein kinase 8 Homo sapiens 150-153 20965247-9 2011 Finally, we demonstrated that CTGF induction in response to LPA requires the activation of JNK, but not ERK, signaling pathways. lysophosphatidic acid 60-63 mitogen-activated protein kinase 8 Homo sapiens 91-94