PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 14500380-2 2003 ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. lysophosphatidic acid 88-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 14500380-2 2003 ATX was shown recently to be identical to serum lysophospholipase D activity, producing lysophosphatidic acid (LPA) from lyso-glycerophospholipids. lysophosphatidic acid 111-114 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 12642576-0 2003 Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. lysophosphatidic acid 49-70 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 12642576-11 2003 The specific effect of ATX on preadipocyte proliferation was completely suppressed by co-treatment with a LPA-hydrolyzing phospholipase, phospholipase B. lysophosphatidic acid 106-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 23-26 12642576-13 2003 In conclusion, the present work shows that ATX is responsible for the LPLDact released by adipocytes and exerts a paracrine control on preadipocyte growth via an LPA-dependent mechanism. lysophosphatidic acid 162-165 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 43-46 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 16-21 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 33778909-2 2021 Autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular lysophosphatidic acid (LPA) production, has been suggested to play a pathogenic role in, among others, pulmonary inflammation and fibrosis. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 16-21 34742015-1 2022 In recent decades, pharmacological targeting of the autotaxin (ATX)/lysophosphatidic acid (LPA) axis accounted for excellent disease management benefits. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 52-61 34742015-1 2022 In recent decades, pharmacological targeting of the autotaxin (ATX)/lysophosphatidic acid (LPA) axis accounted for excellent disease management benefits. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 63-66 34742015-1 2022 In recent decades, pharmacological targeting of the autotaxin (ATX)/lysophosphatidic acid (LPA) axis accounted for excellent disease management benefits. lysophosphatidic acid 91-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 52-61 34847837-8 2022 Furthermore, ENPP2 knockdown decreased the levels of LPA, osteoclastogenesis mediators in sera of mice with MM. lysophosphatidic acid 53-56 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 13-18 34829956-1 2021 Enpp2 is an enzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which exhibits a wide variety of biological functions. lysophosphatidic acid 85-106 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-5 34829956-1 2021 Enpp2 is an enzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which exhibits a wide variety of biological functions. lysophosphatidic acid 108-111 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-5 34319110-1 2021 Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). lysophosphatidic acid 63-84 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 34514847-0 2021 Disrupted Blood-Brain Barrier and Mitochondrial Impairment by Autotaxin-Lysophosphatidic Acid Axis in Postischemic Stroke. lysophosphatidic acid 72-93 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 62-71 34514847-3 2021 Recently, we have shown that endothelial permeability is mediated by lysophosphatidic acid (LPA), but the role of autotaxin, which produces LPA, remains unclear in stroke. lysophosphatidic acid 140-143 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 114-123 34319110-1 2021 Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). lysophosphatidic acid 86-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 32-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 32-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 32-53 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 16-21 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 55-58 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 55-58 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 34788605-1 2021 Autotaxin (ATX; ENPP2) produces lysophosphatidic acid (LPA) that regulates multiple biological functions via cognate G protein-coupled receptors LPAR1-6. lysophosphatidic acid 55-58 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 16-21 34319110-1 2021 Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). lysophosphatidic acid 63-84 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 34319110-1 2021 Autotaxin (ATX) is a secreted enzyme responsible for producing lysophosphatidic acid (LPA). lysophosphatidic acid 86-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 34445223-4 2021 Here, we identify the autotaxin (ATX)/lysophosphatidic acid (LPA)/LPA-receptor axis as a potential pharmacological target to modulate the LPS-mediated neuroinflammatory response in vitro (the murine BV-2 microglia cell line) and in vivo (C57BL/6J mice receiving a single i.p. lysophosphatidic acid 38-59 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 22-31 34445223-4 2021 Here, we identify the autotaxin (ATX)/lysophosphatidic acid (LPA)/LPA-receptor axis as a potential pharmacological target to modulate the LPS-mediated neuroinflammatory response in vitro (the murine BV-2 microglia cell line) and in vivo (C57BL/6J mice receiving a single i.p. lysophosphatidic acid 38-59 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 33-36 34445223-4 2021 Here, we identify the autotaxin (ATX)/lysophosphatidic acid (LPA)/LPA-receptor axis as a potential pharmacological target to modulate the LPS-mediated neuroinflammatory response in vitro (the murine BV-2 microglia cell line) and in vivo (C57BL/6J mice receiving a single i.p. lysophosphatidic acid 61-64 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 22-31 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 148-169 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 77-82 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 148-169 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 84-93 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 148-169 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 98-101 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 171-174 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 77-82 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 171-174 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 84-93 35398277-3 2022 RNA sequencing showed that Sirt3-deficient islets had enhanced expression of Enpp2 (Autotaxin, or ATX), a secreted lysophospholipase which produces lysophosphatidic acid (LPA). lysophosphatidic acid 171-174 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 98-101 35398277-5 2022 METHODS: We applied LPA, or lysophosphatidylcoline (LPC), the substrate of ATX for producing LPA, to MIN6 cell line and mouse islets with altered Sirt3 expression to investigate the effect of LPA on beta cell dedifferentiation and its underlying mechanisms. lysophosphatidic acid 93-96 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 75-78 35398277-7 2022 RESULTS: In Sirt3f/f;Cre/+ mouse islets and Sirt3 knockdown MIN6 cells, ATX upregulation led to increased LPC with increased production of LPA. lysophosphatidic acid 139-142 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 72-75 33128578-1 2020 Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) and choline. lysophosphatidic acid 86-107 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 40-43 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 83-92 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 40-43 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-97 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 62-65 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 83-92 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 62-65 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-97 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 62-65 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 83-92 33524376-4 2021 Previous studies focused on suppressing LPA production by the LPA-producing enzyme autotaxin (ATX) but did not take the artificial LPA degradation into account. lysophosphatidic acid 62-65 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-97 33524376-6 2021 The main features of the devised method were suppression of LPA production and degradation after blood collection by keeping whole blood samples at low temperature and followed by adding an ATX inhibitor to plasma samples. lysophosphatidic acid 60-63 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 190-193 35456953-13 2022 The upregulation of ATX with hypoxic reperfusion leads to LPA production in brain endothelial cells favoring permeability. lysophosphatidic acid 58-61 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 20-23 33597645-2 2021 Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX) and is known to induce NP via LPA1 receptor signaling in mice. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 128-137 33597645-2 2021 Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX) and is known to induce NP via LPA1 receptor signaling in mice. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 139-142 33597645-2 2021 Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX) and is known to induce NP via LPA1 receptor signaling in mice. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 128-137 33597645-2 2021 Lysophosphatidic acid (LPA) is a potent bioactive lipid mediator that is produced mainly from lysophosphatidylcholine (LPC) via autotaxin (ATX) and is known to induce NP via LPA1 receptor signaling in mice. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 139-142 33017574-2 2020 Lysophosphatidic acid (LPA), produced by autotaxin (ATX), promotes inflammation and the development of atherosclerosis. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 41-50 33017574-2 2020 Lysophosphatidic acid (LPA), produced by autotaxin (ATX), promotes inflammation and the development of atherosclerosis. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 52-55 33017574-2 2020 Lysophosphatidic acid (LPA), produced by autotaxin (ATX), promotes inflammation and the development of atherosclerosis. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 41-50 33017574-2 2020 Lysophosphatidic acid (LPA), produced by autotaxin (ATX), promotes inflammation and the development of atherosclerosis. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 52-55 33128578-1 2020 Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) and choline. lysophosphatidic acid 86-107 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 33128578-1 2020 Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) and choline. lysophosphatidic acid 109-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 33128578-1 2020 Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) and choline. lysophosphatidic acid 109-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 32479084-1 2020 Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). lysophosphatidic acid 83-104 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 32479084-1 2020 Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). lysophosphatidic acid 83-104 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 32479084-1 2020 Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). lysophosphatidic acid 106-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 32479084-1 2020 Autotaxin (ATX) is the dominant catalytic enzyme accounting for the lipid mediator lysophosphatidic acid (LPA) through hydrolysis of lysophosphatidylcholine (LPC). lysophosphatidic acid 106-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 32326963-1 2020 BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. lysophosphatidic acid 46-67 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 100-109 32326963-1 2020 BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. lysophosphatidic acid 46-67 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 111-114 32326963-1 2020 BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. lysophosphatidic acid 69-72 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 100-109 32326963-1 2020 BACKGROUND: In the extracellular environment, lysophosphatidic acid (LPA) species are generated via autotaxin (ATX)-mediated hydrolysis of lysophospholipid precursors. lysophosphatidic acid 69-72 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 111-114 31548293-1 2020 Autotaxin catalyzes the formation of lysophosphatidic acid, which stimulates tumor growth and metastasis and decreases the effectiveness of cancer therapies. lysophosphatidic acid 37-58 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 31429784-1 2019 BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1-6), and serves as an important mediator in inflammation. lysophosphatidic acid 12-33 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 54-63 31429784-1 2019 BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1-6), and serves as an important mediator in inflammation. lysophosphatidic acid 12-33 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 65-68 31429784-1 2019 BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1-6), and serves as an important mediator in inflammation. lysophosphatidic acid 35-38 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 54-63 31429784-1 2019 BACKGROUND: Lysophosphatidic acid (LPA), generated by autotaxin (ATX), is a bioactive lipid mediator that binds to the receptors (LPA1-6), and serves as an important mediator in inflammation. lysophosphatidic acid 35-38 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 65-68 30395215-11 2019 The binding of ATX to GPIIb/IIIa of platelets generated lysophosphatidic acid (LysoPA) with pro-osteogenic properties. lysophosphatidic acid 56-77 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 15-18 30395215-11 2019 The binding of ATX to GPIIb/IIIa of platelets generated lysophosphatidic acid (LysoPA) with pro-osteogenic properties. lysophosphatidic acid 79-85 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 15-18 30999934-1 2019 BACKGROUND: Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic sclerosis (SSc). lysophosphatidic acid 91-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 75-84 30999934-1 2019 BACKGROUND: Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic sclerosis (SSc). lysophosphatidic acid 91-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 86-89 30999934-1 2019 BACKGROUND: Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic sclerosis (SSc). lysophosphatidic acid 114-117 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 75-84 30999934-1 2019 BACKGROUND: Cyclic phosphatidic acid (cPA) has an inhibitory effect on the autotaxin (ATX)/lysophosphatidic acid (LPA) axis, which has been implicated to play an important role in the progression of fibrosis in systemic sclerosis (SSc). lysophosphatidic acid 114-117 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 86-89 30881959-5 2019 As such, ATX converts phospholipids into lysophosphatidic acid (LysoPA), a metabolite with potent and diverse biological properties. lysophosphatidic acid 41-62 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 9-12 30881959-5 2019 As such, ATX converts phospholipids into lysophosphatidic acid (LysoPA), a metabolite with potent and diverse biological properties. lysophosphatidic acid 64-70 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 9-12 32875703-1 2020 Autotaxin (ATX) converts lysophosphatidylcholine and sphingosyl-phosphorylcholine into lysophosphatidic acid and sphingosine 1-phosphate, respectively. lysophosphatidic acid 87-108 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 32875703-1 2020 Autotaxin (ATX) converts lysophosphatidylcholine and sphingosyl-phosphorylcholine into lysophosphatidic acid and sphingosine 1-phosphate, respectively. lysophosphatidic acid 87-108 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 185-206 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 56-61 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 185-206 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 78-87 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 185-206 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 89-92 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 208-211 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 56-61 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 208-211 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 78-87 31805399-1 2020 Ectonucleotide pyrophosphate phosphodiesterase type II (ENPP2), also known as Autotaxin (ATX), is an enzyme present in blood circulation that converts lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). lysophosphatidic acid 208-211 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 89-92 31805399-4 2020 As RSPO2 promotes myogenic differentiation via the WNT/beta-Catenin signaling pathway, we hypothesized that ENPP2 may act as a key mediator for the crosstalk between WNT and LPA signaling during myogenic differentiation. lysophosphatidic acid 174-177 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 108-113 31794025-1 2019 We previously purified lysophospholipase D (lysoPLD), which hydrolyzes lysophosphatidylcholine (lysoPC) to lysophosphatidic acid (LPA), from rat brain and identified the heterotrimeric G protein subunits Galphaq and Gbeta1 in the lysoPLD active fractions. lysophosphatidic acid 130-133 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 230-237 31092842-2 2019 Autotaxin (ATX) is a key LPA-producing enzyme, and we hypothesized that ATX contributes to the development of renal interstitial fibrosis through LPA-mediated effects on fibroblast functions. lysophosphatidic acid 25-28 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 31092842-2 2019 Autotaxin (ATX) is a key LPA-producing enzyme, and we hypothesized that ATX contributes to the development of renal interstitial fibrosis through LPA-mediated effects on fibroblast functions. lysophosphatidic acid 25-28 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 31092842-2 2019 Autotaxin (ATX) is a key LPA-producing enzyme, and we hypothesized that ATX contributes to the development of renal interstitial fibrosis through LPA-mediated effects on fibroblast functions. lysophosphatidic acid 25-28 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 72-75 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 73-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 18-23 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30481488-1 2019 Autotaxin (ATX or ENPP2) is a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediator acting on specific GPCRs. lysophosphatidic acid 96-99 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 18-23 29620892-1 2018 Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 104-125 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30450805-0 2019 Autotaxin/lysophosphatidic acid signaling mediates obesity-related cardiomyopathy in mice and human subjects. lysophosphatidic acid 10-31 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30072447-1 2018 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30072447-1 2018 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30072447-1 2018 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). lysophosphatidic acid 91-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30072447-1 2018 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). lysophosphatidic acid 91-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30237860-1 2018 Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). lysophosphatidic acid 74-95 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30237860-1 2018 Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). lysophosphatidic acid 74-95 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30237860-1 2018 Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). lysophosphatidic acid 97-100 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30237860-1 2018 Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). lysophosphatidic acid 97-100 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30730895-1 2019 Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). lysophosphatidic acid 72-93 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30730895-1 2019 Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). lysophosphatidic acid 72-93 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30730895-1 2019 Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). lysophosphatidic acid 95-98 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 30730895-1 2019 Autotaxin (ATX) is a secreted enzyme that generates the bioactive lipid lysophosphatidic acid (LPA). lysophosphatidic acid 95-98 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 30118349-2 2018 Autotaxin (ATX) is a secreted enzyme that produces extracellular lysophosphatidic acid. lysophosphatidic acid 65-86 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 29620892-1 2018 Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 104-125 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 29620892-1 2018 Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 127-130 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 29620892-1 2018 Autotaxin (ATX) catalyzes the hydrolysis of lysophosphatidylcholine (LPC) generating the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 127-130 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 28111010-4 2017 The expression of autotaxin, an LPA synthesis enzyme, and LPA receptor 1 was significantly increased in both mesangial cells (SV40 MES13) maintained in high-glucose media and the kidney cortex of diabetic db/db mice. lysophosphatidic acid 32-35 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 18-27 28758906-8 2017 Moreover, we identified ENPP2, an enzyme that generates lysophosphatidic acid, as a linker of FOP-ACVR1 and mTOR signaling in chondrogenesis. lysophosphatidic acid 56-77 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 24-29 28874440-1 2017 Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. lysophosphatidic acid 111-132 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 28874440-1 2017 Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. lysophosphatidic acid 111-132 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 28874440-1 2017 Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. lysophosphatidic acid 134-137 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 28874440-1 2017 Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. lysophosphatidic acid 134-137 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 28324037-1 2017 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 28460477-3 2017 We found that autotaxin, an LPA producing enzyme, and LPAR1 and LPAR3 mRNA, and IL-17 mRNA were highly expressed in the exocrine glands of 20-week-old nonobese diabetic (NOD) mice, which show SS symptoms at this age, as compared with non-symptomatic 8-week-old NOD mice. lysophosphatidic acid 28-31 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 14-23 28240604-3 2017 Here, we have identified an autocrine pathway linking nuclear factor of activated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and beta-catenin that contributes to progression of fibrosis in lung allografts. lysophosphatidic acid 141-144 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 101-110 28324037-1 2017 Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 27981605-4 2017 In mice, different hepatotoxic stimuli linked with the development of different forms of CLDs were shown to stimulate hepatocyte ATX expression, leading to increased LPA levels, activation of hepatic stellate cells (HSCs), and amplification of profibrotic signals. lysophosphatidic acid 166-169 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 129-132 28073697-3 2017 LPA is produced by autotaxin (ATX) and induces various kinds of cellular processes including migration, proliferation and inhibition of cell death possibly through six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 19-28 28069607-5 2017 Lysophosphatidic acid (LPA), a lipid by-product of autotaxin activity, is involved in cancer, vascular defects, and neural tissue, but is largely unexplored in immune system. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 51-60 28069607-5 2017 Lysophosphatidic acid (LPA), a lipid by-product of autotaxin activity, is involved in cancer, vascular defects, and neural tissue, but is largely unexplored in immune system. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 51-60 28073697-3 2017 LPA is produced by autotaxin (ATX) and induces various kinds of cellular processes including migration, proliferation and inhibition of cell death possibly through six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 30-33 27754931-3 2017 However, other LPA-generating pathways exist, and the role of ATX in localized tissue LPA production and fibrosis remains unclear and controversial. lysophosphatidic acid 86-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 62-65 27754931-1 2017 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid 140-143 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 27754931-1 2017 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid 140-143 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 27754931-1 2017 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid 192-195 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 27754931-1 2017 Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. lysophosphatidic acid 192-195 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 27390295-9 2016 IL-6 knockdown abrogated LPA-induced ATX expression in fibroblasts, and ATX inhibition attenuated IL-6 expression in fibroblasts and the skin of bleomycin-challenged mice. lysophosphatidic acid 25-28 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 37-40 27516465-1 2016 Autotaxin is a secreted enzyme that catalyzes the conversion of lysophosphatidyl choline into the bioactive lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 123-144 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 27516465-1 2016 Autotaxin is a secreted enzyme that catalyzes the conversion of lysophosphatidyl choline into the bioactive lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 146-149 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 27178323-3 2016 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid 147-150 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 190-199 27019050-4 2016 In support of this, ATX heterozygous mice have 50% of normal LPA plasma levels. lysophosphatidic acid 61-64 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 20-23 27178323-3 2016 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid 147-150 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 201-204 27178323-3 2016 The generation of LPC by PMVECs required Prdx6-PLA2 We propose that Prdx6-PLA2 modulates NOX2 activation by generation of LPC that is converted to LPA by the lysophospholipase D activity of autotaxin (ATX/lysoPLD). lysophosphatidic acid 147-150 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 205-212 26345369-1 2015 Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice and fish. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 115-124 27283020-4 2016 Furthermore, fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin. lysophosphatidic acid 52-55 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 106-115 27005960-2 2016 LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, from lysophosphatidylcholine. lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 35-44 27005960-2 2016 LPA is produced extracellularly by autotaxin (ATX), a secreted lysophospholipase D, from lysophosphatidylcholine. lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 46-49 27006447-2 2016 In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but alternative enzymatic pathways also exist for LPA production. lysophosphatidic acid 54-57 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 35-44 27006447-2 2016 In blood and multiple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D activity, but alternative enzymatic pathways also exist for LPA production. lysophosphatidic acid 177-180 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 35-44 27006447-3 2016 We examined the role of autotaxin (ATX) in pulmonary LPA production during fibrogenesis in a bleomycin mouse model. lysophosphatidic acid 53-56 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 24-33 27006447-3 2016 We examined the role of autotaxin (ATX) in pulmonary LPA production during fibrogenesis in a bleomycin mouse model. lysophosphatidic acid 53-56 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 35-38 26714589-3 2016 We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 26-35 26714589-3 2016 We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 37-40 26714589-3 2016 We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs. lysophosphatidic acid 68-89 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 139-142 26714589-3 2016 We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs. lysophosphatidic acid 91-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 26-35 26714589-3 2016 We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs. lysophosphatidic acid 91-94 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 37-40 26808693-1 2016 Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 103-112 26808693-1 2016 Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 103-112 26808693-1 2016 Lysophosphatidic acid (LPA), a lipid mediator in biological fluids and tissues, is generated mainly by autotaxin that hydrolyzes lysophosphatidylcholine to LPA and choline. lysophosphatidic acid 156-159 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 103-112 26569406-1 2015 Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. lysophosphatidic acid 86-107 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 26569406-1 2015 Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. lysophosphatidic acid 86-107 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 26569406-1 2015 Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid. lysophosphatidic acid 86-107 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 16-21 26345369-1 2015 Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice and fish. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 140-145 26345369-1 2015 Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice and fish. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 115-124 26345369-1 2015 Lysophosphatidic acid (LPA) is emerging as an angiogenic factor, because knockdown of the enzyme that produces it (autotaxin, also known as ENPP2) and its receptors cause severe developmental vascular defects in both mice and fish. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 140-145 26224810-3 2015 Autotaxin (ATX) transforms lysophosphatidylcholine into lysophosphatidic acid. lysophosphatidic acid 56-77 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 26224810-3 2015 Autotaxin (ATX) transforms lysophosphatidylcholine into lysophosphatidic acid. lysophosphatidic acid 56-77 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 24278115-1 2013 Autotaxin (ATX), an autocrine motility factor that is highly upregulated in metastatic cancer, is a lysophospholipase D enzyme that produces the lipid second messenger lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). lysophosphatidic acid 168-189 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 232-253 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 111-120 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 232-253 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 122-125 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 232-253 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 127-132 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 255-258 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 111-120 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 255-258 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 122-125 26196781-3 2015 Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. lysophosphatidic acid 255-258 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 127-132 25769037-2 2015 LPA is generated through the action of autotaxin or phospholipases, and degradation begins with lipid phosphate phosphohydrolase (LPP)-dependent removal of the phosphate. lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 39-48 25669348-1 2015 Autotaxin is an extracellular, two zinc-centered enzyme that hydrolyzes lysophosphatidyl choline to lysophosphatidic acid, involved in various cancerous processes, e.g. migration, proliferation and tumor progression. lysophosphatidic acid 100-121 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 25053164-4 2014 Autotaxin (ATX), a phospholipase D, converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA) and is upregulated in several CNS injuries. lysophosphatidic acid 80-101 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 25053164-4 2014 Autotaxin (ATX), a phospholipase D, converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA) and is upregulated in several CNS injuries. lysophosphatidic acid 80-101 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 25053164-4 2014 Autotaxin (ATX), a phospholipase D, converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA) and is upregulated in several CNS injuries. lysophosphatidic acid 103-106 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 25053164-4 2014 Autotaxin (ATX), a phospholipase D, converts lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA) and is upregulated in several CNS injuries. lysophosphatidic acid 103-106 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 24641902-6 2014 The sequestration of ATX protein on the blood cells by heparan sulfate proteoglycan may accelerate the transport of LPA to the local apical surface of vascular endothelium with LPA receptors, promoting the hyperpermeability of venules and the pathological uptake of immune cells, aggravating lesion progression and itching in Naruto Research Institute Otsuka Atrichia mice. lysophosphatidic acid 116-119 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 21-24 24504738-8 2014 Endothelial barrier function was restored by pharmacological or genetic inhibition of either LPA production by the circulating lysophospholipase D autotaxin or of G-protein-coupled receptor-dependent LPA signaling. lysophosphatidic acid 93-96 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 147-156 23639740-1 2014 Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. lysophosphatidic acid 75-96 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23639740-1 2014 Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. lysophosphatidic acid 75-96 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 23639740-1 2014 Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. lysophosphatidic acid 98-101 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23639740-1 2014 Autotaxin (ATX) is a secreted lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA), a phospholipid growth factor acting via specific receptors (LPA1R to LPA6R) and involved in several pathologies including obesity. lysophosphatidic acid 98-101 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 23639740-2 2014 ATX is secreted by adipocytes and contributes to circulating LPA. lysophosphatidic acid 61-64 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 24120919-1 2014 Lysophosphatidic acid (LPA) is a pro-fibrotic mediator acting via specific receptors (LPARs) and is synthesized by autotaxin, that increases with obesity. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 115-124 24120919-1 2014 Lysophosphatidic acid (LPA) is a pro-fibrotic mediator acting via specific receptors (LPARs) and is synthesized by autotaxin, that increases with obesity. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 115-124 25992708-1 2015 Autotaxin (ATX) is a secretory protein, which converts lysophospholipids to lysophosphatidic acid (LPA), and is essential for embryonic vascular formation. lysophosphatidic acid 76-97 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 25992708-1 2015 Autotaxin (ATX) is a secretory protein, which converts lysophospholipids to lysophosphatidic acid (LPA), and is essential for embryonic vascular formation. lysophosphatidic acid 76-97 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 25992708-1 2015 Autotaxin (ATX) is a secretory protein, which converts lysophospholipids to lysophosphatidic acid (LPA), and is essential for embryonic vascular formation. lysophosphatidic acid 99-102 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 25992708-1 2015 Autotaxin (ATX) is a secretory protein, which converts lysophospholipids to lysophosphatidic acid (LPA), and is essential for embryonic vascular formation. lysophosphatidic acid 99-102 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 25992708-6 2015 ATX was conditionally overexpressed in the neonatal period using the Cre/loxP system, which resulted in a marked increase in the plasma LPA level. lysophosphatidic acid 136-139 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 25596343-9 2015 Moreover, the expression of GDE4 increased most species of lysophosphatidic acid (LPA), which can be produced from various lysophospholipids by the lysoPLD activity of GDE4. lysophosphatidic acid 59-80 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 148-155 25596343-9 2015 Moreover, the expression of GDE4 increased most species of lysophosphatidic acid (LPA), which can be produced from various lysophospholipids by the lysoPLD activity of GDE4. lysophosphatidic acid 82-85 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 148-155 25596343-11 2015 In conclusion, GDE4 may act as a lysoPLD, which is involved in the generation of N-acylethanolamines and LPA. lysophosphatidic acid 105-108 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 33-40 25646365-7 2015 We conclude that i) intestinally derived unsaturated (but not saturated) LPA can cause atherosclerosis in LDLR(-/-) mice, and ii) autotaxin mediates the conversion of unsaturated (but not saturated) LysoPC to LPA. lysophosphatidic acid 209-212 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 130-139 24278115-1 2013 Autotaxin (ATX), an autocrine motility factor that is highly upregulated in metastatic cancer, is a lysophospholipase D enzyme that produces the lipid second messenger lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). lysophosphatidic acid 168-189 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 24278115-1 2013 Autotaxin (ATX), an autocrine motility factor that is highly upregulated in metastatic cancer, is a lysophospholipase D enzyme that produces the lipid second messenger lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). lysophosphatidic acid 191-194 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 24278115-1 2013 Autotaxin (ATX), an autocrine motility factor that is highly upregulated in metastatic cancer, is a lysophospholipase D enzyme that produces the lipid second messenger lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). lysophosphatidic acid 191-194 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 24278115-3 2013 Consequently, the ATX/LPA pathway has emerged as an important source of biomarkers and therapeutic targets. lysophosphatidic acid 22-25 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 18-21 24175745-2 2013 In serum and plasma, LPA production occurs mainly by the hydrolysis of lysophosphatidylcholine by the phospholipase D activity of autotaxin (ATX). lysophosphatidic acid 21-24 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 130-139 24050723-0 2013 Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. lysophosphatidic acid 24-45 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 24050723-2 2013 Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 109-118 24050723-2 2013 Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis. lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 120-123 24050723-2 2013 Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 109-118 24050723-2 2013 Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on cell proliferation, migration, survival, differentiation, and motility, and therefore could mediate asthma pathogenesis. lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 120-123 24050723-3 2013 OBJECTIVES: To define a role for the ATX-LPA pathway in human asthma pathogenesis and a murine model of allergic lung inflammation. lysophosphatidic acid 41-44 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 37-40 24175745-2 2013 In serum and plasma, LPA production occurs mainly by the hydrolysis of lysophosphatidylcholine by the phospholipase D activity of autotaxin (ATX). lysophosphatidic acid 21-24 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 141-144 23948545-2 2013 Concentrations of the major LPA species in mouse plasma decreased uniformly following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D autotaxin, identifying an active mechanism for removal of LPA from the circulation. lysophosphatidic acid 28-31 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 175-184 23948545-2 2013 Concentrations of the major LPA species in mouse plasma decreased uniformly following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D autotaxin, identifying an active mechanism for removal of LPA from the circulation. lysophosphatidic acid 140-143 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 175-184 23793291-1 2013 Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 264-285 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23793291-1 2013 Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 264-285 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 23793291-1 2013 Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 287-290 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23793291-1 2013 Autotaxin (ATX), a lysophospholipase D, plays an important role in cancer invasion, metastasis, tumor progression, tumorigenesis, neuropathic pain, fibrotic diseases, cholestatic pruritus, lymphocyte homing, and thrombotic diseases by producing the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 287-290 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 159-180 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 12-21 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 159-180 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 23-26 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 159-180 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 81-100 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 159-180 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 102-109 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 182-185 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 12-21 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 182-185 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 23-26 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 182-185 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 81-100 23063960-1 2013 BACKGROUND: Autotaxin (ATX), secreted mainly from adipose tissue, functions as a lysophospholipase D (lysoPLD) to hydrolyze lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA). lysophosphatidic acid 182-185 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 102-109 22744859-3 2012 In this report, increased concentrations of autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular LPA production, were detected in both murine and human fibrotic lungs. lysophosphatidic acid 117-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 44-53 23022664-1 2013 Autotaxin (ATX) is a secreted lysophospholipase D that generates the multifunctional lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 100-121 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23022664-1 2013 Autotaxin (ATX) is a secreted lysophospholipase D that generates the multifunctional lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 100-121 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 23022664-1 2013 Autotaxin (ATX) is a secreted lysophospholipase D that generates the multifunctional lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 123-126 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 23022664-1 2013 Autotaxin (ATX) is a secreted lysophospholipase D that generates the multifunctional lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 123-126 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 22744859-3 2012 In this report, increased concentrations of autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular LPA production, were detected in both murine and human fibrotic lungs. lysophosphatidic acid 117-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 55-58 22744859-3 2012 In this report, increased concentrations of autotaxin (ATX; ENPP2), the enzyme largely responsible for extracellular LPA production, were detected in both murine and human fibrotic lungs. lysophosphatidic acid 117-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 60-65 22474126-0 2012 Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. lysophosphatidic acid 26-47 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22962684-3 2012 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. lysophosphatidic acid 122-125 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 22962684-11 2012 ATX must bind to these receptors to elicit a maximal TEM response, providing a mechanism to focus the action of LPA onto arrested lymphocytes in flowing blood. lysophosphatidic acid 112-115 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 22962684-0 2012 Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. lysophosphatidic acid 18-39 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22962684-3 2012 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. lysophosphatidic acid 99-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22962684-3 2012 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. lysophosphatidic acid 99-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 22962684-3 2012 Autotaxin (ATX) is an ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a close relative of sphingosine 1-phosphate. lysophosphatidic acid 122-125 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22474126-3 2012 We report that the bioactive lipid mediator lysophosphatidic acid (LPA) markedly decreases differentiation of cultured primary brown adipocyte precursors, whereas potent selective inhibitors of the LPA-generating enzyme autotaxin (ATX) promote differentiation. lysophosphatidic acid 67-70 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 220-229 21569544-1 2011 BACKGROUND: Cyclic phosphatidic acid (cPA) is a structural analog of lysophosphatidic acid (LPA), but possesses different biological functions, such as the inhibition of autotaxin (ATX), an LPA-synthesizing enzyme. lysophosphatidic acid 92-95 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 170-179 21696367-2 2011 In the present paper we hypothesize that secreted ATX (autotaxin), which exhibits lysoPLD (lysophospholipase D) activity, stimulates lung epithelial cell migration through LPA (lysophosphatidic acid) generation-dependent and -independent pathways. lysophosphatidic acid 172-175 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 50-53 21696367-2 2011 In the present paper we hypothesize that secreted ATX (autotaxin), which exhibits lysoPLD (lysophospholipase D) activity, stimulates lung epithelial cell migration through LPA (lysophosphatidic acid) generation-dependent and -independent pathways. lysophosphatidic acid 172-175 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 55-64 21696367-2 2011 In the present paper we hypothesize that secreted ATX (autotaxin), which exhibits lysoPLD (lysophospholipase D) activity, stimulates lung epithelial cell migration through LPA (lysophosphatidic acid) generation-dependent and -independent pathways. lysophosphatidic acid 177-198 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 50-53 21696367-2 2011 In the present paper we hypothesize that secreted ATX (autotaxin), which exhibits lysoPLD (lysophospholipase D) activity, stimulates lung epithelial cell migration through LPA (lysophosphatidic acid) generation-dependent and -independent pathways. lysophosphatidic acid 177-198 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 55-64 21696367-4 2011 ATX with V5 tag overexpressed conditional medium had higher LPA levels compared with control medium and stimulated cell migration through G(alphai)-coupled LPA receptors, cytoskeleton rearrangement, phosphorylation of PKC (protein kinase C) delta and cortactin at the leading edge of migrating cells. lysophosphatidic acid 60-63 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 21696367-9 2011 These results suggested a significant role for ATX in lung epithelial cell migration and remodelling through its ability to induce LPA production-mediated phosphorylation of PKCdelta and cortactin. lysophosphatidic acid 131-134 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 47-50 21542849-4 2011 The levels of 16:0-, 18:0- and 18:1-LPC in the spinal cord and dorsal root were maximally increased at 75 min after SCNI and then declined, as LPC is converted to LPA by autotaxin (ATX). lysophosphatidic acid 163-166 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 170-179 21542849-4 2011 The levels of 16:0-, 18:0- and 18:1-LPC in the spinal cord and dorsal root were maximally increased at 75 min after SCNI and then declined, as LPC is converted to LPA by autotaxin (ATX). lysophosphatidic acid 163-166 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 181-184 21542849-5 2011 In atx(+/-)-mice, on the other hand, these levels were similar to wild-type mice at 75 min, but maximal at 120 min, suggesting that this difference is partly due to the low conversion of LPC to LPA in atx(+/-)-mice. lysophosphatidic acid 194-197 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 201-204 21421848-0 2011 Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. lysophosphatidic acid 91-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 31-40 21421848-1 2011 Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 84-105 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 21421848-1 2011 Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 84-105 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 21421848-1 2011 Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 107-110 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 21421848-1 2011 Autotaxin (ATX) is a secreted lysophospholipase D that generates the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 107-110 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 21421848-10 2011 These results show that adipose-ATX is a negative regulator of fat mass expansion in response to an HFD and contributes to plasma LPA levels. lysophosphatidic acid 130-133 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 32-35 22155714-3 2012 Autotaxin (ATX) plays an important role in the modulation of critical cellular functions, through its enzymatic production of lysophosphatidic acid (LPA). lysophosphatidic acid 126-147 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22155714-3 2012 Autotaxin (ATX) plays an important role in the modulation of critical cellular functions, through its enzymatic production of lysophosphatidic acid (LPA). lysophosphatidic acid 126-147 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 22155714-3 2012 Autotaxin (ATX) plays an important role in the modulation of critical cellular functions, through its enzymatic production of lysophosphatidic acid (LPA). lysophosphatidic acid 149-152 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 22155714-3 2012 Autotaxin (ATX) plays an important role in the modulation of critical cellular functions, through its enzymatic production of lysophosphatidic acid (LPA). lysophosphatidic acid 149-152 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 22015657-1 2012 OBJECTIVE: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at >=100 nmol/L in plasma. lysophosphatidic acid 11-32 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 119-128 22015657-1 2012 OBJECTIVE: Lysophosphatidic acid (LPA) is a bioactive lipid molecule produced by the plasma lysophospholipase D enzyme autotaxin that is present at >=100 nmol/L in plasma. lysophosphatidic acid 34-37 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 119-128 21531341-3 2011 Oxidation of LDL generates lysophosphatidylcholine, which is the main substrate for the lysophosphatidic acid (LPA) generating enzyme autotaxin. lysophosphatidic acid 88-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 134-143 21531341-3 2011 Oxidation of LDL generates lysophosphatidylcholine, which is the main substrate for the lysophosphatidic acid (LPA) generating enzyme autotaxin. lysophosphatidic acid 111-114 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 134-143 21465666-2 2011 ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipase D activity, which leads to generation of the growth-factor-like lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 171-192 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 21465666-2 2011 ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipase D activity, which leads to generation of the growth-factor-like lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 194-197 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 20692235-1 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors. lysophosphatidic acid 48-69 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 123-144 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 123-144 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 123-144 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 30-35 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 146-149 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 146-149 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 21240269-1 2011 Autotaxin (ATX, also known as Enpp2) is a secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine to generate lysophosphatidic acid (LPA), a lipid mediator that activates G protein-coupled receptors to evoke various cellular responses. lysophosphatidic acid 146-149 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 30-35 20692235-1 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors. lysophosphatidic acid 48-69 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 26-31 20692235-1 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors. lysophosphatidic acid 71-74 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 20692235-1 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors. lysophosphatidic acid 71-74 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 26-31 20231358-3 2010 Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). lysophosphatidic acid 113-134 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-43 20123931-0 2010 Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain. lysophosphatidic acid 34-55 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 104-113 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 68-71 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 125-134 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 68-71 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 136-139 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 88-91 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 125-134 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 88-91 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 136-139 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 88-91 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 125-134 20123931-2 2010 In addition, we recently demonstrated that intrathecal injection of LPA induces de novo LPA production through the action of autotaxin (ATX), which converts lysophosphatidylcholine to LPA. lysophosphatidic acid 88-91 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 136-139 20123931-5 2010 Nerve injury-induced LPA production reached its maximum at 3 h after injury, followed by a rapid decline by 6 h. The LPA production was significantly attenuated in ATX heterozygous mutant mice, whereas the concentration and activity of ATX in cerebrospinal fluid were not affected by nerve injury. lysophosphatidic acid 21-24 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 236-239 20123931-5 2010 Nerve injury-induced LPA production reached its maximum at 3 h after injury, followed by a rapid decline by 6 h. The LPA production was significantly attenuated in ATX heterozygous mutant mice, whereas the concentration and activity of ATX in cerebrospinal fluid were not affected by nerve injury. lysophosphatidic acid 117-120 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 164-167 20123931-9 2010 These findings provide evidence that PLA2- and ATX-mediated de novo LPA production in the early phase is involved in nerve injury-induced neuropathic pain. lysophosphatidic acid 68-71 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 47-50 20417246-0 2010 Biological roles of lysophosphatidic acid signaling through its production by autotaxin. lysophosphatidic acid 20-41 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 78-87 20417246-5 2010 A plasma enzyme called autotaxin (ATX) is responsible for the most of LPA production in our bodies. lysophosphatidic acid 70-73 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 23-32 20417246-5 2010 A plasma enzyme called autotaxin (ATX) is responsible for the most of LPA production in our bodies. lysophosphatidic acid 70-73 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-37 20417246-6 2010 ATX converts lysophospholipids such as lysophosphatidylcholine to LPA by its lysophospholipase D activity. lysophosphatidic acid 66-69 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 20417246-7 2010 Recent studies on ATX have revealed new aspects of LPA. lysophosphatidic acid 51-54 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 18-21 20231358-3 2010 Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). lysophosphatidic acid 113-134 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 45-48 20231358-3 2010 Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). lysophosphatidic acid 136-139 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-43 20231358-3 2010 Namely, it increased the level of autotaxin (ATX), which is a secreted form of lysophospholipase D that produces lysophosphatidic acid (LPA). lysophosphatidic acid 136-139 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 45-48 20305819-0 2010 Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts. lysophosphatidic acid 88-109 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 26-35 20360563-0 2010 Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. lysophosphatidic acid 68-71 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 32-41 20360563-1 2010 Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. lysophosphatidic acid 145-166 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 20360563-1 2010 Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. lysophosphatidic acid 145-166 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 20360563-1 2010 Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. lysophosphatidic acid 168-171 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 20360563-1 2010 Autotaxin (ATX) is a secreted nucleotide pyrophosphatase/phosphodiesterase that functions as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA), a mitogen, chemoattractant, and survival factor for many cell types. lysophosphatidic acid 168-171 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 20360563-4 2010 By screening a chemical library, we have identified thiazolidinediones that selectively inhibit ATX-mediated LPA production both in vitro and in vivo. lysophosphatidic acid 109-112 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 96-99 20079728-7 2010 More importantly, neurite outgrowth in embryo explants was severely compromised in mutant embryos but could be rescued upon the addition of LPA, thus confirming a role for ATX and LPA signalling in the development of the nervous system. lysophosphatidic acid 140-143 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 172-175 20079728-8 2010 Finally, expression profiling of mutant embryos revealed attenuated embryonic expression of HIF-1a in the absence of ATX, suggesting a novel effector pathway of ATX/LPA. lysophosphatidic acid 165-168 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 161-164 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 79-100 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 12-32 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 79-100 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-41 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 79-100 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 53-56 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 102-105 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 12-32 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 102-105 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-41 20305819-4 2010 Through its lysosphospholipase D (lysoPLD) activity, ATX controls the level of lysophosphatidic acid (LPA) in the blood. lysophosphatidic acid 102-105 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 53-56 19184538-3 2009 A major pathway for LPA generation is the hydrolysis of lysophosphatidylcholine by the enzyme autotaxin (ATX). lysophosphatidic acid 20-23 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-103 19184538-3 2009 A major pathway for LPA generation is the hydrolysis of lysophosphatidylcholine by the enzyme autotaxin (ATX). lysophosphatidic acid 20-23 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 105-108 19509223-4 2009 The syn and anti diastereomers of BrP-LPA are pan-LPA GPCR antagonists and are also nanomolar inhibitors of the lysophospholipase D activity of autotaxin, the dominant biosynthetic source of LPA. lysophosphatidic acid 38-41 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 144-153 19808661-0 2009 Autotaxin/lysophospholipase D-mediated lysophosphatidic acid signaling is required to form distinctive large lysosomes in the visceral endoderm cells of the mouse yolk sac. lysophosphatidic acid 39-60 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 19808661-1 2009 Autotaxin, a lysophospholipase D encoded by the Enpp2 gene, is an exoenzyme that produces lysophosphatidic acid in the extracellular space. lysophosphatidic acid 90-111 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 19808661-1 2009 Autotaxin, a lysophospholipase D encoded by the Enpp2 gene, is an exoenzyme that produces lysophosphatidic acid in the extracellular space. lysophosphatidic acid 90-111 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 48-53 19808661-12 2009 These results suggest that constitutive activation of the Rho-ROCK-LIM kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin is required to maintain the large size of lysosomes in visceral endoderm cells. lysophosphatidic acid 117-138 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 156-165 19912636-1 2009 BACKGROUND: We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). lysophosphatidic acid 169-172 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 220-229 19912636-1 2009 BACKGROUND: We previously reported that intrathecal injection of lysophosphatidylcholine (LPC) induced neuropathic pain through activation of the lysophosphatidic acid (LPA)-1 receptor, possibly via conversion to LPA by autotaxin (ATX). lysophosphatidic acid 169-172 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 231-234 19912636-4 2009 LPC-induced LPA production was markedly diminished in ATX heterozygotes, and was abolished in mice that were deficient in LPA3, but not LPA1 or LPA2 receptors. lysophosphatidic acid 12-15 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 54-57 19912636-6 2009 In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor. lysophosphatidic acid 47-50 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 95-98 19912636-6 2009 In an in vitro study using spinal cord slices, LPA-induced LPA production was also mediated by ATX and the LPA3 receptor. lysophosphatidic acid 59-62 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 95-98 19416959-6 2009 We found that, when fetal calf serum was incubated in the presence of methanol, formation of LPM occurred rapidly, whereas it was completely blocked by depletion of autotaxin (ATX), a plasma enzyme that converts lysophosphatidylcholine (LPC) to LPA. lysophosphatidic acid 245-248 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 165-174 19416959-6 2009 We found that, when fetal calf serum was incubated in the presence of methanol, formation of LPM occurred rapidly, whereas it was completely blocked by depletion of autotaxin (ATX), a plasma enzyme that converts lysophosphatidylcholine (LPC) to LPA. lysophosphatidic acid 245-248 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 176-179 19482419-1 2009 Autotaxin, also known as NPP2 (nucleotide pyrophosphatase/phosphodiesterase 2), is a secreted lysophospholipase-D that generates lysophosphatidic acid and thereby promotes the metastatic and invasive properties of tumor cell as well as angiogenesis. lysophosphatidic acid 129-150 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 19477432-2 2009 LPA receptors and autotaxin (ATX/LysoPLD), the primary enzyme producing LPA, are aberrantly expressed in multiple cancer lineages. lysophosphatidic acid 0-3 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 33-40 19139100-6 2009 Enpp2+/- mice, which have approximately 50% normal plasma LPA levels, were more prone to thrombosis. lysophosphatidic acid 58-61 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-5 19139100-4 2009 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necessary for production of the bulk of biologically active LPA in plasma, elevated circulating LPA levels and induced a bleeding diathesis and attenuation of thrombosis in mice. lysophosphatidic acid 139-142 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 29-38 19139100-4 2009 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necessary for production of the bulk of biologically active LPA in plasma, elevated circulating LPA levels and induced a bleeding diathesis and attenuation of thrombosis in mice. lysophosphatidic acid 139-142 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 60-65 19139100-4 2009 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necessary for production of the bulk of biologically active LPA in plasma, elevated circulating LPA levels and induced a bleeding diathesis and attenuation of thrombosis in mice. lysophosphatidic acid 175-178 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 29-38 19139100-4 2009 Transgenic overexpression of autotaxin/lysophospholipase D (Enpp2), the enzyme necessary for production of the bulk of biologically active LPA in plasma, elevated circulating LPA levels and induced a bleeding diathesis and attenuation of thrombosis in mice. lysophosphatidic acid 175-178 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 60-65 19139100-5 2009 Intravascular administration of exogenous LPA recapitulated the prolonged bleeding time observed in Enpp2-Tg mice. lysophosphatidic acid 42-45 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 100-105 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 48-51 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 66-75 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 48-51 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 76-83 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 48-51 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 155-164 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 48-51 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 165-172 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 232-235 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 66-75 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 232-235 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 76-83 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 232-235 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 155-164 19139100-8 2009 These results identify a novel pathway in which LPA production by autotaxin/lysoPLD regulates murine hemostasis and thrombosis and suggest that binding of autotaxin/lysoPLD to activated platelets may provide a mechanism to localize LPA production. lysophosphatidic acid 232-235 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 165-172 18691016-6 2008 Recent work identifies a secreted enzyme, autotaxin (ATX), as the key component of an extracellular pathway for generation of lysophosphatidic acid by lysophospholipase D catalyzed hydrolysis of lysophospholipid substrates. lysophosphatidic acid 126-147 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 42-51 18703779-3 2008 Ligation injury of the carotid artery in mice increased levels in the vessel of both autotaxin, the lysophospholipase D enzyme responsible for generation of extracellular LPA, and 2 LPA responsive G protein-coupled receptors 1 (LPA1) and 2 (LPA2). lysophosphatidic acid 171-174 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 85-94 18621144-7 2008 In serum or plasma, LPA is predominantly produced by a plasma enzyme called autotaxin (ATX). lysophosphatidic acid 20-23 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 76-85 18621144-7 2008 In serum or plasma, LPA is predominantly produced by a plasma enzyme called autotaxin (ATX). lysophosphatidic acid 20-23 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 87-90 18378389-2 2008 Here we show that FTY720-phosphate is a competitive inhibitor (Ki approximately 0.2microM) of autotaxin (ATX or NPP2), a nucleotide phosphodiesterase/pyrophosphatase (NPP) that enhances metastasis and angiogenesis and acts as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 278-299 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-103 18378389-2 2008 Here we show that FTY720-phosphate is a competitive inhibitor (Ki approximately 0.2microM) of autotaxin (ATX or NPP2), a nucleotide phosphodiesterase/pyrophosphatase (NPP) that enhances metastasis and angiogenesis and acts as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 278-299 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 105-108 18378389-2 2008 Here we show that FTY720-phosphate is a competitive inhibitor (Ki approximately 0.2microM) of autotaxin (ATX or NPP2), a nucleotide phosphodiesterase/pyrophosphatase (NPP) that enhances metastasis and angiogenesis and acts as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 301-304 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 94-103 18378389-2 2008 Here we show that FTY720-phosphate is a competitive inhibitor (Ki approximately 0.2microM) of autotaxin (ATX or NPP2), a nucleotide phosphodiesterase/pyrophosphatase (NPP) that enhances metastasis and angiogenesis and acts as a lysophospholipase D to produce the lipid mediator lysophosphatidic acid (LPA). lysophosphatidic acid 301-304 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 105-108 18691016-6 2008 Recent work identifies a secreted enzyme, autotaxin (ATX), as the key component of an extracellular pathway for generation of lysophosphatidic acid by lysophospholipase D catalyzed hydrolysis of lysophospholipid substrates. lysophosphatidic acid 126-147 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 53-56 18691016-7 2008 In contrast to the apparently redundant functions of LPA receptors, studies using ATX knock out and transgenic mice indicate that this enzyme is uniquely required for LPA signaling during early development and serves as the primary determinant of circulating LPA levels in adult animals. lysophosphatidic acid 167-170 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 82-85 18691016-8 2008 Accordingly, pharmacological inhibition of ATX may be a viable and potentially effective way to interfere with LPA signaling in the cardiovascular system and possibly other settings such as tumor metastasis for therapeutic benefit. lysophosphatidic acid 111-114 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 43-46 17208043-1 2007 Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). lysophosphatidic acid 66-87 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 18280050-0 2008 Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid. lysophosphatidic acid 92-113 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 70-79 18280050-3 2008 Lysophosphatidylcholine (LPC), also known as lysolecithin, which is hydrolyzed by autotaxin/ATX into LPA, induces similar plastic changes. lysophosphatidic acid 101-104 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 82-91 18280050-3 2008 Lysophosphatidylcholine (LPC), also known as lysolecithin, which is hydrolyzed by autotaxin/ATX into LPA, induces similar plastic changes. lysophosphatidic acid 101-104 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 92-95 18280050-9 2008 These findings suggest that intrathecally-injected LPC is converted to LPA by ATX, and this LPA activates the LPA(1) receptor to initiate neuropathic pain. lysophosphatidic acid 71-74 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 78-81 18261210-0 2008 Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. lysophosphatidic acid 33-54 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 18261210-0 2008 Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. lysophosphatidic acid 56-59 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 18261210-9 2008 Taken together, these findings suggest that LPA biosynthesis through ATX is the source of LPA for LPA1 receptor-mediated neuropathic pain. lysophosphatidic acid 44-47 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 69-72 18261210-9 2008 Taken together, these findings suggest that LPA biosynthesis through ATX is the source of LPA for LPA1 receptor-mediated neuropathic pain. lysophosphatidic acid 90-93 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 69-72 18261210-10 2008 Therefore, targeted inhibition of ATX-mediated LPA biosynthesis as well as LPA1 receptor and its downstream pathways may represent a novel way to prevent nerve injury-induced neuropathic pain. lysophosphatidic acid 47-50 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 34-37 17208043-1 2007 Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). lysophosphatidic acid 66-87 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 17208043-1 2007 Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). lysophosphatidic acid 89-92 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 17208043-1 2007 Autotaxin (ATX) is a lysophospholipase D involved in synthesis of lysophosphatidic acid (LPA). lysophosphatidic acid 89-92 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 16829511-0 2006 Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. lysophosphatidic acid 90-111 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 16829511-1 2006 Autotaxin (ATX) is a cancer-associated motogen that has multiple biological activities in vitro through the production of bioactive small lipids, lysophosphatidic acid (LPA). lysophosphatidic acid 146-167 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 16829511-1 2006 Autotaxin (ATX) is a cancer-associated motogen that has multiple biological activities in vitro through the production of bioactive small lipids, lysophosphatidic acid (LPA). lysophosphatidic acid 146-167 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 16829511-1 2006 Autotaxin (ATX) is a cancer-associated motogen that has multiple biological activities in vitro through the production of bioactive small lipids, lysophosphatidic acid (LPA). lysophosphatidic acid 169-172 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 16829511-1 2006 Autotaxin (ATX) is a cancer-associated motogen that has multiple biological activities in vitro through the production of bioactive small lipids, lysophosphatidic acid (LPA). lysophosphatidic acid 169-172 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-14 16829511-10 2006 In serum from heterozygous mice both lysophospholipase D activity and LPA level were about half of those from wild-type mice, showing that ATX is responsible for the bulk of LPA production in serum. lysophosphatidic acid 70-73 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 139-142 16829511-10 2006 In serum from heterozygous mice both lysophospholipase D activity and LPA level were about half of those from wild-type mice, showing that ATX is responsible for the bulk of LPA production in serum. lysophosphatidic acid 174-177 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 139-142 16219296-0 2005 Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate. lysophosphatidic acid 92-113 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-9 16782709-3 2006 Recently ATX was shown to be responsible for the lysophospholipase D activity that generates lysophosphatidic acid (LPA). lysophosphatidic acid 93-114 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 9-12 16782709-3 2006 Recently ATX was shown to be responsible for the lysophospholipase D activity that generates lysophosphatidic acid (LPA). lysophosphatidic acid 116-119 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 9-12 16782709-4 2006 Production of LPA is sufficient to explain the effects of ATX on tumor cells. lysophosphatidic acid 14-17 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 58-61 16782887-2 2006 ATX generates lysophosphatidic acid (LPA), a lipid mitogen and motility factor that acts on several G protein-coupled receptors. lysophosphatidic acid 14-35 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 16782887-2 2006 ATX generates lysophosphatidic acid (LPA), a lipid mitogen and motility factor that acts on several G protein-coupled receptors. lysophosphatidic acid 37-40 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 16782887-6 2006 ATX heterozygous mice appear healthy but show half-normal ATX activity and plasma LPA levels. lysophosphatidic acid 82-85 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 0-3 16219296-2 2005 We demonstrate herein that ATX is a key regulator of extracellular lysophosphatidic acid (LPA) that can act as survival factor, in addition to its mitogenic activity in mouse fibroblasts. lysophosphatidic acid 90-93 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 27-30 16219296-0 2005 Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate. lysophosphatidic acid 92-113 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 11-18 16219296-2 2005 We demonstrate herein that ATX is a key regulator of extracellular lysophosphatidic acid (LPA) that can act as survival factor, in addition to its mitogenic activity in mouse fibroblasts. lysophosphatidic acid 67-88 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 27-30 15710620-1 2005 Lysophosphatidic acid (LPA) is a bioactive phospholipid acting via specific G protein-coupled receptors that is synthesized at the extracellular face of adipocytes by a secreted lysophospholipase D (autotaxin). lysophosphatidic acid 0-21 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 199-208 15710620-1 2005 Lysophosphatidic acid (LPA) is a bioactive phospholipid acting via specific G protein-coupled receptors that is synthesized at the extracellular face of adipocytes by a secreted lysophospholipase D (autotaxin). lysophosphatidic acid 23-26 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 199-208