PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17932426-9 2008 The data obtained showed that hypoxia/SD-induced apoptosis was significantly attenuated by LPA through Gi-coupled LPA(1) receptors linked to the downstream ERK1/2 and PI3K/Akt signaling pathways that function in parallel. lysophosphatidic acid 91-94 mitogen activated protein kinase 3 Rattus norvegicus 156-162 18407464-6 2008 On the other hand, LPA alone activated ERK1/2 via Gbetagamma subunits and Ras and potentiated EGF-induced ERK1/2 phosphorylation at late time points. lysophosphatidic acid 19-22 mitogen activated protein kinase 3 Rattus norvegicus 106-112 23015549-9 2012 PRG-1 overexpression abolished the activation of the p42/p44 signaling pathway in LPA-stimulated rat VSMCs in culture and in balloon-injured rat carotids. lysophosphatidic acid 82-85 mitogen activated protein kinase 3 Rattus norvegicus 57-60 18407464-6 2008 On the other hand, LPA alone activated ERK1/2 via Gbetagamma subunits and Ras and potentiated EGF-induced ERK1/2 phosphorylation at late time points. lysophosphatidic acid 19-22 mitogen activated protein kinase 3 Rattus norvegicus 39-45 16176063-4 2005 LPA induced transient (10 min) phosphorylations of ERK 1/2, Akt and the transcription factor CREB. lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 51-58 16176063-5 2005 The LPA-induced phosphorylation of ERK 1/2 and CREB was blocked by inhibition of PI3K, PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor. lysophosphatidic acid 4-7 mitogen activated protein kinase 3 Rattus norvegicus 35-42 16010968-5 2005 Moreover, the LPA-induced activation of Akt, a downstream target of PI3K, was completely inhibited by physiological concentrations of ANP, which were also able to inhibit p42/p44 phosphorylation. lysophosphatidic acid 14-17 mitogen activated protein kinase 3 Rattus norvegicus 175-178 12684213-5 2003 LPA elicited ERK1/ERK2 and PKB/Akt phosphorylation. lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 13-17 15081308-3 2004 LPA inhibits isoproterenol-stimulated cyclic AMP accumulation with an IC(50) approximately 40 nM and promotes phosphorylation of ERK-1/2. lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 129-136 12763014-5 2003 LPA-induced phosphorylation of CREB was dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK). lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 71-112 12763014-5 2003 LPA-induced phosphorylation of CREB was dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38 MAPK). lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 114-120 12763014-6 2003 Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked LPA-mediated phosphorylation of CREB. lysophosphatidic acid 84-87 mitogen activated protein kinase 3 Rattus norvegicus 14-20 12763014-6 2003 Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked LPA-mediated phosphorylation of CREB. lysophosphatidic acid 84-87 mitogen activated protein kinase 3 Rattus norvegicus 45-49 12763014-8 2003 Together, these data suggest that LPA stimulates nuclear transcription factor CREB via mitogen-activated protein kinase signaling components, ERK1/2, p38 MAPK, and MSK1 in Rat-2 fibroblast cells. lysophosphatidic acid 34-37 mitogen activated protein kinase 3 Rattus norvegicus 142-148 10318809-6 1999 In PC12 rat pheochromocytoma cells, both agents block lysophosphatidic acid (LPA)- and bradykinin-stimulated Erk 1/2 phosphorylation, suggesting that intact focal adhesion complexes are required for GPCR-induced mitogen-activated protein kinase activation in these cells. lysophosphatidic acid 54-75 mitogen activated protein kinase 3 Rattus norvegicus 109-116 12098668-12 2002 Exposure to 20 microM LPA increased the phosphorylation of extracellular signal-regulated kinases ERK1/2 by approximately 3-fold in L5pBJI cells (FRTL-5 cells transfected with the empty vector pBJI) while it induced a modest increase in L5betaarr1 and was ineffective in L5GRK2. lysophosphatidic acid 22-25 mitogen activated protein kinase 3 Rattus norvegicus 98-104 11855845-2 2002 Src-dependent transactivation of receptor tyrosine kinases has been previously demonstrated to mediate LPA-induced activation of MAP kinase ERK1/2. lysophosphatidic acid 103-106 mitogen activated protein kinase 3 Rattus norvegicus 140-146 10704947-5 2000 The activation of ERK1 and ERK2 by LPA was PKC- and phosphatidylinositol 3-kinase (PI 3-kinase)-dependent. lysophosphatidic acid 35-38 mitogen activated protein kinase 3 Rattus norvegicus 18-22 9855625-5 1998 LPA and alkenyl-GP both stimulated the activity of the mitogen-actived protein kinases extracellular signal regulated kinases 1 and 2 and c-Jun NH2-terminal kinase, whereas cyclic-PA did not. lysophosphatidic acid 0-3 mitogen activated protein kinase 3 Rattus norvegicus 87-133 8947493-5 1996 Activation of protein kinase C and Ca2+ fluxes played a minor and transient role in regulation of ERK1 activity by LPA in Rat-1 cells. lysophosphatidic acid 115-118 mitogen activated protein kinase 3 Rattus norvegicus 98-102 9148952-1 1997 Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF) results in a biphasic, sustained activation of extracellular signal-regulated kinase 1 (ERK1). lysophosphatidic acid 32-53 mitogen activated protein kinase 3 Rattus norvegicus 140-179 9148952-1 1997 Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF) results in a biphasic, sustained activation of extracellular signal-regulated kinase 1 (ERK1). lysophosphatidic acid 32-53 mitogen activated protein kinase 3 Rattus norvegicus 181-185 9148952-1 1997 Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF) results in a biphasic, sustained activation of extracellular signal-regulated kinase 1 (ERK1). lysophosphatidic acid 55-58 mitogen activated protein kinase 3 Rattus norvegicus 140-179 9148952-1 1997 Stimulation of Rat-1 cells with lysophosphatidic acid (LPA) or epidermal growth factor (EGF) results in a biphasic, sustained activation of extracellular signal-regulated kinase 1 (ERK1). lysophosphatidic acid 55-58 mitogen activated protein kinase 3 Rattus norvegicus 181-185 9083266-5 1997 At 10 to 20 microM, LPA stimulated thymidine incorporation as well as phosphorylation of mitogen-activated protein kinases (MAP-kinases) p42-p44 in dose- and time-dependent manner, which demonstrated a positive effect on cell proliferation. lysophosphatidic acid 20-23 mitogen activated protein kinase 3 Rattus norvegicus 141-144 9083266-6 1997 However, higher concentrations of LPA (100 microM) were unable to stimulate thymidine incorporation and partly inhibited the proliferative effect as well as p42-p44 phosphorylation evoked by serum. lysophosphatidic acid 34-37 mitogen activated protein kinase 3 Rattus norvegicus 161-164 9032468-2 1997 The activation of ERK1 by lysophosphatidic acid (LPA) and endothelin 1 (Et-1) was compared in Rat-1 cells. lysophosphatidic acid 26-47 mitogen activated protein kinase 3 Rattus norvegicus 18-22 9032468-2 1997 The activation of ERK1 by lysophosphatidic acid (LPA) and endothelin 1 (Et-1) was compared in Rat-1 cells. lysophosphatidic acid 49-52 mitogen activated protein kinase 3 Rattus norvegicus 18-22 8947492-10 1996 By contrast, lysophosphatidic acid, acting at an endogenously expressed G-protein-coupled receptor, also activated p44MAPK in both clones in a pertussis toxinsensitive manner, but both the kinetics and the concentration-response curve for activation of p44MAPK by this ligand were similar. lysophosphatidic acid 13-34 mitogen activated protein kinase 3 Rattus norvegicus 115-122 8947492-10 1996 By contrast, lysophosphatidic acid, acting at an endogenously expressed G-protein-coupled receptor, also activated p44MAPK in both clones in a pertussis toxinsensitive manner, but both the kinetics and the concentration-response curve for activation of p44MAPK by this ligand were similar. lysophosphatidic acid 13-34 mitogen activated protein kinase 3 Rattus norvegicus 253-260 8947493-0 1996 Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. lysophosphatidic acid 126-147 mitogen activated protein kinase 3 Rattus norvegicus 54-61 8947493-0 1996 Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. lysophosphatidic acid 126-147 mitogen activated protein kinase 3 Rattus norvegicus 70-109 8947493-1 1996 Rat-1 fibroblasts were used to study the role of the sustained activation of extracellular signal-regulated kinase 1 (ERK1) in lysophosphatidic acid (LPA)-stimulated mitogenic signalling. lysophosphatidic acid 127-148 mitogen activated protein kinase 3 Rattus norvegicus 77-116 8947493-1 1996 Rat-1 fibroblasts were used to study the role of the sustained activation of extracellular signal-regulated kinase 1 (ERK1) in lysophosphatidic acid (LPA)-stimulated mitogenic signalling. lysophosphatidic acid 127-148 mitogen activated protein kinase 3 Rattus norvegicus 118-122 8947493-1 1996 Rat-1 fibroblasts were used to study the role of the sustained activation of extracellular signal-regulated kinase 1 (ERK1) in lysophosphatidic acid (LPA)-stimulated mitogenic signalling. lysophosphatidic acid 150-153 mitogen activated protein kinase 3 Rattus norvegicus 77-116 8947493-1 1996 Rat-1 fibroblasts were used to study the role of the sustained activation of extracellular signal-regulated kinase 1 (ERK1) in lysophosphatidic acid (LPA)-stimulated mitogenic signalling. lysophosphatidic acid 150-153 mitogen activated protein kinase 3 Rattus norvegicus 118-122 8947493-6 1996 Sustained ERK1 activation stimulated by LPA was completely inhibited by pertussis toxin, whereas the early peak response was only partly affected; this is correlated with the specific inhibition of LPA-stimulated DNA synthesis by pertussis toxin. lysophosphatidic acid 40-43 mitogen activated protein kinase 3 Rattus norvegicus 10-14 8947493-6 1996 Sustained ERK1 activation stimulated by LPA was completely inhibited by pertussis toxin, whereas the early peak response was only partly affected; this is correlated with the specific inhibition of LPA-stimulated DNA synthesis by pertussis toxin. lysophosphatidic acid 198-201 mitogen activated protein kinase 3 Rattus norvegicus 10-14 8947493-7 1996 The selective tyrosine kinase inhibitor herbimycin A completely inhibited sustained ERK1 activation by LPA but, again, the early phase of the response was only partially inhibited. lysophosphatidic acid 103-106 mitogen activated protein kinase 3 Rattus norvegicus 84-88 8947493-8 1996 In addition, low doses of staurosporine inhibited ERK1 activation by LPA. lysophosphatidic acid 69-72 mitogen activated protein kinase 3 Rattus norvegicus 50-54 8947493-10 1996 The results suggest a strong correlation between sustained ERK1 activation and DNA synthesis in LPA-stimulated Rat-1 cells. lysophosphatidic acid 96-99 mitogen activated protein kinase 3 Rattus norvegicus 59-63 8947493-11 1996 Furthermore, the two discrete phases of ERK activation by LPA are regulated by a combination of at least two different signalling pathways; the sustained activation of ERK1 in Rat-1 cells proceeds via a G1- or Gzero-mediated pathway which may also involve a tyrosine kinase. lysophosphatidic acid 58-61 mitogen activated protein kinase 3 Rattus norvegicus 168-172 7478530-4 1995 In Rat6 cells, although both ERK1 and ERK2 are activated in response to mitogens that induce c-fos expression, such as Epidermal Growth Factor (EGF), lysophosphatidic acid (LPA) or serum, expression of v-Raf fails to induce c-fos expression and increase proliferation. lysophosphatidic acid 150-171 mitogen activated protein kinase 3 Rattus norvegicus 29-33 7478530-4 1995 In Rat6 cells, although both ERK1 and ERK2 are activated in response to mitogens that induce c-fos expression, such as Epidermal Growth Factor (EGF), lysophosphatidic acid (LPA) or serum, expression of v-Raf fails to induce c-fos expression and increase proliferation. lysophosphatidic acid 173-176 mitogen activated protein kinase 3 Rattus norvegicus 29-33 32116549-0 2020 Lysophosphatidic Acid Induces Apoptosis of PC12 Cells Through LPA1 Receptor/LPA2 Receptor/MAPK Signaling Pathway. lysophosphatidic acid 0-21 mitogen activated protein kinase 3 Rattus norvegicus 90-94 7626007-6 1995 Pretreatment of cells with PTX for 24 h inhibited the activation of MAPK by carbachol, FCS and lysophosphatidic acid, but not that by endothelin-1, phenylephrine or isoprenaline. lysophosphatidic acid 95-116 mitogen activated protein kinase 3 Rattus norvegicus 68-72 28447863-4 2018 We provide a novel mechanism to achieve this end in functioning, intact rat brain capillaries, whereby the bioactive phospholipid lysophosphatidic acid (LPA) and tricyclic antidepressant (TCA) amitriptyline reduce basal P-glycoprotein transport activity through a distinct lysophosphatidic acid 1 receptor-mediated signaling cascade that requires G-protein coupling, Src kinase, and ERK 1/2. lysophosphatidic acid 130-151 mitogen activated protein kinase 3 Rattus norvegicus 383-390 28447863-4 2018 We provide a novel mechanism to achieve this end in functioning, intact rat brain capillaries, whereby the bioactive phospholipid lysophosphatidic acid (LPA) and tricyclic antidepressant (TCA) amitriptyline reduce basal P-glycoprotein transport activity through a distinct lysophosphatidic acid 1 receptor-mediated signaling cascade that requires G-protein coupling, Src kinase, and ERK 1/2. lysophosphatidic acid 153-156 mitogen activated protein kinase 3 Rattus norvegicus 383-390 30898547-7 2019 Moreover, silencing LPAR1 not only abolished the migration of OECs but also prevented ERK1/2 phosphorylation and beta-catenin activation, suggesting that LPAR1 ligation serves to activate the ERK1/2 and beta-catenin pathways in LPA-induced OEC chemotactic migration. lysophosphatidic acid 20-23 mitogen activated protein kinase 3 Rattus norvegicus 86-92 30898547-7 2019 Moreover, silencing LPAR1 not only abolished the migration of OECs but also prevented ERK1/2 phosphorylation and beta-catenin activation, suggesting that LPAR1 ligation serves to activate the ERK1/2 and beta-catenin pathways in LPA-induced OEC chemotactic migration. lysophosphatidic acid 20-23 mitogen activated protein kinase 3 Rattus norvegicus 192-198 27605627-3 2016 Thus, in C6 glioma cells and rat cortical astrocytes, ERK1/2 activation induced by either amitriptyline or mianserin was antagonized by Ki16425 and VPC 12249 (S), which block LPA1 and LPA3 receptors, and by AM966, which selectively blocks LPA1 Cell depletion of LPA1 with siRNA treatment markedly reduced antidepressant- and LPA-induced ERK1/2 phosphorylation. lysophosphatidic acid 175-178 mitogen activated protein kinase 3 Rattus norvegicus 54-60