PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27637780-8 2016 Moreover, SNx mice showed significant downregulation in the renal expression of lipid phosphate phosphohydrolases (LPP1, 2, and 3) that might be involved in reduced LPA bioavailability through dephosphorylation. lysophosphatidic acid 165-168 phospholipid phosphatase 1 Mus musculus 115-129 28273928-5 2017 Similarly, knockout mice lacking the LPA-degrading enzyme phospholipid phosphate phosphatase type 1 (PLPP1) had a 2-fold increase in endogenous LPA levels, reduced PEPCK levels during fasting, and decreased hepatic gluconeogenesis in response to a pyruvate challenge. lysophosphatidic acid 37-40 phospholipid phosphatase 1 Mus musculus 101-106 28273928-5 2017 Similarly, knockout mice lacking the LPA-degrading enzyme phospholipid phosphate phosphatase type 1 (PLPP1) had a 2-fold increase in endogenous LPA levels, reduced PEPCK levels during fasting, and decreased hepatic gluconeogenesis in response to a pyruvate challenge. lysophosphatidic acid 144-147 phospholipid phosphatase 1 Mus musculus 101-106 19215222-0 2009 Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. lysophosphatidic acid 70-91 phospholipid phosphatase 1 Mus musculus 0-39 25769037-5 2015 Homozygous deletion of LPP1 (LPP1 KO) results in elevated levels and decreased turnover of LPA in vivo. lysophosphatidic acid 91-94 phospholipid phosphatase 1 Mus musculus 23-27 25769037-5 2015 Homozygous deletion of LPP1 (LPP1 KO) results in elevated levels and decreased turnover of LPA in vivo. lysophosphatidic acid 91-94 phospholipid phosphatase 1 Mus musculus 29-33 25769037-10 2015 Together, these observations demonstrate that the elevated levels of LPA per se in LPP1 KO mice do not inhibit tumor growth. lysophosphatidic acid 69-72 phospholipid phosphatase 1 Mus musculus 83-87 19215222-0 2009 Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. lysophosphatidic acid 70-91 phospholipid phosphatase 1 Mus musculus 41-45 19215222-8 2009 Compared with wild-type littermates, Ppap2a(tr/tr) animals have increased levels of plasma LPA, and LPA injected intravenously is metabolized at a 4-fold lower rate. lysophosphatidic acid 91-94 phospholipid phosphatase 1 Mus musculus 37-43 19215222-8 2009 Compared with wild-type littermates, Ppap2a(tr/tr) animals have increased levels of plasma LPA, and LPA injected intravenously is metabolized at a 4-fold lower rate. lysophosphatidic acid 100-103 phospholipid phosphatase 1 Mus musculus 37-43 19215222-9 2009 Our results demonstrate that LPA is rapidly metabolized in the bloodstream and that LPP1 is an important determinant of this turnover. lysophosphatidic acid 29-32 phospholipid phosphatase 1 Mus musculus 84-88 19215222-10 2009 These results indicate that LPP1 is a catabolic enzyme for LPA in vivo. lysophosphatidic acid 59-62 phospholipid phosphatase 1 Mus musculus 28-32 15461590-8 2005 Infection of cells with an adenoviral construct of the mouse LPP-1 (R217K) mutant partially attenuated LPA-induced IL-8 secretion without altering LPA-induced changes in intracellular Ca2+ concentration, phosphorylation of IkappaB, NF-kappaB activation or IL-8 gene expression. lysophosphatidic acid 103-106 phospholipid phosphatase 1 Mus musculus 61-66 14687668-2 2004 The currently prevailing hypothesis based on in vitro studies proposes that LPP-1 should regulate phospholipid lipid growth factors and second messengers, including lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), diacylglycerol (DAG), and phosphatidic acid (PA). lysophosphatidic acid 165-186 phospholipid phosphatase 1 Mus musculus 76-81 14687668-2 2004 The currently prevailing hypothesis based on in vitro studies proposes that LPP-1 should regulate phospholipid lipid growth factors and second messengers, including lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), diacylglycerol (DAG), and phosphatidic acid (PA). lysophosphatidic acid 188-191 phospholipid phosphatase 1 Mus musculus 76-81