PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16197369-7 2006 The LPA-induced secretion of IL-8 was blocked by the p38 MAPK inhibitor SB203580, by p38 MAPK siRNA (small interfering RNA), and by the JNK inhibitor JNK(i) II, but not by the MEK (MAPK/ERK kinase) inhibitor, PD98059. lysophosphatidic acid 4-7 mitogen-activated protein kinase kinase 7 Homo sapiens 176-179 16210650-0 2005 IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cells. lysophosphatidic acid 43-64 mitogen-activated protein kinase kinase 7 Homo sapiens 15-18 9611122-10 1998 LPA stimulated a strong increase in the specific phosphorylation of the mitogen-activated protein kinase (immunoblot analysis) that was prevented by the MEK inhibitor PD-98059. lysophosphatidic acid 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 153-156 10688043-8 2000 Inhibition of EGF- and LPA- induced ERK activation with the EGF receptor inhibitor, AG1478, or the MEK inhibitor, PD98059, attenuated their proliferative effects. lysophosphatidic acid 23-26 mitogen-activated protein kinase kinase 7 Homo sapiens 99-102 15581951-7 2004 The MEK/ERK1/2 kinase cascade is required for FasL upregulation, since the MEK inhibitor PD98059 significantly inhibited FasL upregulation induced by LPA (P < 0.01). lysophosphatidic acid 150-153 mitogen-activated protein kinase kinase 7 Homo sapiens 4-7 15581951-7 2004 The MEK/ERK1/2 kinase cascade is required for FasL upregulation, since the MEK inhibitor PD98059 significantly inhibited FasL upregulation induced by LPA (P < 0.01). lysophosphatidic acid 150-153 mitogen-activated protein kinase kinase 7 Homo sapiens 75-78 12588763-6 2003 Phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signaling-regulated kinases (ERK1/2) was rapidly and markedly induced by LPA. lysophosphatidic acid 156-159 mitogen-activated protein kinase kinase 7 Homo sapiens 19-58 12588763-6 2003 Phosphorylation of mitogen-activated protein kinase kinase (MEK) and extracellular signaling-regulated kinases (ERK1/2) was rapidly and markedly induced by LPA. lysophosphatidic acid 156-159 mitogen-activated protein kinase kinase 7 Homo sapiens 60-63 12181443-2 2002 We show for the first time, with the use of both pharmacological and genetic inhibitors, that the kinase activity and S473 phosphorylation of Akt induced by LPA and S1P requires both mitogen-activated protein (MAP) kinase kinase (MEK) and p38 MAP kinase, and MEK is likely to be upstream of p38, in HEY ovarian cancer cells. lysophosphatidic acid 157-160 mitogen-activated protein kinase kinase 7 Homo sapiens 230-233 12181443-2 2002 We show for the first time, with the use of both pharmacological and genetic inhibitors, that the kinase activity and S473 phosphorylation of Akt induced by LPA and S1P requires both mitogen-activated protein (MAP) kinase kinase (MEK) and p38 MAP kinase, and MEK is likely to be upstream of p38, in HEY ovarian cancer cells. lysophosphatidic acid 157-160 mitogen-activated protein kinase kinase 7 Homo sapiens 259-262 11402047-4 2001 Experiments using a series of inhibitors and overexpression of mutant forms of signaling molecules revealed that the Ras-Raf-MEK signal is essential for the LPA-induced shedding. lysophosphatidic acid 157-160 mitogen-activated protein kinase kinase 7 Homo sapiens 125-128 11402047-5 2001 In addition, the small GTPase Rac is involved in the LPA-induced shedding, possibly to promote MEK activation. lysophosphatidic acid 53-56 mitogen-activated protein kinase kinase 7 Homo sapiens 95-98 21832242-8 2011 However, inhibition of apical EGFR, but not basolateral EGFR, abrogated LPA-induced regulation of MEK and NHE3, indicating that LPA(5) selectively activates apical EGFR. lysophosphatidic acid 72-75 mitogen-activated protein kinase kinase 7 Homo sapiens 98-101 26171059-10 2015 ERK and its upstream activator MAPK kinase (MEK) are also involved in LPA-induced motility/migration of cancer cells. lysophosphatidic acid 70-73 mitogen-activated protein kinase kinase 7 Homo sapiens 44-47 28554198-5 2017 Although TAZ knockdown or knockout did not reduce LPA-induced phosphorylation of ERK and AKT, the MEK inhibitor U0126 or the ROCK inhibitor Y27632 blocked LPA-induced TAZ expression along with the reduction in the proliferation and migration of MSCs. lysophosphatidic acid 155-158 mitogen-activated protein kinase kinase 7 Homo sapiens 98-101 28348459-9 2017 These results suggest that activation of the MEK/ERK pathway and the transcription factor CREB mediate LPA-induced DR6 expression. lysophosphatidic acid 103-106 mitogen-activated protein kinase kinase 7 Homo sapiens 45-48 26171059-14 2015 PKG II also inhibited the activation of PI3K/Akt and MEK/ERK mediated signaling, which is important for LPA-induced Rac1 activation. lysophosphatidic acid 104-107 mitogen-activated protein kinase kinase 7 Homo sapiens 53-56 26171059-15 2015 These results suggest that PKG II affects LPA-stimulated migration of AGS cells by blocking Rac1 activation, via inhibition of PI3K/Akt and MEK/ERK mediated signaling. lysophosphatidic acid 42-45 mitogen-activated protein kinase kinase 7 Homo sapiens 140-143 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 103-106 23942151-7 2013 LPA induced phosphorylation of ERK and p38 MAP kinase in R182 cells and pretreatment of cells with the MEK-ERK pathway inhibitor U0126, but not the p38 MAPK inhibitor SB202190, resulted in abrogation of LPA-induced cell migration. lysophosphatidic acid 203-206 mitogen-activated protein kinase kinase 7 Homo sapiens 103-106 23942151-9 2013 These results suggest that MEK-ERK pathway plays a key role in LPA-induced cell migration and mRNA expression of TAZ in R182 cells, without affecting stability of TAZ protein. lysophosphatidic acid 63-66 mitogen-activated protein kinase kinase 7 Homo sapiens 27-30 22577133-6 2012 We provide the first evidence that MEK-mediated JNK activation leads to LPA-induced gene expression. lysophosphatidic acid 72-75 mitogen-activated protein kinase kinase 7 Homo sapiens 35-38 18592268-10 2009 In DLD1 cells, the scattering activity induced by LPA was partially blocked by pretreatment with PP2 and PD98059, inhibitors of src kinase and MEK, respectively. lysophosphatidic acid 50-53 mitogen-activated protein kinase kinase 7 Homo sapiens 143-146 21209852-5 2010 LPA also increased ERK activity and the MEK inhibitor U0126 could block LPA-induced ERK activity and cell migration. lysophosphatidic acid 72-75 mitogen-activated protein kinase kinase 7 Homo sapiens 40-43 18958425-6 2008 LPA-induced COX-2 expression was significantly attenuated by the MEK inhibitor, PD98059, but not by the JNK inhibitor, SP600125, or the p38 MAPK inhibitor, SB212090. lysophosphatidic acid 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 65-68 18309089-9 2008 Together, the data presented here indicate that LPA mediates the rapid decrease in EGFR binding via EGFR transactivation, MEK/ERK, and PKC, whereas the sustained decrease is regulated primarily by PKC. lysophosphatidic acid 48-51 mitogen-activated protein kinase kinase 7 Homo sapiens 122-125 18027882-5 2008 LPA induced activation of ERK through pertussis toxin-sensitive manner, and pretreatment of MSCs with U0126, a MEK inhibitor, or pertussis toxin attenuated the LPA-induced migration. lysophosphatidic acid 160-163 mitogen-activated protein kinase kinase 7 Homo sapiens 111-114