PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33347862-1 2021 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) exhibits a variety of biological responses. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 57-61 33704695-8 2021 These results indicate that LPA triggers LPA1 and/or LPA3 receptors at the BLM, inducing PKC-dependent phosphorylation with further inhibition of PMCA. lysophosphatidic acid 28-31 lysophosphatidic acid receptor 1 Homo sapiens 41-45 33367557-1 2021 Lysophosphatidic acid (LPA) and its G-protein-coupled receptors (Lpar1~Lpar6) mediate a plethora of activities associated with cancer growth and progression. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 65-70 33367557-6 2021 Furthermore, Lpar1 knockdown abolished the effect of LPA on ESCC cell proliferation and migration. lysophosphatidic acid 53-56 lysophosphatidic acid receptor 1 Homo sapiens 13-18 33689121-7 2021 Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 184-188 33689121-7 2021 Lysophosphatidic acid (LPA) is an active glycerophospholipid mainly synthesized by the secreted enzyme autotaxin (ATX), which activates six different G protein-coupled receptors named LPA1 to LPA6 (LPARs). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 184-188 33367557-1 2021 Lysophosphatidic acid (LPA) and its G-protein-coupled receptors (Lpar1~Lpar6) mediate a plethora of activities associated with cancer growth and progression. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 65-70 33347862-1 2021 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) exhibits a variety of biological responses. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 57-61 32672083-1 2021 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits several biological functions by binding to G-protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 149-163 32438456-0 2021 Microglial lysophosphatidic acid promotes glioblastoma proliferation and migration via lpa1 receptor. lysophosphatidic acid 11-32 lysophosphatidic acid receptor 1 Homo sapiens 87-91 32974731-0 2021 Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis. lysophosphatidic acid 29-50 lysophosphatidic acid receptor 1 Homo sapiens 63-95 32974731-2 2021 Lysophosphatidic acid (LPA) is an endogenous phospholipid involved in multiple immune cell functions and dysregulated in MS. Its receptor LPA1 is expressed in macrophages and regulates their activation, which is of interest due to the role of macrophage activation in MS in both destruction and repair. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 138-142 32974731-2 2021 Lysophosphatidic acid (LPA) is an endogenous phospholipid involved in multiple immune cell functions and dysregulated in MS. Its receptor LPA1 is expressed in macrophages and regulates their activation, which is of interest due to the role of macrophage activation in MS in both destruction and repair. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 138-142 32974731-8 2021 LPA induced a proinflammatory-like response in macrophages through LPA1, providing a plausible way in which LPA and LPA1 dysregulation can lead to the inflammation in MS. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 67-71 32974731-8 2021 LPA induced a proinflammatory-like response in macrophages through LPA1, providing a plausible way in which LPA and LPA1 dysregulation can lead to the inflammation in MS. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 116-120 32672083-1 2021 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits several biological functions by binding to G-protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 165-169 32672083-1 2021 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits several biological functions by binding to G-protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 149-163 32672083-1 2021 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits several biological functions by binding to G-protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 165-169 33553335-0 2021 CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis. lysophosphatidic acid 45-66 lysophosphatidic acid receptor 1 Homo sapiens 12-16 33553335-1 2021 Background: Lysophosphatidic acid (LPA) is known to promote cancer cell invasiveness through LPA1, but the downstream signaling cascades are still not fully clarified. lysophosphatidic acid 12-33 lysophosphatidic acid receptor 1 Homo sapiens 93-97 33553335-1 2021 Background: Lysophosphatidic acid (LPA) is known to promote cancer cell invasiveness through LPA1, but the downstream signaling cascades are still not fully clarified. lysophosphatidic acid 35-38 lysophosphatidic acid receptor 1 Homo sapiens 93-97 33553335-7 2021 LPA treatment led to stabilization of CMTM8 protein, which was impaired by knockdown of LPA1. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 88-92 32301060-1 2020 Lysophosphatidic acid (LPA) signaling through LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties in cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 61-65 32883524-1 2020 Lysophosphatidic acid (LPA) through six subtypes of G protein-coupled LPA receptors (LPA1 to LPA6) mediates a variety of cancer cell functions. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 85-89 32883524-1 2020 Lysophosphatidic acid (LPA) through six subtypes of G protein-coupled LPA receptors (LPA1 to LPA6) mediates a variety of cancer cell functions. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 85-89 32409422-1 2020 Lysophosphatidic acid (LPA) is the natural ligand for two phylogenetically distinct families of receptors (LPA1-3, LPA4-6) whose pathways control a variety of physiologic and pathophysiological responses. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 107-113 32409422-1 2020 Lysophosphatidic acid (LPA) is the natural ligand for two phylogenetically distinct families of receptors (LPA1-3, LPA4-6) whose pathways control a variety of physiologic and pathophysiological responses. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 107-113 32469525-1 2020 Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and acti-vates the family of lysophosphatidic acid receptors (LPA1-6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 157-163 32469525-1 2020 Lysophosphatidic acid (LPA) is a phospholipid that acts as an extracellular signaling molecule and acti-vates the family of lysophosphatidic acid receptors (LPA1-6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 157-163 32301060-1 2020 Lysophosphatidic acid (LPA) signaling through LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties in cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 61-65 32065590-7 2020 Further, the stimulatory effect of G-3-P and LPA on FGF23 required LPA receptor 1 (LPAR1). lysophosphatidic acid 45-48 lysophosphatidic acid receptor 1 Homo sapiens 67-81 32006610-1 2020 Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 123-137 31790581-0 2020 A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration. lysophosphatidic acid 30-51 lysophosphatidic acid receptor 1 Homo sapiens 62-66 31790581-3 2020 Activation of the type 1 lysophosphatidic acid (LPA1) receptor is a crucial factor in the initiation of NP. lysophosphatidic acid 25-46 lysophosphatidic acid receptor 1 Homo sapiens 48-52 32006610-1 2020 Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 139-143 32006610-1 2020 Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 108-111 lysophosphatidic acid receptor 1 Homo sapiens 123-137 32006610-1 2020 Lysophosphatidic acid (LPA) mediates a variety of biological functions via the binding of G protein-coupled LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 108-111 lysophosphatidic acid receptor 1 Homo sapiens 139-143 32007501-4 2020 In both cell types amitriptyline, clomipramine and mianserin mimicked the ability of LPA to induce the phosphorylation/activation of extracellular signal -regulated kinases 1 and 2 (ERK1/2), which was blocked by the selective LPA1 receptor antagonist AM966 and the LPA1/3 antagonist Ki16425. lysophosphatidic acid 85-88 lysophosphatidic acid receptor 1 Homo sapiens 226-230 32007501-4 2020 In both cell types amitriptyline, clomipramine and mianserin mimicked the ability of LPA to induce the phosphorylation/activation of extracellular signal -regulated kinases 1 and 2 (ERK1/2), which was blocked by the selective LPA1 receptor antagonist AM966 and the LPA1/3 antagonist Ki16425. lysophosphatidic acid 85-88 lysophosphatidic acid receptor 1 Homo sapiens 265-271 31906413-3 2020 Lysophosphatidic acid (LPA) is a phospholipid derivative, which acts as a signaling molecule to activate three high affinity G-protein coupled receptors, LPA1, LPA2, and LPA3. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 154-158 31904382-1 2020 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties of cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 57-61 31904382-1 2020 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) regulates a variety of malignant properties of cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 57-61 31866407-1 2020 Lysophosphatidic acid (LPA), as a bioactive lipid, plays a variety of physiological and pathological roles via activating six types of G-protein-coupled LPA receptors (LPA1-6). lysophosphatidic acid 153-156 lysophosphatidic acid receptor 1 Homo sapiens 168-172 31866407-5 2020 LPA1 and LPA3 are preferentially expressed in A549 cells, and both Ki16425 (LPA1 and LPA3 antagonist) and ono7300243 (LPA1 antagonist) completely blocked the LPA-induced actions. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 76-80 31866407-5 2020 LPA1 and LPA3 are preferentially expressed in A549 cells, and both Ki16425 (LPA1 and LPA3 antagonist) and ono7300243 (LPA1 antagonist) completely blocked the LPA-induced actions. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 76-80 31811875-1 2020 The LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1-6) through which lysophosphatidic acid acts, is likely involved in promoting normal emotional behaviours. lysophosphatidic acid 99-120 lysophosphatidic acid receptor 1 Homo sapiens 77-83 31866407-1 2020 Lysophosphatidic acid (LPA), as a bioactive lipid, plays a variety of physiological and pathological roles via activating six types of G-protein-coupled LPA receptors (LPA1-6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 168-172 31866407-1 2020 Lysophosphatidic acid (LPA), as a bioactive lipid, plays a variety of physiological and pathological roles via activating six types of G-protein-coupled LPA receptors (LPA1-6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 168-172 31906413-3 2020 Lysophosphatidic acid (LPA) is a phospholipid derivative, which acts as a signaling molecule to activate three high affinity G-protein coupled receptors, LPA1, LPA2, and LPA3. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 154-158 30849522-7 2019 We found that LPA1 induces PKCalpha translocation to the nucleus, but not to the cell membrane after LPA treatment and the cell number diminished when LPA1/PKCalpha signaling was blocked, suggesting a relevant role of LPA1 and PKCalpha in GBM growth. lysophosphatidic acid 14-17 lysophosphatidic acid receptor 1 Homo sapiens 151-155 31852400-3 2020 Emerging mechanistic findings are the feed-forward amplification of LPA production through LPA1, LPA3 and microglia and the evidence for maintenance of chronic pain by LPA receptor signaling. lysophosphatidic acid 68-71 lysophosphatidic acid receptor 1 Homo sapiens 91-95 31557675-12 2019 CONCLUSIONS: Our results strongly indicated that the LPA-LPA1, 3 receptor-HNF1alpha pathway is involved in the downregulation of Fut8, leading to diminished foam cell migration. lysophosphatidic acid 53-56 lysophosphatidic acid receptor 1 Homo sapiens 57-61 31362892-1 2019 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) contributes to the promotion of malignant potency in cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 57-61 31362892-1 2019 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) contributes to the promotion of malignant potency in cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 57-61 31204173-3 2019 Here, we demonstrate that through the LPA receptor 1 (LPAR1), serum lysophosphatidic acid (LPA) inhibits Rab11a-Rabin8 interaction and ciliogenesis. lysophosphatidic acid 38-41 lysophosphatidic acid receptor 1 Homo sapiens 54-59 31191247-6 2019 Further evidence indicating a role of LPA in the modulation of neuronal transmission has been inferred from animal models with deficits on LPA receptors, mainly LPA1 which is the most prevalent receptor in human and mouse brain tissue. lysophosphatidic acid 38-41 lysophosphatidic acid receptor 1 Homo sapiens 161-165 30447238-6 2019 Here, we show that lysophosphatidic acid induces FLG expression in human keratinocytes via the LPAR1 and LPAR5 receptors and the downstream RHO-ROCK-SRF pathway. lysophosphatidic acid 19-40 lysophosphatidic acid receptor 1 Homo sapiens 95-100 31781264-0 2019 Berberine Modulates LPA Function to Inhibit the Proliferation and Inflammation of FLS-RA via p38/ERK MAPK Pathway Mediated by LPA1. lysophosphatidic acid 20-23 lysophosphatidic acid receptor 1 Homo sapiens 126-130 31781264-8 2019 In addition, berberine inhibited the LPA-induced p-38/ERK-phosphorylation through binding to LPA1. lysophosphatidic acid 37-40 lysophosphatidic acid receptor 1 Homo sapiens 93-97 31781264-10 2019 Berberine potentially modulates LPA function to suppress the proliferation and inflammation of FLS-RA through blocking the p38/ERK MAPK pathway mediated by LPA1. lysophosphatidic acid 32-35 lysophosphatidic acid receptor 1 Homo sapiens 156-160 31633020-7 2019 Pharmacological blockade of LPA1 prevented PHH in LPA-injected animals, supporting the medical tractability of LPA receptor antagonists in preventing PHH and negative CNS sequelae in premature infants. lysophosphatidic acid 50-53 lysophosphatidic acid receptor 1 Homo sapiens 28-32 30998970-0 2019 Lysophosphatidic acid induces integrin beta6 expression in human oral squamous cell carcinomas cells via LPAR1 coupling to Galphai and downstream SMAD3 and ETS-1 activation. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 105-110 30998970-8 2019 Finally, we demonstrate that LPA-induced ITGB6 expression is mediated via the LPA receptors 1 (LPAR1) coupling to Galphai. lysophosphatidic acid 29-32 lysophosphatidic acid receptor 1 Homo sapiens 78-93 30998970-8 2019 Finally, we demonstrate that LPA-induced ITGB6 expression is mediated via the LPA receptors 1 (LPAR1) coupling to Galphai. lysophosphatidic acid 29-32 lysophosphatidic acid receptor 1 Homo sapiens 95-100 31204173-3 2019 Here, we demonstrate that through the LPA receptor 1 (LPAR1), serum lysophosphatidic acid (LPA) inhibits Rab11a-Rabin8 interaction and ciliogenesis. lysophosphatidic acid 68-89 lysophosphatidic acid receptor 1 Homo sapiens 38-52 31204173-3 2019 Here, we demonstrate that through the LPA receptor 1 (LPAR1), serum lysophosphatidic acid (LPA) inhibits Rab11a-Rabin8 interaction and ciliogenesis. lysophosphatidic acid 68-89 lysophosphatidic acid receptor 1 Homo sapiens 54-59 30849522-7 2019 We found that LPA1 induces PKCalpha translocation to the nucleus, but not to the cell membrane after LPA treatment and the cell number diminished when LPA1/PKCalpha signaling was blocked, suggesting a relevant role of LPA1 and PKCalpha in GBM growth. lysophosphatidic acid 14-17 lysophosphatidic acid receptor 1 Homo sapiens 151-155 30153326-0 2018 Lysophosphatidic acid acts on LPA1 receptor to increase H2 O2 during flow-induced dilation in human adipose arterioles. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 30-34 30463988-6 2019 Assessment of 12 different lipids demonstrated that the known LP ligand, 1-oleoyl-LPA, as well as an endocannabinoid metabolite, anandamide phosphate, are specific ligands for LPA1, whereas other LPs tested were not. lysophosphatidic acid 73-85 lysophosphatidic acid receptor 1 Homo sapiens 176-180 30591146-1 2018 Extracellular lysophosphatidic acid (LPA) and the G-protein-coupled LPA receptors (LPAR) are involved in cell migration and invasion and found in the human endometrium. lysophosphatidic acid 14-35 lysophosphatidic acid receptor 1 Homo sapiens 83-87 30591146-6 2018 The LPAR inhibitor Ki16425 (LPAR1/3) attenuated significantly LPA-induced invasiveness of 12Z, which was confirmed by LPAR1 and LPAR3 siRNAs, showing that both LPA receptors contribute to invasiveness of 12Z cells. lysophosphatidic acid 4-7 lysophosphatidic acid receptor 1 Homo sapiens 28-35 30591146-6 2018 The LPAR inhibitor Ki16425 (LPAR1/3) attenuated significantly LPA-induced invasiveness of 12Z, which was confirmed by LPAR1 and LPAR3 siRNAs, showing that both LPA receptors contribute to invasiveness of 12Z cells. lysophosphatidic acid 4-7 lysophosphatidic acid receptor 1 Homo sapiens 28-33 30591146-8 2018 Stimulation with LPA showed a time- and dose-dependent increased secretion of cathepsin B which was inhibited by the Gq inhibitor YM-254890 and Gi/o inhibitor pertussis toxin in the 12Z cells, again highlighting the importance of LPAR1/3. lysophosphatidic acid 17-20 lysophosphatidic acid receptor 1 Homo sapiens 230-235 30591146-11 2018 Our results reveal a novel role of LPA-mediated secretion of cathepsin B which stimulated invasion of endometriotic epithelial cells mainly via LPAR1 and LPAR3. lysophosphatidic acid 35-38 lysophosphatidic acid receptor 1 Homo sapiens 144-149 30064908-11 2018 These results revealed that LPC was converted into LPA by ATX to induce the proliferation and migration in HASMCs through LPA1/Gi/o/MAP Kinase signaling pathway. lysophosphatidic acid 51-54 lysophosphatidic acid receptor 1 Homo sapiens 122-131 30092374-7 2018 50 muM LPA increased the mRNA expressions of COX-2 and iNOS enzymes which were attenuated by the treatment of LPAR1/3 antagonist Ki16425. lysophosphatidic acid 7-10 lysophosphatidic acid receptor 1 Homo sapiens 110-115 30092374-10 2018 LPA also increased the total nitrite level in tissue homogenates in LPAR1/3- and iNOS-dependent manner. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 68-73 29407582-8 2018 ATRA plus LPA enhanced the motility of leukemia cells as well as breast cancer cells in an EDG2-dependent manner. lysophosphatidic acid 10-13 lysophosphatidic acid receptor 1 Homo sapiens 91-95 29182028-5 2018 However, positive correlation between CYP19A1 and LPAR1 accounts for supporting role of LPA acting via LPAR1 in intratumoral DHT concentration and the ethiology of endometrial cancer progression. lysophosphatidic acid 50-53 lysophosphatidic acid receptor 1 Homo sapiens 103-108 30396320-1 2018 Lysophosphatidic acid (LPA) is a simple biological lipid and mediates several biological functions with LPA receptors (LPA1 to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 119-123 30396320-1 2018 Lysophosphatidic acid (LPA) is a simple biological lipid and mediates several biological functions with LPA receptors (LPA1 to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 119-123 29329782-0 2018 LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 86-90 29329782-8 2018 Importantly, LPA-induced migration of OVCAR-3 cells was completely abolished not only by gene silencing of LPA1 or LPA2, but also by overexpression of a dominant negative ezrin mutant (ezrin-T567A). lysophosphatidic acid 13-16 lysophosphatidic acid receptor 1 Homo sapiens 107-111 29570618-1 2018 Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). lysophosphatidic acid 30-51 lysophosphatidic acid receptor 1 Homo sapiens 190-196 29570618-1 2018 Although simple in structure, lysophosphatidic acid (LPA) is a potent bioactive lipid that profoundly influences cellular signaling and function upon binding to G protein-coupled receptors (LPA1-6). lysophosphatidic acid 53-56 lysophosphatidic acid receptor 1 Homo sapiens 190-196 30317243-3 2018 Our previous study demonstrated that lysophosphatidic acid (LPA) enhances vascular endothelial growth factor-C (VEGF-C) expression, a lymphangiogenic factor, through activating it receptors LPA1/3 in prostate cancer (PCa) cells. lysophosphatidic acid 37-58 lysophosphatidic acid receptor 1 Homo sapiens 190-196 29369010-1 2018 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits a variety of cellular responses via the activation of G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 174-188 29369010-1 2018 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits a variety of cellular responses via the activation of G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 190-194 29369010-1 2018 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits a variety of cellular responses via the activation of G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 174-188 29369010-1 2018 Lysophosphatidic acid (LPA) is a simple physiological lipid and exhibits a variety of cellular responses via the activation of G protein-coupled transmembrane LPA receptors (LPA receptor-1 (LPA1) to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 190-194 29309788-1 2018 Lysophosphatidic acid (LPA) signaling through six subtypes of LPA receptors (LPA1 to LPA6) regulates a variety of biological responses in cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 77-81 29309788-1 2018 Lysophosphatidic acid (LPA) signaling through six subtypes of LPA receptors (LPA1 to LPA6) regulates a variety of biological responses in cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 77-81 29466791-0 2018 Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 72-77 29466791-3 2018 This study aimed to further unveil how LPA regulates LF hypertrophy Methods: We studied LPAR1 expression in human LF cells using PCR and western blotting. lysophosphatidic acid 39-42 lysophosphatidic acid receptor 1 Homo sapiens 88-93 29466791-7 2018 Moreover, LPA promoted LF cell proliferation by interacting with LPAR1. lysophosphatidic acid 10-13 lysophosphatidic acid receptor 1 Homo sapiens 65-70 29466791-9 2018 LPA also inhibits apoptosis in LF cells through the receptor LPAR1. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 61-66 29466791-11 2018 Our in vitro findings were supported by our in vivo evidence that lyophilized LPA significantly induced LF hypertrophy via the LPAR1-Akt signaling pathway. lysophosphatidic acid 78-81 lysophosphatidic acid receptor 1 Homo sapiens 127-132 29466791-13 2018 Taken together, these data indicate that LPA binds to the receptor LPAR1 to induce LF cell proliferation and inhibit apoptosis by activating AKT signaling cascades. lysophosphatidic acid 41-44 lysophosphatidic acid receptor 1 Homo sapiens 67-72 30317243-3 2018 Our previous study demonstrated that lysophosphatidic acid (LPA) enhances vascular endothelial growth factor-C (VEGF-C) expression, a lymphangiogenic factor, through activating it receptors LPA1/3 in prostate cancer (PCa) cells. lysophosphatidic acid 60-63 lysophosphatidic acid receptor 1 Homo sapiens 190-196 29051083-0 2018 Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA1 signaling. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 84-88 29051083-10 2018 LPA mediated effects were largely blocked by the addition of the LPA1 receptor antagonist AM095. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 65-69 28708504-2 2017 LPA exerts its action through six G-protein-coupled receptors (LPA1-LPA6). lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 63-67 29258556-1 2017 BACKGROUND: Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1-6) and are indispensible for brain development and function of the nervous system. lysophosphatidic acid 26-47 lysophosphatidic acid receptor 1 Homo sapiens 126-133 29258556-1 2017 BACKGROUND: Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1-6) and are indispensible for brain development and function of the nervous system. lysophosphatidic acid 49-52 lysophosphatidic acid receptor 1 Homo sapiens 126-133 28716732-3 2017 We demonstrated that LPA activates peroxisome proliferator-activated receptor gamma (PPARgamma), a ligand-activated nuclear receptor, as well as its cognate receptor LPA1 on human iPSC-derived neurons to enhance proliferation and neurite outgrowth. lysophosphatidic acid 21-24 lysophosphatidic acid receptor 1 Homo sapiens 166-170 28943105-3 2017 Here we show that these cells expressed messenger RNA coding for LPA1-3 receptors with the following order of abundance: LPA1 > LPA2 > LPA3 and that LPA was able to increase intracellular calcium, extracellular signal-regulated kinases 1/2 phosphorylation, and cell contraction. lysophosphatidic acid 65-68 lysophosphatidic acid receptor 1 Homo sapiens 121-125 28766061-9 2017 LPA stimulated cell proliferation was associated with LPAR1 mediated Gi/o-proteins/ERK1/2 pathway. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 54-59 28766061-10 2017 On the other hand, LPA protected hUC-MSCs from LPS-induced apoptosis through suppressing caspase-3 activation by LPAR1 coupled with a G protein, but not Gi/o or Gq/11 in hUC-MSC. lysophosphatidic acid 19-22 lysophosphatidic acid receptor 1 Homo sapiens 113-118 28766061-11 2017 Collectively, this study demonstrated that LPA increased the proliferation and survival of hUC-MSCs without differentiation through LPAR1 mediated manner. lysophosphatidic acid 43-46 lysophosphatidic acid receptor 1 Homo sapiens 132-137 27864940-0 2017 Endogenous lysophosphatidic acid (LPA1 ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts. lysophosphatidic acid 11-32 lysophosphatidic acid receptor 1 Homo sapiens 34-38 28346103-1 2017 Lysophosphatidic acid (LPA) activates the G-protein-coupled receptor LPA1, which regulates various cellular processes, including cell proliferation and migration. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 69-73 28346103-1 2017 Lysophosphatidic acid (LPA) activates the G-protein-coupled receptor LPA1, which regulates various cellular processes, including cell proliferation and migration. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 69-73 28346103-4 2017 LPA caused dramatic changes in cellular impedance in LPA1-expressing recombinant cells, which were susceptible to G-protein and protein kinase inhibitors. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 53-57 28205098-1 2017 Lysophosphatidic acid (LPA) is a simple biophysical lipid which interacts with at least six subtypes of G protein-coupled LPA receptors (LPA1-LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 137-141 28205098-1 2017 Lysophosphatidic acid (LPA) is a simple biophysical lipid which interacts with at least six subtypes of G protein-coupled LPA receptors (LPA1-LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 137-141 28189636-0 2017 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 36-40 27864940-1 2017 BACKGROUND AND PURPOSE: Human lung fibroblasts (HLF) express high levels of the LPA1 receptor, a GPCR that responds to the endogenous lipid mediator, lysophosphatidic acid (LPA). lysophosphatidic acid 150-171 lysophosphatidic acid receptor 1 Homo sapiens 80-84 27864940-4 2017 This promiscuity of coupling raises the possibility that some of the LPA analogues may bias the LPA1 receptor towards one signalling pathway over another. lysophosphatidic acid 69-72 lysophosphatidic acid receptor 1 Homo sapiens 96-100 27864940-5 2017 EXPERIMENTAL APPROACH: Here, we have explored the signalling profiles of a range of LPA analogues in HLF that endogenously express the LPA1 receptor. lysophosphatidic acid 84-87 lysophosphatidic acid receptor 1 Homo sapiens 135-139 26701886-2 2016 Lysophosphatidic acid (LPA) signaling, via LPA receptors 1-6 (LPARs1-6), regulates diverse cell functions including motility, migration, and proliferation, yet the role of LPARs in hepatic tumor pathology is poorly understood. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 43-60 27993681-1 2017 Lysophosphatidic acid (LPA) is an extracellular biological lipid and interacts with six subtypes of G protein-coupled LPA receptors (LPA1 to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 133-137 27993681-1 2017 Lysophosphatidic acid (LPA) is an extracellular biological lipid and interacts with six subtypes of G protein-coupled LPA receptors (LPA1 to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 133-137 27474750-4 2016 The LPA receptor LPA1 is particularly important for LPA response in human prostate cancer cells. lysophosphatidic acid 4-7 lysophosphatidic acid receptor 1 Homo sapiens 17-21 26701886-2 2016 Lysophosphatidic acid (LPA) signaling, via LPA receptors 1-6 (LPARs1-6), regulates diverse cell functions including motility, migration, and proliferation, yet the role of LPARs in hepatic tumor pathology is poorly understood. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 62-70 26701886-2 2016 Lysophosphatidic acid (LPA) signaling, via LPA receptors 1-6 (LPARs1-6), regulates diverse cell functions including motility, migration, and proliferation, yet the role of LPARs in hepatic tumor pathology is poorly understood. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 43-60 26701886-2 2016 Lysophosphatidic acid (LPA) signaling, via LPA receptors 1-6 (LPARs1-6), regulates diverse cell functions including motility, migration, and proliferation, yet the role of LPARs in hepatic tumor pathology is poorly understood. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 62-70 26098771-10 2015 Collectively, our results elucidate a new molecular pathway driving LPA-induced metastasis, thus underscoring the therapeutic potential of targeting LPA1 in patients with basal breast carcinomas. lysophosphatidic acid 68-71 lysophosphatidic acid receptor 1 Homo sapiens 149-153 27500235-12 2015 Lysophosphatidic acid inhibited the attachment of human airway epithelial cells to the ECM and induced cell detachment from the ECM, which was mediated by LPA1 and Rho-kinase pathway. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 155-159 26473723-6 2015 Lysophosphatidic acid and phorbol myristate acetate were able to induce LPA1-3 phosphorylation, in time- and concentration-dependent fashions. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 72-76 26098771-2 2015 LPA activates a series of six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 59-65 26098771-7 2015 DNA microarray and real-time PCR analyses further demonstrated that LPA up-regulated the oncomiR miR-21 through an LPA1/Pi3K/ZEB1-dependent mechanism. lysophosphatidic acid 68-71 lysophosphatidic acid receptor 1 Homo sapiens 115-119 26268898-1 2015 Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 40-44 25849892-1 2015 Lysophosphatidic acid (LPA) is an extracellular biological lipid which interacts with G protein-coupled LPA receptors (LPA1 to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 119-123 25857358-1 2015 Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein-coupled receptors: LPA1 -LPA6 . lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 105-109 25857358-1 2015 Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein-coupled receptors: LPA1 -LPA6 . lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 105-109 25857358-11 2015 Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein-coupled receptors (GPCR), LPA1 to LPA6 . lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 112-116 25857358-11 2015 Lysophosphatidic acid (LPA) is a signaling molecule that binds to six known G protein-coupled receptors (GPCR), LPA1 to LPA6 . lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 112-116 25888927-8 2015 Antidepressants and LPA induced tyrosine phosphorylation of IGF-IR and insulin receptor-substrate-1 through LPA1 and Src. lysophosphatidic acid 20-23 lysophosphatidic acid receptor 1 Homo sapiens 108-112 25996636-6 2015 At excitatory synapses, LPA-induced depression depended on LPA1/Galphai/o-protein/phospholipase C/myosin light chain kinase cascade at the presynaptic site. lysophosphatidic acid 24-27 lysophosphatidic acid receptor 1 Homo sapiens 59-63 25996636-8 2015 At inhibitory synapses, postsynaptic LPA signaling led to dephosphorylation, and internalization of the GABAAgamma2 subunit through the LPA1/Galpha12/13-protein/RhoA/Rho kinase/calcineurin pathway. lysophosphatidic acid 37-40 lysophosphatidic acid receptor 1 Homo sapiens 136-140 25849892-1 2015 Lysophosphatidic acid (LPA) is an extracellular biological lipid which interacts with G protein-coupled LPA receptors (LPA1 to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 119-123 25593637-1 2015 Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 120-124 25376707-12 2015 In conclusion, ATX/LPA stimulates the migration of hMSCs through LPAR1/3-dependent E-cadherin reduction and cytoskeletal rearrangement via PKC/GSK3beta/beta-catenin and PKC/Rho GTPase pathways. lysophosphatidic acid 19-22 lysophosphatidic acid receptor 1 Homo sapiens 65-70 25593637-1 2015 Lysophosphatidic acid (LPA) is a signaling lipid that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 120-124 24845645-10 2014 These results demonstrate for the first time that cPA and LPA induce hyaluronic acid synthesis in human skin fibroblasts mainly through the activation of LPAR1-Gi/o followed by the PI3K, ERK, and CREB signaling pathway. lysophosphatidic acid 58-61 lysophosphatidic acid receptor 1 Homo sapiens 154-159 25424429-0 2014 Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. lysophosphatidic acid 110-131 lysophosphatidic acid receptor 1 Homo sapiens 190-194 25273676-1 2014 INTRODUCTION: Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein-coupled receptors (LPA1-6). lysophosphatidic acid 14-35 lysophosphatidic acid receptor 1 Homo sapiens 106-110 24845645-9 2014 Pharmacological inhibition and reporter gene assays revealed that the activation of the LPA receptor LPAR1, Gi/o protein, phosphatidylinositol-3 kinase (PI3K), extracellular-signal-regulated kinase (ERK), and cyclic adenosine monophosphate response element-binding protein (CREB) but not nuclear factor kappaB induced hyaluronic acid synthesis by the treatment with cPA and LPA in NB1RGB cells. lysophosphatidic acid 88-91 lysophosphatidic acid receptor 1 Homo sapiens 101-106 25313567-6 2014 The principal chemoattractant, unexpectedly active across all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA receptor LPAR1. lysophosphatidic acid 98-119 lysophosphatidic acid receptor 1 Homo sapiens 158-163 25313567-6 2014 The principal chemoattractant, unexpectedly active across all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA receptor LPAR1. lysophosphatidic acid 121-124 lysophosphatidic acid receptor 1 Homo sapiens 158-163 24460191-1 2014 Lysophosphatidic acid (LPA) is a bioactive lipid that interacts with G protein-coupled transmembrane LPA receptors (LPA1 to LPA6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 116-120 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 60-81 lysophosphatidic acid receptor 1 Homo sapiens 103-107 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 60-81 lysophosphatidic acid receptor 1 Homo sapiens 141-146 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 60-81 lysophosphatidic acid receptor 1 Homo sapiens 165-170 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 83-86 lysophosphatidic acid receptor 1 Homo sapiens 103-107 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 83-86 lysophosphatidic acid receptor 1 Homo sapiens 141-146 24602016-4 2014 There are six lysophospholipid receptors that interact with lysophosphatidic acid (LPA): protein names LPA1 - LPA6 and italicized gene names LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human). lysophosphatidic acid 83-86 lysophosphatidic acid receptor 1 Homo sapiens 165-170 24993134-4 2014 LPA-induced migration of PC-3M-luc-C6 cells was abrogated by pretreatment of PC-3M-luc-C6 cells with the LPA receptor 1/3 inhibitor Ki16425 or small interfering RNA (siRNA)-mediated silencing of endogenous LPA receptor 1, implicating a key role of the LPA-LPA receptor 1 signaling axis in migration of PC-3M-luc-C6 cells. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 105-119 24993134-4 2014 LPA-induced migration of PC-3M-luc-C6 cells was abrogated by pretreatment of PC-3M-luc-C6 cells with the LPA receptor 1/3 inhibitor Ki16425 or small interfering RNA (siRNA)-mediated silencing of endogenous LPA receptor 1, implicating a key role of the LPA-LPA receptor 1 signaling axis in migration of PC-3M-luc-C6 cells. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 206-220 24993134-4 2014 LPA-induced migration of PC-3M-luc-C6 cells was abrogated by pretreatment of PC-3M-luc-C6 cells with the LPA receptor 1/3 inhibitor Ki16425 or small interfering RNA (siRNA)-mediated silencing of endogenous LPA receptor 1, implicating a key role of the LPA-LPA receptor 1 signaling axis in migration of PC-3M-luc-C6 cells. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 206-220 24928086-3 2014 LPA is present in most tissues and can activate cells through six different LPA receptors (LPAR1-6). lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 91-96 24460191-1 2014 Lysophosphatidic acid (LPA) is a bioactive lipid that interacts with G protein-coupled transmembrane LPA receptors (LPA1 to LPA6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 116-120 24980231-9 2014 Sinus mucosa explant stimulated with LPA increasingly produced IL-4, IL-5, interferon gamma, and TNF-alpha, and in cultured epithelial cells stimulated with CRS-relevant cytokines, ATX, and LPA1-3 were differentially induced. lysophosphatidic acid 37-40 lysophosphatidic acid receptor 1 Homo sapiens 190-196 24828490-1 2014 Lysophosphatidic acid (LPA) is a natural bioactive lipid with growth factor-like functions due to activation of a series of six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 157-161 24828490-1 2014 Lysophosphatidic acid (LPA) is a natural bioactive lipid with growth factor-like functions due to activation of a series of six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 157-161 24355769-6 2014 It was also observed that protein kinase C alpha and beta II isozymes co-immunoprecipitate with LPA1 receptors and that such an association was further increased by cell treatments with phorbol esters or lysophosphatidic acid. lysophosphatidic acid 204-225 lysophosphatidic acid receptor 1 Homo sapiens 96-100 24962280-1 2014 Lysophosphatidic acid (LPA) and its receptors, LPA1-6, are integral parts of signaling pathways involved in cellular proliferation, migration and survival. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 47-53 24962280-1 2014 Lysophosphatidic acid (LPA) and its receptors, LPA1-6, are integral parts of signaling pathways involved in cellular proliferation, migration and survival. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 47-53 24753818-10 2014 Furthermore, although LPE and LPA utilized LPA1, LPA utilized more signaling cascades than LPE, resulting in stronger responses by LPA in proliferation and migration than LPE in MDA-MB-231 cells. lysophosphatidic acid 30-33 lysophosphatidic acid receptor 1 Homo sapiens 43-47 22659570-0 2012 LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 84-90 24744506-1 2014 Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1-6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 80-88 24744506-1 2014 Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1-6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 80-88 24122794-8 2013 Functional blockage of LPA receptor 1 (LPA1) using an LPA1 antagonist, Ki16425, or gene silencing of LPA1 in RCC cells attenuated LPA-mediated intracellular signaling and invasion responses in vitro. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 39-43 24122794-8 2013 Functional blockage of LPA receptor 1 (LPA1) using an LPA1 antagonist, Ki16425, or gene silencing of LPA1 in RCC cells attenuated LPA-mediated intracellular signaling and invasion responses in vitro. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 54-58 24122794-8 2013 Functional blockage of LPA receptor 1 (LPA1) using an LPA1 antagonist, Ki16425, or gene silencing of LPA1 in RCC cells attenuated LPA-mediated intracellular signaling and invasion responses in vitro. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 54-58 24061591-0 2013 Lysophosphatidic acid stimulates activation of focal adhesion kinase and paxillin and promotes cell motility, via LPA1-3, in human pancreatic cancer. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 114-120 24061591-13 2013 CONCLUSIONS: These results suggest LPA induces activation of FAK and paxillin via LPA1-3, which may contribute to the increased cell motility in human pancreatic cancer PANC-1 cells. lysophosphatidic acid 35-38 lysophosphatidic acid receptor 1 Homo sapiens 82-88 23773289-8 2013 CONCLUSION: These results suggest that 18:1 LPA is the predominant ligand responsible for LPA1 and LPA3 receptors-mediated amplification of LPA production through microglial activation. lysophosphatidic acid 44-47 lysophosphatidic acid receptor 1 Homo sapiens 90-94 22744859-2 2012 Increased lysophosphatidic acid (LPA) concentrations have been reported in the alveolar space of both idiopathic pulmonary fibrosis patients and a corresponding animal model, whereas the genetic deletion or pharmacological inhibition of LPA receptor 1 attenuated the development of the modeled disease, suggesting a direct involvement of LPA in disease pathogenesis. lysophosphatidic acid 10-31 lysophosphatidic acid receptor 1 Homo sapiens 237-251 22744859-2 2012 Increased lysophosphatidic acid (LPA) concentrations have been reported in the alveolar space of both idiopathic pulmonary fibrosis patients and a corresponding animal model, whereas the genetic deletion or pharmacological inhibition of LPA receptor 1 attenuated the development of the modeled disease, suggesting a direct involvement of LPA in disease pathogenesis. lysophosphatidic acid 33-36 lysophosphatidic acid receptor 1 Homo sapiens 237-251 22820196-1 2012 The lipidic metabolite, diacylglycerol pyrophosphate (DGPP), in its dioctanoyl form (DGPP 8:0), has been described as an antagonist for mammalian lysophosphatidic acid (LPA) receptors LPA1 and LPA3. lysophosphatidic acid 146-167 lysophosphatidic acid receptor 1 Homo sapiens 184-188 22659570-4 2012 Stimulation of MG-63 cells with LPA or synthetic LPA receptor agonists resulted in p42/44 MAPK phosphorylation via LPA(1)-LPA(3) receptors. lysophosphatidic acid 32-35 lysophosphatidic acid receptor 1 Homo sapiens 115-121 22782863-4 2012 We demonstrate that bioactive lipid lysophosphatidic acid (LPA) plays a principal role in the migration of human LR-MSCs through a signaling pathway involving LPA1-induced beta-catenin activation. lysophosphatidic acid 36-57 lysophosphatidic acid receptor 1 Homo sapiens 159-163 22782863-4 2012 We demonstrate that bioactive lipid lysophosphatidic acid (LPA) plays a principal role in the migration of human LR-MSCs through a signaling pathway involving LPA1-induced beta-catenin activation. lysophosphatidic acid 59-62 lysophosphatidic acid receptor 1 Homo sapiens 159-163 22021336-5 2012 Consistent with these in vivo results, we found that LPA signaling through LPA(1) induced apoptosis in normal human bronchial epithelial cells in culture. lysophosphatidic acid 53-56 lysophosphatidic acid receptor 1 Homo sapiens 75-80 22577133-12 2012 Our data reveal an intracellular regulatory mechanism: LPA induction of Egr-1 expression is via LPA cognate receptor (LPA receptor 1)-dependent and PKCdelta-mediated ERK and JNK activation. lysophosphatidic acid 55-58 lysophosphatidic acid receptor 1 Homo sapiens 118-132 22465753-1 2012 The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) are aberrantly expressed in many types of human cancer. lysophosphatidic acid 27-48 lysophosphatidic acid receptor 1 Homo sapiens 73-80 22465753-1 2012 The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) are aberrantly expressed in many types of human cancer. lysophosphatidic acid 50-53 lysophosphatidic acid receptor 1 Homo sapiens 73-80 21632882-3 2011 Knockdown experiments of major LPA receptor subtypes, i.e. LPA(1) and p2y5 (also termed LPA(6)), with their specific small interfering RNAs, showed that LPA(1) and LPA(6) mediate the LPA-induced disruptive and protective actions on barrier integrity, respectively. lysophosphatidic acid 31-34 lysophosphatidic acid receptor 1 Homo sapiens 59-65 22159598-6 2012 LPA-induced betaig-h3 expression was abrogated by pretreating hASCs with the LPA receptor(1/3) inhibitor Ki16425 or small interfering RNA-mediated silencing of endogenous LPA(1). lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 171-177 22159598-7 2012 LPA-induced betaig-h3 expression was blocked by treating the cells with the Rho kinase inhibitor Y27632, implying that LPA-induced betaig-h3 expression is mediated by the LPA(1)- Rho kinase pathway. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 171-177 22159598-7 2012 LPA-induced betaig-h3 expression was blocked by treating the cells with the Rho kinase inhibitor Y27632, implying that LPA-induced betaig-h3 expression is mediated by the LPA(1)- Rho kinase pathway. lysophosphatidic acid 119-122 lysophosphatidic acid receptor 1 Homo sapiens 171-177 22911748-7 2012 In PC-3 human prostate cancer cells, the enhancing effects of LPA were mediated through both LPA1 and LPA3. lysophosphatidic acid 62-65 lysophosphatidic acid receptor 1 Homo sapiens 93-97 21632882-3 2011 Knockdown experiments of major LPA receptor subtypes, i.e. LPA(1) and p2y5 (also termed LPA(6)), with their specific small interfering RNAs, showed that LPA(1) and LPA(6) mediate the LPA-induced disruptive and protective actions on barrier integrity, respectively. lysophosphatidic acid 31-34 lysophosphatidic acid receptor 1 Homo sapiens 153-159 21632882-9 2011 CONCLUSION: LPA induced disruption and protection of VE-cadherin integrity through LPA(1)-G(i) protein-Rac1-JNK/p38MAPK and LPA(6)-G(12/13) protein-Src-C3G-Rap1 pathways, respectively. lysophosphatidic acid 12-15 lysophosphatidic acid receptor 1 Homo sapiens 83-89 20304626-5 2010 LPA1 is one of a group of known cell surface receptors for lysophosphatidic acid (LPA), which has been shown to be inversely correlated with Nm23 expression. lysophosphatidic acid 59-80 lysophosphatidic acid receptor 1 Homo sapiens 0-4 21878565-3 2011 Lysophosphatidic acid (LPA) is a bioactive lipid capable of cortical influences via one or more of six cognate G protein-coupled receptors, LPA(1-6), several of which are enriched in fetal neural progenitor cells (NPCs). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 140-147 21878565-3 2011 Lysophosphatidic acid (LPA) is a bioactive lipid capable of cortical influences via one or more of six cognate G protein-coupled receptors, LPA(1-6), several of which are enriched in fetal neural progenitor cells (NPCs). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 140-147 21746769-2 2011 Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth subtype, LPA4. lysophosphatidic acid 12-15 lysophosphatidic acid receptor 1 Homo sapiens 164-168 21102517-0 2011 Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 84-88 21118970-4 2010 LPA-stimulated cell migration is required for metastatic colonization because knockdown of LPA receptor subtype 1 (LPAR(1)) abolishes this event. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 91-113 21118970-4 2010 LPA-stimulated cell migration is required for metastatic colonization because knockdown of LPA receptor subtype 1 (LPAR(1)) abolishes this event. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 115-122 20427710-6 2010 Moreover, rather than acting directly on mTORC1, the results suggest that exogenous PA must be metabolized to lysophosphatidic acid (LPA), which subsequently activates the LPA receptor endothelial differentiation gene (EDG-2). lysophosphatidic acid 110-131 lysophosphatidic acid receptor 1 Homo sapiens 219-224 20427710-6 2010 Moreover, rather than acting directly on mTORC1, the results suggest that exogenous PA must be metabolized to lysophosphatidic acid (LPA), which subsequently activates the LPA receptor endothelial differentiation gene (EDG-2). lysophosphatidic acid 133-136 lysophosphatidic acid receptor 1 Homo sapiens 219-224 21102517-6 2011 Further, reducing MMP-9 activity or expression significantly inhibits LPA-induced HCC cell invasion, demonstrating that MMP-9 is downstream of LPA1. lysophosphatidic acid 70-73 lysophosphatidic acid receptor 1 Homo sapiens 143-147 21102517-8 2011 We thus demonstrate a mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades, providing novel biomarkers and potential therapeutic targets for HCC. lysophosphatidic acid 59-62 lysophosphatidic acid receptor 1 Homo sapiens 83-87 21102517-8 2011 We thus demonstrate a mechanistic cascade of ATX-producing LPA with LPA activating LPA1 and inducing MMP-9 through coordinate activation of the PI3K and the p38 MPAK signaling cascades, providing novel biomarkers and potential therapeutic targets for HCC. lysophosphatidic acid 68-71 lysophosphatidic acid receptor 1 Homo sapiens 83-87 19906815-11 2010 Mechanistic dissection disclosed that LPA functioned mainly via the LPA1 receptor, Gi protein, various signal mediators of ERK, protein kinase C, p38, Akt, and c-Jun N-terminal kinase, and nuclear factor-kappaB pathways to secrete these chemokines. lysophosphatidic acid 38-41 lysophosphatidic acid receptor 1 Homo sapiens 68-72 20044439-0 2010 LPA induces IL-6 secretion from aortic smooth muscle cells via an LPA1-regulated, PKC-dependent, and p38alpha-mediated pathway. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 66-70 20044439-7 2010 Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. lysophosphatidic acid 29-32 lysophosphatidic acid receptor 1 Homo sapiens 54-60 20044439-7 2010 Our results demonstrate that LPA-specific receptor 1 (LPA(1)) mediates LPA-induced IL-6 secretion and that LPA induction of IL-6 is independent of the EGF receptor pathway. lysophosphatidic acid 54-57 lysophosphatidic acid receptor 1 Homo sapiens 29-52 20197381-3 2010 VEGF stimulated expression of ATX and LPA1, a receptor for the ATX enzymatic product lysophosphatidic acid (LPA), in human umbilical vein endothelial cells. lysophosphatidic acid 85-106 lysophosphatidic acid receptor 1 Homo sapiens 38-42 19524700-3 2009 It was originally thought that the cellular effects of LPA are mediated by three subtypes of G-protein-coupled receptors: LPA(1)/Edg2, LPA(2)/Edg4, and LPA(3)/Edg7. lysophosphatidic acid 55-58 lysophosphatidic acid receptor 1 Homo sapiens 122-128 19193014-1 2009 Lysophosphatidic acid (LPA), as an endogenous lipid mediator, has been revealed to regulate many important biological and pathophysiological processes via specific G-protein-coupled receptors termed LPA1-5. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 199-205 19193014-1 2009 Lysophosphatidic acid (LPA), as an endogenous lipid mediator, has been revealed to regulate many important biological and pathophysiological processes via specific G-protein-coupled receptors termed LPA1-5. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 199-205 20141599-3 2010 RESULTS: Topical acute LPA application dose-dependently increased permeability (log EC(50)-9.4; similar to the K(d) of the LPA1 receptor). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 123-127 19524700-3 2009 It was originally thought that the cellular effects of LPA are mediated by three subtypes of G-protein-coupled receptors: LPA(1)/Edg2, LPA(2)/Edg4, and LPA(3)/Edg7. lysophosphatidic acid 55-58 lysophosphatidic acid receptor 1 Homo sapiens 129-133 19656035-6 2009 RESULTS: LPA stimulated ERK1/2 phosphorylation via LPA(1)(-3). lysophosphatidic acid 9-12 lysophosphatidic acid receptor 1 Homo sapiens 51-57 19423373-11 2009 Based on these analyses, LPA is predicted to bind to LPA(4) in an orientation similar to that reported for LPA(1-3), but through a different network of hydrogen bonds. lysophosphatidic acid 25-28 lysophosphatidic acid receptor 1 Homo sapiens 107-114 19563736-2 2009 The LDL- and LPA-induced DNA synthesis was markedly inhibited by the LPA receptor antagonist Ki16425, pertussis toxin, small interfering RNAs targeted for LPA1 receptors, and a potent calcineurin inhibitor cyclosporine A. lysophosphatidic acid 13-16 lysophosphatidic acid receptor 1 Homo sapiens 155-159 19366702-1 2009 Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 44-51 19366702-1 2009 Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of the endothelial differentiation gene family G-protein-coupled receptors, and LPA(4-8) is related to the purinergic family G-protein-coupled receptor. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 44-51 19609003-1 2009 The lipid mediator lysophosphatidic acid (LPA) plays a role in cancer progression and signals via specific G protein-coupled receptors, LPA(1-3). lysophosphatidic acid 19-40 lysophosphatidic acid receptor 1 Homo sapiens 136-143 19609003-1 2009 The lipid mediator lysophosphatidic acid (LPA) plays a role in cancer progression and signals via specific G protein-coupled receptors, LPA(1-3). lysophosphatidic acid 42-45 lysophosphatidic acid receptor 1 Homo sapiens 136-143 18592268-15 2009 CONCLUSION: These results demonstrate that LPA1 mediates LPA-stimulated cell scattering of gastrointestinal carcinomas, but that activation of other intracellular pathways, besides those contributing to ERK phosphorylation, is also necessary for cell scattering in response to LPA. lysophosphatidic acid 57-60 lysophosphatidic acid receptor 1 Homo sapiens 43-47 19129242-0 2009 LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites. lysophosphatidic acid 134-155 lysophosphatidic acid receptor 1 Homo sapiens 0-4 18996473-5 2009 The most significant effects of LPA appear to be through activation of the G-protein-coupled receptors (GPCRs), termed LPA(1-6). lysophosphatidic acid 32-35 lysophosphatidic acid receptor 1 Homo sapiens 119-126 18627789-0 2008 Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 125-132 19001604-1 2008 BACKGROUND: Lysophosphatidic acid (LPA) acts through the cell surface G protein-coupled receptors, LPA1, LPA2, or LPA3, to elicit a wide range of cellular responses. lysophosphatidic acid 12-33 lysophosphatidic acid receptor 1 Homo sapiens 99-103 19001604-1 2008 BACKGROUND: Lysophosphatidic acid (LPA) acts through the cell surface G protein-coupled receptors, LPA1, LPA2, or LPA3, to elicit a wide range of cellular responses. lysophosphatidic acid 35-38 lysophosphatidic acid receptor 1 Homo sapiens 99-103 18754873-0 2008 Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 145-149 18754873-3 2008 Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPA(1) and LPA(2), in several cancer cell lines, the role of LPA and LPA receptors for malignant pleural mesothelioma (MPM) has been unknown. lysophosphatidic acid 9-12 lysophosphatidic acid receptor 1 Homo sapiens 81-87 18754873-9 2008 Moreover, LPA-induced proliferation was inhibited by Ki16425, an inhibitor of LPA(1), and small interfering RNA against LPA(1), but not LPA(2). lysophosphatidic acid 10-13 lysophosphatidic acid receptor 1 Homo sapiens 78-84 18754873-9 2008 Moreover, LPA-induced proliferation was inhibited by Ki16425, an inhibitor of LPA(1), and small interfering RNA against LPA(1), but not LPA(2). lysophosphatidic acid 10-13 lysophosphatidic acid receptor 1 Homo sapiens 120-126 17915188-0 2008 Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 72-76 18325907-4 2008 Through the stepwise association study, an SNP located in the promoter region of EDG2 [endothelial differentiation, lysophosphatidic acid (LPA) GPCR, 2] (-2,820G/A; rs10980705) showed significant association with knee OA in two independent populations (pooled P = 2.6 x 10(-5)). lysophosphatidic acid 116-137 lysophosphatidic acid receptor 1 Homo sapiens 81-85 18408217-9 2008 Reducing the expression of the LPA receptor LPA(1) also blocked LPA-induced HDAC activation. lysophosphatidic acid 31-34 lysophosphatidic acid receptor 1 Homo sapiens 44-49 17915188-8 2008 These findings suggest that extracellular LPA-induced IL-6 and IL-8 synthesis occurred through Edg-2 (LPA(1) receptor) and the activation of PLC and IP(3)-mediated intracellular calcium release in SaM-1 cells. lysophosphatidic acid 42-45 lysophosphatidic acid receptor 1 Homo sapiens 95-100 17923111-0 2007 Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 94-98 17923111-3 2007 Introduction of siRNA against LPA1 significantly suppressed LPA-induced ICAM-1 mRNA, total protein, and cell surface expressions, and subsequent U937 monocyte adhesion to LPA-treated human umbilical endothelial cells (HUVECs). lysophosphatidic acid 60-63 lysophosphatidic acid receptor 1 Homo sapiens 30-34 17923111-6 2007 These results suggest that the expression of LPA-induced inflammatory response genes is mediated by LPA1 and LPA3. lysophosphatidic acid 45-48 lysophosphatidic acid receptor 1 Homo sapiens 100-104 17531530-0 2007 Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 83-89 17531530-2 2007 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid 20-41 lysophosphatidic acid receptor 1 Homo sapiens 151-156 17531530-2 2007 We report here that lysophosphatidic acid (LPA), a potent bioactive phospholipid, induces prostate cancer PC3 cell migration via the activation of the LPA(1) receptor, which is linked to a PTX-sensitive activation mechanism of the mitogen-activated protein kinases (MAPK). lysophosphatidic acid 43-46 lysophosphatidic acid receptor 1 Homo sapiens 151-156 17531530-5 2007 Our study provides the first evidence for a functional role of p42 and p38alpha in LPA-induced mammalian cell migration, and also demonstrates, for the first time, that the receptor LPA(1) mediates prostate cancer cell migration. lysophosphatidic acid 83-86 lysophosphatidic acid receptor 1 Homo sapiens 182-187 16809448-2 2006 We profiled gene expression of LPA receptors in androgen-dependent and androgen-insensitive prostate cancer cells and found that LPA(1) gene is differentially expressed in androgen-insensitive and LPA-responsive but not androgen-dependent and LPA-resistant cells. lysophosphatidic acid 31-34 lysophosphatidic acid receptor 1 Homo sapiens 129-135 16809448-1 2006 The bioactive phospholipid lysophosphatidic acid (LPA) promotes cell proliferation, survival, and migration by acting on cognate G protein-coupled receptors named LPA(1), LPA(2), and LPA(3). lysophosphatidic acid 27-48 lysophosphatidic acid receptor 1 Homo sapiens 163-168 16809448-1 2006 The bioactive phospholipid lysophosphatidic acid (LPA) promotes cell proliferation, survival, and migration by acting on cognate G protein-coupled receptors named LPA(1), LPA(2), and LPA(3). lysophosphatidic acid 50-53 lysophosphatidic acid receptor 1 Homo sapiens 163-168 16809448-8 2006 In addition, treatment with bicalutamide inhibited LPA-induced cell cycle progression and proliferation of LNCaP-LPA(1) cells. lysophosphatidic acid 51-54 lysophosphatidic acid receptor 1 Homo sapiens 113-118 16890224-7 2006 Apoptosis induced by LPA might be mediated by LPA1. lysophosphatidic acid 21-24 lysophosphatidic acid receptor 1 Homo sapiens 46-50 16890224-1 2006 Lysophosphatidic acid (LPA) is a phospholipid messenger with diverse effects mediated via receptors LPA1, LPA2 and LPA3. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 100-104 16890224-1 2006 Lysophosphatidic acid (LPA) is a phospholipid messenger with diverse effects mediated via receptors LPA1, LPA2 and LPA3. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 100-104 16716145-2 2006 LPA1 also traffics from cell membranes to the nucleus in response to LPA (lysophosphatidic acid). lysophosphatidic acid 74-95 lysophosphatidic acid receptor 1 Homo sapiens 0-4 16716145-7 2006 The addition of LPA and/or Ki16425 (which binds to LPA1) to isolated nuclei containing LPA1 induced the phosphorylation of several proteins with molecular masses of 34, 32, 14 and 11 kDa. lysophosphatidic acid 16-19 lysophosphatidic acid receptor 1 Homo sapiens 51-55 16716145-7 2006 The addition of LPA and/or Ki16425 (which binds to LPA1) to isolated nuclei containing LPA1 induced the phosphorylation of several proteins with molecular masses of 34, 32, 14 and 11 kDa. lysophosphatidic acid 16-19 lysophosphatidic acid receptor 1 Homo sapiens 87-91 16307479-2 2005 Generally, lysophosphatidic acid triggers physiological responses through interaction with specific plasma membrane receptors called LPA 1-4. lysophosphatidic acid 11-32 lysophosphatidic acid receptor 1 Homo sapiens 133-140 16769891-4 2006 Moreover, functional blockade of LPA action on its cognate receptor LPA(1) using a pharmacological antagonist mimics the effects of silencing LPA(1) in tumor cells in vitro and substantially reduces bone metastasis progression in animals. lysophosphatidic acid 33-36 lysophosphatidic acid receptor 1 Homo sapiens 68-74 16769891-4 2006 Moreover, functional blockade of LPA action on its cognate receptor LPA(1) using a pharmacological antagonist mimics the effects of silencing LPA(1) in tumor cells in vitro and substantially reduces bone metastasis progression in animals. lysophosphatidic acid 33-36 lysophosphatidic acid receptor 1 Homo sapiens 142-148 16224106-1 2006 The phospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via transmembrane receptors S1P 1-5 and LPA 1-3, respectively. lysophosphatidic acid 52-73 lysophosphatidic acid receptor 1 Homo sapiens 124-129 16224106-1 2006 The phospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) act via transmembrane receptors S1P 1-5 and LPA 1-3, respectively. lysophosphatidic acid 75-78 lysophosphatidic acid receptor 1 Homo sapiens 124-129 16224106-10 2006 LPA treatment reduced the amount of LPA 1/CXCR1 heterodimer. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 36-41 16353194-1 2006 BACKGROUND AND OBJECTIVES: Lysophosphatidic acid (LPA), a natural phospholipid, can modulate diverse cellular responses through LPA receptor, LPA1-4. lysophosphatidic acid 27-48 lysophosphatidic acid receptor 1 Homo sapiens 142-148 16353194-1 2006 BACKGROUND AND OBJECTIVES: Lysophosphatidic acid (LPA), a natural phospholipid, can modulate diverse cellular responses through LPA receptor, LPA1-4. lysophosphatidic acid 50-53 lysophosphatidic acid receptor 1 Homo sapiens 142-148 15857137-5 2005 We first tested these LPA analogues on insect Sf9 cells induced to express human LPA(1), LPA(2), and LPA(3) receptors. lysophosphatidic acid 22-25 lysophosphatidic acid receptor 1 Homo sapiens 81-86 15728708-2 2005 LPA mediates its effects predominantly through the G protein-coupled receptors LPA1, LPA2, and LPA3. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 79-83 15755723-1 2005 Lysophosphatidic acid (LPA) is a serum-derived phospholipid that induces a variety of biological responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 189-193 15755723-1 2005 Lysophosphatidic acid (LPA) is a serum-derived phospholipid that induces a variety of biological responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 189-193 15755723-5 2005 In LPA1- and LPA2-transfected HEK293 cells, LPA-induced RhoA activation was observed although the C terminus of LPA1 and LPA2 mutants, which failed to interact with the PDZ domains, did not cause LPA-induced RhoA activation. lysophosphatidic acid 3-6 lysophosphatidic acid receptor 1 Homo sapiens 112-116 15755723-5 2005 In LPA1- and LPA2-transfected HEK293 cells, LPA-induced RhoA activation was observed although the C terminus of LPA1 and LPA2 mutants, which failed to interact with the PDZ domains, did not cause LPA-induced RhoA activation. lysophosphatidic acid 13-16 lysophosphatidic acid receptor 1 Homo sapiens 112-116 15857137-6 2005 While none of the analogues were found to be more potent than 1-oleoyl-LPA at LPA(1) and LPA(2), several LPA analogues were potent LPA(3)-selective agonists. lysophosphatidic acid 62-74 lysophosphatidic acid receptor 1 Homo sapiens 78-83 15857137-6 2005 While none of the analogues were found to be more potent than 1-oleoyl-LPA at LPA(1) and LPA(2), several LPA analogues were potent LPA(3)-selective agonists. lysophosphatidic acid 71-74 lysophosphatidic acid receptor 1 Homo sapiens 78-83 15461590-1 2005 LPA (lysophosphatidic acid), a potent bioactive phospholipid, elicits diverse cellular responses through activation of the G-protein-coupled receptors LPA1-LPA4. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 151-155 15837931-1 2005 Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled receptors (GPCRs) LPA(1), LPA(2), or LPA(3) may play a role in the development of several types of cancers, including colorectal cancer. lysophosphatidic acid 28-49 lysophosphatidic acid receptor 1 Homo sapiens 100-105 15837931-1 2005 Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled receptors (GPCRs) LPA(1), LPA(2), or LPA(3) may play a role in the development of several types of cancers, including colorectal cancer. lysophosphatidic acid 51-54 lysophosphatidic acid receptor 1 Homo sapiens 100-105 15618220-9 2005 Treatment of primary CLL cells with the LPA receptor antagonist, diacylglycerol pyrophosphate, reverses the protective effect of LPA against apoptosis, and down-regulation of the LPA1 by siRNA blocked LPA-mediated protection against spontaneous apoptosis in primary CLL cells. lysophosphatidic acid 40-43 lysophosphatidic acid receptor 1 Homo sapiens 179-183 15461590-1 2005 LPA (lysophosphatidic acid), a potent bioactive phospholipid, elicits diverse cellular responses through activation of the G-protein-coupled receptors LPA1-LPA4. lysophosphatidic acid 5-26 lysophosphatidic acid receptor 1 Homo sapiens 151-155 15280372-1 2004 Lysophosphatidic acid (LPA), a potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled receptors LPA1, LPA2, LPA3, and LPA4. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 139-143 15530853-1 2004 Lysophosphatidic acid (LPA), which interacts with at least three G protein-coupled receptors (GPCRs), LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7, is a lipid mediator with diverse effects on various cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 102-106 15530853-1 2004 Lysophosphatidic acid (LPA), which interacts with at least three G protein-coupled receptors (GPCRs), LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7, is a lipid mediator with diverse effects on various cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 107-112 15530853-1 2004 Lysophosphatidic acid (LPA), which interacts with at least three G protein-coupled receptors (GPCRs), LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7, is a lipid mediator with diverse effects on various cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 102-106 15530853-1 2004 Lysophosphatidic acid (LPA), which interacts with at least three G protein-coupled receptors (GPCRs), LPA1/Edg-2, LPA2/Edg-4, and LPA3/Edg-7, is a lipid mediator with diverse effects on various cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 107-112 15530853-4 2004 Using a Boyden chamber assay, LPA markedly increased cell migration of LPA1-expressing cells, the effects of which were almost totally abrogated by Ki16425, an LPA antagonist against LPA1 and LPA3. lysophosphatidic acid 30-33 lysophosphatidic acid receptor 1 Homo sapiens 71-75 15530853-4 2004 Using a Boyden chamber assay, LPA markedly increased cell migration of LPA1-expressing cells, the effects of which were almost totally abrogated by Ki16425, an LPA antagonist against LPA1 and LPA3. lysophosphatidic acid 30-33 lysophosphatidic acid receptor 1 Homo sapiens 183-187 15220934-1 2004 Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse effects on various cells, that interacts with three G protein-coupled transmembrane receptors, LPA1, LPA2, and LPA3. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 171-175 15220934-1 2004 Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse effects on various cells, that interacts with three G protein-coupled transmembrane receptors, LPA1, LPA2, and LPA3. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 171-175 15280372-1 2004 Lysophosphatidic acid (LPA), a potent bioactive lipid, elicits many of its biological actions via the specific G-protein-coupled receptors LPA1, LPA2, LPA3, and LPA4. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 139-143 15361348-4 2004 The bioactivity of LPA is mediated by the activation of specific G-protein coupled receptors (LPA1, LPA2, and LPA3) leading to the activation of a number of intracellular effectors. lysophosphatidic acid 19-22 lysophosphatidic acid receptor 1 Homo sapiens 94-98 15034064-6 2004 Cell responses elicited by LPA were inhibited by pertussis toxin indicating that in eosinophils the LPA receptor(s), presumably EDG-2 and/or EDG-7, are coupled to G(i/o) proteins. lysophosphatidic acid 27-30 lysophosphatidic acid receptor 1 Homo sapiens 128-133 14744855-0 2004 Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 107-111 14744855-5 2004 In the lpa(1)(-/-) cells, LPA-stimulated lamellipodia formation was markedly diminished with a concomitant decrease in Rac1 activation. lysophosphatidic acid 26-29 lysophosphatidic acid receptor 1 Homo sapiens 7-13 14744855-6 2004 LPA stimulated the motility of multiple human cancer cell lines expressing LPA(1), and the motility was attenuated by an LPA(1)-selective antagonist, Ki16425. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 75-81 14744855-6 2004 LPA stimulated the motility of multiple human cancer cell lines expressing LPA(1), and the motility was attenuated by an LPA(1)-selective antagonist, Ki16425. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 121-127 15034064-7 2004 Moreover, LPA-induced activation of eosinophils could be completely blocked by the EDG-2/EDG-7 antagonist diacylglycerol pyrophosphate. lysophosphatidic acid 10-13 lysophosphatidic acid receptor 1 Homo sapiens 83-88 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 141-145 14660630-0 2004 Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 110-114 14660630-0 2004 Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 110-114 14660630-5 2004 This response was inhibited or abolished by pertussis toxin, monoglyceride lipase, an enzyme hydrolyzing lysophosphatidic acid (LPA), and Ki16425 and VPC12249, antagonists for LPA receptors (LPA1 and LPA3), but not by an LPA3-selective antagonist. lysophosphatidic acid 128-131 lysophosphatidic acid receptor 1 Homo sapiens 191-195 14696401-1 2003 BACKGROUND/AIMS: The EDG-2 (endothelial cell differentiation gene-2) has been characterized as one of the high-affinity receptors of lysophosphatidic acid: an extracellular lipid mediator which can induce tumor progression. lysophosphatidic acid 133-154 lysophosphatidic acid receptor 1 Homo sapiens 21-26 14696401-1 2003 BACKGROUND/AIMS: The EDG-2 (endothelial cell differentiation gene-2) has been characterized as one of the high-affinity receptors of lysophosphatidic acid: an extracellular lipid mediator which can induce tumor progression. lysophosphatidic acid 133-154 lysophosphatidic acid receptor 1 Homo sapiens 28-67 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 141-145 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 181-186 14500756-1 2003 Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively), and LPA4/GPR23, structurally distinct from the EDG-family receptors, have so far been identified. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 181-186 14500756-5 2003 Ki16425 inhibited the LPA-induced response in the decreasing order of LPA1 >/= LPA3 >> LPA2, whereas DGPP 8:0 preferentially inhibited the LPA3-induced actions. lysophosphatidic acid 22-25 lysophosphatidic acid receptor 1 Homo sapiens 70-74 12730329-0 2003 Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 147-151 12885756-11 2003 CONCLUSIONS: LPA molecules present in the core region of atherosclerotic plaques trigger rapid platelet activation through the stimulation of LPA1 and LPA3 receptors. lysophosphatidic acid 13-16 lysophosphatidic acid receptor 1 Homo sapiens 142-146 12730329-7 2003 The findings indicate that LPA transiently stimulates MAPK ERK in LPA1/edg2-expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway. lysophosphatidic acid 27-30 lysophosphatidic acid receptor 1 Homo sapiens 66-70 12730329-7 2003 The findings indicate that LPA transiently stimulates MAPK ERK in LPA1/edg2-expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway. lysophosphatidic acid 27-30 lysophosphatidic acid receptor 1 Homo sapiens 71-75 12730329-0 2003 Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway? lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 152-156 12668728-0 2003 Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. lysophosphatidic acid 31-52 lysophosphatidic acid receptor 1 Homo sapiens 61-65 12668728-0 2003 Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway. lysophosphatidic acid 31-52 lysophosphatidic acid receptor 1 Homo sapiens 66-71 12668728-1 2003 Lysophosphatidic acid (LPA) is a serum-borne phospholipid that exerts a pleiotropic range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA1/EDG-2, LPA2/EDG-4 and LPA3/EDG-7. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 189-193 12668728-1 2003 Lysophosphatidic acid (LPA) is a serum-borne phospholipid that exerts a pleiotropic range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA1/EDG-2, LPA2/EDG-4 and LPA3/EDG-7. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 194-199 12668728-1 2003 Lysophosphatidic acid (LPA) is a serum-borne phospholipid that exerts a pleiotropic range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA1/EDG-2, LPA2/EDG-4 and LPA3/EDG-7. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 189-193 12668728-1 2003 Lysophosphatidic acid (LPA) is a serum-borne phospholipid that exerts a pleiotropic range of effects on cells through activation of three closely related G-protein-coupled receptors termed LPA1/EDG-2, LPA2/EDG-4 and LPA3/EDG-7. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 194-199 12668728-4 2003 Treatment with LPA induced the rapid endocytosis of approximately 40% of surface LPA1 within 15 minutes. lysophosphatidic acid 15-18 lysophosphatidic acid receptor 1 Homo sapiens 81-85 12769191-1 2003 We have previously found that adult Schwann cells express receptors for lysophosphatidic acid (EDG2, EDG7) and sphingosine-1-phosphate (EDG5) and that expression of these receptors is significantly upregulated in injured sciatic nerve coincident with postaxotomy Schwann cell proliferation. lysophosphatidic acid 72-93 lysophosphatidic acid receptor 1 Homo sapiens 95-99 12623301-10 2003 Our results suggest that LPA exerts antiadrenergic effects on force of contraction in human and rodent myocardium via a Galpha(i/o) protein-mediated mechanism, most probably by LPA binding to the mammalian LPA receptors EDG-2 and/or EDG-7. lysophosphatidic acid 25-28 lysophosphatidic acid receptor 1 Homo sapiens 220-225 12668280-1 2003 Lysophosphatidic acid (LPA) receptors including LPA(1), LPA(2), and LPA(3) mediate lysophosphatidic acid signals. lysophosphatidic acid 83-104 lysophosphatidic acid receptor 1 Homo sapiens 48-53 12623301-10 2003 Our results suggest that LPA exerts antiadrenergic effects on force of contraction in human and rodent myocardium via a Galpha(i/o) protein-mediated mechanism, most probably by LPA binding to the mammalian LPA receptors EDG-2 and/or EDG-7. lysophosphatidic acid 177-180 lysophosphatidic acid receptor 1 Homo sapiens 220-225 12670925-0 2003 Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 106-110 12670925-0 2003 Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 106-110 12670925-13 2003 Our results suggest that LPA acts as a potent stimulator of colon cancer progression, although the binding to LPA1 and LPA2 induces slightly different responses. lysophosphatidic acid 25-28 lysophosphatidic acid receptor 1 Homo sapiens 110-114 12401212-1 2002 In a comparison of embryonic brain expression patterns of lysophosphatidic acid and sphingosine 1-phosphate receptor genes (lpa(1-3) and s1p(1-5), respectively), transcripts detected by Northern blot were subsequently localized using in situ hybridization. lysophosphatidic acid 58-79 lysophosphatidic acid receptor 1 Homo sapiens 124-131 12069837-7 2002 Finally, we present data demonstrating a correlation between the mitogenic effects of LPA and expression of the lp(A1) gene in the prostate cancer cells. lysophosphatidic acid 86-89 lysophosphatidic acid receptor 1 Homo sapiens 112-117 12098668-3 2002 The LPAr are endogenously expressed in the rat thyroid cell line FRTL-5 and we used the FRTL-5 cells permanently transfected to obtain moderate overexpression of G-protein-coupled receptor kinase-2 (GRK2) or beta-arrestin1 to study whether GRK2 and beta-arrestin1 desensitise LPAr-mediated signalling and regulate LPA-stimulated functional effects. lysophosphatidic acid 4-7 lysophosphatidic acid receptor 1 Homo sapiens 276-280 12139919-0 2002 Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid. lysophosphatidic acid 103-124 lysophosphatidic acid receptor 1 Homo sapiens 31-36 12139919-3 2002 Lysophosphatidic acid (LPA) has been reported to be a ligand of Edg-2 receptor in different cell types. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 64-69 12139919-3 2002 Lysophosphatidic acid (LPA) has been reported to be a ligand of Edg-2 receptor in different cell types. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 64-69 12139919-8 2002 Therefore, in contrast to other cell types, in which LPA exerts pleiotropic effects, Edg-2-positive postmitotic oligodendrocytes display a restricted responsiveness to LPA. lysophosphatidic acid 168-171 lysophosphatidic acid receptor 1 Homo sapiens 85-90 12069841-5 2002 In the present study, we review the stereochemical aspects of LPA pharmacology and describe the chemical synthesis of pure LPA enantiomers together with their ligand-binding properties toward the LPA1, LPA2, and LPA3 receptors and their metabolism by lipid phosphate phosphatase 1 (LPP1). lysophosphatidic acid 123-126 lysophosphatidic acid receptor 1 Homo sapiens 196-200 11700008-4 2001 Successive studies have revealed that edg2 activation by LPA mediates several neurobiological actions related to neurogenesis, neuronal excitability and survival activity on developing and postnatal neurons. lysophosphatidic acid 57-60 lysophosphatidic acid receptor 1 Homo sapiens 38-42 11604399-1 2001 The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are ligands for the related G protein-coupled receptors S1P(1)/EDG1 and LPA(1)/EDG2, respectively. lysophosphatidic acid 66-87 lysophosphatidic acid receptor 1 Homo sapiens 166-172 11604399-1 2001 The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are ligands for the related G protein-coupled receptors S1P(1)/EDG1 and LPA(1)/EDG2, respectively. lysophosphatidic acid 66-87 lysophosphatidic acid receptor 1 Homo sapiens 173-177 11604399-1 2001 The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are ligands for the related G protein-coupled receptors S1P(1)/EDG1 and LPA(1)/EDG2, respectively. lysophosphatidic acid 89-92 lysophosphatidic acid receptor 1 Homo sapiens 166-172 11604399-1 2001 The phospholipid growth factors sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) are ligands for the related G protein-coupled receptors S1P(1)/EDG1 and LPA(1)/EDG2, respectively. lysophosphatidic acid 89-92 lysophosphatidic acid receptor 1 Homo sapiens 173-177 11024010-4 2000 Secretion of IL-2 by unactivated Edg-4 R-predominant CD4+ T cells incubated with anti-CD3 plus anti-CD28 antibodies was suppressed significantly and by up to 60% by 10-10 M to 10-6 M LPA, whereas secretion of IL-2 by mitogen-activated Edg-2 R and Edg-4 R codominant CD4+ T cells was enhanced by up to twofold by the same concentrations of LPA. lysophosphatidic acid 183-186 lysophosphatidic acid receptor 1 Homo sapiens 235-240 11152468-5 2001 To determine the involvement of the EDG-2 receptor in the responses of growing preadipocytes to LPA, stable transfection of antisense EDG-2 cDNA was performed in growing 3T3F442A preadipocytes. lysophosphatidic acid 96-99 lysophosphatidic acid receptor 1 Homo sapiens 36-41 11152468-9 2001 Results demonstrate the significant contribution of the EDG-2 receptor in the biological responses generated by LPA in 3T3F442A preadipocytes. lysophosphatidic acid 112-115 lysophosphatidic acid receptor 1 Homo sapiens 56-61 11087622-2 2000 We previously identified lp(A1), the first receptor gene for a signaling phospholipid called lysophosphatidic acid (LPA) and showed its enriched expression in the VZ. lysophosphatidic acid 93-114 lysophosphatidic acid receptor 1 Homo sapiens 25-30 11087622-2 2000 We previously identified lp(A1), the first receptor gene for a signaling phospholipid called lysophosphatidic acid (LPA) and showed its enriched expression in the VZ. lysophosphatidic acid 116-119 lysophosphatidic acid receptor 1 Homo sapiens 25-30 11160288-1 2001 Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) from platelets and mononuclear phagocytes mediate T cell functions through endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) specific for LPA (Edg-2, -4, and -7) or S1P (Edg-1, -3, -5, -6, and -8). lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 233-238 11160288-1 2001 Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) from platelets and mononuclear phagocytes mediate T cell functions through endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) specific for LPA (Edg-2, -4, and -7) or S1P (Edg-1, -3, -5, -6, and -8). lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 233-238 11087877-3 2000 Here, we show that targeted deletion of lp(A1) results in approximately 50% neonatal lethality, impaired suckling in neonatal pups, and loss of LPA responsivity in embryonic cerebral cortical neuroblasts with survivors showing reduced size, craniofacial dysmorphism, and increased apoptosis in sciatic nerve Schwann cells. lysophosphatidic acid 144-147 lysophosphatidic acid receptor 1 Homo sapiens 40-45 11040035-6 2000 LPA induced cell rounding in LP(A1)- and LP(A2)-expressing cells. lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 29-34 10908309-4 2000 The functional heterologous assay system described is for the hEdg2 receptor, which uses lysophosphatidic acid as its endogenous ligand. lysophosphatidic acid 89-110 lysophosphatidic acid receptor 1 Homo sapiens 62-67 11027575-7 2000 These receptor did not respond to LPA by GTPgammaS binding assays, while Edg2 or Edg4 showed responses to LPA under the same assay conditions. lysophosphatidic acid 106-109 lysophosphatidic acid receptor 1 Homo sapiens 73-77 10961347-0 2000 Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate. lysophosphatidic acid 81-102 lysophosphatidic acid receptor 1 Homo sapiens 60-65 10727522-1 2000 Two G protein-coupled receptors (Edg-2) and (Edg-4) for the lysolipid phosphoric acid mediator lysophosphatidic acid have been described by molecular cloning. lysophosphatidic acid 95-116 lysophosphatidic acid receptor 1 Homo sapiens 33-38 10632375-0 1999 Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. lysophosphatidic acid 89-110 lysophosphatidic acid receptor 1 Homo sapiens 18-23 10632375-0 1999 Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. lysophosphatidic acid 89-110 lysophosphatidic acid receptor 1 Homo sapiens 24-29 10632375-6 1999 Stable overexpression of Edg-2 in A2780 cells induced an exogenous LPA-independent decrease in proliferation but did not alter cisplatin sensitivity. lysophosphatidic acid 67-70 lysophosphatidic acid receptor 1 Homo sapiens 25-30 10354366-5 1999 Stabilized transfection of Tsup-1 cells with a combination of plasmids encoding Edg-2 plus -4 antisense mRNA suppressed the levels of Edg-2 and -4, but not Edg-3 and -5, in Western blots and reduced in parallel the increments in HB-EGF and susceptibility to DT evoked by LPA but not S1P. lysophosphatidic acid 271-274 lysophosphatidic acid receptor 1 Homo sapiens 80-85 10537322-1 1999 Endothelial differentiation gene (edg)-encoded G protein-coupled receptors (Edg Rs)-1, -3, and -5 bind sphingosine 1-phosphate (S1P), and Edg-2 and -4 bind lysophosphatidic acid (LPA). lysophosphatidic acid 156-177 lysophosphatidic acid receptor 1 Homo sapiens 138-150 10493533-1 1999 Endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) Edg-1, Edg-3, and Edg-5 bind sphingosine 1-phosphate (S1P), and Edg-2 and Edg-4 Rs bind lysophosphatidic acid (LPA). lysophosphatidic acid 166-187 lysophosphatidic acid receptor 1 Homo sapiens 142-147 10493533-1 1999 Endothelial differentiation gene-encoded G protein-coupled receptors (Edg Rs) Edg-1, Edg-3, and Edg-5 bind sphingosine 1-phosphate (S1P), and Edg-2 and Edg-4 Rs bind lysophosphatidic acid (LPA). lysophosphatidic acid 189-192 lysophosphatidic acid receptor 1 Homo sapiens 142-147 10381367-1 1999 AGR16/H218/EDG5 and EDG1 are functional receptors for lysosphingolipids, whereas EDG2 and EGD4 are receptors for lysophosphatidic acid (LPA). lysophosphatidic acid 113-134 lysophosphatidic acid receptor 1 Homo sapiens 81-85 10381367-1 1999 AGR16/H218/EDG5 and EDG1 are functional receptors for lysosphingolipids, whereas EDG2 and EGD4 are receptors for lysophosphatidic acid (LPA). lysophosphatidic acid 136-139 lysophosphatidic acid receptor 1 Homo sapiens 81-85 10354366-5 1999 Stabilized transfection of Tsup-1 cells with a combination of plasmids encoding Edg-2 plus -4 antisense mRNA suppressed the levels of Edg-2 and -4, but not Edg-3 and -5, in Western blots and reduced in parallel the increments in HB-EGF and susceptibility to DT evoked by LPA but not S1P. lysophosphatidic acid 271-274 lysophosphatidic acid receptor 1 Homo sapiens 134-146 10220449-3 1999 Recent studies of the first such gene, encoding the G protein-coupled receptor LPA1/VZG-1 (lysophospholipid receptor A1/ventricular zone gene-1), revealed a major locus of expression in oligodendrocytes and Schwann cells (SCs) during development, suggesting an influence of LPA on these myelinating cells. lysophosphatidic acid 79-82 lysophosphatidic acid receptor 1 Homo sapiens 84-89 9952414-3 1999 Developmental expression patterns of its first cloned receptor gene, lpA1/vzg-1 (Hecht et al., 1996; Fukushima et al., 1998) in the VZ suggested that functional LPA receptors were synthesized at these early times, and thus, LPA could be an earlier stimulus to VZ cells than the neurotransmitters GABA and L-glutamate. lysophosphatidic acid 161-164 lysophosphatidic acid receptor 1 Homo sapiens 69-73 9952414-3 1999 Developmental expression patterns of its first cloned receptor gene, lpA1/vzg-1 (Hecht et al., 1996; Fukushima et al., 1998) in the VZ suggested that functional LPA receptors were synthesized at these early times, and thus, LPA could be an earlier stimulus to VZ cells than the neurotransmitters GABA and L-glutamate. lysophosphatidic acid 161-164 lysophosphatidic acid receptor 1 Homo sapiens 74-79 9600933-0 1998 A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. lysophosphatidic acid 112-133 lysophosphatidic acid receptor 1 Homo sapiens 29-34 9600933-0 1998 A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. lysophosphatidic acid 112-133 lysophosphatidic acid receptor 1 Homo sapiens 35-39 9600933-0 1998 A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid. lysophosphatidic acid 112-133 lysophosphatidic acid receptor 1 Homo sapiens 40-45 9600933-4 1998 VZG-1 expression was necessary and sufficient in mediating multiple effects of LPA: [3H]-LPA binding, G protein activation, stress fiber formation, neurite retraction, serum response element activation, and increased DNA synthesis. lysophosphatidic acid 79-82 lysophosphatidic acid receptor 1 Homo sapiens 0-5 9600933-4 1998 VZG-1 expression was necessary and sufficient in mediating multiple effects of LPA: [3H]-LPA binding, G protein activation, stress fiber formation, neurite retraction, serum response element activation, and increased DNA synthesis. lysophosphatidic acid 89-92 lysophosphatidic acid receptor 1 Homo sapiens 0-5 9430689-0 1998 Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. lysophosphatidic acid 87-108 lysophosphatidic acid receptor 1 Homo sapiens 6-11 9525886-1 1998 The recent identification of the Vzg-1/Edg2 protein as a functional G protein-coupled receptor for lysophosphatidic acid (LPA) has allowed a sequence-based search for new genes that may encode novel subtypes of LPA receptors. lysophosphatidic acid 99-120 lysophosphatidic acid receptor 1 Homo sapiens 33-38 9525886-1 1998 The recent identification of the Vzg-1/Edg2 protein as a functional G protein-coupled receptor for lysophosphatidic acid (LPA) has allowed a sequence-based search for new genes that may encode novel subtypes of LPA receptors. lysophosphatidic acid 99-120 lysophosphatidic acid receptor 1 Homo sapiens 39-43 9525886-1 1998 The recent identification of the Vzg-1/Edg2 protein as a functional G protein-coupled receptor for lysophosphatidic acid (LPA) has allowed a sequence-based search for new genes that may encode novel subtypes of LPA receptors. lysophosphatidic acid 122-125 lysophosphatidic acid receptor 1 Homo sapiens 33-38 9525886-1 1998 The recent identification of the Vzg-1/Edg2 protein as a functional G protein-coupled receptor for lysophosphatidic acid (LPA) has allowed a sequence-based search for new genes that may encode novel subtypes of LPA receptors. lysophosphatidic acid 122-125 lysophosphatidic acid receptor 1 Homo sapiens 39-43 9409733-1 1997 The structural similarity of lysosphingolipids to lysophosphatidic acid (LPA) prompted a sequence-based search for lysosphingolipid receptors using cDNA sequence of the Edg2 human LPA receptor. lysophosphatidic acid 50-71 lysophosphatidic acid receptor 1 Homo sapiens 169-173 34699844-7 2022 A synthetic LPA1/3 inhibitor, Ki16425, suppressed the cPA-augmented tube formation and migration of the HDLECs, and the LPA-induced migration. lysophosphatidic acid 120-123 lysophosphatidic acid receptor 1 Homo sapiens 12-18 9070858-0 1997 Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. lysophosphatidic acid 105-126 lysophosphatidic acid receptor 1 Homo sapiens 31-35 9070858-4 1997 HEK293 cells expressing the human Edg2 protein showed an elevated response to lysophosphatidic acid (LPA) in a serum response element reporter gene assay, which was LPA concentration-dependent and specific to LPA compared to other lysophospholipids. lysophosphatidic acid 78-99 lysophosphatidic acid receptor 1 Homo sapiens 34-38 9070858-4 1997 HEK293 cells expressing the human Edg2 protein showed an elevated response to lysophosphatidic acid (LPA) in a serum response element reporter gene assay, which was LPA concentration-dependent and specific to LPA compared to other lysophospholipids. lysophosphatidic acid 101-104 lysophosphatidic acid receptor 1 Homo sapiens 34-38 9070858-4 1997 HEK293 cells expressing the human Edg2 protein showed an elevated response to lysophosphatidic acid (LPA) in a serum response element reporter gene assay, which was LPA concentration-dependent and specific to LPA compared to other lysophospholipids. lysophosphatidic acid 165-168 lysophosphatidic acid receptor 1 Homo sapiens 34-38 9070858-5 1997 Over-expression of human Edg2 in CHO cells correlated with increases in specific binding of [3H]-LPA. lysophosphatidic acid 97-100 lysophosphatidic acid receptor 1 Homo sapiens 25-29 9070858-9 1997 Therefore, it is concluded that the human Edg2 protein functions as a cellular receptor for LPA. lysophosphatidic acid 92-95 lysophosphatidic acid receptor 1 Homo sapiens 42-46 8922387-7 1996 Vzg-1 overexpression decreased the EC50 of both cell rounding and Gi activation in response to LPA. lysophosphatidic acid 95-98 lysophosphatidic acid receptor 1 Homo sapiens 0-5 8922387-9 1996 Membrane binding studies indicated that vzg-1 overexpression increased specific LPA binding. lysophosphatidic acid 80-83 lysophosphatidic acid receptor 1 Homo sapiens 40-45 8922387-10 1996 These analyses identify the vzg-1 gene product as a receptor for LPA, suggesting the operation of LPA signaling mechanisms in cortical neurogenesis. lysophosphatidic acid 65-68 lysophosphatidic acid receptor 1 Homo sapiens 28-33 8922387-11 1996 Vzg-1 therefore provides a link between extracellular LPA and the activation of LPA-mediated signaling pathways through a single receptor and will allow new investigations into LPA signaling both in neural and nonneural systems. lysophosphatidic acid 54-57 lysophosphatidic acid receptor 1 Homo sapiens 0-5 8922387-11 1996 Vzg-1 therefore provides a link between extracellular LPA and the activation of LPA-mediated signaling pathways through a single receptor and will allow new investigations into LPA signaling both in neural and nonneural systems. lysophosphatidic acid 80-83 lysophosphatidic acid receptor 1 Homo sapiens 0-5 8922387-11 1996 Vzg-1 therefore provides a link between extracellular LPA and the activation of LPA-mediated signaling pathways through a single receptor and will allow new investigations into LPA signaling both in neural and nonneural systems. lysophosphatidic acid 80-83 lysophosphatidic acid receptor 1 Homo sapiens 0-5 34969771-3 2021 Fibrotic diseases such as these can be mediated by lysophosphatidic acid (LPA), which signals via six LPA receptors (LPA1-6). lysophosphatidic acid 51-72 lysophosphatidic acid receptor 1 Homo sapiens 117-123 34969771-3 2021 Fibrotic diseases such as these can be mediated by lysophosphatidic acid (LPA), which signals via six LPA receptors (LPA1-6). lysophosphatidic acid 74-77 lysophosphatidic acid receptor 1 Homo sapiens 117-123 34832985-2 2021 LPA can induce various responses, such as cell proliferation, migration, and cytokine production, through six G protein-coupled receptors (LPA1-6). lysophosphatidic acid 0-3 lysophosphatidic acid receptor 1 Homo sapiens 139-145 34302117-0 2021 Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis. lysophosphatidic acid 17-38 lysophosphatidic acid receptor 1 Homo sapiens 48-53 34126459-1 2021 Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR1-6) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 57-64 34126459-1 2021 Lysophosphatidic acid (LPA) activates six LPA receptors (LPAR1-6) and regulates various cellular activities such as cell proliferation, cytoprotection, and wound healing. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 57-64 34639115-7 2021 LPAR1 knockdown in HaCaT cells reduced LPA-induced proliferation, suppressed cyclin A2 and CDK2 expression, and restored p27Kip1 expression. lysophosphatidic acid 39-42 lysophosphatidic acid receptor 1 Homo sapiens 0-5 34685560-3 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mainly produced by the catalytic action of autotaxin (ATX), and its ligation to LPA receptor-1 (LPAR1) is associated with chronic inflammation and renal fibrosis; however, its role in renal aging is unclear. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 129-143 34685560-3 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mainly produced by the catalytic action of autotaxin (ATX), and its ligation to LPA receptor-1 (LPAR1) is associated with chronic inflammation and renal fibrosis; however, its role in renal aging is unclear. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 145-150 34685560-3 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mainly produced by the catalytic action of autotaxin (ATX), and its ligation to LPA receptor-1 (LPAR1) is associated with chronic inflammation and renal fibrosis; however, its role in renal aging is unclear. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 129-143 34685560-3 2021 Lysophosphatidic acid (LPA) is a bioactive lipid mainly produced by the catalytic action of autotaxin (ATX), and its ligation to LPA receptor-1 (LPAR1) is associated with chronic inflammation and renal fibrosis; however, its role in renal aging is unclear. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 145-150 35113924-2 2022 LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA) signal across the cell membrane and evoke various responses, including cellular survival, proliferation, differentiation, and migration. lysophosphatidic acid 75-96 lysophosphatidic acid receptor 1 Homo sapiens 15-21 35391830-3 2022 This action of LPA was mediated by the RHO/ROCK-SRF signaling downstream of LPA1 and LPA5 receptors and required ERK activity. lysophosphatidic acid 15-18 lysophosphatidic acid receptor 1 Homo sapiens 76-80 35440138-5 2022 The current compounds modulated LPA-mediated ATX allostery and achieved indirect blockage of LPA1 internalization, in line with the observed reduction in downstream signaling cascades and chemotaxis induction. lysophosphatidic acid 32-35 lysophosphatidic acid receptor 1 Homo sapiens 93-97 35151977-1 2022 Lysophosphatidic acid (LPA) is a bioactive lipid that activates the G protein-coupled receptors, LPA1-6, which are associated with a wide number of cellular responses including proliferation, migration, differentiation, and survival. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 97-103 35151977-1 2022 Lysophosphatidic acid (LPA) is a bioactive lipid that activates the G protein-coupled receptors, LPA1-6, which are associated with a wide number of cellular responses including proliferation, migration, differentiation, and survival. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 97-103 35260987-1 2022 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) exhibits a variety of malignant properties in cancer cells. lysophosphatidic acid 0-21 lysophosphatidic acid receptor 1 Homo sapiens 57-61 35260987-1 2022 Lysophosphatidic acid (LPA) signaling via LPA receptors (LPA1 to LPA6) exhibits a variety of malignant properties in cancer cells. lysophosphatidic acid 23-26 lysophosphatidic acid receptor 1 Homo sapiens 57-61 35113924-2 2022 LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA) signal across the cell membrane and evoke various responses, including cellular survival, proliferation, differentiation, and migration. lysophosphatidic acid 98-101 lysophosphatidic acid receptor 1 Homo sapiens 15-21 34982278-6 2022 Importantly, LPA significantly promoted the proliferation and migration of LPA3-overexpressing ovarian cancer cells, while the LPA-induced actions blocked by Ki16425, a LPAR1/3 antagonist treated, and LPA3-shRNA transfected. lysophosphatidic acid 13-16 lysophosphatidic acid receptor 1 Homo sapiens 169-176 34982278-6 2022 Importantly, LPA significantly promoted the proliferation and migration of LPA3-overexpressing ovarian cancer cells, while the LPA-induced actions blocked by Ki16425, a LPAR1/3 antagonist treated, and LPA3-shRNA transfected. lysophosphatidic acid 127-130 lysophosphatidic acid receptor 1 Homo sapiens 169-176