PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8939924-2 1996 scd1 expression had previously been observed only in late-stage differentiation, during the period of triacylglycerol accumulation. Triglycerides 102-117 stearoyl-CoA desaturase Homo sapiens 0-4 31744651-2 2020 Stearoyl-CoA desaturase (SCD) activity is required for TG synthesis, while lipoprotein lipase mass (LPLm) facilitates TG clearance. Triglycerides 55-57 stearoyl-CoA desaturase Homo sapiens 0-23 35126846-6 2022 Among several lipogenic genes, the endoplasmic reticulum-bound stearoyl-CoA desaturase 1 (SCD1) is the key determinant of triglycerides biosynthesis pathway, by providing monounsaturated fatty acids, through the incorporation of a double bond at the delta-9 position of saturated fatty acids, specifically, palmitic (C16:0) and stearic (C18:0) acids, yielding palmitoleic (C16:1) and oleic (C18:1) acids, respectively. Triglycerides 122-135 stearoyl-CoA desaturase Homo sapiens 63-88 35126846-6 2022 Among several lipogenic genes, the endoplasmic reticulum-bound stearoyl-CoA desaturase 1 (SCD1) is the key determinant of triglycerides biosynthesis pathway, by providing monounsaturated fatty acids, through the incorporation of a double bond at the delta-9 position of saturated fatty acids, specifically, palmitic (C16:0) and stearic (C18:0) acids, yielding palmitoleic (C16:1) and oleic (C18:1) acids, respectively. Triglycerides 122-135 stearoyl-CoA desaturase Homo sapiens 90-94 35126846-7 2022 Various experimental studies involving SCD1 gene knockout and diet-induced rodent models have demonstrated that SCD1 plays a key role in the development of NAFLD, by modulating hepatic lipogenesis and thus triglyceride accumulation in the liver. Triglycerides 206-218 stearoyl-CoA desaturase Homo sapiens 112-116 31744651-2 2020 Stearoyl-CoA desaturase (SCD) activity is required for TG synthesis, while lipoprotein lipase mass (LPLm) facilitates TG clearance. Triglycerides 55-57 stearoyl-CoA desaturase Homo sapiens 25-28 31744651-3 2020 The purpose of this study is to reveal whether SCD activity or LPLm is the cause of high TG levels in SGA newborns. Triglycerides 89-91 stearoyl-CoA desaturase Homo sapiens 47-50 32567273-8 2020 SCD-1 gene overexpression was negatively correlated with triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), and positively correlated with Ca ion, total cholesterol (TC), very low-density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Triglycerides 57-69 stearoyl-CoA desaturase Homo sapiens 0-5 32567273-8 2020 SCD-1 gene overexpression was negatively correlated with triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), and positively correlated with Ca ion, total cholesterol (TC), very low-density lipoprotein cholesterol (VLDL-C) and low density lipoprotein cholesterol (LDL-C) levels. Triglycerides 71-73 stearoyl-CoA desaturase Homo sapiens 0-5 27357269-6 2016 4-Phenylbutyric acid, an inhibitor of ERS, lowered the TG content by reducing the mRNA expression levels of sterol regulatory element-binding protein 1 (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), and the protein expression levels of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and stearoyl-CoA desaturase-1 (SCD-1). Triglycerides 55-57 stearoyl-CoA desaturase Homo sapiens 322-347 32122301-6 2020 We investigated the transcriptional and biological role of Stearoyl-CoA Desaturase 1 (SCD1) in the buffalo mammary epithelial cells (BMECs) during FA and triacylglycerol (TAG) synthesis. Triglycerides 154-169 stearoyl-CoA desaturase Homo sapiens 59-84 32122301-6 2020 We investigated the transcriptional and biological role of Stearoyl-CoA Desaturase 1 (SCD1) in the buffalo mammary epithelial cells (BMECs) during FA and triacylglycerol (TAG) synthesis. Triglycerides 154-169 stearoyl-CoA desaturase Homo sapiens 86-90 31623522-0 2020 Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women. Triglycerides 0-12 stearoyl-CoA desaturase Homo sapiens 76-99 28345489-2 2018 The objective of the present study was to evaluate the effect of SCD1 inhibition in human cumulus cells on triglyceride content, steroidogenesis, and oocyte in vitro maturation. Triglycerides 107-119 stearoyl-CoA desaturase Homo sapiens 65-69 29759071-4 2018 Therefore, the aim of this study was to investigate whether SCD1 mediated the effect of metformin on TG accumulation. Triglycerides 101-103 stearoyl-CoA desaturase Homo sapiens 60-64 29847832-6 2018 RESULTS: Among 6 FADS SNPs, we found that carriers of the C-allele of the FADS1-rs174546 showed a significant association with lower TG concentrations (beta = -12.6 mg/dL, p = 0.009) and lower VLDL concentrations (beta = -2.52 mg/dL, p = 0.005). Triglycerides 133-135 stearoyl-CoA desaturase Homo sapiens 17-21 29759071-15 2018 CONCLUSIONS: Together, these results reveal that metformin reduces TG accumulation in HepG2 cells via inhibiting the expression of SCD1. Triglycerides 67-69 stearoyl-CoA desaturase Homo sapiens 131-135 28237083-1 2017 We investigated the association of single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster with coronary artery disease (CAD) in a case-control study and evaluated the possible influence of genetic variation on total cholesterol (TC) and triglyceride concentrations in the controls. Triglycerides 270-282 stearoyl-CoA desaturase Homo sapiens 81-102 28237083-1 2017 We investigated the association of single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster with coronary artery disease (CAD) in a case-control study and evaluated the possible influence of genetic variation on total cholesterol (TC) and triglyceride concentrations in the controls. Triglycerides 270-282 stearoyl-CoA desaturase Homo sapiens 104-108 27357269-6 2016 4-Phenylbutyric acid, an inhibitor of ERS, lowered the TG content by reducing the mRNA expression levels of sterol regulatory element-binding protein 1 (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), and the protein expression levels of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and stearoyl-CoA desaturase-1 (SCD-1). Triglycerides 55-57 stearoyl-CoA desaturase Homo sapiens 349-354 26892124-8 2016 Estimated stearoyl-CoA-desaturase and Delta6-desaturase activities in plasma TG and PL were directly associated with CRS, whereas estimated elongase activity in plasma TG and PL was inversely related to CRS. Triglycerides 77-79 stearoyl-CoA desaturase Homo sapiens 10-33 26676854-5 2015 Measures of hepatocyte-specific function and triglyceride accumulation in later stages were strongly inhibited a minimum of -29% (P < 0.05) by SCD1 inhibitor in the early stage of hepatic differentiation and effectively reversed (>30%, P < 0.01) by the addition of oleate. Triglycerides 45-57 stearoyl-CoA desaturase Homo sapiens 146-150 23221600-1 2013 Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Triglycerides 73-85 stearoyl-CoA desaturase Homo sapiens 0-25 25971719-6 2015 The association between estimated D5D, D6D, and SCD activities and risk of T2D was statistically significantly and markedly attenuated after adjustment for the FLI and, to a lesser extent, after adjustment for triglycerides, whereas adjustment for other desaturase-associated biomarkers (CRP, fetuin-A, ALT, and GGT) did not lead to appreciable attenuations. Triglycerides 210-223 stearoyl-CoA desaturase Homo sapiens 48-51 25971719-7 2015 CONCLUSIONS: Liver fat accumulation, as reflected by the FLI, and dyslipidemia, as reflected by triglycerides, may partly explain the association between estimated D5D, D6D, and SCD activity and T2D risk. Triglycerides 96-109 stearoyl-CoA desaturase Homo sapiens 178-181 26098370-2 2015 Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in fatty acid metabolism. Triglycerides 113-126 stearoyl-CoA desaturase Homo sapiens 40-43 26098370-2 2015 Because the monounsaturated products of SCD are key precursors of membrane phospholipids, cholesterol esters and triglycerides, SCD is pivotal in fatty acid metabolism. Triglycerides 113-126 stearoyl-CoA desaturase Homo sapiens 128-131 23245208-2 2013 Studies have demonstrated that rodents lacking a functional SCD1 gene have an improved metabolic profile, including reduced weight gain, lower triglycerides, and improved insulin response. Triglycerides 143-156 stearoyl-CoA desaturase Homo sapiens 60-64 23221600-1 2013 Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Triglycerides 73-85 stearoyl-CoA desaturase Homo sapiens 27-32 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Triglycerides 114-130 stearoyl-CoA desaturase Homo sapiens 45-49 23016130-0 2012 Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation. Triglycerides 91-106 stearoyl-CoA desaturase Homo sapiens 41-62 23016130-8 2012 In summary, our data support the notion that the FADS gene cluster is a major determinant of plasma TG levels. Triglycerides 100-102 stearoyl-CoA desaturase Homo sapiens 49-53 22978399-3 2012 Due to its central role in lipid metabolism in the liver, recent studies have focused on the involvement of SCD-1 in the development of fatty liver during obesity, diabetes mellitus, hypertension, excessive alcohol consumption, and in subjects with high triglyceride blood concentrations. Triglycerides 254-266 stearoyl-CoA desaturase Homo sapiens 108-113 21980230-5 2011 The results showed that stearoyl-coA desaturase was correlated with body mass index (r = 0.235, p<0.05), triglyceride (r = 0.261, p<0.001), and HDL-cholesterol (r = -0.226, p<0.05). Triglycerides 108-120 stearoyl-CoA desaturase Homo sapiens 24-47 21980230-6 2011 Stearoyl-coA desaturase was associated with only triglyceride (r = 0.283, p<0.01). Triglycerides 49-61 stearoyl-CoA desaturase Homo sapiens 0-23 20713121-4 2011 Furthermore, oleic acid, the main product of SCD1 reaction, is the predominant fatty acid of human adipose tissue triacylglycerols, associating SCD1 with the development of obesity and the metabolic syndrome. Triglycerides 114-130 stearoyl-CoA desaturase Homo sapiens 144-148 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Triglycerides 175-187 stearoyl-CoA desaturase Homo sapiens 0-32 20022128-7 2010 After further adjustment for factors previously linked to fatty liver (i.e. serum lipids, adiponectin concentrations), SCD-1 index (p=0.004) and insulin resistance (p<0.0001) were independent determinants of ALT activity, whereas waist circumference, triglycerides, non-esterified FA and adiponectin were not. Triglycerides 254-267 stearoyl-CoA desaturase Homo sapiens 119-124 21291825-0 2009 Regulation of human stearoyl-CoA desaturase by omega-3 and omega-6 fatty acids: Implications for the dietary management of elevated serum triglycerides. Triglycerides 138-151 stearoyl-CoA desaturase Homo sapiens 20-43 21291825-1 2009 BACKGROUND: Polyunsaturated fatty acids lower serum triglycerides by a mechanism that may involve the inhibition of stearoyl-CoA desaturase (SCD). Triglycerides 52-65 stearoyl-CoA desaturase Homo sapiens 116-139 21291825-1 2009 BACKGROUND: Polyunsaturated fatty acids lower serum triglycerides by a mechanism that may involve the inhibition of stearoyl-CoA desaturase (SCD). Triglycerides 52-65 stearoyl-CoA desaturase Homo sapiens 141-144 19850634-1 2009 BACKGROUND: Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. Triglycerides 160-172 stearoyl-CoA desaturase Homo sapiens 12-44 19850634-1 2009 BACKGROUND: Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the limiting step of monounsaturated fatty acid synthesis in humans and is an important player in triglyceride generation. Triglycerides 160-172 stearoyl-CoA desaturase Homo sapiens 46-50 19850634-4 2009 In this study we aimed to evaluate a hepatic SCD1 activity index derived from plasma VLDL triglyceride composition as a tool to estimate hepatic SCD1 expression in humans. Triglycerides 90-102 stearoyl-CoA desaturase Homo sapiens 45-49 19850634-11 2009 The 16:1/16:0 ratio in hepatic and VLDL triglycerides as well as the 18:1/18:0 ratio in plasma VLDL were closely associated with hepatic SCD1 expression. Triglycerides 40-53 stearoyl-CoA desaturase Homo sapiens 137-141 21291825-12 2009 CONCLUSIONS: Diets enriched in LA, ALA, and by metabolic inference EPA, can regulate SCD activity at the level of transcription, a nutritional intervention that may be useful in the management of increased levels of serum triglycerides in cardiometabolic disorders. Triglycerides 222-235 stearoyl-CoA desaturase Homo sapiens 85-88 18599738-1 2008 Stearoyl-coenzyme A desaturase 1 (SCD1) catalyzes the conversion of stearate (18:0) to oleate (18:1n-9) and of palmitate (16:0) to palmitoleate (16:1), which are key steps in triglyceride synthesis in the fatty acid metabolic network. Triglycerides 175-187 stearoyl-CoA desaturase Homo sapiens 34-38 12401889-0 2002 Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. Triglycerides 65-78 stearoyl-CoA desaturase Homo sapiens 21-44 18068341-1 2008 BACKGROUND AND AIM: In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. Triglycerides 44-56 stearoyl-CoA desaturase Homo sapiens 90-113 18068341-1 2008 BACKGROUND AND AIM: In an animal model VLDL-triglyceride secretion is highly dependent on stearoyl-coA desaturase (SCD) activity and could explain abdominal fattening. Triglycerides 44-56 stearoyl-CoA desaturase Homo sapiens 115-118 17823443-0 2007 Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response. Triglycerides 138-153 stearoyl-CoA desaturase Homo sapiens 0-21 17823443-8 2007 Triacylglycerol responses to changes in dietary composition were independently correlated with SCD (P = 0.003) and DGAT2 (P = 0.05) responses. Triglycerides 0-15 stearoyl-CoA desaturase Homo sapiens 95-98 17823443-10 2007 Moreover, SCD and DGAT2 expression may be involved in dietary regulation of systemic triacylglycerol metabolism. Triglycerides 85-100 stearoyl-CoA desaturase Homo sapiens 10-13 16213227-3 2005 High expression and activity of SCD1, an enzyme that catalyzes the synthesis of monounsaturated fatty acids, corresponded with low rates of fatty acid oxidation, increased triacylglycerol synthesis and increased monounsaturation of muscle lipids. Triglycerides 172-187 stearoyl-CoA desaturase Homo sapiens 32-36 18523127-7 2008 Increased hSCD-1 activity was determined as increased C16:1/16:0 ratio and enhanced triglyceride storage in palmitate treated cells. Triglycerides 84-96 stearoyl-CoA desaturase Homo sapiens 10-16 12538076-2 2003 SCD is required for the biosynthesis of monounsaturated fatty acids, and plays a key role in hepatic synthesis of triglycerides and very-low-density lipoproteins. Triglycerides 114-127 stearoyl-CoA desaturase Homo sapiens 0-3 12401889-9 2002 We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity. Triglycerides 58-70 stearoyl-CoA desaturase Homo sapiens 121-124 11396956-1 2001 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides. Triglycerides 273-286 stearoyl-CoA desaturase Homo sapiens 0-23 11396956-1 2001 Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides. Triglycerides 273-286 stearoyl-CoA desaturase Homo sapiens 25-28 11414710-1 2001 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides and cholesterol esters. Triglycerides 201-214 stearoyl-CoA desaturase Homo sapiens 0-23 11414710-1 2001 Stearoyl-CoA desaturase (SCD) is a microsomal enzyme required for the biosynthesis of oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, triglycerides and cholesterol esters. Triglycerides 201-214 stearoyl-CoA desaturase Homo sapiens 25-28