PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28768565-3 2017 We found that caspase-2 activity is increased in TG-treated THP-1 macrophages, and that inhibition of caspase-2 activity drastically inhibits TG-induced cell death. Triglycerides 142-144 GLI family zinc finger 2 Homo sapiens 60-65 28768565-3 2017 We found that caspase-2 activity is increased in TG-treated THP-1 macrophages, and that inhibition of caspase-2 activity drastically inhibits TG-induced cell death. Triglycerides 49-51 GLI family zinc finger 2 Homo sapiens 60-65 23302643-8 2013 We found an increase in caspase-1 activity in TG-treated THP-1 macrophages and inhibition of caspase-1 activity using a specific inhibitor partially rescued cell death. Triglycerides 46-48 GLI family zinc finger 2 Homo sapiens 57-62 27392709-6 2016 We also found that the levels of oil red O-staining, triglyceride (TG) and total cholesterol (TC) were significantly upregulated in ox-LDL-treated THP1 cells, but inhibited by Lp-PLA2 silencing. Triglycerides 53-65 GLI family zinc finger 2 Homo sapiens 147-151 27392709-6 2016 We also found that the levels of oil red O-staining, triglyceride (TG) and total cholesterol (TC) were significantly upregulated in ox-LDL-treated THP1 cells, but inhibited by Lp-PLA2 silencing. Triglycerides 67-69 GLI family zinc finger 2 Homo sapiens 147-151 23023367-6 2012 METHODS AND RESULTS: THP-1 macrophages exposed to VLDL displayed significant triglyceride accumulation, which was attenuated by PPARdelta activation. Triglycerides 77-89 GLI family zinc finger 2 Homo sapiens 21-26 21336983-0 2011 Receptor mediated elevation in FABP4 levels by advanced glycation end products induces cholesterol and triacylglycerol accumulation in THP-1 macrophages. Triglycerides 103-118 GLI family zinc finger 2 Homo sapiens 135-140 15169972-6 2004 The rate of incorporation of [(3)H]oleate into CE and TG in THP-1 macrophages was increased by oxLDL, CMR-LPs, and oxCMR-LPs, but incorporation into TG was increased to a greater extent with CMR-LPs and oxCMR-LPs compared with oxLDL. Triglycerides 54-56 GLI family zinc finger 2 Homo sapiens 60-65 18435438-3 2008 Phorbol-12-myristic-13-acetate (PMA)-treated THP-1 monocytes differentiated into macrophages and synthesized lipoprotein lipase (LPL), the major enzyme for hydrolysis of triglycerides. Triglycerides 170-183 GLI family zinc finger 2 Homo sapiens 45-50 21512280-5 2011 When non-oxidized sd-LDL were incubated with THP1 macrophages, there was much greater lipid accumulation as assessed by oil red O staining, and more than a 2-fold increase (p < 0.05) in intracellular triglyceride content as compared to non-oxidized total LDL. Triglycerides 203-215 GLI family zinc finger 2 Homo sapiens 45-49 16609875-9 2006 In contrast, the differentiation of both subcutaneous and omental stromal preadipocytes was completely inhibited by THP-1-MacCM, as determined on the basis of morphology and triacylglycerol accumulation, as well as fatty acid synthase and adiponectin protein expression. Triglycerides 174-189 GLI family zinc finger 2 Homo sapiens 116-121 15182357-2 2004 The total lipid content of THP-1 macrophages was markedly higher (x2.2) after 48 h of incubation of THP-1 macrophages with CRLPs containing probucol (pCRLPs) when compared to CRLPs without probucol, and this was because of increases in triacylglycerol (x2.3) and cholesterol (x1.8) levels, while cholesteryl ester concentrations were not significantly changed. Triglycerides 236-251 GLI family zinc finger 2 Homo sapiens 27-32 12562836-2 2003 Incubation of THP-1 macrophages with acetylated LDL (AcLDL) from each of the four diet groups resulted in both CE and triglyceride (TG) accumulation, in addition to alterations of cellular CE, TG, and phospholipid fatty acyl compositions reflective of the individual LDLs. Triglycerides 118-130 GLI family zinc finger 2 Homo sapiens 14-19 12562836-2 2003 Incubation of THP-1 macrophages with acetylated LDL (AcLDL) from each of the four diet groups resulted in both CE and triglyceride (TG) accumulation, in addition to alterations of cellular CE, TG, and phospholipid fatty acyl compositions reflective of the individual LDLs. Triglycerides 132-134 GLI family zinc finger 2 Homo sapiens 14-19 12562836-2 2003 Incubation of THP-1 macrophages with acetylated LDL (AcLDL) from each of the four diet groups resulted in both CE and triglyceride (TG) accumulation, in addition to alterations of cellular CE, TG, and phospholipid fatty acyl compositions reflective of the individual LDLs. Triglycerides 193-195 GLI family zinc finger 2 Homo sapiens 14-19 11907145-0 2002 Triglyceride depletion in THP-1 cells alters cholesteryl ester physical state and cholesterol efflux. Triglycerides 0-12 GLI family zinc finger 2 Homo sapiens 26-31 10347212-4 1999 Incubation of THP-1 macrophages at a concentration of 100 micrograms/ml protein LDL specifically enriched (10 nmol/mg LDL protein) with synthetically prepared Glc-PtdEtn resulted in a significant increase in CE and TG accumulation when compared with LDL enriched in non-glucosylated PtdEtn. Triglycerides 215-217 GLI family zinc finger 2 Homo sapiens 14-19 9763531-7 1998 In addition, the mass of triglyceride in THP-1 macrophages exceeded that of EC both before and after exposure to AcLDL. Triglycerides 25-37 GLI family zinc finger 2 Homo sapiens 41-46 9763531-17 1998 In conclusion, human THP-1 macrophages contain a large and metabolically active pool of triglyceride and a relatively inactive pool of EC. Triglycerides 88-100 GLI family zinc finger 2 Homo sapiens 21-26