PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2744931-4 1989 Plasma fibrinogen concentrations were elevated in 34 percent of patients; the values did not relate to excess weight and they correlated negatively (P less than 0.04) with increasing serum triglycerides and grades of liver fat content. Triglycerides 189-202 fibrinogen beta chain Homo sapiens 7-17 6132131-1 1983 18 patients with severe hypertriglyceridaemia (mean fasting plasma triglyceride 5.7 mmol/l) had significantly higher concentrations of plasma fibrinogen and clotting factor Xc than did a normolipidaemic comparison group. Triglycerides 67-79 fibrinogen beta chain Homo sapiens 142-152 25397464-10 2014 The fibrinogen was positively associated with dRoms (p=0.052) and the positive correlation between triglycerides and antiRoms has been confirmed (p<0.001); the impact of antiRoms on HDL/triglycerides ratio (p=0.006) was observed after adjustment for PI use. Triglycerides 189-202 fibrinogen beta chain Homo sapiens 4-14 33178875-5 2020 In addition, the levels of IMA, hs-CRP and FIB levels showed a strong link to BMI, WHR, TC, TG, LDL and glycated hemoglobin. Triglycerides 92-94 fibrinogen beta chain Homo sapiens 43-46 25471221-7 2014 TG may also stimulate atherogenesis by mechanisms, such excessive free fatty acids (FFA) release, production of proinflammatory cytokines, fibrinogen, coagulation factors and impairment of fibrinolysis. Triglycerides 0-2 fibrinogen beta chain Homo sapiens 139-149 23985811-8 2013 Within dizygotic twin pairs only, associations between growth and triglycerides and fibrinogen (eg, fibrinogen: b = 0.07 ln mg/dL per change in z score, P = 0.31 in monozygotic twins; b = 0.79, P = 0.01 in dizygotic twins from 0 to 1 mo) were identified. Triglycerides 66-79 fibrinogen beta chain Homo sapiens 84-94 15690309-3 2005 In multiple linear regression analyses concerning control subjects, family disposition, social class, a score based on serum triglyceride and high-density lipoprotein (HDL) cholesterol concentrations, and fasting capillary blood glucose concentration were significantly associated with plasma fibrinogen concentration (P < .00005, R2 = 0.81). Triglycerides 125-137 fibrinogen beta chain Homo sapiens 293-303 23849212-4 2013 The assessment of the fibrinogen as a predictor variable has been calculated after adjusting it by age, hypertension, diabetes mellitus, obesity, total cholesterol, HDL-cholesterol/triglycerides ratio, and smoking habit applying a Cox regression model. Triglycerides 181-194 fibrinogen beta chain Homo sapiens 22-32 23177973-6 2013 After multivariable adjustments, fibrinogen generally rose with increasing BMI (p < 0.001; all sex/race groups), LDL cholesterol, log triglycerides and diastolic blood pressure; and fell with increasing HDL cholesterol and physical activity. Triglycerides 137-150 fibrinogen beta chain Homo sapiens 33-43 17785713-3 2007 Fibrinogen levels increased with age and showed continuous, approximately linear relations with several risk markers and slightly curvilinear associations with log triglycerides, albumin, and tobacco and alcohol consumption. Triglycerides 164-177 fibrinogen beta chain Homo sapiens 0-10 17787042-6 2007 Triglycerides were best predicted by fibrinogen, nephritis, and pleuritis (model R2 = 0.6). Triglycerides 0-13 fibrinogen beta chain Homo sapiens 37-47 12716802-3 2003 In men, but not women, waist-to-hip ratio (r = 0.20; P < 0.0001) and triglycerides (r = 0.13; P = 0.0047) also became powerful predictors of fibrinogen level; in women, but not men, fibrinogen was correlated with both diastolic (r = 0.16; P = 0.0011) and systolic (r = 0.11; P = 0.0241) blood pressure. Triglycerides 72-85 fibrinogen beta chain Homo sapiens 144-154 14631552-8 2003 The results, which show correlation between the plasma fibrinogen and triglyceride levels, are presented. Triglycerides 70-82 fibrinogen beta chain Homo sapiens 55-65 11755933-4 2002 Fibrinogen concentrations were higher at baseline among individuals treated with statins (n=130) compared to those treated with fibrates (n=251), even after adjustment for confounding factors (including total cholesterol, HDL cholesterol and triglycerides) (mean (S.D. Triglycerides 242-255 fibrinogen beta chain Homo sapiens 0-10 12717506-3 2003 The increase in fibrinogen content was associated with high levels of total lipids and triglycerides and low concentration of high-density lipoprotein cholesterol. Triglycerides 87-100 fibrinogen beta chain Homo sapiens 16-26 12393098-7 2002 Fibrinogen level was significantly correlated with body mass index, systolic blood pressure, plasma triglycerides, fasting plasma glucose, HbA1c, PAI(active), tPA and von Willebrandt factor, as well as with smoking and low physical activity. Triglycerides 100-113 fibrinogen beta chain Homo sapiens 0-10 11755933-7 2002 After adjustment for baseline fibrinogen level, age, sex and changes in total cholesterol, triglycerides and alcohol intake, fibrinogen concentration decreased after fibrate treatment, while it increased after statin treatment and in those not using lipid lowering drugs (-0.07 (0.54) vs. 0.10 (0.54) vs. 0.08 (0.52) g/l respectively, P=0.01). Triglycerides 91-104 fibrinogen beta chain Homo sapiens 125-135 11063957-8 2000 Levels of plasma fibrinogen (P = 0.009) and D-dimer (P = 0.003) were correlated with renal function independent of age, blood pressure, duration of hypertension, triglyceride level, urinary protein excretion, and erythrocyte sedimentation rate. Triglycerides 162-174 fibrinogen beta chain Homo sapiens 17-27 11225135-4 2001 Fibrinogen levels were associated with age (r = 0.873), hypertension (p = 0.032), body mass index (r = 0.898), triglyceride level (r = 0.9396), cholesterol level (r = 0.99), glycosylated hemoglobin (r = 0.99) and urine albumin excretion rate (r = 0.930) in diabetics, in a significant manner. Triglycerides 111-123 fibrinogen beta chain Homo sapiens 0-10 11015340-6 2000 With the immunoprecipitation method, there were significant linear trends across fibrinogen tertiles (P:<0.001) for age, body mass index, smoking, diabetes mellitus, total cholesterol, HDL cholesterol, and triglycerides in men and women. Triglycerides 209-222 fibrinogen beta chain Homo sapiens 81-91 11131105-6 2000 Age, obesity, systolic blood pressure and triglycerides were significantly associated with diabetes status in both sexes, fibrinogen in men only and high density lipoprotein cholesterol negatively in women. Triglycerides 42-55 fibrinogen beta chain Homo sapiens 122-132 10216095-9 1999 The effect of fibrates is specific for peroxisome proliferator-activated receptor-alpha (PPARalpha) because a high-affinity ligand for PPARgamma, the thiazolidinedione BRL 49653, lowered triglyceride levels, but was unable to suppress fibrinogen expression. Triglycerides 187-199 fibrinogen beta chain Homo sapiens 235-245 11026518-8 2000 In the 101 diabetic subjects, only changes in plasma triglyceride correlated with the changes in fibrinogen concentration. Triglycerides 53-65 fibrinogen beta chain Homo sapiens 97-107 11447466-11 2000 The significant relationships between triglycerides, blood pressure, weight, percentage of high-density lipoprotein (HDL) cholesterol and fibrinogen further suggest a clustering of risk factors all known to be associated with an insulin-resistant state. Triglycerides 38-51 fibrinogen beta chain Homo sapiens 138-148 10669661-3 2000 Fibrinogen increased more in older participants, those with or who developed diabetes, those who at any time smoked, and those whose plasma HDL cholesterol or triglycerides decreased and increased less in female participants who started hormonal replacement therapy. Triglycerides 159-172 fibrinogen beta chain Homo sapiens 0-10 10873614-5 2000 HepG2 cells overexpressing fibrinogen chains had increased 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels, enhanced cholesterol production but normal levels of triglyceride and phospholipid synthesis and of sterol response binding proteins. Triglycerides 173-185 fibrinogen beta chain Homo sapiens 27-37 10877212-1 2000 Epidemiological studies suggest that the plasma fibrinogen concentration is the main determinant of plasma viscosity (PV), but the concentration of other macromolecules (eg, immunoglobulins) and low-density lipoprotein (LDL) cholesterol and triglycerides are also correlated with PV. Triglycerides 241-254 fibrinogen beta chain Homo sapiens 48-58 10877212-8 2000 Second, hypertriglyceridemic samples (n = 7) were pumped through the fibrinogen-depleting column, which reduced the fibrinogen concentration from 4.29 +/- 0.79 to 1.62 +/- 0.69 g/L (P < .001) and PV from 1.42 +/- 0.06 to 1.03 +/- 0.05 mPas (P < .01) while the triglyceride concentration remained unchanged. Triglycerides 13-25 fibrinogen beta chain Homo sapiens 69-79 10877212-8 2000 Second, hypertriglyceridemic samples (n = 7) were pumped through the fibrinogen-depleting column, which reduced the fibrinogen concentration from 4.29 +/- 0.79 to 1.62 +/- 0.69 g/L (P < .001) and PV from 1.42 +/- 0.06 to 1.03 +/- 0.05 mPas (P < .01) while the triglyceride concentration remained unchanged. Triglycerides 13-25 fibrinogen beta chain Homo sapiens 116-126 9222650-5 1997 There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. Triglycerides 114-126 fibrinogen beta chain Homo sapiens 93-103 9726698-1 1998 Elevated serum triglyceride levels may be related to the following clinical features: increased blood coagulation and viscosity, increased serum fibrinogen levels, decreased fibrinolysis, and for serum levels over 1000 mg/dl, a strong increase of acute pancreatitis rate. Triglycerides 15-27 fibrinogen beta chain Homo sapiens 145-155 9571358-6 1998 RESULTS: Age-adjusted fibrinogen levels correlated significantly with BMI, waist-to-hip ratio, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, triglycerides, insulin, and HDL cholesterol (inversely). Triglycerides 177-190 fibrinogen beta chain Homo sapiens 22-32 9585395-7 1998 Multiple linear regression analysis showed associations between HbA1c and fibrinogen (p < 0.001), total cholesterol (p = 0.006), and triglycerides (p = 0.04), independent of age, sex, duration of diabetes, and antidiabetic treatment. Triglycerides 136-149 fibrinogen beta chain Homo sapiens 64-84 9843175-3 1998 Fibrinogen values were higher in subjects with C reactive protein (C-RP) >0.33 mg/dl, BMI >23.9 kg/m2, total cholesterol >4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p<0.01). Triglycerides 144-157 fibrinogen beta chain Homo sapiens 0-10 10933414-9 1998 Univariate and multivariate analyses revealed significant (P<0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. Triglycerides 207-220 fibrinogen beta chain Homo sapiens 95-105 9717004-9 1998 Platelet activation measures were not consistently related to other coronary risk factors, while fibrinogen was related to triglyceride and insulin levels among Indians. Triglycerides 123-135 fibrinogen beta chain Homo sapiens 97-107 9199274-8 1997 On stratification of the subjects into 4 quartiles based on plasma fibrinogen concentrations, we found that increased plasma fibrinogen was associated with older age, higher body mass index (BMI), systolic and diastolic blood pressure (BP), fasting and 2 h plasma glucose (PG), prevalence of diabetes, glycated haemoglobin (HbA1c) and triglyceride (TG) level. Triglycerides 335-347 fibrinogen beta chain Homo sapiens 125-135 9199274-8 1997 On stratification of the subjects into 4 quartiles based on plasma fibrinogen concentrations, we found that increased plasma fibrinogen was associated with older age, higher body mass index (BMI), systolic and diastolic blood pressure (BP), fasting and 2 h plasma glucose (PG), prevalence of diabetes, glycated haemoglobin (HbA1c) and triglyceride (TG) level. Triglycerides 349-351 fibrinogen beta chain Homo sapiens 125-135 9199274-9 1997 After adjustment for age and sex, increased plasma fibrinogen concentration remained associated with higher BMI, systolic BP, 2 h PG and TG level. Triglycerides 137-139 fibrinogen beta chain Homo sapiens 51-61 9199274-10 1997 On multivariate analysis using age, BMI, BP, TG, HbA1c and PG as independent variables, plasma fibrinogen was independently related to plasma TG concentration and HbA1c. Triglycerides 45-47 fibrinogen beta chain Homo sapiens 95-105 9199274-12 1997 change in TG concentration and HbA1c, there were 3.7 and 5.2% changes in plasma fibrinogen concentration respectively. Triglycerides 10-12 fibrinogen beta chain Homo sapiens 80-90 9217177-5 1997 Serum cholesterol and triglyceride were associated with increases in factors VII and IX, as well as antithrombin, protein C and protein S; and with increased fibrinogen and factor VIII in women. Triglycerides 22-34 fibrinogen beta chain Homo sapiens 158-168 9184398-11 1997 Fbg was positively correlated with age, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides in women, but Fbg had few positive correlations with risk factors in men. Triglycerides 130-143 fibrinogen beta chain Homo sapiens 0-3 8172846-6 1994 Fb was positively correlated with body mass index (r = .27 to .48, P < .001), total cholesterol (r = .13 to .17, P < .05), and low-density lipoprotein cholesterol (r = .15 to .22, P < .01) in all groups and with blood pressure, triglycerides, and cigarette smoking in white men. Triglycerides 237-250 fibrinogen beta chain Homo sapiens 0-2 8908392-6 1996 In a logistic regression model, including age, BMI, cholesterol, sex, smoking, triglycerides, and plasminogen activator inhibitor antigen as covariates, genotype and fibrinogen levels were significantly associated with CAD. Triglycerides 79-92 fibrinogen beta chain Homo sapiens 166-176 7621318-7 1994 A weaker but significant relationship was noted between the fibrinogen level and triglyceride levels (P = 0.0017) and between the fibrinogen level and the ratio of total-cholesterol to HDL-cholesterol levels (P = 0.0006). Triglycerides 81-93 fibrinogen beta chain Homo sapiens 60-70 9012636-5 1997 Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis. Triglycerides 56-69 fibrinogen beta chain Homo sapiens 151-161 9034837-1 1997 BACKGROUND: Heparin-induced extracorporeal LDL/fibrinogen precipitation (HELP) eliminates selectively fibrinogen, LDL, cholesterol, triglycerides and LP(a) from blood plasma using extracorporeal circulation. Triglycerides 132-145 fibrinogen beta chain Homo sapiens 47-57 8867564-9 1996 Fibrinogen was associated with total cholesterol (r = 0.479; P = 0.037), HDL cholesterol (r = -0.467; P = 0.028), plasma triglycerides (r = 0.414; P = 0.012) and fasting plasma glucose level (r = 0.358; P = 0.032). Triglycerides 121-134 fibrinogen beta chain Homo sapiens 0-10 8677203-10 1996 However there was a negative correlation between the fibrinogen and the triglycerides concentration in sons of patients but not in the control group. Triglycerides 72-85 fibrinogen beta chain Homo sapiens 53-63 8548415-5 1996 Multivariate regression analysis revealed that the association between fibrinogen and small, dense LDL particles was independent of serum triglycerides, cholesterol, body mass index, and age. Triglycerides 138-151 fibrinogen beta chain Homo sapiens 71-81 8548415-6 1996 In contrast, the relationship between fibrinogen and HDL2 cholesterol was primarily influenced by triglycerides and cholesterol and not independently influenced by fibrinogen. Triglycerides 98-111 fibrinogen beta chain Homo sapiens 38-48 7495060-5 1995 Very low density lipoprotein (VLDL) triglyceride was a strong determinant of VIIag and PAI-1 activity levels in both cases and controls, whereas VLDL triglyceride in controls and LDL cholesterol in patients related significantly to the plasma fibrinogen concentration. Triglycerides 36-48 fibrinogen beta chain Homo sapiens 243-253 7981844-3 1994 In both genders univariate analyses revealed significantly positive correlations between plasma fibrinogen and age, body mass index (BMI), waist/hip ratio (WHR), systolic blood pressure, serum cholesterol and triglycerides and a negative correlation to high-density lipoprotein (HDL) cholesterol; however, the degree of relationship varied between men and women. Triglycerides 209-222 fibrinogen beta chain Homo sapiens 96-106 7981844-7 1994 Furthermore, the association of fibrinogen to HDL cholesterol was significant only in men and to triglycerides only in women. Triglycerides 97-110 fibrinogen beta chain Homo sapiens 32-42 8084430-4 1994 STUDY DESIGN AND SUBJECTS: In this retrospective study on 139 out-patients, affected by hyperlipoproteinemia type II, the relationship between fibrinogen plasma levels and some lipid parameters, such as total cholesterol (CT), triglycerides, LDL-cholesterol, HDL-cholesterol (HDL-C), lipoprotein (a), apolipoproteins (Apo) A-I and B was evaluated. Triglycerides 227-240 fibrinogen beta chain Homo sapiens 143-153 8084430-5 1994 RESULTS: Fibrinogen plasma levels showed a significant inverse correlation with HDL-C (r = -0.25), HDL-C/CT (Rho = -0.22), Apo A-I (r = -0.33) serum concentration and a direct significant correlation with triglycerides serum levels (r = 0.22). Triglycerides 205-218 fibrinogen beta chain Homo sapiens 9-19 8084430-7 1994 CONCLUSION: In patients with type II hyperlipoproteinemia, the increase of fibrinogen plasma levels seems to be related to the modification of serum concentration of specific lipoprotein, such as those rich in triglycerides and those with high density. Triglycerides 210-223 fibrinogen beta chain Homo sapiens 75-85 8228555-5 1993 Testosterone was an inverse, independent predictor of fibrinogen (p = 0.002); 53% of the variance of fibrinogen could be accounted for by age and triglyceride level (positive; p = 0.001, p = 0.01), and by apolipoprotein A-I and testosterone (negative; p = 0.02, p = 0.002). Triglycerides 146-158 fibrinogen beta chain Homo sapiens 101-111 8338001-7 1993 In both groups we determined plasma levels of total cholesterol, triglycerides, and very low-density lipoprotein (VLDL) cholesterol and found these parameters significantly higher in the group with an FG level > 394 mg/dl (p < 0.05). Triglycerides 65-78 fibrinogen beta chain Homo sapiens 201-203 8206082-5 1994 The most significant difference in fibrinogen level was found among the tertiles of fasting serum insulin (F-ANOVA = 4.5; P < 0.01) with the highest plasma fibrinogen values in the third insulin tertile, whereas body mass index (BMI), waist/hip circumference ratio (WHR) and serum triglycerides were more weakly related. Triglycerides 284-297 fibrinogen beta chain Homo sapiens 35-45 8266905-4 1993 Fibrinogen (overall mean +/- standard deviation = 263 +/- 57 mg/dl) was greater in women than in men and in blacks than in whites; it was associated positively with cigarette smoking, body mass index, low density lipoprotein cholesterol, triglycerides, and blood pressure, and negatively with physical activity, high density lipoprotein cholesterol, and ethanol intake. Triglycerides 238-251 fibrinogen beta chain Homo sapiens 0-10 8326289-10 1993 In smokers, platelet count, heart rate, serum triglyceride concentration, age and fasting glucose explained 22.5% of the variation in fibrinogen concentration. Triglycerides 46-58 fibrinogen beta chain Homo sapiens 134-144 1425083-8 1992 Fibrinogen was correlated significantly with age (P less than 0.001), cholesterol (P = 0.002), CRP (P less than 0.001), and factor VII activity (P = 0.032), but not with plasma glucose, triglycerides, HDL cholesterol, or disease duration. Triglycerides 186-199 fibrinogen beta chain Homo sapiens 0-10