PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23952905-7 2013 Although acetylated TDG has reduced glycosylase activity towards T/G, 5-formylcytosine/G and 5-carboxylcytosine/G, it has a stronger activity towards a 5-fluorouracil/G substrate as compared with unmodified TDG. 5-carboxylcytosine 93-111 thymine DNA glycosylase Homo sapiens 20-23 23952905-8 2013 SIRT1 weakly stimulates acetylated hTDG activity towards T/G, 5-formylcytosine/G and 5-carboxylcytosine/G as compared with control hTDG. 5-carboxylcytosine 85-103 thymine DNA glycosylase Homo sapiens 35-39 24063363-2 2013 Active DNA demethylation involves stepwise oxidation of mC to 5-hydroxymethylcytosine, 5-formylcytosine (fC), and potentially 5-carboxylcytosine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration of cytosine via follow-on base excision repair. 5-carboxylcytosine 126-144 thymine DNA glycosylase Homo sapiens 202-205 23680598-0 2013 Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. 5-carboxylcytosine 82-100 thymine DNA glycosylase Homo sapiens 40-63 23680598-1 2013 The mammalian thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5caC) when paired with a guanine in a CpG sequence, in addition to mismatched bases. 5-carboxylcytosine 52-70 thymine DNA glycosylase Homo sapiens 14-37 23680598-1 2013 The mammalian thymine DNA glycosylase (TDG) excises 5-carboxylcytosine (5caC) when paired with a guanine in a CpG sequence, in addition to mismatched bases. 5-carboxylcytosine 52-70 thymine DNA glycosylase Homo sapiens 39-42 23337108-0 2013 Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. 5-carboxylcytosine 22-40 thymine DNA glycosylase Homo sapiens 46-69 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-carboxylcytosine 168-186 thymine DNA glycosylase Homo sapiens 14-37 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-carboxylcytosine 168-186 thymine DNA glycosylase Homo sapiens 39-42 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-carboxylcytosine 188-192 thymine DNA glycosylase Homo sapiens 14-37 23337108-1 2013 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uracil, thymine or 5-hydroxymethyluracil (5hmU), as well as removes 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) when paired with a guanine. 5-carboxylcytosine 188-192 thymine DNA glycosylase Homo sapiens 39-42 22962365-0 2012 Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation. 5-carboxylcytosine 38-56 thymine DNA glycosylase Homo sapiens 64-87 22962365-4 2012 In addition, TDG excises the Tet protein products 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) but not 5hmC and 5mC, when paired with a guanine. 5-carboxylcytosine 77-95 thymine DNA glycosylase Homo sapiens 13-16 29660017-1 2018 Thymine DNA glycosylase (TDG) excises thymine from mutagenic G T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5-formylcytosine (fC) and 5-carboxylcytosine (caC), in a multistep pathway for DNA demethylation. 5-carboxylcytosine 185-203 thymine DNA glycosylase Homo sapiens 0-23 32728616-5 2020 Thymine DNA glycosylase (TDG), a DNA demethylase, was transactivated by c-Myc upon insulin treatment, thereby decreasing 5-carboxylcytosine (5caC) abundance in the SREBP1 promoter. 5-carboxylcytosine 121-139 thymine DNA glycosylase Homo sapiens 0-23 32728616-5 2020 Thymine DNA glycosylase (TDG), a DNA demethylase, was transactivated by c-Myc upon insulin treatment, thereby decreasing 5-carboxylcytosine (5caC) abundance in the SREBP1 promoter. 5-carboxylcytosine 121-139 thymine DNA glycosylase Homo sapiens 25-28 31489163-0 2019 Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine. 5-carboxylcytosine 108-126 thymine DNA glycosylase Homo sapiens 0-23 22711938-1 2012 As an important step of the active demethylation of 5-methylcytosine (5mC), human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC) from double-stranded DNA (dsDNA). 5-carboxylcytosine 133-151 thymine DNA glycosylase Homo sapiens 82-105 22711938-1 2012 As an important step of the active demethylation of 5-methylcytosine (5mC), human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC) from double-stranded DNA (dsDNA). 5-carboxylcytosine 133-151 thymine DNA glycosylase Homo sapiens 107-111 22573813-3 2012 TDG also removes 5-formylcytosine and 5-carboxylcytosine, oxidized forms of mC produced by Tet enzymes. 5-carboxylcytosine 38-56 thymine DNA glycosylase Homo sapiens 0-3 22327402-1 2012 Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in genomic DNA, in a recently discovered cytosine demethylation pathway. 5-carboxylcytosine 57-75 thymine DNA glycosylase Homo sapiens 31-35 21862836-0 2011 Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites. 5-carboxylcytosine 64-82 thymine DNA glycosylase Homo sapiens 0-23 21817016-0 2011 Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. 5-carboxylcytosine 26-44 thymine DNA glycosylase Homo sapiens 65-68 31693361-0 2019 Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase. 5-carboxylcytosine 12-30 thymine DNA glycosylase Homo sapiens 34-57 29660017-1 2018 Thymine DNA glycosylase (TDG) excises thymine from mutagenic G T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5-formylcytosine (fC) and 5-carboxylcytosine (caC), in a multistep pathway for DNA demethylation. 5-carboxylcytosine 185-203 thymine DNA glycosylase Homo sapiens 25-28 29660017-1 2018 Thymine DNA glycosylase (TDG) excises thymine from mutagenic G T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5-formylcytosine (fC) and 5-carboxylcytosine (caC), in a multistep pathway for DNA demethylation. 5-carboxylcytosine 205-208 thymine DNA glycosylase Homo sapiens 0-23 29660017-1 2018 Thymine DNA glycosylase (TDG) excises thymine from mutagenic G T mispairs generated by deamination of 5-methylcytosine (mC) and it removes two mC derivatives, 5-formylcytosine (fC) and 5-carboxylcytosine (caC), in a multistep pathway for DNA demethylation. 5-carboxylcytosine 205-208 thymine DNA glycosylase Homo sapiens 25-28 28555658-1 2017 In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), followed by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision repair. 5-carboxylcytosine 230-248 thymine DNA glycosylase Homo sapiens 303-326 28555658-1 2017 In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), followed by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision repair. 5-carboxylcytosine 230-248 thymine DNA glycosylase Homo sapiens 328-331 28827588-0 2017 Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision. 5-carboxylcytosine 96-114 thymine DNA glycosylase Homo sapiens 70-73 28827588-2 2017 The robust glycosylase activity of TDG on DNA substrates containing 5-formylcytosine (5fC) or 5-carboxylcytosine (5caC) is universally accepted, but the mode of action of NEIL1 is still debated. 5-carboxylcytosine 94-112 thymine DNA glycosylase Homo sapiens 35-38 26358812-3 2015 In DNA demethylation, TDG excises 5-formylcytosine (fC) and 5-carboxylcytosine (caC), which are generated from mC by Tet (ten-eleven translocation) enzymes. 5-carboxylcytosine 60-78 thymine DNA glycosylase Homo sapiens 22-25 27580719-3 2016 Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-carboxylcytosine, derivatives of mC generated by Tet (ten-eleven translocation) enzymes. 5-carboxylcytosine 66-84 thymine DNA glycosylase Homo sapiens 33-36 27587280-5 2016 In fact, TETs catalyze the stepwise oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), driving the DNA demethylation process based on thymine DNA glycosylase (TDG)-mediated DNA repair pathway. 5-carboxylcytosine 115-133 thymine DNA glycosylase Homo sapiens 189-212 27587280-5 2016 In fact, TETs catalyze the stepwise oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), driving the DNA demethylation process based on thymine DNA glycosylase (TDG)-mediated DNA repair pathway. 5-carboxylcytosine 115-133 thymine DNA glycosylase Homo sapiens 214-217 27805810-2 2016 Performing a critical step in a pathway for active DNA demethylation, TDG removes 5-formylcytosine and 5-carboxylcytosine, oxidized derivatives of 5-methylcytosine that are generated by TET (ten-eleven translocation) enzymes. 5-carboxylcytosine 103-121 thymine DNA glycosylase Homo sapiens 70-73 26917720-4 2016 We have developed an in vivo assay for TDG activity that takes advantage of its recently discovered role in DNA demethylation and selective recognition and repair of 5-carboxylcytosine. 5-carboxylcytosine 166-184 thymine DNA glycosylase Homo sapiens 39-42 26358812-3 2015 In DNA demethylation, TDG excises 5-formylcytosine (fC) and 5-carboxylcytosine (caC), which are generated from mC by Tet (ten-eleven translocation) enzymes. 5-carboxylcytosine 80-83 thymine DNA glycosylase Homo sapiens 22-25 25845601-3 2015 Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA glycosylase (TDG) which has recently been shown to excise 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) generated in Ten-eleven-translocation (Tet)-initiated oxidative demethylation. 5-carboxylcytosine 173-191 thymine DNA glycosylase Homo sapiens 76-99 25845601-3 2015 Here, we demonstrate that Gadd45a promotes active DNA demethylation through thymine DNA glycosylase (TDG) which has recently been shown to excise 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) generated in Ten-eleven-translocation (Tet)-initiated oxidative demethylation. 5-carboxylcytosine 173-191 thymine DNA glycosylase Homo sapiens 101-104 27493500-3 2014 In addition, TDG excises 5mC oxidized bases i.e. when X is 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) not 5-hydroxymethylcytosine (5hmC). 5-carboxylcytosine 87-105 thymine DNA glycosylase Homo sapiens 13-16