PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33117724-0 2020 The Shigella Type III Secretion Effector IpaH4.5 Targets NLRP3 to Activate Inflammasome Signaling. ipah4 41-46 NLR family pyrin domain containing 3 Homo sapiens 57-62 33117724-3 2020 Here, we demonstrate that IpaH4.5, a Shigella T3SS effector, triggers inflammasome activation by regulating NLRP3 expression through the E3 ubiquitin ligase activity of IpaH4.5. ipah4 26-31 NLR family pyrin domain containing 3 Homo sapiens 108-113 33117724-3 2020 Here, we demonstrate that IpaH4.5, a Shigella T3SS effector, triggers inflammasome activation by regulating NLRP3 expression through the E3 ubiquitin ligase activity of IpaH4.5. ipah4 169-174 NLR family pyrin domain containing 3 Homo sapiens 108-113 33117724-4 2020 First, we found that IpaH4.5 interacted with NLRP3. ipah4 21-26 NLR family pyrin domain containing 3 Homo sapiens 45-50 33117724-5 2020 As a result, IpaH4.5 modulated NLRP3 protein stability and inflammasome activation. ipah4 13-18 NLR family pyrin domain containing 3 Homo sapiens 31-36