PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12665390-6 2003 Atypical antipsychotics are metabolised predominantly by cytochrome p450 (CYP) isoenzymes, particularly CYP1A2 (clozapine and olanzapine), CYP3A4 (clozapine, quetiapine and ziprasidone) and CYP2D6 (olanzapine and risperidone). ziprasidone 173-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-72 12665390-6 2003 Atypical antipsychotics are metabolised predominantly by cytochrome p450 (CYP) isoenzymes, particularly CYP1A2 (clozapine and olanzapine), CYP3A4 (clozapine, quetiapine and ziprasidone) and CYP2D6 (olanzapine and risperidone). ziprasidone 173-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-77 10771452-13 2000 CONCLUSIONS: Ziprasidone is predominantly metabolized by CYP3A4 in human liver microsomes and is not expected to mediate drug interactions with coadministered CYP substrates, at clinically effective doses. ziprasidone 13-24 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-60 10771452-0 2000 Identification of the major human liver cytochrome P450 isoform(s) responsible for the formation of the primary metabolites of ziprasidone and prediction of possible drug interactions. ziprasidone 127-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. ziprasidone 114-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 22-37 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. ziprasidone 114-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-42 10771452-1 2000 AIMS: To identify the cytochrome P450 (CYP) isoform(s) responsible for the formation of the primary metabolite of ziprasidone (ziprasidone sulphoxide), to determine the kinetics of its formation and to predict possible drug interactions by investigating CYP isoform inhibition in an in vitro study. ziprasidone 114-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 254-257