PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17270371-5	2007	Caco-2 cells were treated with methanol extracts from two Curcuma rhizomes (0.1mg/ml) or curcumin (30 microM) for 72 h. Both extracts significantly decreased the activity of CYP3A4 by about 85-98%.	Methanol	31-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	174-180	
20937259-4	2010	Our initial results showed that methanol, ethanol, isopropanol, isobutanol, and isoamyl alcohol bind in the active site of CYP3A4 and exhibit type I spectra.	Methanol	32-40	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	123-129	
19451401-6	2009	The comparatively higher inhibitory effects of DMSO relative to that for acetonitrile and methanol on LIPA metabolism were consistent with its known CYP3A4 inhibitory effects reported by others.	Methanol	90-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155	
19905875-2	2010	The inactivation kinetics of CYP3A4 by diazepam dissolved in acetonitrile and methanol were almost equal with k(inact)/K(I) values, 0.095 and 0.15 min(-1) mM(-1) for HLM and 1.1 and 1.4 min(-1) mM(-1) for rCYP3A4, respectively.	Methanol	78-86	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35	
34842392-6	2021	In BeWo cells, all concentrations of PI-MeOH induced <i>CYP2E1</i>, 100 and 500 mug Ml<sup>1</sup> PI-MeOH and PI-EtOH up-regulated <i>CYP1A2</i>, <i>CYP3A4 </i>and <i>ABCG2 </i>and 500 mug mL<sup>1</sup> PI-EtOH induced <i>ABCG2</i> expression.	Methanol	102-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	150-156	
16360935-2	2006	The MeOH-soluble fractions of 25 samples, prepared from water extracts, demonstrated inhibitory activity more than 50% on the metabolism mediated by CYP3A4, and 21 samples on the metabolism mediated by CYP2D6.	Methanol	4-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155	
30981185-11	2019	RESULTS: Passively diffused constituents of the methanol acai extract (IC50 of 28.03 microg/microl) demonstrated the highest inhibition potential, and, at 1.5 microg/microl, induced significant changes in CYP3A4 gene expression.	Methanol	48-56	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	205-211	
30981185-15	2019	CONCLUSION: The passively absorbable portion of a methanol acai extract exhibited inhibition and induction effects on CYP3A4 suggesting the potential to produce botanical-drug interactions.	Methanol	50-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124	
30955332-4	2019	The MeOH extract exhibited significant inhibition of the major human CYP450 isozymes (CYP3A4, CYP1A2, CYP2D6, CYP2C9, and CYP2C19).	Methanol	4-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92	
25600201-7	2015	The results showed significant time-dependent inhibition of tested samples on CYP3A4 with crude methanol (39KC), fractions 45A, 45B and 45D given IC50 fold decrease of 3.29, 2.26, 1.91 and 1.49, respective.	Methanol	96-104	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	78-84	
25600201-11	2015	At least one phytoconstituent in the crude methanol extract of Kalanchoe crenata is a reversible and time-dependent inhibitor of CYP3A4.	Methanol	43-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	129-135