PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30242672-11	2018	The production of ROS, caspase-3 activity and depolarized MMP were quite significant in MDA-MB-231 cell line treated with methanol and ethyl acetate extracts.	Methanol	122-130	caspase 3	Homo sapiens	23-32	
26855733-11	2016	Caspase assay and RT-PCR analysis revealed that brittle star methanol extract induced caspase dependent apoptosis in HeLa cells through up-regulation of caspase-3 followed by up-regulation of Bax gene which is a hallmark of intrinsic pathway recruitment.	Methanol	61-69	caspase 3	Homo sapiens	153-162	
15588681-11	2005	Thus, the results from this study strongly suggest that the methanol extract of Pereskia bleo may contain bioactive compound(s) that caused breast carcinoma, T-47D cell death by apoptosis mechanism via the activation of caspase-3 and c-myc pathways.	Methanol	60-68	caspase 3	Homo sapiens	220-229	
11231926-7	2001	Ethanol, methanol, isopropanol, tert-butanol, and red wine all potentiated oxysterol-induced cell death up to 5-fold, paralleled by further induction of caspase-3.	Methanol	9-17	caspase 3	Homo sapiens	153-162	
31031969-13	2019	However, methanol crude extract has high efficacy to induce apoptosis through caspase-3 activation compared to the other extracts.	Methanol	9-17	caspase 3	Homo sapiens	78-87	
29800742-8	2018	RESULTS: The MeOH extract of I. obliquus reduced cell viability in all lung cancer cell lines tested through induction of apoptosis accompanied by caspase-3 cleavage.	Methanol	13-17	caspase 3	Homo sapiens	147-156	
30008816-9	2018	Alkaloid and carbinol extracts enhanced caspase-3, and Fas expression, but reduced FasL expression in SGC-7901 cells.	Methanol	13-21	caspase 3	Homo sapiens	40-49