PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26690417-5 2015 The phenolic-rich methanol fraction of seed shell (SM) reduced nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Methanol 18-26 nitric oxide synthase 2, inducible Mus musculus 97-128 34684679-6 2021 MeOH extract, EtOAc fraction, and 1-3 suppressed NO formation in LPS-stimulated RAW 264.7 cells and decreased iNOS and COX-2 expression. Methanol 0-4 nitric oxide synthase 2, inducible Mus musculus 110-114 28726396-4 2017 Surprisingly, the EtOAc fraction of MeOH extracts from native Korean plant species Sasa coreana Nakai (SCN) has shown potent anti-inflammatory properties; SCN pretreatment inhibited nitric oxide (NO) production (p < 0.01) and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated macrophages. Methanol 36-40 nitric oxide synthase 2, inducible Mus musculus 229-260 28726396-4 2017 Surprisingly, the EtOAc fraction of MeOH extracts from native Korean plant species Sasa coreana Nakai (SCN) has shown potent anti-inflammatory properties; SCN pretreatment inhibited nitric oxide (NO) production (p < 0.01) and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated macrophages. Methanol 36-40 nitric oxide synthase 2, inducible Mus musculus 262-266 28487900-7 2016 MATERIALS AND METHODS: In this study, the anti-inflammatory effects of the ethyl acetate fraction of the methanol extract of FF (FFE) were assessed by measuring NO and PGE2 production by and intracellular ROS and protein levels of iNOS and COX-2 in RAW 264.7 cells. Methanol 105-113 nitric oxide synthase 2, inducible Mus musculus 231-235 22991570-8 2012 Additionally, CR(MeOH) also decreased IL-1beta, IL-6, NFkappaB, TNF-alpha, COX-2, and iNOS levels. Methanol 17-21 nitric oxide synthase 2, inducible Mus musculus 86-90 24534870-4 2014 A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 (PGE2) and of two proteins regulated by these, interleukin-1beta (IL-1beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Methanol 16-24 nitric oxide synthase 2, inducible Mus musculus 67-88 24534870-4 2014 A non-cytotoxic methanol extract of AT inhibited the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to significantly reduced levels of nitric oxide (NO) and prostaglandin E2 (PGE2) and of two proteins regulated by these, interleukin-1beta (IL-1beta) and IL-6, in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. Methanol 16-24 nitric oxide synthase 2, inducible Mus musculus 90-94 23631356-5 2013 RESULTS: The results indicate that (50, 100 mug/mL) methanol and ethyl acetate fractionation extracts of PY not only inhibited LPS-mediated NO production and iNOS expression, but also decreased LPS-induced PGE2 production and COX-2 expression. Methanol 52-60 nitric oxide synthase 2, inducible Mus musculus 158-162 24250718-2 2013 This study investigated the effects of methanol extracts of A. apiacea Hance (MEAH) on the induction of inducible nitric oxide synthase (iNOS) and proinflammatory mediators by lipopolysaccharide (LPS) in Raw264.7 macrophage cells and also evaluated the in vivo effect of MEAH on carrageenan-induced paw edema in rats. Methanol 39-47 nitric oxide synthase 2, inducible Mus musculus 137-141 24009873-0 2013 A Methanol Extract of Adansonia digitata L. Leaves Inhibits Pro-Inflammatory iNOS Possibly via the Inhibition of NF-kappaB Activation. Methanol 2-10 nitric oxide synthase 2, inducible Mus musculus 77-81 23110456-8 2012 RESULTS: CJ methanol extract reduced NO release via iNOS protein inhibition. Methanol 12-20 nitric oxide synthase 2, inducible Mus musculus 52-56 17646715-0 2007 Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-kappaB transactivation in LPS-activated RAW 264.7 cells. Methanol 0-8 nitric oxide synthase 2, inducible Mus musculus 76-107 17499198-0 2007 Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. Methanol 98-106 nitric oxide synthase 2, inducible Mus musculus 48-52 17646715-0 2007 Methanol extracts of Stewartia koreana inhibit cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) gene expression by blocking NF-kappaB transactivation in LPS-activated RAW 264.7 cells. Methanol 0-8 nitric oxide synthase 2, inducible Mus musculus 109-113 17292351-1 2007 The methanol (50%) extract of the whole plant was observed to inhibit the expression of inducible nitric oxide synthase (iNOS) and the cycloxygenase-2 (COX-2) gene in lipopolysaccharide (LPS)-induced macrophage cells (J774A.1, [Raghav, S.K., Gupta, B., Agrawal, C., Goswami, K., Das, H.R., 2006b. Methanol 4-12 nitric oxide synthase 2, inducible Mus musculus 88-119 17292351-1 2007 The methanol (50%) extract of the whole plant was observed to inhibit the expression of inducible nitric oxide synthase (iNOS) and the cycloxygenase-2 (COX-2) gene in lipopolysaccharide (LPS)-induced macrophage cells (J774A.1, [Raghav, S.K., Gupta, B., Agrawal, C., Goswami, K., Das, H.R., 2006b. Methanol 4-12 nitric oxide synthase 2, inducible Mus musculus 121-125 16644126-5 2006 U. conglobata methanol extract treatments were also examined and it was found that they almost completely suppressed the expression of the proinflammatory enzyme cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS). Methanol 14-22 nitric oxide synthase 2, inducible Mus musculus 191-222 15551374-0 2004 Suppressive effect of inducible nitric oxide synthase (iNOS) expression by the methanol extract of Actinodaphne lancifolia. Methanol 79-87 nitric oxide synthase 2, inducible Mus musculus 22-53 15635170-8 2005 Thus, our study suggests that the inhibitions of iNOS, COX-2 expression, and TNF-alpha release by the methanol extract of the semen of Xanthium strumarium L. are achieved by blocking NF-kappaB activation, and that this is also responsible for its anti-inflammatory effects. Methanol 102-110 nitric oxide synthase 2, inducible Mus musculus 49-53 15452455-0 2004 Suppressive effects of nitric oxide production and inducible nitric oxide synthase (iNOS) gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells. Methanol 131-139 nitric oxide synthase 2, inducible Mus musculus 84-88 15452455-2 2004 In this study, to procure the iNOS inhibitors from natural products, we evaluated 57 methanol extracts of natural products including Korean indigenous plants for the inhibition of NO formation on lipopolysaccharide (LPS)-activated mouse macrophage-like RAW 264.7 cells. Methanol 85-93 nitric oxide synthase 2, inducible Mus musculus 30-34 15551374-0 2004 Suppressive effect of inducible nitric oxide synthase (iNOS) expression by the methanol extract of Actinodaphne lancifolia. Methanol 79-87 nitric oxide synthase 2, inducible Mus musculus 55-59 11811897-6 2001 The bioassay-directed analysis of flavonols 1-3 indicated that kaempferol (3) was the most active compound contained in the MeOH extract because it reduced in vitro both NO production and iNOS expression in LPS-primed J774.A1 cells, whereas rutin (1) and kaempferol 3-O-rutinoside (2) showed no significant activity. Methanol 124-128 nitric oxide synthase 2, inducible Mus musculus 188-192 12673029-4 2003 Consistent with these observations, the protein and mRNA expression level of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was inhibited by MeOH extracts of the aerial part of S. chinensis (SCM) in a dose-dependent manner. Methanol 150-154 nitric oxide synthase 2, inducible Mus musculus 100-104 10624880-5 1999 The generation of NO as well as the expression of inducible nitric oxide synthase (iNOS) protein from IFN-gamma primed RAW 264.7 cells is markedly decreased by the methanol extract in a dose dependent manner. Methanol 164-172 nitric oxide synthase 2, inducible Mus musculus 50-81 10624880-5 1999 The generation of NO as well as the expression of inducible nitric oxide synthase (iNOS) protein from IFN-gamma primed RAW 264.7 cells is markedly decreased by the methanol extract in a dose dependent manner. Methanol 164-172 nitric oxide synthase 2, inducible Mus musculus 83-87 10946831-8 2000 The MeOH extract showed marked inhibition of NO production by activated RAW 264.7 cells in a dose-dependent manner via suppression of inducible NO synthase mRNA expression. Methanol 4-8 nitric oxide synthase 2, inducible Mus musculus 134-155