PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7128475-2 1982 Chloramphenicol, an inhibitor of cytochrome P-450, blocked the increase of serum glutamate-oxaloacetate transaminase activity enhanced by methanol pretreatment of rats exposed to CCl4. Methanol 138-146 C-C motif chemokine ligand 4 Rattus norvegicus 179-183 1812278-4 1991 As previously reported, the methanol extract from the bark of AN and the fractions of the methanol extract have protective effects for liver injury induced by carbon tetrachloride (CCl4) in rats. Methanol 28-36 C-C motif chemokine ligand 4 Rattus norvegicus 181-185 1812278-4 1991 As previously reported, the methanol extract from the bark of AN and the fractions of the methanol extract have protective effects for liver injury induced by carbon tetrachloride (CCl4) in rats. Methanol 90-98 C-C motif chemokine ligand 4 Rattus norvegicus 181-185 1812278-6 1991 The active principles for the protection of CCl4-induced liver injury were recognized in a fraction (EF 3-3) obtained by using silica gel chromatography (solvent: CHCl3-MeOH-H2O). Methanol 169-173 C-C motif chemokine ligand 4 Rattus norvegicus 44-48 7128475-0 1982 Modification of methanol potentiation of CCl4 toxicity in rats by chloramphenicol and salicylate. Methanol 16-24 C-C motif chemokine ligand 4 Rattus norvegicus 41-45 7128475-1 1982 The mechanisms by which methanol potentiates CCl4 hepatotoxicity was studied in rats. Methanol 24-32 C-C motif chemokine ligand 4 Rattus norvegicus 45-49 2074541-3 1990 Among them methanol extracts of Caryophylli Flos, Angelicae Dahuricae Radix, Polygoni Avicularis Herba, Myricae Cortex and Forsythiae Fructus were newly found to have protective effects against acute hepatic injury induced by CCl4. Methanol 11-19 C-C motif chemokine ligand 4 Rattus norvegicus 226-230 7128475-5 1982 Sodium salicylate, which lowers the level of NADPH in the hepatocyte, blocked methanol potentiation of CCl4 damage as measured by the elevation of serum GOT activity. Methanol 78-86 C-C motif chemokine ligand 4 Rattus norvegicus 103-107 7128475-6 1982 Therefore, methanol may potentiate CCl4 hepatotoxicity by stimulation of CCl4 bioactivation by cytochrome P-450 via an increase in the level of reduced NAD(P)H in the liver. Methanol 11-19 C-C motif chemokine ligand 4 Rattus norvegicus 35-39 7128475-6 1982 Therefore, methanol may potentiate CCl4 hepatotoxicity by stimulation of CCl4 bioactivation by cytochrome P-450 via an increase in the level of reduced NAD(P)H in the liver. Methanol 11-19 C-C motif chemokine ligand 4 Rattus norvegicus 73-77 31847463-3 2019 In this work, in vivo and in silico studies were conducted to evaluate their methanol extracts potential to alleviate liver damage in CCl4-intoxicated rats, in addition to their antioxidant activity and identifying the molecular mechanisms of their phenolic constituents. Methanol 77-85 C-C motif chemokine ligand 4 Rattus norvegicus 134-138 31068038-0 2019 Methanol extract of Muntingia calabura leaves attenuates CCl4-induced liver injury: possible synergistic action of flavonoids and volatile bioactive compounds on endogenous defence system. Methanol 0-8 C-C motif chemokine ligand 4 Rattus norvegicus 57-61 31068038-2 2019 OBJECTIVE: This study investigates the effect of methanol extract of M. calabura leaves (MMCL) on hepatic antioxidant and anti-inflammatory activities in CCl4-induced hepatotoxic rat. Methanol 49-57 C-C motif chemokine ligand 4 Rattus norvegicus 154-158 30021348-9 2018 The altered levels of various parameters provoked by CCl4 toxicity restored towards the control level by the methanol extract of P. hydaspidis in a dose dependent manner. Methanol 109-117 C-C motif chemokine ligand 4 Rattus norvegicus 53-57 31397186-1 2021 The present study aimed to investigate the preventive effects of methanol fraction from Cassia angustifolia leaf extract (MECA), associated with its phytochemical content, on CCl4-induced hepatic toxicity in adult rats. Methanol 65-73 C-C motif chemokine ligand 4 Rattus norvegicus 175-179 34055308-0 2019 Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats. Methanol 0-8 C-C motif chemokine ligand 4 Rattus norvegicus 48-52 34055308-1 2019 We have investigated the protective potential of methanol extract of Iphiona aucheri (IAM) on the expression of endoplasmic reticulum (ER) stress associated genes and inflammatory genes on carbon tetrachloride (CCl4) induced hepatic toxicity in rats. Methanol 49-57 C-C motif chemokine ligand 4 Rattus norvegicus 211-215 30643530-6 2018 CCl4-treated rats that were given 250 or 500 mg/kg of the methanol extract of E. Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma-glutamyl transferase, and bilirubin levels than those of the CCl4 positive group. Methanol 58-66 C-C motif chemokine ligand 4 Rattus norvegicus 0-4 30643530-6 2018 CCl4-treated rats that were given 250 or 500 mg/kg of the methanol extract of E. Japonica leaves, or its ethyl acetate, butanol, or aqueous fractions, had significantly lower levels of biochemical parameters such as alanine aminotransferase, aspartate transaminase, alkaline phosphate, total protein, gamma-glutamyl transferase, and bilirubin levels than those of the CCl4 positive group. Methanol 58-66 C-C motif chemokine ligand 4 Rattus norvegicus 368-372 27233360-2 2016 This study aimed at scrutinizing the nephroprotective prospective of A. scoparia methanol extract against carbon tetrachloride (CCl4) provoked DNA damages and oxidative stress in kidneys of rat. Methanol 81-89 C-C motif chemokine ligand 4 Rattus norvegicus 128-132 27530158-4 2016 We have evaluated the protective potential of the methanol extract of M. buxifolia (MBM) in rat exposed to carbon tetrachloride (CCl4) toxicity. Methanol 50-58 C-C motif chemokine ligand 4 Rattus norvegicus 129-133 27351070-2 2016 The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats. Methanol 82-90 C-C motif chemokine ligand 4 Rattus norvegicus 140-144 27471465-9 2016 RD leaf and bark methanol extracts pre-treatment exhibited protection against CCl4 induced hepatotoxicity by reversing all the abnormal parameters to significant levels. Methanol 17-25 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 26428528-7 2016 DISCUSSION AND CONCLUSION: Crataegus songarica methanol extract has a potential antioxidant effect as it protects the kidney and heart tissue against CCl4-induced toxicity, prevents DNA damage and showed strong anticancer activity. Methanol 47-55 C-C motif chemokine ligand 4 Rattus norvegicus 150-154 28649059-2 2017 The aim of this study was to evaluate the potential protective effects of methanol extract of R. sativus seeds (RSME) against hypogonadism induced with carbon tetrachloride (CCl4) in Sprague-Dawley male rats. Methanol 74-82 C-C motif chemokine ligand 4 Rattus norvegicus 174-178 27824613-2 2017 In this study, the protective effect of methanol extract of NL against carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats was investigated. Methanol 40-48 C-C motif chemokine ligand 4 Rattus norvegicus 93-97 27776508-5 2016 In this investigation we have evaluated the methanol extract of leaves for its hepatoprotective potential against CCl4 induced hepatic injuries in rat. Methanol 44-52 C-C motif chemokine ligand 4 Rattus norvegicus 114-118 25702903-0 2015 Ameliorative effect of methanol extract of Rumex vesicarius on CCl4-induced liver damage in Wistar albino rats. Methanol 23-31 C-C motif chemokine ligand 4 Rattus norvegicus 63-67 21506498-2 2010 Aim of the study was to investigate the methanol and aqueous extracts of heartwood of C. sappan for its hepatoprotective activity against CCl4 induced toxicity in freshly isolated rat hepatocytes and animals. Methanol 40-48 C-C motif chemokine ligand 4 Rattus norvegicus 138-142 25243876-2 2015 OBJECTIVE: The current research investigated the protective effect of the methanol extract of N. biserrata leaves against carbon tetrachloride (CCl4)-induced hepatic damage in rats. Methanol 74-82 C-C motif chemokine ligand 4 Rattus norvegicus 144-148 23413565-6 2012 The administered methanol extracts with the highest antioxidant potential showed a significant dose-dependent hepatoprotective action against CCl4-induced liver damage in both decreasing the levels of liver transaminases and bilirubin and in reducing the extent of morphological malformations of the liver. Methanol 17-25 C-C motif chemokine ligand 4 Rattus norvegicus 142-146 21121258-3 2010 This paper describes the hepatoprotective effects of the methanol extract and four isolated compounds from Ficus chlamydocarpa on CCl4-induced liver damage, as well as the possible antioxidant mechanisms involved in this protection. Methanol 57-65 C-C motif chemokine ligand 4 Rattus norvegicus 130-134 24708543-2 2014 The aim of the present study was to determine the hepatoprotective effect of methanol extracts of D. linearis (MEDL) against carbon tetrachloride (CCl4)-induced acute liver injury in rats. Methanol 77-85 C-C motif chemokine ligand 4 Rattus norvegicus 147-151 22776436-2 2012 In this study, the hepatoprotective effects of the methanol extract of SAME was evaluated against carbon tetrachloride (CCl4)-induced liver injuries in rats. Methanol 51-59 C-C motif chemokine ligand 4 Rattus norvegicus 120-124 21699742-0 2011 Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat. Methanol 28-36 C-C motif chemokine ligand 4 Rattus norvegicus 72-76 7563218-2 1995 Because oral exposure to MeOH potentiates the hepatotoxicity of carbon tetrachloride (CCl4), we examined the ability of inhaled MeOH to potentiate CCl4 hepatotoxicity and the time course of injury and recovery. Methanol 128-132 C-C motif chemokine ligand 4 Rattus norvegicus 147-151 16121714-6 2005 The results revealed that methanol leaf extract followed by aqueous extract of L. hirta could afford significant protection against CCl4 induced hepatocellular injury. Methanol 26-34 C-C motif chemokine ligand 4 Rattus norvegicus 132-136 9145214-4 1997 The methanol extract showed significant hepatoprotective activity against CCl4-toxicity in rats and D-galactosamine (D-GalN)/lipopolysaccharide-induced liver injury in mice. Methanol 4-12 C-C motif chemokine ligand 4 Rattus norvegicus 74-78 9145214-5 1997 The methanol extract also significantly protected against CCl4-toxicity in primary cultured rat hepatocytes. Methanol 4-12 C-C motif chemokine ligand 4 Rattus norvegicus 58-62 8887440-1 1996 A single 6-hr exposure to inhaled methanol (MeOH) has been shown to enhance carbon tetrachloride (CCl4) hepatotoxicity. Methanol 34-42 C-C motif chemokine ligand 4 Rattus norvegicus 98-102 8887440-1 1996 A single 6-hr exposure to inhaled methanol (MeOH) has been shown to enhance carbon tetrachloride (CCl4) hepatotoxicity. Methanol 44-48 C-C motif chemokine ligand 4 Rattus norvegicus 98-102 8887440-2 1996 The objective of the present study was to use gas uptake data and the development of a physiologically based pharmacokinetic model (PBPK) to determine in vivo changes in CCl4 metabolism resulting from MeOH pretreatment. Methanol 201-205 C-C motif chemokine ligand 4 Rattus norvegicus 170-174 8887440-10 1996 Both serum markers of hepatotoxicity in the 24-hr MeOH + CCl4 group increased as a function of CCl4 concentration when compared with 0 ppm CCl4 controls. Methanol 50-54 C-C motif chemokine ligand 4 Rattus norvegicus 95-99 8887440-10 1996 Both serum markers of hepatotoxicity in the 24-hr MeOH + CCl4 group increased as a function of CCl4 concentration when compared with 0 ppm CCl4 controls. Methanol 50-54 C-C motif chemokine ligand 4 Rattus norvegicus 95-99 8887440-12 1996 At 100, 250, and 1000 ppm CCl4, ALT and SDH values for the 24-hr MeOH + CCl4 groups were significantly increased relative to control (0 ppm CCl4), CCl4 alone, and 48-hr MeOH + CCl4. Methanol 65-69 C-C motif chemokine ligand 4 Rattus norvegicus 26-30 8814342-1 1996 Evidence to explain the enhanced hepatotoxicity of carbon tetrachloride (CCl4) following methanol exposure by inhalation is presented. Methanol 89-97 C-C motif chemokine ligand 4 Rattus norvegicus 73-77 8814342-4 1996 In vitro metabolism of CCl4 was also increased in microsomes from methanol-treated animals. Methanol 66-74 C-C motif chemokine ligand 4 Rattus norvegicus 23-27 8814342-6 1996 This study shows that methanol exposure induces cytochrome P450 2E1, which appears to be the principal toxicokinetic mechanism responsible for the increased metabolism and thus the increased hepatotoxicity of CCl4. Methanol 22-30 C-C motif chemokine ligand 4 Rattus norvegicus 209-213 11999134-1 2002 This study was carried out to investigate the antifibrotic effects of methanol extracts from the traditional Chinese medicinal herb, the root of Scutellaria baicalensis Georgi, on liver fibrosis induced by bile duct ligation and scission (BDL) or carbon tetrachloride (CCl4) in rats. Methanol 70-78 C-C motif chemokine ligand 4 Rattus norvegicus 269-273 11999134-7 2002 A methanol extract of S. baicalensis root inhibits fibrosis and lipid peroxidation in rat liver induced by BDL or CCl4. Methanol 2-10 C-C motif chemokine ligand 4 Rattus norvegicus 114-118 7563218-8 1995 MeOH+CCl4 resulted in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) that were increased, relative to CCl4 alone, 171- and 113-fold, respectively, on d 1, and 166- and 140-fold, respectively, on d 1.5. Methanol 0-4 C-C motif chemokine ligand 4 Rattus norvegicus 139-143 7563218-13 1995 These data demonstrate that inhaled MeOH potentiates the hepatotoxicity of orally ingested CCl4, increasing the severity of CCl4 hepatotoxicity as well as the time required for recovery. Methanol 36-40 C-C motif chemokine ligand 4 Rattus norvegicus 91-95 7563218-13 1995 These data demonstrate that inhaled MeOH potentiates the hepatotoxicity of orally ingested CCl4, increasing the severity of CCl4 hepatotoxicity as well as the time required for recovery. Methanol 36-40 C-C motif chemokine ligand 4 Rattus norvegicus 124-128 8301540-2 1993 The methanol extracts of Elephantopi Herba and Lonicerae Flos inhibited the release of intrahepatic enzymes and histological changes by CCl4. Methanol 4-12 C-C motif chemokine ligand 4 Rattus norvegicus 136-140