PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14595107-1	2004	The Saccharomyces cerevisiae high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway is required for osmoadaptation and contains two branches that activate a mitogen-activated protein kinase (Hog1) via a mitogen-activated protein kinase kinase (Pbs2).	Glycerol	45-53	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	261-265	
16765917-5	2006	In yeast external high osmolarity activates HOG (high osmolarity glycerol) MAPK pathway that consists of MAPKKK (Ste11p or Ssk2p/Ssk22p), MAPKK (Pbs2p), and MAPK (Hog1p).	Glycerol	65-73	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	145-150	
16371351-3	2006	Phosphorylation of Hog1p was dependent on Pbs2p, the MAPK kinase (MAPKK) of the high osmolarity glycerol (HOG) pathway, and Ssk1p, the response regulator of the two-component system Sln1p-Ypd1p.	Glycerol	96-104	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	42-47	
19061190-1	2008	In yeast, external signals such as high osmolarity or oxidant conditions activate the high osmolarity glycerol (HOG) mitogen-activated protein kinase (MAPK) cascade pathway, which consists of two upstream branches, i.e. Sho1p and Sln1p and common downstream elements, including the Pbs2p MAPK kinase and the Hog1p MAPK.	Glycerol	102-110	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	282-286	
15707964-2	2005	In baker"s yeast external high osmolarity activates high osmolarity glycerol (HOG) MAPK pathway which consists of two upstream branches (SHO1 and SLN1) and common downstream elements Pbs2p MAPKK and Hog1p MAPK.	Glycerol	68-76	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	183-187	
14685261-1	2004	The yeast high osmolarity glycerol (HOG) pathway signals via the Pbs2 MEK and the Hog1 MAPK, whose activity requires phosphorylation of Thr and Tyr in the activation loop.	Glycerol	26-34	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	65-69	
12853477-3	2003	In yeast, external high osmolarity activates the HOG (high osmolarity glycerol) MAPK pathway, which consists of two upstream branches (SHO1 and SLN1) and common downstream elements including the Pbs2 MAPKK and the Hog1 MAPK.	Glycerol	70-78	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	195-199	
11042259-2	2000	Deletion of SGD1 results in loss of cell viability, while an increased dosage of SGD1 partially suppresses the osmosensitivity of pbs2 delta and hog1 delta mutants that are defective in the osmosignaling high osmolarity glycerol (HOG) mitogen-activated protein kinase pathway.	Glycerol	220-228	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	130-134	
10762242-1	2000	We have isolated several Saccharomyces cerevisiae mutants resistant to calcofluor that contain mutations in the PBS2 or HOG1 genes, which encode the mitogen-activated protein kinase (MAPK) and MAP kinases, respectively, of the high-osmolarity glycerol response (HOG) pathway.	Glycerol	243-251	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	112-116	
10970855-1	2000	The adaptive response to hyperosmotic stress in yeast, termed the high osmolarity glycerol (HOG) response, is mediated by two independent upstream pathways that converge on the Pbs2 MAP kinase kinase (MAPKK), leading to the activation of the Hog1 MAP kinase.	Glycerol	82-90	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	177-181	
9042961-1	1997	We deleted the PBS2 gene encoding the MAP kinase activator of the osmosignaling HOG pathway in Saccharomyces cerevisiae and examined the effects on the kinetics of the osmoregulatory glycerol response and protein induction during adaptation to 0.7 M NaCl.	Glycerol	183-191	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	15-19	
9042961-5	1997	Northern analysis of the salt induced transcription of GPD1 and GPP2, encoding the cytosolic glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase involved in the osmostress induced glycerol production, demonstrated an about 20-fold PBS2-dependent transient activation, in agreement with the previously reported transient nature of the signal transduced by the HOG pathway.	Glycerol	93-101	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	241-245	
34492172-4	2022	We also identified PBS2 encoding MAPKK in the high-osmolarity glycerol (HOG) pathway as a multicopy suppressor gene that rescues the hypersensitivity to AUR1 repression caused by deletion of IRA2, which causes hyperactivation of the cAMP/PKA pathway.	Glycerol	62-70	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	19-23	
28797224-8	2017	High osmolarity glycerol (HOG) pathway loss-of-functions mutations, including genes such as SSK2 and SSK4, represented a major adaptive strategy during environmental adaptation.	Glycerol	16-24	mitogen-activated protein kinase kinase PBS2	Saccharomyces cerevisiae S288C	101-105