PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20952680-4 2010 Second, specific pharmacological inhibition of SHP-1 enzymatic activity via the cancer drug sodium stibogluconate potently augmented Treg suppressor activity both in vivo and ex vivo. Antimony Sodium Gluconate 92-113 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 47-52 20421638-1 2010 Src homology region 2 domain-containing phosphatase 1 (SHP-1) has been implicated as a potential cancer therapeutic target by its negative regulation of immune cell activation and the activity of the SHP-1 inhibitor sodium stibogluconate that induced IFN-gamma(+) cells for anti-tumor action. Antimony Sodium Gluconate 216-237 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 55-60 20421638-1 2010 Src homology region 2 domain-containing phosphatase 1 (SHP-1) has been implicated as a potential cancer therapeutic target by its negative regulation of immune cell activation and the activity of the SHP-1 inhibitor sodium stibogluconate that induced IFN-gamma(+) cells for anti-tumor action. Antimony Sodium Gluconate 216-237 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 200-205 19514839-1 2009 Sodium stibogluconate (SSG), an inhibitor of SHP-1 that negatively regulates cytokine signaling and immunity, suppressed growth of murine Renca tumors in combination with interleukin-2 (IL-2) via a T-cell-dependent mechanism. Antimony Sodium Gluconate 0-21 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 45-50 19514839-1 2009 Sodium stibogluconate (SSG), an inhibitor of SHP-1 that negatively regulates cytokine signaling and immunity, suppressed growth of murine Renca tumors in combination with interleukin-2 (IL-2) via a T-cell-dependent mechanism. Antimony Sodium Gluconate 23-26 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 45-50 11544330-1 2001 Using in vitro protein tyrosine phosphatase (PTPase) assays, we found that sodium stibogluconate, a drug used in treatment of leishmaniasis, is a potent inhibitor of PTPases Src homology PTPase1 (SHP-1), SHP-2, and PTP1B but not the dual-specificity phosphatase mitogen-activated protein kinase phosphatase 1. Antimony Sodium Gluconate 75-96 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 196-201 11544330-2 2001 Sodium stibogluconate inhibited 99% of SHP-1 activity at 10 micrograms/ml, a therapeutic concentration of the drug for leishmaniasis. Antimony Sodium Gluconate 0-21 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 39-44 23766558-5 2013 RESULTS: Inhibition of SHP-1 by the specific pharmacological inhibitor sodium stibogluconate did not significantly enhance platelet-endothelium interaction in vivo under physiological conditions but led to an augmented fraction of rolling platelets in TNFalpha -induced systemic inflammation. Antimony Sodium Gluconate 71-92 protein tyrosine phosphatase, non-receptor type 6 Mus musculus 23-28