PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8569706-3 1996 Most of the receptor-activated GTPase, stimulated by both thrombin and SFLLRNP in platelet membranes, was inhibited by prior treatment with pertussis toxin or N-ethylmaleimide, suggesting that under these conditions much of the thrombin receptor-stimulated GTPase in platelet membranes is a member of the pertussis toxin-sensitive G alpha i family. Ethylmaleimide 159-175 coagulation factor II, thrombin Homo sapiens 58-66 24081657-5 2014 Using siRNA in cultured human umbilical vein ECs and human pulmonary artery ECs, depletion of Galpha12 and soluble N-ethylmaleimide-sensitive-fusion factor attachment protein alpha (alpha-SNAP), but not Galpha13, inhibited both basal and thrombin-induced vWF secretion, whereas overexpression of activated Galpha12 promoted vWF secretion. Ethylmaleimide 115-131 coagulation factor II, thrombin Homo sapiens 238-246 10713553-0 2000 N-Ethylmaleimide induces disaggregation of platelets preaggregated by ADP and thrombin and decreases cytoplasmic calcium level. Ethylmaleimide 0-16 coagulation factor II, thrombin Homo sapiens 78-86 10713553-1 2000 The effect of N-ethylmaleimide (NEM, 1-200 microM) on ADP- and thrombin-induced platelet aggregation and thrombin-induced increase in intracellular Ca2+ concentration was studied. Ethylmaleimide 32-35 coagulation factor II, thrombin Homo sapiens 63-71 10487531-0 1999 N-ethylmaleimide inhibition of thrombin-induced platelet aggregation. Ethylmaleimide 0-16 coagulation factor II, thrombin Homo sapiens 31-39 10487531-1 1999 The data presented in this report show that N-ethylmaleimide (NEM) is a powerful inhibitor of thrombin-induced platelet aggregation. Ethylmaleimide 44-60 coagulation factor II, thrombin Homo sapiens 94-102 10487531-1 1999 The data presented in this report show that N-ethylmaleimide (NEM) is a powerful inhibitor of thrombin-induced platelet aggregation. Ethylmaleimide 62-65 coagulation factor II, thrombin Homo sapiens 94-102 10487531-4 1999 NEM dose dependently blocked the thrombin-stimulated, but not the phorbol myristate acetate-dependent phosphorylation of the protein kinase C substrate pleckstrin. Ethylmaleimide 0-3 coagulation factor II, thrombin Homo sapiens 33-41 8569706-3 1996 Most of the receptor-activated GTPase, stimulated by both thrombin and SFLLRNP in platelet membranes, was inhibited by prior treatment with pertussis toxin or N-ethylmaleimide, suggesting that under these conditions much of the thrombin receptor-stimulated GTPase in platelet membranes is a member of the pertussis toxin-sensitive G alpha i family. Ethylmaleimide 159-175 coagulation factor II, thrombin Homo sapiens 228-236 3026330-5 1986 Additionally, the thiol reagent N-ethylmalemide (NEM) at rather low concentrations abolished thrombin- and adrenaline-induced stimulation of GTP hydrolysis was decreased by only 30-40% by treatment of platelet membranes with even high concentrations of NEM. Ethylmaleimide 49-52 coagulation factor II, thrombin Homo sapiens 93-101 7849614-0 1994 N-ethylmaleimide inhibits platelet aggregation and potentiates hydrogen peroxide formation induced by thrombin. Ethylmaleimide 0-16 coagulation factor II, thrombin Homo sapiens 102-110 6437813-9 1984 Finally, the thrombin inhibition of human platelet adenylate cyclase was impaired or abolished by Mn2+ and by treatment of the platelet membranes with N-ethylmaleimide or pertussis toxin. Ethylmaleimide 151-167 coagulation factor II, thrombin Homo sapiens 13-21