PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31157769-1 2019 The immunomodulatory drugs (IMiDs) thalidomide and its analogs, lenalidomide and pomalidomide, all FDA approved drugs for the treatment of multiple myeloma, induce ubiquitination and degradation of the lymphoid transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) via the cereblon (CRBN) E3 ubiquitin ligase for proteasomal degradation. Thalidomide 35-46 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 291-310