PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11546657-3 2001 Ionic substitution and pharmacological experiments showed that the large anoxia-induced pH(i) increase in HEPES buffer was totally Na(+) dependent and was blocked by HOE-694, strongly suggesting the activation of the Na(+)/H(+) exchanger (NHE). HEPES 106-111 glucose-6-phosphate isomerase 1 Mus musculus 88-93 11546657-2 2001 After total O(2) deprivation or anoxia (PO(2) approximately equal to 0 Torr), a large increase in pH(i) was seen in CA1 neurons in HEPES buffer, but a drop in pH(i), albeit small, was observed in the presence of HCO(3)(-). HEPES 131-136 glucose-6-phosphate isomerase 1 Mus musculus 98-103 17289818-9 2007 Our results revealed that cells with SHP-2 overexpression exhibited a higher steady-state pHi and a faster, NHE1-dependent pHi recovery rate from acid load in HEPES buffer. HEPES 159-164 glucose-6-phosphate isomerase 1 Mus musculus 123-126 17146194-3 2006 In a steady-state condition in Hepes-buffered solution, the pHi in the mTALs was 7.29 +/- 0.04 (n = 9). HEPES 31-36 glucose-6-phosphate isomerase 1 Mus musculus 60-63 11546657-4 2001 Also, this pH(i) increase in HEPES buffer was significantly smaller in Na(+)/H(+) exchanger isoform 1 (NHE1) null mutant CA1 neurons than in wild-type neurons, demonstrating that NHE1 is responsible for part of the pH(i) increase following anoxia. HEPES 29-34 glucose-6-phosphate isomerase 1 Mus musculus 11-16 11546657-4 2001 Also, this pH(i) increase in HEPES buffer was significantly smaller in Na(+)/H(+) exchanger isoform 1 (NHE1) null mutant CA1 neurons than in wild-type neurons, demonstrating that NHE1 is responsible for part of the pH(i) increase following anoxia. HEPES 29-34 glucose-6-phosphate isomerase 1 Mus musculus 215-220 1396416-3 1992 In nominal HCO3(-)-free HEPES-buffered Hanks" balanced salt solution (HEPES HBSS), when the pH of medium (pHo) was maintained at 7.4, the steady-state pHi of cultured astrocytes from DBA mice was 6.98 +/- 0.03, and that from C57 mice was 7.01 +/- 0.03. HEPES 24-29 glucose-6-phosphate isomerase 1 Mus musculus 151-154 7713887-7 1995 After inhibition of the Na+/H+ exchanger by dimethylamiloride, glucose produced a marked and sustained fall in pHi in HEPES buffer. HEPES 118-123 glucose-6-phosphate isomerase 1 Mus musculus 111-114 8593817-8 1996 A similar rapid rise in pHi was produced by KIC in both HCO3- and HEPES buffers when its effects on [Ca2+]i were prevented, whether [Ca2+]i was kept low (4.8 mM KCl plus diazoxide) or high (30 mM KCl plus diazoxide). HEPES 66-71 glucose-6-phosphate isomerase 1 Mus musculus 24-27 1396416-3 1992 In nominal HCO3(-)-free HEPES-buffered Hanks" balanced salt solution (HEPES HBSS), when the pH of medium (pHo) was maintained at 7.4, the steady-state pHi of cultured astrocytes from DBA mice was 6.98 +/- 0.03, and that from C57 mice was 7.01 +/- 0.03. HEPES 70-75 glucose-6-phosphate isomerase 1 Mus musculus 151-154 1396416-6 1992 The decrease in pHi was greater in HEPES HBSS than in HCO3- HBSS. HEPES 35-40 glucose-6-phosphate isomerase 1 Mus musculus 16-19 1396416-7 1992 Reducing the Cl- concentration ([Cl-]o) in either HEPES or HCO3- HBSS, pHi of astrocytes increased by 0.05-0.1 pH units. HEPES 50-55 glucose-6-phosphate isomerase 1 Mus musculus 71-74 1396416-11 1992 Amiloride, a Na(+)-H+ exchange inhibitor, decreased the pHi of both DBA and C57 astrocytes more in HEPES HBSS than in HCO3- HBSS. HEPES 99-104 glucose-6-phosphate isomerase 1 Mus musculus 56-59 1396416-12 1992 It enhanced the response of pHi to reduction in pHo and [Na+]o. Ouabain, an Na+,K(+)-ATPase inhibitor, decreased the pHi of cultured astrocytes in HEPES HBSS, but not in HCO3- HBSS. HEPES 147-152 glucose-6-phosphate isomerase 1 Mus musculus 28-31 1396416-12 1992 It enhanced the response of pHi to reduction in pHo and [Na+]o. Ouabain, an Na+,K(+)-ATPase inhibitor, decreased the pHi of cultured astrocytes in HEPES HBSS, but not in HCO3- HBSS. HEPES 147-152 glucose-6-phosphate isomerase 1 Mus musculus 117-120 1396416-13 1992 It also enhanced the response of pHi to changing pHo and [Na+]o in HEPES HBSS. HEPES 67-72 glucose-6-phosphate isomerase 1 Mus musculus 33-36 1396416-14 1992 Acetazolamide, a carbonic anhydrase inhibitor, decreased the pHi of astrocytes in both HEPES and HCO3- HBSS. HEPES 87-92 glucose-6-phosphate isomerase 1 Mus musculus 61-64 1592012-9 1992 Intracellular pH (pHi) as determined with 14C-DMO of astrocytes in HEPES-buffered saline solution averaged 7.04 +/- 0.03 for DBA, 7.01 +/- 0.02 for C57, and 6.97 +/- 0.02 for SW mice when pH of medium was maintained at 7.4. HEPES 67-72 glucose-6-phosphate isomerase 1 Mus musculus 18-21 1914146-3 1991 Exposure of the cells to NH4Cl for 2 min and reincubation in HEPES HBSS decreased pHi further within 1-2 min after removal of NH4Cl; pHi then recovered toward the control value. HEPES 61-66 glucose-6-phosphate isomerase 1 Mus musculus 82-85 1914146-3 1991 Exposure of the cells to NH4Cl for 2 min and reincubation in HEPES HBSS decreased pHi further within 1-2 min after removal of NH4Cl; pHi then recovered toward the control value. HEPES 61-66 glucose-6-phosphate isomerase 1 Mus musculus 133-136 1914146-6 1991 Recovery of pHi after NH4Cl prepulse was markedly inhibited in low-Na+ and in amiloride-containing HEPES HBSS. HEPES 99-104 glucose-6-phosphate isomerase 1 Mus musculus 12-15 2156445-4 1990 The resting pHi was 7.41 +/- 0.02 (means +/- SE) in N-2-hydroxyethylpiperazine-N"-2-ethanesulfonic acid-buffered media and 7.23 +/- 0.02 in CO2- HCO3(-)-buffered media, both at extracellular pH 7.4. HEPES 52-103 glucose-6-phosphate isomerase 1 Mus musculus 12-15