PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11546657-3	2001	Ionic substitution and pharmacological experiments showed that the large anoxia-induced pH(i) increase in HEPES buffer was totally Na(+) dependent and was blocked by HOE-694, strongly suggesting the activation of the Na(+)/H(+) exchanger (NHE).	HEPES	106-111	glucose-6-phosphate isomerase 1	Mus musculus	88-93	
11546657-2	2001	After total O(2) deprivation or anoxia (PO(2) approximately equal to 0 Torr), a large increase in pH(i) was seen in CA1 neurons in HEPES buffer, but a drop in pH(i), albeit small, was observed in the presence of HCO(3)(-).	HEPES	131-136	glucose-6-phosphate isomerase 1	Mus musculus	98-103	
17289818-9	2007	Our results revealed that cells with SHP-2 overexpression exhibited a higher steady-state pHi and a faster, NHE1-dependent pHi recovery rate from acid load in HEPES buffer.	HEPES	159-164	glucose-6-phosphate isomerase 1	Mus musculus	123-126	
17146194-3	2006	In a steady-state condition in Hepes-buffered solution, the pHi in the mTALs was 7.29 +/- 0.04 (n = 9).	HEPES	31-36	glucose-6-phosphate isomerase 1	Mus musculus	60-63	
11546657-4	2001	Also, this pH(i) increase in HEPES buffer was significantly smaller in Na(+)/H(+) exchanger isoform 1 (NHE1) null mutant CA1 neurons than in wild-type neurons, demonstrating that NHE1 is responsible for part of the pH(i) increase following anoxia.	HEPES	29-34	glucose-6-phosphate isomerase 1	Mus musculus	11-16	
11546657-4	2001	Also, this pH(i) increase in HEPES buffer was significantly smaller in Na(+)/H(+) exchanger isoform 1 (NHE1) null mutant CA1 neurons than in wild-type neurons, demonstrating that NHE1 is responsible for part of the pH(i) increase following anoxia.	HEPES	29-34	glucose-6-phosphate isomerase 1	Mus musculus	215-220	
1396416-3	1992	In nominal HCO3(-)-free HEPES-buffered Hanks" balanced salt solution (HEPES HBSS), when the pH of medium (pHo) was maintained at 7.4, the steady-state pHi of cultured astrocytes from DBA mice was 6.98 +/- 0.03, and that from C57 mice was 7.01 +/- 0.03.	HEPES	24-29	glucose-6-phosphate isomerase 1	Mus musculus	151-154	
7713887-7	1995	After inhibition of the Na+/H+ exchanger by dimethylamiloride, glucose produced a marked and sustained fall in pHi in HEPES buffer.	HEPES	118-123	glucose-6-phosphate isomerase 1	Mus musculus	111-114	
8593817-8	1996	A similar rapid rise in pHi was produced by KIC in both HCO3- and HEPES buffers when its effects on [Ca2+]i were prevented, whether [Ca2+]i was kept low (4.8 mM KCl plus diazoxide) or high (30 mM KCl plus diazoxide).	HEPES	66-71	glucose-6-phosphate isomerase 1	Mus musculus	24-27	
1396416-3	1992	In nominal HCO3(-)-free HEPES-buffered Hanks" balanced salt solution (HEPES HBSS), when the pH of medium (pHo) was maintained at 7.4, the steady-state pHi of cultured astrocytes from DBA mice was 6.98 +/- 0.03, and that from C57 mice was 7.01 +/- 0.03.	HEPES	70-75	glucose-6-phosphate isomerase 1	Mus musculus	151-154	
1396416-6	1992	The decrease in pHi was greater in HEPES HBSS than in HCO3- HBSS.	HEPES	35-40	glucose-6-phosphate isomerase 1	Mus musculus	16-19	
1396416-7	1992	Reducing the Cl- concentration ([Cl-]o) in either HEPES or HCO3- HBSS, pHi of astrocytes increased by 0.05-0.1 pH units.	HEPES	50-55	glucose-6-phosphate isomerase 1	Mus musculus	71-74	
1396416-11	1992	Amiloride, a Na(+)-H+ exchange inhibitor, decreased the pHi of both DBA and C57 astrocytes more in HEPES HBSS than in HCO3- HBSS.	HEPES	99-104	glucose-6-phosphate isomerase 1	Mus musculus	56-59	
1396416-12	1992	It enhanced the response of pHi to reduction in pHo and [Na+]o. Ouabain, an Na+,K(+)-ATPase inhibitor, decreased the pHi of cultured astrocytes in HEPES HBSS, but not in HCO3- HBSS.	HEPES	147-152	glucose-6-phosphate isomerase 1	Mus musculus	28-31	
1396416-12	1992	It enhanced the response of pHi to reduction in pHo and [Na+]o. Ouabain, an Na+,K(+)-ATPase inhibitor, decreased the pHi of cultured astrocytes in HEPES HBSS, but not in HCO3- HBSS.	HEPES	147-152	glucose-6-phosphate isomerase 1	Mus musculus	117-120	
1396416-13	1992	It also enhanced the response of pHi to changing pHo and [Na+]o in HEPES HBSS.	HEPES	67-72	glucose-6-phosphate isomerase 1	Mus musculus	33-36	
1396416-14	1992	Acetazolamide, a carbonic anhydrase inhibitor, decreased the pHi of astrocytes in both HEPES and HCO3- HBSS.	HEPES	87-92	glucose-6-phosphate isomerase 1	Mus musculus	61-64	
1592012-9	1992	Intracellular pH (pHi) as determined with 14C-DMO of astrocytes in HEPES-buffered saline solution averaged 7.04 +/- 0.03 for DBA, 7.01 +/- 0.02 for C57, and 6.97 +/- 0.02 for SW mice when pH of medium was maintained at 7.4.	HEPES	67-72	glucose-6-phosphate isomerase 1	Mus musculus	18-21	
1914146-3	1991	Exposure of the cells to NH4Cl for 2 min and reincubation in HEPES HBSS decreased pHi further within 1-2 min after removal of NH4Cl; pHi then recovered toward the control value.	HEPES	61-66	glucose-6-phosphate isomerase 1	Mus musculus	82-85	
1914146-3	1991	Exposure of the cells to NH4Cl for 2 min and reincubation in HEPES HBSS decreased pHi further within 1-2 min after removal of NH4Cl; pHi then recovered toward the control value.	HEPES	61-66	glucose-6-phosphate isomerase 1	Mus musculus	133-136	
1914146-6	1991	Recovery of pHi after NH4Cl prepulse was markedly inhibited in low-Na+ and in amiloride-containing HEPES HBSS.	HEPES	99-104	glucose-6-phosphate isomerase 1	Mus musculus	12-15	
2156445-4	1990	The resting pHi was 7.41 +/- 0.02 (means +/- SE) in N-2-hydroxyethylpiperazine-N"-2-ethanesulfonic acid-buffered media and 7.23 +/- 0.02 in CO2- HCO3(-)-buffered media, both at extracellular pH 7.4.	HEPES	52-103	glucose-6-phosphate isomerase 1	Mus musculus	12-15