PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11470893-2	2001	We find that exposure to phosphatidylinositol-specific phospholipase C (PIPLC) or to the monoclonal anti-prion protein (PrP) antibody 6H4 not only prevents infection of susceptible N2a cells but also cures chronically scrapie-infected cultures, as judged by the long-term abrogation of PrP(Sc) accumulation after cessation of treatment.	Phosphatidylinositols	25-45	prion protein	Mus musculus	286-289	
7592679-5	1995	Surprisingly, however, cleavage of the GPI anchor using phosphatidylinositol-specific phospholipase C fails to release the mutant PrP from the surface of intact cells, suggesting that it has an additional mode of membrane attachment.	Phosphatidylinositols	56-76	prion protein	Mus musculus	130-133	
1687386-18	1991	1989) of normal PrP biosynthesis and shown that most of the PrP of normal cells is linked to the cell surface by phosphatidylinositol (Stahl et al.	Phosphatidylinositols	113-133	prion protein	Mus musculus	60-63	
2562814-6	1989	Treatments of the live cells with trypsin and phosphatidylinositol-specific phospholipase C indicated that the mature PrP species were expressed solely on the cell surface, where they were anchored by covalent linkage to phosphatidylinositol.	Phosphatidylinositols	46-66	prion protein	Mus musculus	118-121	
2562814-6	1989	Treatments of the live cells with trypsin and phosphatidylinositol-specific phospholipase C indicated that the mature PrP species were expressed solely on the cell surface, where they were anchored by covalent linkage to phosphatidylinositol.	Phosphatidylinositols	221-241	prion protein	Mus musculus	118-121	
16574930-10	2006	CONCLUSIONS: These results demonstrate that PrPc deletion impairs the antiapoptotic phosphatidylinositol 3-kinase/Akt pathway by resulting in reduced postischemic phospho-Akt expression, followed by enhanced postischemic caspase-3 activation, and aggravated neuronal injury after transient and permanent cerebral ischemia.	Phosphatidylinositols	84-104	prion protein	Mus musculus	44-48	
10606888-8	1999	The PrPC on mononuclear cells and platelets was sensitive to enzymatic treatment of cells by proteinase k and phosphatidylinositol-specific phospholipase C. Certain anti-PrPC MAbs which showed equivalent intensity of staining to MAb 3F4 on fresh cells showed relative reductions of staining compared to MAb 3F4 on stored cells, indicating possible structural alterations of PrPC under these conditions.	Phosphatidylinositols	110-130	prion protein	Mus musculus	4-8	
1680859-5	1991	More significantly, we found that the precursor of protease-resistant PrP was eliminated from intact cells by treatments with phosphatidylinositol-specific phospholipase C and trypsin.	Phosphatidylinositols	126-146	prion protein	Mus musculus	70-73	
1968466-3	1990	We report here that PrPC can be released from the surface of both normal-control and scrapie-infected murine neuroblastoma (N2a) cells by phosphatidylinositol-specific phospholipase C (PIPLC) digestion and it can be selectively labeled with sulfo-NHS-biotin, a membrane impermeant reagent.	Phosphatidylinositols	138-158	prion protein	Mus musculus	20-24	
2574873-8	1989	The major PrP species were glycoproteins anchored at the cell surface by covalent linkage to phosphatidylinositol.	Phosphatidylinositols	93-113	prion protein	Mus musculus	10-13	
19936054-4	2009	We then utilised a transmembrane-anchored form of PrP (PrP-TM), which is targeted to rafts solely by its N-terminal domain, to show that both heparin and phosphatidylinositol-specific phospholipase C can inhibit its association with detergent-resistant rafts, implying that a GPI-anchored HSPG targets PrP(C) to rafts.	Phosphatidylinositols	154-174	prion protein	Mus musculus	50-53	
19936054-4	2009	We then utilised a transmembrane-anchored form of PrP (PrP-TM), which is targeted to rafts solely by its N-terminal domain, to show that both heparin and phosphatidylinositol-specific phospholipase C can inhibit its association with detergent-resistant rafts, implying that a GPI-anchored HSPG targets PrP(C) to rafts.	Phosphatidylinositols	154-174	prion protein	Mus musculus	302-308