PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3000001-0 1985 Variant of A431 cells isolated by ricin A-conjugated monoclonal antibody directed to EGF receptor: phosphorylation of EGF receptor and phosphatidylinositol. Phosphatidylinositols 135-155 epidermal growth factor Homo sapiens 85-88 3000001-7 1985 After addition of EGF to A431 membrane, phosphatidylinositol phosphorylation was significantly decreased with a concomitant increase in EGF-dependent protein phosphorylation. Phosphatidylinositols 40-60 epidermal growth factor Homo sapiens 18-21 3000001-8 1985 Thus, the EGF-dependent receptor-mediated protein phosphorylation precedes phosphatidylinositol phosphorylation. Phosphatidylinositols 75-95 epidermal growth factor Homo sapiens 10-13 6272837-5 1981 The phosphatidylinositol response to EGF appears to be dependent on an influx of calcium since (a) external calcium is required for the enhancement of phosphatidylinositol turnover, (2) the accumulation of 45Ca by A-431 cells is stimulated by EGF, (3) blockage of calcium influx with LaCl3 inhibits stimulation of phosphatidylinositol turnover, and (4) calcium influx via ionophore A23187 is sufficient to stimulate phosphatidylinositol turnover. Phosphatidylinositols 151-171 epidermal growth factor Homo sapiens 37-40 2993780-6 1985 Thus, it appears that in A431 membranes the EGF receptor/kinase does not utilize phosphatidylinositol as a substrate, but does phosphorylate a membrane proteolipid. Phosphatidylinositols 81-101 epidermal growth factor Homo sapiens 44-47 6311852-0 1983 Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells. Phosphatidylinositols 92-112 epidermal growth factor Homo sapiens 139-162 6311852-0 1983 Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on the growth inhibitory and increased phosphatidylinositol (PI) responses induced by epidermal growth factor (EGF) in A431 cells. Phosphatidylinositols 92-112 epidermal growth factor Homo sapiens 164-167 6311852-4 1983 EGF increased the production of diacylglycerol (60-70%) and stimulated the synthesis of phosphatidylinositol (PI) from 3H-inositol (three- to fourfold increase). Phosphatidylinositols 88-108 epidermal growth factor Homo sapiens 0-3 6272837-0 1981 Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells. Phosphatidylinositols 34-54 epidermal growth factor Homo sapiens 67-90 6272837-1 1981 Epidermal growth factor (EGF) stimulates the incorporation of 32Pi and [3H]inositol into phosphatidylinositol (5-10-fold) in A-431 cells. Phosphatidylinositols 89-109 epidermal growth factor Homo sapiens 0-23 6272837-1 1981 Epidermal growth factor (EGF) stimulates the incorporation of 32Pi and [3H]inositol into phosphatidylinositol (5-10-fold) in A-431 cells. Phosphatidylinositols 89-109 epidermal growth factor Homo sapiens 25-28 6272837-3 1981 These effects are attributed to an acceleration of the turnover of phosphatidylinositol as a consequence of the binding of EGF to its membrane receptor. Phosphatidylinositols 67-87 epidermal growth factor Homo sapiens 123-126 6272837-4 1981 The extent of the phosphatidylinositol response to EGF parallels the extent of hormone binding. Phosphatidylinositols 18-38 epidermal growth factor Homo sapiens 51-54 6272837-5 1981 The phosphatidylinositol response to EGF appears to be dependent on an influx of calcium since (a) external calcium is required for the enhancement of phosphatidylinositol turnover, (2) the accumulation of 45Ca by A-431 cells is stimulated by EGF, (3) blockage of calcium influx with LaCl3 inhibits stimulation of phosphatidylinositol turnover, and (4) calcium influx via ionophore A23187 is sufficient to stimulate phosphatidylinositol turnover. Phosphatidylinositols 4-24 epidermal growth factor Homo sapiens 37-40 6272837-5 1981 The phosphatidylinositol response to EGF appears to be dependent on an influx of calcium since (a) external calcium is required for the enhancement of phosphatidylinositol turnover, (2) the accumulation of 45Ca by A-431 cells is stimulated by EGF, (3) blockage of calcium influx with LaCl3 inhibits stimulation of phosphatidylinositol turnover, and (4) calcium influx via ionophore A23187 is sufficient to stimulate phosphatidylinositol turnover. Phosphatidylinositols 4-24 epidermal growth factor Homo sapiens 243-246 6272837-5 1981 The phosphatidylinositol response to EGF appears to be dependent on an influx of calcium since (a) external calcium is required for the enhancement of phosphatidylinositol turnover, (2) the accumulation of 45Ca by A-431 cells is stimulated by EGF, (3) blockage of calcium influx with LaCl3 inhibits stimulation of phosphatidylinositol turnover, and (4) calcium influx via ionophore A23187 is sufficient to stimulate phosphatidylinositol turnover. Phosphatidylinositols 151-171 epidermal growth factor Homo sapiens 37-40 6272837-5 1981 The phosphatidylinositol response to EGF appears to be dependent on an influx of calcium since (a) external calcium is required for the enhancement of phosphatidylinositol turnover, (2) the accumulation of 45Ca by A-431 cells is stimulated by EGF, (3) blockage of calcium influx with LaCl3 inhibits stimulation of phosphatidylinositol turnover, and (4) calcium influx via ionophore A23187 is sufficient to stimulate phosphatidylinositol turnover. Phosphatidylinositols 151-171 epidermal growth factor Homo sapiens 37-40 12083795-0 2002 Identification of myo-inositol 1,2-cyclic monophosphate by electrospray tandem mass spectrometry, a major constituent of EGF-stimulated phosphoinositide turnover in MDA 468 cells. Phosphatidylinositols 136-152 epidermal growth factor Homo sapiens 121-124 15901830-9 2005 Moreover, the phosphatidylinositol 3 (PI3)-kinase inhibitor (wortmannin) and p38(MAPK) inhibitor (SB203580) inhibited the EGF-induced CREB phosphorylation and the expression of NF-IL6beta gene in cells. Phosphatidylinositols 14-34 epidermal growth factor Homo sapiens 122-125 31754329-4 2019 In the present study, we demonstrated that EGF could inhibit miR-124a expression in beta cell lines through downstream signaling pathways, including mitogen-activated protein kinase kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) cascades. Phosphatidylinositols 199-219 epidermal growth factor Homo sapiens 43-46 30476538-0 2019 Inactivation of the PtdIns(4)P phosphatase Sac1 at the Golgi by H2O2 produced via Ca2+-dependent Duox in EGF-stimulated cells. Phosphatidylinositols 20-26 epidermal growth factor Homo sapiens 105-108 12083795-1 2002 Epidermal growth factor (EGF) caused an increase in phosphoinositide (PI) turnover in MDA 468 cells. Phosphatidylinositols 52-68 epidermal growth factor Homo sapiens 0-23 12083795-1 2002 Epidermal growth factor (EGF) caused an increase in phosphoinositide (PI) turnover in MDA 468 cells. Phosphatidylinositols 52-68 epidermal growth factor Homo sapiens 25-28 8130082-4 1993 With increasing incubation time EGF affects the pools of both phosphatidylinositols and other phospholipids parallel with the activation of the tyrosine kinase activity. Phosphatidylinositols 62-83 epidermal growth factor Homo sapiens 32-35 11226408-0 2001 Localization of phospholipase C-gamma1 signaling in caveolae: importance in EGF-induced phosphoinositide hydrolysis but not in tyrosine phosphorylation. Phosphatidylinositols 88-104 epidermal growth factor Homo sapiens 76-79 10801833-1 2000 Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance. Phosphatidylinositols 141-161 epidermal growth factor Homo sapiens 0-23 10801833-1 2000 Epidermal growth factor (EGF) inhibits carbachol-induced chloride secretion in T(84) colonic epithelial cells and has been shown to activate phosphatidylinositol (PI) 3-kinase, leading to inhibition of a basolateral potassium conductance. Phosphatidylinositols 141-161 epidermal growth factor Homo sapiens 25-28 9345355-13 1997 These results suggest that EGF, at least partially, exerts its effects on the endometrial adenocarcinoma cell line by activating protein kinase C through increased breakdown of phosphatidyl inositol (PI). Phosphatidylinositols 177-198 epidermal growth factor Homo sapiens 27-30 8593248-4 1995 Here we investigate the effect of well-known PKC activator 12-O-tetradecanoyl-2 phorbol-13-acetate (TPA), on the levels of 32P incorporation into EGF induced phosphatidylinositols (PI, PI4P, PI4, 5P2) and different phospholipids (PC, PA, PS) as well as on induced tyrosine kinase activity. Phosphatidylinositols 158-179 epidermal growth factor Homo sapiens 146-149 7650054-8 1995 Moreover, we have demonstrated that the extracellular Ca(2+)-dependent increase in diacylglycerol levels in response to EGF is associated with an increase in extracellular choline release, which is indicative of an activation of a phosphatidylcholine-linked phospholipase D. These results suggest that diacylglycerol sources other than PtdIns"s may be important in the extracellular Ca(2+)-dependent regulation of EGF-mediated cell replication. Phosphatidylinositols 336-342 epidermal growth factor Homo sapiens 120-123 7929151-3 1994 When phosphorylated by the epidermal growth factor receptor in vitro, the ErbB3 protein strongly associated with the regulatory p85 subunit and the catalytic activity of phosphatidylinositol (PI) 3-kinase. Phosphatidylinositols 170-190 epidermal growth factor Homo sapiens 27-50 9753221-6 1998 Other pathways potentially activated by EGF include the phosphatidylinositol pathway (leading to activation of protein kinase C and an increase in cytosolic calcium) and the JAK/STAT signaling pathway. Phosphatidylinositols 56-76 epidermal growth factor Homo sapiens 40-43 9202421-6 1997 As a well studied example of the primary signalling events that take place on the cytoplasmic leaflet of the plasma membrane following receptor activation, we will discuss how the widely expressed receptor for epidermal growth factor (EGF) causes the phosphorylation and hydrolysis of a signalling precursor, the membrane lipid phosphatidylinositol. Phosphatidylinositols 328-348 epidermal growth factor Homo sapiens 210-233 9202421-6 1997 As a well studied example of the primary signalling events that take place on the cytoplasmic leaflet of the plasma membrane following receptor activation, we will discuss how the widely expressed receptor for epidermal growth factor (EGF) causes the phosphorylation and hydrolysis of a signalling precursor, the membrane lipid phosphatidylinositol. Phosphatidylinositols 328-348 epidermal growth factor Homo sapiens 235-238 7640657-7 1995 The signal transduction pathways activated by EGF include the phosphatidylinositol pathway, leading to activation of protein kinase C and to increase in the intracellular Ca2+ concentration, and to the ras pathway leading to MAP kinase activation. Phosphatidylinositols 62-82 epidermal growth factor Homo sapiens 46-49 8169630-6 1994 Kinetic analysis of EGF-stimulated inositol phospholipid hydrolysis showed that a sharp and transient increase in IP3 from 5 to 12 minutes post-EGF and a transient but more gradual increase in IP2 from 2 to 12 minutes post-EGF were followed by a gradual and steady increase in IP1, which was significantly greater than control after 5 minutes. Phosphatidylinositols 35-56 epidermal growth factor Homo sapiens 20-23 8169630-10 1994 The results suggest a close involvement of inositol phospholipid turnover in human meningioma cells in response to mitogenic stimulation by EGF. Phosphatidylinositols 43-64 epidermal growth factor Homo sapiens 140-143 1984783-2 1991 They displayed a significant phospholipase (PLC) activity against phosphoinositides, which was stimulated by guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S), epidermal growth factor (EGF) and fetal calf serum (FCS) (24%, 11% and 97% over controls, respectively). Phosphatidylinositols 66-83 epidermal growth factor Homo sapiens 160-183 8364119-2 1993 In 58% of tumours EGF increased the 32P incorporation into two basic cell phospholipids--phosphatidylcholine and phosphoinositides. Phosphatidylinositols 113-130 epidermal growth factor Homo sapiens 18-21 8350679-7 1993 Taken together, the results suggest that EGF-induced growth inhibition of A431 cells may be due to a quantitative changes of EGF-receptor tyrosine kinase activity in areas other than the recruitment and activation of phosphatidylinositol-specific phospholipase C gamma. Phosphatidylinositols 217-237 epidermal growth factor Homo sapiens 41-44 1328172-1 1992 Inostamycin, a novel microbial secondary metabolite, inhibited [3H]inositol and 32P1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC50 being 0.5 micrograms/ml, without inhibiting macromolecular synthesis. Phosphatidylinositols 104-124 epidermal growth factor Homo sapiens 145-168 1328172-1 1992 Inostamycin, a novel microbial secondary metabolite, inhibited [3H]inositol and 32P1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC50 being 0.5 micrograms/ml, without inhibiting macromolecular synthesis. Phosphatidylinositols 104-124 epidermal growth factor Homo sapiens 170-173 1328172-1 1992 Inostamycin, a novel microbial secondary metabolite, inhibited [3H]inositol and 32P1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC50 being 0.5 micrograms/ml, without inhibiting macromolecular synthesis. Phosphatidylinositols 126-132 epidermal growth factor Homo sapiens 145-168 8395924-5 1993 The metabolism of phosphoinositides also increased in HA22T/VGH cells as compared with both Hep3B and Chang liver cells under basal and EGF-treated conditions. Phosphatidylinositols 18-35 epidermal growth factor Homo sapiens 136-139 1322351-8 1992 The pattern of the oscillations with epidermal growth factor, especially the latency, was considerably different from that with phenylephrine, which is known to use the phosphatidylinositol pathway, possibly because of the difference in the pathway toward phosphatidylinositol turnover between these agonists. Phosphatidylinositols 169-189 epidermal growth factor Homo sapiens 37-60 1322351-8 1992 The pattern of the oscillations with epidermal growth factor, especially the latency, was considerably different from that with phenylephrine, which is known to use the phosphatidylinositol pathway, possibly because of the difference in the pathway toward phosphatidylinositol turnover between these agonists. Phosphatidylinositols 256-276 epidermal growth factor Homo sapiens 37-60 1328172-1 1992 Inostamycin, a novel microbial secondary metabolite, inhibited [3H]inositol and 32P1 incorporation into phosphatidylinositol (PtdIns) induced by epidermal growth factor (EGF) in cultured A431 cells, the IC50 being 0.5 micrograms/ml, without inhibiting macromolecular synthesis. Phosphatidylinositols 126-132 epidermal growth factor Homo sapiens 170-173 1600863-0 1992 Inhibition of EGF-induced cytoskeletal change in A431 cells by inhibitors of phosphatidylinositol turnover. Phosphatidylinositols 77-97 epidermal growth factor Homo sapiens 14-17 1600863-8 1992 Thus tyrosine kinase and phosphatidylinositol turnover inhibitors were shown to inhibit the signaling pathways of EGF-induced cytoskeletal organization of A431 cells. Phosphatidylinositols 25-45 epidermal growth factor Homo sapiens 114-117 1984783-2 1991 They displayed a significant phospholipase (PLC) activity against phosphoinositides, which was stimulated by guanosine 5"-O-(3-thiotriphosphate) (GTP gamma S), epidermal growth factor (EGF) and fetal calf serum (FCS) (24%, 11% and 97% over controls, respectively). Phosphatidylinositols 66-83 epidermal growth factor Homo sapiens 185-188 1984783-7 1991 It is concluded that EGF might stimulate hydrolysis of phosphoinositides by PLC through complex interactions between plasma membrane and cytosolic factors which still remain to be identified. Phosphatidylinositols 55-72 epidermal growth factor Homo sapiens 21-24 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 163-169 epidermal growth factor Homo sapiens 280-283 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 145-161 epidermal growth factor Homo sapiens 48-71 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 145-161 epidermal growth factor Homo sapiens 73-76 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 145-161 epidermal growth factor Homo sapiens 280-283 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 163-169 epidermal growth factor Homo sapiens 48-71 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 163-169 epidermal growth factor Homo sapiens 73-76 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 259-265 epidermal growth factor Homo sapiens 48-71 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 259-265 epidermal growth factor Homo sapiens 73-76 1698145-1 1990 Recent studies have shown that the receptor for epidermal growth factor (EGF) can associate with and tyrosine-phosphorylate the gamma-isozyme of phosphoinositide (PtdIns)-specific phospholipase C (PLC gamma), suggesting a possible mechanism for activation of PtdIns hydrolysis by EGF. Phosphatidylinositols 259-265 epidermal growth factor Homo sapiens 280-283 1698145-4 1990 The termination of PtdIns hydrolysis after EGF stimulation was accompanied by return of [P-Tyr]PLC gamma to near-basal levels. Phosphatidylinositols 19-25 epidermal growth factor Homo sapiens 43-46 1698145-5 1990 Activation of protein kinase C (PKC) with a phorbol ester inhibited (IC50 = 3-10 nM) both EGF-dependent PtdIns hydrolysis and PLC gamma phosphorylation by more than 90%. Phosphatidylinositols 104-110 epidermal growth factor Homo sapiens 90-93 1698145-9 1990 In conclusion, EGF-stimulated tyrosine phosphorylation of PLC gamma is broadly correlated with stimulation of PtdIns hydrolysis, consistent with a role for tyrosine phosphorylation in PLC activation. Phosphatidylinositols 110-116 epidermal growth factor Homo sapiens 15-18 2433285-1 1987 The effects of epidermal growth factor (EGF) on the metabolism of phosphatidylinositol were examined using A431 cells labeled with either 32PO3(4)- or myo-[3H] inositol. Phosphatidylinositols 66-86 epidermal growth factor Homo sapiens 15-38 2555218-3 1989 Tyrphostins which are potent EGF-receptor kinase inhibitors were also potent in blocking the EGF-induced production of phosphoinositides. Phosphatidylinositols 119-136 epidermal growth factor Homo sapiens 29-32 2555218-3 1989 Tyrphostins which are potent EGF-receptor kinase inhibitors were also potent in blocking the EGF-induced production of phosphoinositides. Phosphatidylinositols 119-136 epidermal growth factor Homo sapiens 93-96 2549060-0 1989 Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover. Phosphatidylinositols 101-121 epidermal growth factor Homo sapiens 29-52 2549060-0 1989 Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover. Phosphatidylinositols 101-121 epidermal growth factor Homo sapiens 54-57 2549060-0 1989 Treatment of A431 cells with epidermal growth factor (EGF) induces desensitization of EGF-stimulated phosphatidylinositol turnover. Phosphatidylinositols 101-121 epidermal growth factor Homo sapiens 86-89 2549060-1 1989 Epidermal growth factor (EGF) stimulates the turnover of phosphoinositides in A431 cells. Phosphatidylinositols 57-74 epidermal growth factor Homo sapiens 0-23 2549060-1 1989 Epidermal growth factor (EGF) stimulates the turnover of phosphoinositides in A431 cells. Phosphatidylinositols 57-74 epidermal growth factor Homo sapiens 25-28 2549060-7 1989 Desensitization to EGF was observed in cells in which protein kinase C had been down-regulated by prolonged treatment with 12-O-tetradecanoylphorbol-13-acetate, implying that EGF receptor desensitization is independent of protein kinase C. The desensitizing effects of EGF on growth factor-induced phosphatidylinositol turnover could be prevented by pretreatment of the cells with the calmodulin antagonist trifluoperazine, suggesting that calmodulin may be involved in the regulation of EGF receptor sensitivity. Phosphatidylinositols 298-318 epidermal growth factor Homo sapiens 19-22 2830907-0 1988 Epidermal growth factor stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides but does not affect phosphoinositide breakdown by phospholipase C in renal cortical slices. Phosphatidylinositols 93-110 epidermal growth factor Homo sapiens 0-23 2830907-0 1988 Epidermal growth factor stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides but does not affect phosphoinositide breakdown by phospholipase C in renal cortical slices. Phosphatidylinositols 93-109 epidermal growth factor Homo sapiens 0-23 2830907-1 1988 The effects of epidermal growth factor (EGF) on the metabolism of phosphatidic acid and phosphoinositides were examined using renal cortical slices labelled with either sodium [32P]orthophosphate or myo-[3H]inositol. Phosphatidylinositols 88-105 epidermal growth factor Homo sapiens 40-43 2830907-2 1988 EGF was found to increase the incorporation of phosphate into phosphatidic acid and phosphoinositides. Phosphatidylinositols 84-101 epidermal growth factor Homo sapiens 0-3 2830907-5 1988 The results show that EGF stimulates the incorporation of phosphate into phosphatidic acid and phosphoinositides, but does not affect breakdown of phosphoinositides by phospholipase C in renal cortical slices. Phosphatidylinositols 95-112 epidermal growth factor Homo sapiens 22-25 3258153-3 1988 In cultured porcine thyroid cells, 10 nM EGF produces a breakdown of phosphatidylinositol and stimulates inositol phosphate production. Phosphatidylinositols 69-89 epidermal growth factor Homo sapiens 41-44 3494624-2 1987 The changes in Ca2+ homeostasis and phosphoinositide hydrolysis induced by EGF were studied in human epidermoid carcinoma A431 cells both when attached to a substratum and after detachment and suspension. Phosphatidylinositols 36-52 epidermal growth factor Homo sapiens 75-78 3262342-0 1988 Epidermal growth factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal Growth Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours. Phosphatidylinositols 35-55 epidermal growth factor Homo sapiens 0-23 3262342-0 1988 Epidermal growth factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal Growth Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours. Phosphatidylinositols 35-55 epidermal growth factor Homo sapiens 133-156 3262342-0 1988 Epidermal growth factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal Growth Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours. Phosphatidylinositols 168-188 epidermal growth factor Homo sapiens 0-23 3262342-0 1988 Epidermal growth factor stimulates phosphatidylinositol turnover for ten hours in A431 cells without activation of protein kinase C. Epidermal Growth Factor stimulated phosphatidylinositol turnover in A431 cells for up to ten hours. Phosphatidylinositols 168-188 epidermal growth factor Homo sapiens 133-156 3138977-2 1988 In human A431 epidermoid carcinoma cells, epidermal growth factor (EGF) rapidly stimulates the breakdown of inositol phospholipids and raises cytoplasmic free [Ca2+]. Phosphatidylinositols 108-130 epidermal growth factor Homo sapiens 42-65 3138977-2 1988 In human A431 epidermoid carcinoma cells, epidermal growth factor (EGF) rapidly stimulates the breakdown of inositol phospholipids and raises cytoplasmic free [Ca2+]. Phosphatidylinositols 108-130 epidermal growth factor Homo sapiens 67-70 3494731-12 1987 Although we confirmed that EGF stimulated the incorporation of phosphate into phosphatidylinositol in A431 cells, it failed to do so in the MDA468 cells. Phosphatidylinositols 78-98 epidermal growth factor Homo sapiens 27-30 2433285-1 1987 The effects of epidermal growth factor (EGF) on the metabolism of phosphatidylinositol were examined using A431 cells labeled with either 32PO3(4)- or myo-[3H] inositol. Phosphatidylinositols 66-86 epidermal growth factor Homo sapiens 40-43 2433285-3 1987 These changes were found to be due to two effects of EGF on the phosphatidylinositol cycle. Phosphatidylinositols 64-84 epidermal growth factor Homo sapiens 53-56