PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8382669-8 1993 The V1 receptor antagonist [beta-mercapto-beta,beta-cyclopentamethylenepropionyl1,-O-Me-Tyr2, A rg8]- vasopressin completely inhibited AVP-induced PPI hydrolysis. Phosphatidylinositols 147-150 arginine vasopressin Homo sapiens 102-113 8812299-7 1996 ET-induced activation of the phosphoinositide/Ca(2+)- mobilizing pathway in neuronal and endocrine cells is associated with rapid stimulation of secretory responses, including release of gonadotropin-releasing hormone, oxytocin, vasopressin, substance P, atrial natriuretic peptides, gonadotropins, thyrotropin, growth hormone, parathyroid hormone, aldosterone, and catecholamines. Phosphatidylinositols 29-45 arginine vasopressin Homo sapiens 229-240 7867583-5 1995 In glomerulosa cell-enriched primary cultures, vasopressin increased aldosterone secretion (ED50, 0.4 nM; maximal stimulation, 2.5-fold) and was found to be as potent as angiotensin-II in stimulating aldosterone secretion, phosphoinositide turnover, and calcium mobilization. Phosphatidylinositols 223-239 arginine vasopressin Homo sapiens 47-58 2543367-0 1989 The effect of cholera toxin on the inhibition of vasopressin-stimulated inositol phospholipid hydrolysis is a cyclic AMP-mediated event at the level of receptor binding. Phosphatidylinositols 72-93 arginine vasopressin Homo sapiens 49-60 1652269-0 1991 ADH-dependent phosphoinositide signalling system and prostaglandin E production in the frog urinary bladder. Phosphatidylinositols 14-30 arginine vasopressin Homo sapiens 0-3 2169360-1 1990 We have studied the inositol phospholipid turnover response to thyrotrophin-releasing hormone (TRH) gonadotrophin-releasing hormone (GnRH) and arginine vasopressin (AVP) in five corticotroph and six somatotroph pituitary adenomas. Phosphatidylinositols 20-41 arginine vasopressin Homo sapiens 152-163 2165391-3 1990 Exposure of the hepatocytes to 100 nM-vasopressin produced an increased phosphoinositide turnover, as reflected by the changes in the concentrations of inositol trisphosphate and Ca2+, and in glycogen phosphorylase a activity. Phosphatidylinositols 72-88 arginine vasopressin Homo sapiens 38-49 2543367-7 1989 We suggest that the effect of cholera toxin and agents which increase intracellular cyclic AMP on vasopressin-stimulated inositol lipid hydrolysis is an effect on receptor number, and that there is no requirement to postulate a role for a novel G-protein, which is a substrate for cholera toxin, in the regulation of inositol phospholipid metabolism. Phosphatidylinositols 317-338 arginine vasopressin Homo sapiens 98-109 2534942-6 1989 It is concluded that AVP induced both homologous and heterologous desensitization of phosphatidylinositol turnover and calcium release in smooth muscle cells. Phosphatidylinositols 85-105 arginine vasopressin Homo sapiens 21-24 2536741-4 1989 When platelets were stimulated with vasopressin in the presence of the compound, protein kinase C activity was markedly increased; the formation of inositol phosphates, the increase in intracellular Ca2+ and shape-change reaction were antagonized while the vasopressin-induced polyphosphoinositide synthesis was amplified, and this in a distinct inositolphospholipid pool. Phosphatidylinositols 346-366 arginine vasopressin Homo sapiens 36-47 2822282-3 1987 In contrast, vasopressin stimulated phosphatidylinositol labelling to a much greater extent than epinephrine or angiotension II. Phosphatidylinositols 36-56 arginine vasopressin Homo sapiens 13-24 2850247-0 1988 Vasopressin induces breakdown of phosphoinositides in adrenal tumor Y-1 cells without a steroidogenic effect. Phosphatidylinositols 33-50 arginine vasopressin Homo sapiens 0-11 3130896-7 1988 It is concluded that in hepatocytes vasopressin increases diacylglycerols by a process which does not principally involve the conversion of phosphoinositides to diacylglycerol or the de novo synthesis of diacylglycerol from glycerol 3-phosphate, but does involve the Ca2+-dependent conversion of phosphatidylethanolamine and phosphatidylcholine to diacylglycerol. Phosphatidylinositols 140-157 arginine vasopressin Homo sapiens 36-47 2829912-0 1988 Effects of quinacrine on vasopressin-induced changes in glycogen phosphorylase activity, Ca2+ transport and phosphoinositide metabolism in isolated hepatocytes. Phosphatidylinositols 108-124 arginine vasopressin Homo sapiens 25-36 3593215-5 1987 These results suggest that the potentiation of vasopressin-induced platelet activation by adrenaline is mediated via enhancement of inositol phospholipid hydrolysis and elevation of [Ca2+]i. Phosphatidylinositols 132-153 arginine vasopressin Homo sapiens 47-58 2820960-7 1987 Time course studies indicate that the relative rates of incorporation of [3H]inositol into sensitive and insensitive phosphoinositide remain constant from 2 to 24 h. Several factors are capable of increasing [3H]inositol incorporation into hormone-insensitive phosphoinositide including vasopressin, calcium ionophores, and manganese. Phosphatidylinositols 117-133 arginine vasopressin Homo sapiens 287-298 2820960-7 1987 Time course studies indicate that the relative rates of incorporation of [3H]inositol into sensitive and insensitive phosphoinositide remain constant from 2 to 24 h. Several factors are capable of increasing [3H]inositol incorporation into hormone-insensitive phosphoinositide including vasopressin, calcium ionophores, and manganese. Phosphatidylinositols 260-276 arginine vasopressin Homo sapiens 287-298 2820960-8 1987 On the other hand, vasopressin treatment appears to decrease incorporation of [3H]inositol into the hormone-sensitive pool, probably by shifting the equilibrium between phosphoinositides and inositol phosphates, since the decrease in radioactivity observed in the phosphoinositides is equaled by the increase observed in that in the inositol phosphates. Phosphatidylinositols 169-186 arginine vasopressin Homo sapiens 19-30 2820960-8 1987 On the other hand, vasopressin treatment appears to decrease incorporation of [3H]inositol into the hormone-sensitive pool, probably by shifting the equilibrium between phosphoinositides and inositol phosphates, since the decrease in radioactivity observed in the phosphoinositides is equaled by the increase observed in that in the inositol phosphates. Phosphatidylinositols 264-281 arginine vasopressin Homo sapiens 19-30 3117041-11 1987 It is concluded that an early action of vasopressin on the liver cell is to increase the flux of carbon from phospholipids, including the phosphoinositides, to diacylglycerols. Phosphatidylinositols 138-155 arginine vasopressin Homo sapiens 40-51 3010956-9 1986 These results indicate that vasopressin-induced human platelet activation is initiated by combination with specific V1 receptors on the platelet, and that the sequelae of receptor occupancy (stimulation of phosphoinositide metabolism and elevation of [Ca2+]i) are equally susceptible to inhibition by receptor antagonists and by receptor desensitization. Phosphatidylinositols 206-222 arginine vasopressin Homo sapiens 28-39 3027529-1 1987 We have reported previously that in the vascular smooth muscle cell line A-10 (ATCC CRL 1476), vasopressin stimulated phosphatidylinositol turnover Ca2+ efflux and inhibited isoproterenol-stimulated cAMP accumulation. Phosphatidylinositols 118-138 arginine vasopressin Homo sapiens 95-106 3021903-5 1986 In contrast, glutamate, carbachol, histamine, substance P, and vasopressin, agents that increase phosphoinositide hydrolysis in other tissues, do not stimulate this response in choroid plexus. Phosphatidylinositols 97-113 arginine vasopressin Homo sapiens 63-74 3015563-0 1986 Vasopressin induces breakdown of membrane phosphoinositides in adrenal glomerulosa and fasciculata cells. Phosphatidylinositols 42-59 arginine vasopressin Homo sapiens 0-11 3010956-0 1986 Desensitization and antagonism of vasopressin-induced phosphoinositide metabolism and elevation of cytosolic free calcium concentration in human platelets. Phosphatidylinositols 54-70 arginine vasopressin Homo sapiens 34-45 3010956-2 1986 Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). Phosphatidylinositols 23-39 arginine vasopressin Homo sapiens 0-11 3010956-2 1986 Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). Phosphatidylinositols 157-177 arginine vasopressin Homo sapiens 0-11 3010956-2 1986 Vasopressin stimulated phosphoinositide metabolism, as indicated by the early formation of [32P]phosphatidic acid ([32P]PtdA) and later accumulation of [32P]phosphatidylinositol ([32P]PtdIns). Phosphatidylinositols 184-190 arginine vasopressin Homo sapiens 0-11 3010956-3 1986 In addition, vasopressin elicited a transient depletion of [glycerol-3H]PtdIns and accumulation of [glycerol-3H]PtdA. Phosphatidylinositols 72-78 arginine vasopressin Homo sapiens 13-24 3010956-4 1986 The effects of vasopressin on phosphoinositide metabolism were concentration-dependent, with half maximal [32P]PtdA formation occurring at 30 +/- 15 nM-vasopressin. Phosphatidylinositols 30-46 arginine vasopressin Homo sapiens 15-26 3010956-4 1986 The effects of vasopressin on phosphoinositide metabolism were concentration-dependent, with half maximal [32P]PtdA formation occurring at 30 +/- 15 nM-vasopressin. Phosphatidylinositols 30-46 arginine vasopressin Homo sapiens 152-163 3014249-0 1986 Vascular vasopressin receptors mediate phosphatidylinositol turnover and calcium efflux in an established smooth muscle cell line. Phosphatidylinositols 39-59 arginine vasopressin Homo sapiens 9-20 3014249-1 1986 Vasopressin-induced phosphatidylinositol turnover and mobilization of intracellular Ca2+ was studied using an established smooth muscle cell line (A-10). Phosphatidylinositols 20-40 arginine vasopressin Homo sapiens 0-11 3014249-9 1986 Pertussis toxin pretreatment partially inhibited vasopressin-induced phosphatidylinositol turnover. Phosphatidylinositols 69-89 arginine vasopressin Homo sapiens 49-60 3779039-1 1986 The involvement of phosphoinositide hydrolysis in the action of oxytocin and vasopressin on the uterus was investigated in gestational myometrium and decidua cells by measuring the production of inositol phosphates. Phosphatidylinositols 19-35 arginine vasopressin Homo sapiens 77-88 6811579-0 1982 Phosphatidylinositol breakdown induced by vasopressin and epinephrine in hepatocytes is calcium-dependent. Phosphatidylinositols 0-20 arginine vasopressin Homo sapiens 42-53 3006664-1 1986 The activation of platelet V1-receptors by vasopressin (0.01-1 microM) induces the rapid formation of inositol phosphates, 1,2-diacylglycerol and phosphatidic acid, indicating inositol phospholipid hydrolysis by phospholipase C. Vasopressin immediately induces the formation of inositol bisphosphate and inositol trisphosphate. Phosphatidylinositols 176-197 arginine vasopressin Homo sapiens 43-54 3002355-5 1985 ADH initially inhibited and subsequently stimulated 32Pi incorporation into phosphatidic acid (PA) and phosphatidylinositol (PI). Phosphatidylinositols 103-123 arginine vasopressin Homo sapiens 0-3 3001069-5 1986 The stimulation of phosphatidylinositol labeling induced by vasopressin was decreased by PMA, whereas that induced by angiotensin II was not affected. Phosphatidylinositols 19-39 arginine vasopressin Homo sapiens 60-71 3006664-0 1986 Activation of V1-receptors by vasopressin stimulates inositol phospholipid hydrolysis and arachidonate metabolism in human platelets. Phosphatidylinositols 53-74 arginine vasopressin Homo sapiens 30-41 3000601-2 1985 Both direct activators of kinase C (e.g. phorbol ester analogues) and hormones that activate kinase C via receptor-mediated phosphoinositide turnover (e.g. PDGF, bradykinin, or vasopressin) elicited a rapid increase in c-myc mRNA expression. Phosphatidylinositols 124-140 arginine vasopressin Homo sapiens 177-188 2995443-1 1985 Evidence for modulation of action of vasopressin by protein kinase C. The action of vasopressin (AVP) in transporting epithelia is mediated by cyclic AMP(cAMP), whereas its effects in hepatocytes are mediated by calcium and phosphoinositides. Phosphatidylinositols 224-241 arginine vasopressin Homo sapiens 37-48 2995443-1 1985 Evidence for modulation of action of vasopressin by protein kinase C. The action of vasopressin (AVP) in transporting epithelia is mediated by cyclic AMP(cAMP), whereas its effects in hepatocytes are mediated by calcium and phosphoinositides. Phosphatidylinositols 224-241 arginine vasopressin Homo sapiens 84-95 2579584-8 1985 VP enhanced 32P labeling of phosphatidylinositol (PI) and phosphatidic acid. Phosphatidylinositols 28-48 arginine vasopressin Homo sapiens 0-2 6412700-5 1983 Incorporation of [32P]Pi into mitochondrial phosphatidylinositol was enhanced by phenylephrine and vasopressin. Phosphatidylinositols 44-64 arginine vasopressin Homo sapiens 99-110 744313-0 1978 The influence of extracellular calcium concentration on the vasopressin-stimulated incorporation of inorganic phosphate into phosphatidylinositol in hepatocyte suspensions. Phosphatidylinositols 125-145 arginine vasopressin Homo sapiens 60-71 444224-3 1979 The molecular specificity of the hepatic vasopressin receptor and the role of vasopressin-stimulated phosphatidylinositol turnover are discussed. Phosphatidylinositols 101-121 arginine vasopressin Homo sapiens 78-89 30862571-1 2019 Chronic stimulation (24 h) with vasopressin leads to hypertrophy in H9c2 cardiomyoblasts and this is accompanied by continuous activation of phospholipase C. Consequently, vasopressin stimulation leads to a depletion of phosphatidylinositol levels. Phosphatidylinositols 220-240 arginine vasopressin Homo sapiens 32-43 590505-0 1977 Rapid stimulation, by vasopressin and adrenaline, of inorganic phosphate incorporation into phosphatidyl inositol in isolated hepatocytes. Phosphatidylinositols 92-113 arginine vasopressin Homo sapiens 22-33 30862571-1 2019 Chronic stimulation (24 h) with vasopressin leads to hypertrophy in H9c2 cardiomyoblasts and this is accompanied by continuous activation of phospholipase C. Consequently, vasopressin stimulation leads to a depletion of phosphatidylinositol levels. Phosphatidylinositols 220-240 arginine vasopressin Homo sapiens 172-183 30862571-8 2019 We conclude that vasopressin stimulates CDS1 mRNA through phospholipase C, protein kinase C and cFos and provides a potential mechanism for maintenance of phosphatidylinositol levels during long-term phospholipase C signalling. Phosphatidylinositols 155-175 arginine vasopressin Homo sapiens 17-28 11068133-7 2000 Results of experiments to determine the mechanism of vasopressin-induced neurotrophism demonstrated that vasopressin-induced neurotrophism is dependent on V(1)a receptor activation, requires L-type calcium channel activation and activation of both pathways of the phosphatidylinositol signaling cascade, inositol trisphosphate and protein kinase C. These studies are the first to describe a functional cellular response for vasopressin in the cerebral cortex. Phosphatidylinositols 264-284 arginine vasopressin Homo sapiens 53-64 11068133-7 2000 Results of experiments to determine the mechanism of vasopressin-induced neurotrophism demonstrated that vasopressin-induced neurotrophism is dependent on V(1)a receptor activation, requires L-type calcium channel activation and activation of both pathways of the phosphatidylinositol signaling cascade, inositol trisphosphate and protein kinase C. These studies are the first to describe a functional cellular response for vasopressin in the cerebral cortex. Phosphatidylinositols 264-284 arginine vasopressin Homo sapiens 105-116 11068133-7 2000 Results of experiments to determine the mechanism of vasopressin-induced neurotrophism demonstrated that vasopressin-induced neurotrophism is dependent on V(1)a receptor activation, requires L-type calcium channel activation and activation of both pathways of the phosphatidylinositol signaling cascade, inositol trisphosphate and protein kinase C. These studies are the first to describe a functional cellular response for vasopressin in the cerebral cortex. Phosphatidylinositols 264-284 arginine vasopressin Homo sapiens 105-116 9581826-10 1998 Functional engagement of vasopressin V2 receptors is reported to produce rises in cAMP and activation of protein kinase A, whereas stimulation of V1b receptors is believed to produce similar changes to those produced by V1a receptors, i.e., activation of phospholipases and of protein kinase C. Stimulation of VACM receptors raises intracellular free Ca2+ through currently unknown but phosphoinositide-independent mechanisms. Phosphatidylinositols 386-402 arginine vasopressin Homo sapiens 25-36