PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18071753-0 2008 GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3-kinase pathway. Phosphatidylinositols 137-157 mitogen-activated protein kinase 1 Homo sapiens 120-123 18556704-5 2008 Studies on promoter activity measurements indicated that phosphoinositide turnover, cellular homologue of v-src (c-Src), protein kinase C (PKC), extracellular signal-regulated kinase (ERK), and p38 are involved in upregulating GRP78 gene transcription. Phosphatidylinositols 57-73 mitogen-activated protein kinase 1 Homo sapiens 145-182 18556704-5 2008 Studies on promoter activity measurements indicated that phosphoinositide turnover, cellular homologue of v-src (c-Src), protein kinase C (PKC), extracellular signal-regulated kinase (ERK), and p38 are involved in upregulating GRP78 gene transcription. Phosphatidylinositols 57-73 mitogen-activated protein kinase 1 Homo sapiens 184-187 18351459-4 2008 The conventional mGluR1/5 signaling cascade (phosphoinositide hydrolysis and intracellular Ca(2+) release) participates in linking mGluR1/5 to ERK. Phosphatidylinositols 45-61 mitogen-activated protein kinase 1 Homo sapiens 143-146 19801633-5 2009 Furthermore, we found that overexpression of the dominant negative mutant of p85 (regulatory subunit of phosphatidylinositol 3-kinase) or Akt dramatically suppressed B[a]PDE-induced JNK and Erk activation as well as cyclin D1 expression, suggesting that cyclin D1 induction by B[a]PDE is via the phosphatidylinositol 3-kinase/Akt/MAPK-dependent pathway. Phosphatidylinositols 104-124 mitogen-activated protein kinase 1 Homo sapiens 190-193 15047712-10 2004 These data suggest that LGI1 plays a major role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. Phosphatidylinositols 100-120 mitogen-activated protein kinase 1 Homo sapiens 130-133 17591797-4 2007 Phosphatidylinositol-specific phospholipase C, which inhibits VacA-induced p38 MAPK activation, blocked VacA-induced COX-2 expression. Phosphatidylinositols 0-20 mitogen-activated protein kinase 1 Homo sapiens 75-78 16445858-3 2006 We recently found that phosphatidylinositol-specific phospholipase C-gamma1 (PLC-gamma1) directly binds to extracellular signal-regulated kinase 2 (ERK2), a MAPK, via a D-domain-dependent mechanism. Phosphatidylinositols 23-43 mitogen-activated protein kinase 1 Homo sapiens 107-146 16445858-3 2006 We recently found that phosphatidylinositol-specific phospholipase C-gamma1 (PLC-gamma1) directly binds to extracellular signal-regulated kinase 2 (ERK2), a MAPK, via a D-domain-dependent mechanism. Phosphatidylinositols 23-43 mitogen-activated protein kinase 1 Homo sapiens 148-152 16445858-3 2006 We recently found that phosphatidylinositol-specific phospholipase C-gamma1 (PLC-gamma1) directly binds to extracellular signal-regulated kinase 2 (ERK2), a MAPK, via a D-domain-dependent mechanism. Phosphatidylinositols 23-43 mitogen-activated protein kinase 1 Homo sapiens 157-161 16445858-5 2006 In the present studies we sought to determine whether MAPK docking sequences could be recognized in other enzymes that metabolize phosphatidylinositols (PIs), as well as in enzymes that metabolize inositol phosphates (IPs). Phosphatidylinositols 130-151 mitogen-activated protein kinase 1 Homo sapiens 54-58 16445858-5 2006 In the present studies we sought to determine whether MAPK docking sequences could be recognized in other enzymes that metabolize phosphatidylinositols (PIs), as well as in enzymes that metabolize inositol phosphates (IPs). Phosphatidylinositols 153-156 mitogen-activated protein kinase 1 Homo sapiens 54-58 16445858-8 2006 CONCLUSION: The results indicate that there may be extensive crosstalk between MAPK signaling and signaling pathways that are regulated by cellular levels of PIs or IPs. Phosphatidylinositols 158-161 mitogen-activated protein kinase 1 Homo sapiens 79-83 16081678-10 2005 These results suggest that PGE(2) enhances neurotrophin-4 production by activating Sp1 via the EP3/phosphatidylinositol-specific phospholipase C/protein kinase Calpha/MEK1/ERK pathway. Phosphatidylinositols 99-119 mitogen-activated protein kinase 1 Homo sapiens 172-175 12502866-0 2003 Kaposi"s sarcoma-associated herpesvirus induces the phosphatidylinositol 3-kinase-PKC-zeta-MEK-ERK signaling pathway in target cells early during infection: implications for infectivity. Phosphatidylinositols 52-72 mitogen-activated protein kinase 1 Homo sapiens 95-98 14676841-7 2004 Therefore, we conclude that CD81 stimulates synthesis of phosphoinositides with the recruitment of Shc to the plasma membrane via PTB domain, and this sequence of events induces activation of ERK/MAPKinase. Phosphatidylinositols 57-74 mitogen-activated protein kinase 1 Homo sapiens 192-195 11594774-4 2001 ERK activation by insulin, IGF-I, or PDGF was unaffected by the phosphatidylinositol 3-kinase inhibitor wortmannin but was abolished by the MEK inhibitor PD98059. Phosphatidylinositols 64-84 mitogen-activated protein kinase 1 Homo sapiens 0-3 11278479-7 2001 The role of ERK in store-mediated Ca(2+) entry was found to be independent of phosphatidylinositol 3- and 4-kinases, the tyrosine kinase pathway, and actin polymerization but sensitive to treatment with inhibitors of Ras, suggesting that the ERK pathway might be a downstream effector of Ras in mediating store-mediated Ca(2+) entry in human platelets. Phosphatidylinositols 78-98 mitogen-activated protein kinase 1 Homo sapiens 12-15 8654435-7 1996 Our results suggest that the production of 3-phosphorylated inositol phospholipids is involved in the activation of Erk2, but does not regulate the enzymes that are thought to be upstream of Erk2. Phosphatidylinositols 60-82 mitogen-activated protein kinase 1 Homo sapiens 116-120 27105323-6 2016 Further analysis revealed that down-regulation of TCF3 gene expression inhibits Akt and Erk1/2 activation, suggesting that the carcinogenic properties of TCF3 in GBM are partially mediated by the phosphatidylinositol 3-kinase-Akt and MAPK-Erk signaling pathways. Phosphatidylinositols 196-216 mitogen-activated protein kinase 1 Homo sapiens 88-91 11687581-7 2001 Furthermore, pretreatment with wortmannin, an inhibitor of phosphatidylinositol 3 (PI3)-kinase, inhibited 15-d-PGJ2-induced ERK activation and c-fos mRNA expression, suggesting that PI3-kinase is involved in the process. Phosphatidylinositols 59-79 mitogen-activated protein kinase 1 Homo sapiens 124-127 11278310-9 2001 The transient phase of the ERK activity was partially inhibited either by the phosphatidylinositol 3-kinase inhibitor, LY 294002, or the PKC inhibitor, Go 6976. Phosphatidylinositols 78-98 mitogen-activated protein kinase 1 Homo sapiens 27-30 10801448-1 2000 We have previously shown that inhibition of phosphatidylinositol (PI) 3-kinase severely attenuates the activation of extracellular signal-regulated kinase (Erk) following engagement of integrin/fibronectin receptors and that Raf is the critical target of PI 3-kinase regulation [1]. Phosphatidylinositols 44-64 mitogen-activated protein kinase 1 Homo sapiens 117-154 10801448-1 2000 We have previously shown that inhibition of phosphatidylinositol (PI) 3-kinase severely attenuates the activation of extracellular signal-regulated kinase (Erk) following engagement of integrin/fibronectin receptors and that Raf is the critical target of PI 3-kinase regulation [1]. Phosphatidylinositols 44-64 mitogen-activated protein kinase 1 Homo sapiens 156-159 25903517-5 2015 The phosphoinositide pathway, rather than the cyclic AMP pathway, mediated the odorant-induced activation of the MEK-Erk pathway. Phosphatidylinositols 4-20 mitogen-activated protein kinase 1 Homo sapiens 117-120