PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8545053-0 1995 Arginine vasopressin stimulates 32P labeling of phosphoinositides in rat pineal gland. Phosphatidylinositols 48-65 arginine vasopressin Rattus norvegicus 9-20 9184819-10 1997 It seems that in rat urinary bladder vasopressin-induced contraction is mediated through phosphoinositide metabolism. Phosphatidylinositols 89-105 arginine vasopressin Rattus norvegicus 37-48 9175129-1 1997 The role of phosphatidylcholine (PC) and phosphatidylinositol (PI) specific phospholipase C (PLC) enzymes in the release of immunoreactive arginine vasopressin (ir-AVP) from rat hypothalami in vitro was examined. Phosphatidylinositols 41-61 arginine vasopressin Rattus norvegicus 148-159 9065736-3 1997 Arachidonate transfer from phosphatidylcholine to phosphatidylethanolamine was an early event for both agonists, but phosphatidylinositol hydrolysis was an early event for AVP-stimulated cells and a late event for cells triggered with AlF4-. Phosphatidylinositols 117-137 arginine vasopressin Rattus norvegicus 172-175 9564830-8 1998 Thus, AVP triggers intracellular Ca2+ release from the (IP3)-sensitive store via a GTP binding protein-coupled phosphoinositide pathway. Phosphatidylinositols 111-127 arginine vasopressin Rattus norvegicus 6-9 9566621-4 1998 Both bradykinin and vasopressin rapidly increased phosphatidylinositol (PI) turnover in PC-12 and in NRK-49F cells, indicating that these cell lines constitutively expressed functional PI-linked receptors for these neuropeptides. Phosphatidylinositols 50-70 arginine vasopressin Rattus norvegicus 20-31 8545053-7 1995 The data indicate that AVP activates the phosphoinositide signaling system via V1 receptors and is without effect on the cAMP system. Phosphatidylinositols 41-57 arginine vasopressin Rattus norvegicus 23-26 8089151-3 1994 Phosphatidylinositol-specific phospholipase C was activated in response to vasopressin but not to PMA. Phosphatidylinositols 0-20 arginine vasopressin Rattus norvegicus 75-86 7998993-1 1994 Rat hepatocytes respond to glycogenolytic stimuli acting via phosphoinositide breakdown (e.g. alpha 1-adrenergic agonists, vasopressin) by oscillations of the free intracellular Ca2+ concentration ([Ca2+]i). Phosphatidylinositols 61-77 arginine vasopressin Rattus norvegicus 123-134 8393622-1 1993 In renal collecting duct epithelial cells, arginine vasopressin (AVP) at greater than nanomolar concentrations has been reported to transiently increase intracellular free calcium ([Ca2+]i) in a manner consistent with activation of the phosphoinositide pathway. Phosphatidylinositols 236-252 arginine vasopressin Rattus norvegicus 52-63 7905713-8 1994 These effects were partially blocked by calphostin C, an inhibitor of protein kinase C. These results demonstrate that activation of phosphatidylinositol hydrolysis and/or activation of protein kinase C markedly inhibits osmotic water permeability in isolated perfused IMCD segments, even in the absence of prior stimulation by vasopressin. Phosphatidylinositols 133-153 arginine vasopressin Rattus norvegicus 328-339 1329268-0 1992 Phosphoinositide hydrolysis and calcium mobilization induced by vasopressin and angiotensin II in cultured vascular smooth muscle cells. Phosphatidylinositols 0-16 arginine vasopressin Rattus norvegicus 64-75 1560825-2 1992 Arginine vasopressin receptors are G protein-coupled and have been divided into at least three types; the V1a (vascular/hepatic) and V1b (anterior pituitary) receptors which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+, and the V2 (kidney) receptor which is coupled to adenylate cyclase. Phosphatidylinositols 186-206 arginine vasopressin Rattus norvegicus 9-20 1329268-6 1992 These results indicate that, unlike voltage-dependent calcium influx across the cell membrane, AII and AVP induce receptor-mediated increases in cytosolic free calcium via phosphoinositide hydrolysis creating an intracellular messenger for calcium release from intracellular calcium stores. Phosphatidylinositols 172-188 arginine vasopressin Rattus norvegicus 103-106 8149696-5 1993 Arginine-vasopressin-triggered hydrolysis of phosphoinositides by phospholipase C was evaluated by measuring [3H]inositol phosphate formation. Phosphatidylinositols 45-62 arginine vasopressin Rattus norvegicus 9-20 8384449-1 1993 The hydrolysis of inositol phospholipids induced by vasopressin in hepatocytes during 60 min was quantified chemically. Phosphatidylinositols 18-40 arginine vasopressin Rattus norvegicus 52-63 8384449-19 1993 In summary, the results indicate that inositol phospholipid hydrolysis by phospholipase C can account for most of the diacylglycerol and phosphatidate that accumulate during 60 min of vasopressin action, but that these phospholipids are probably not the major source of the phosphatidate that is formed during the first 2 min by phospholipase D, or of the diacylglycerol and phosphatidate that are formed beyond 30 min. Phosphatidylinositols 38-59 arginine vasopressin Rattus norvegicus 184-195 1654901-2 1991 We report here that okadaic acid inhibits in isolated hepatocytes the stimulations of phosphoinositide turnover induced by epinephrine, angiotensin II and vasopressin. Phosphatidylinositols 86-102 arginine vasopressin Rattus norvegicus 155-166 2167661-1 1990 Both vasopressin and bradykinin activate the phosphoinositide cycle in WRK-1 rat mammary tumour cells. Phosphatidylinositols 45-61 arginine vasopressin Rattus norvegicus 5-16 1830269-1 1991 We have previously shown that arginine vasopressin (AVP) possesses specific binding sites on rat adrenal glomerulosa cells and stimulates phosphoinositide breakdown and accumulation of inositol phosphates (IP) and diacylglycerol. Phosphatidylinositols 138-154 arginine vasopressin Rattus norvegicus 39-50 1830269-1 1991 We have previously shown that arginine vasopressin (AVP) possesses specific binding sites on rat adrenal glomerulosa cells and stimulates phosphoinositide breakdown and accumulation of inositol phosphates (IP) and diacylglycerol. Phosphatidylinositols 138-154 arginine vasopressin Rattus norvegicus 52-55 1859365-7 1991 Since the time courses for the release of choline into the medium and the accumulation of phosphatidate and diacylglycerol caused by vasopressin and glucagon were similar, the more rapid activation of PKC by vasopressin probably reflects diacylglycerol formation from phosphoinositide breakdown. Phosphatidylinositols 268-284 arginine vasopressin Rattus norvegicus 208-219 1645753-0 1991 Vasopressin-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting duct cells is mediated by the oxytocin receptor. Phosphatidylinositols 23-39 arginine vasopressin Rattus norvegicus 0-11 2244879-3 1990 The steroidogenic activities of angiotensin II and vasopressin are probably mediated via the phosphatidylinositol-turnover pathway and associated changes in cytosolic Ca2+ concentration. Phosphatidylinositols 93-113 arginine vasopressin Rattus norvegicus 51-62 1846589-9 1991 These results indicate that phorbol ester inhibits the cellular action of AVP mediated through the activation of protein kinase-C and suggest that there is an interaction between cAMP and phosphatidylinositol systems in modulating the AVP action in renal papillary collecting tubule cells. Phosphatidylinositols 188-208 arginine vasopressin Rattus norvegicus 74-77 1846589-9 1991 These results indicate that phorbol ester inhibits the cellular action of AVP mediated through the activation of protein kinase-C and suggest that there is an interaction between cAMP and phosphatidylinositol systems in modulating the AVP action in renal papillary collecting tubule cells. Phosphatidylinositols 188-208 arginine vasopressin Rattus norvegicus 235-238 2167661-7 1990 Thus although there is a significant overlap between the phosphoinositide pools responding to vasopressin and bradykinin, there is a small fraction of the hormone-sensitive lipid which responds only to bradykinin. Phosphatidylinositols 57-73 arginine vasopressin Rattus norvegicus 94-105 2107881-8 1990 These data indicate that the stimulation of phospholipase C activity in rat hepatocytes by 3 nM vasopressin is enhanced by cyclic AMP-dependent kinase but inhibited by protein kinase C. In contrast, down regulation of protein kinase C markedly enhanced the maximal phosphoinositide response due to both vasopressin and norepinephrine. Phosphatidylinositols 265-281 arginine vasopressin Rattus norvegicus 96-107 2106433-1 1990 We have previously shown that vasopressin (VP) induces breakdown of membrane phosphoinositides in adrenal glomerulosa cells. Phosphatidylinositols 77-94 arginine vasopressin Rattus norvegicus 30-41 2106433-10 1990 Together, these results signify that VP acts on rat glomerulosa cells by two distinct mechanisms: calcium influx, which is IAP sensitive, and phosphoinositide turnover, which is IAP insensitive. Phosphatidylinositols 142-158 arginine vasopressin Rattus norvegicus 37-39 2106433-1 1990 We have previously shown that vasopressin (VP) induces breakdown of membrane phosphoinositides in adrenal glomerulosa cells. Phosphatidylinositols 77-94 arginine vasopressin Rattus norvegicus 43-45 2544440-5 1989 In vasopressin-deleted medium, vasopressin elicited a rapid increase of intracellular inositol phosphate levels in REF52 cells and the control of phosphoinositide turnover was strictly regulated. Phosphatidylinositols 146-162 arginine vasopressin Rattus norvegicus 3-14 2551383-1 1989 In rat adipocytes, the breakdown of phosphoinositides labelled by a 3 h incubation with [3H]inositol resulted in the accumulation of labelled inositol mono-, bis- and trisphosphates in the presence of oxytocin, vasotocin or vasopressin. Phosphatidylinositols 36-53 arginine vasopressin Rattus norvegicus 224-235 2544440-5 1989 In vasopressin-deleted medium, vasopressin elicited a rapid increase of intracellular inositol phosphate levels in REF52 cells and the control of phosphoinositide turnover was strictly regulated. Phosphatidylinositols 146-162 arginine vasopressin Rattus norvegicus 31-42 2538419-1 1989 Arginine vasopressin (AVP) has been shown previously to enhance phosphatidylinositol (PI) turnover and mobilize calcium in the rat aortic smooth muscle cell-line (A10; ATCC CRL 1476) via the V1 receptor (Aiyar, N., Nambi, P., Stassen, F. L., and Crooke, S. T. (1986) Life Sci. Phosphatidylinositols 64-84 arginine vasopressin Rattus norvegicus 9-20 2544169-0 1989 Ca2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells. Phosphatidylinositols 53-69 arginine vasopressin Rattus norvegicus 26-37 2744081-0 1989 Calcium mobilization and phosphatidylinositol turnover in vas deferens smooth muscle of diabetic rats. Phosphatidylinositols 25-45 arginine vasopressin Rattus norvegicus 58-61 2744081-1 1989 The study concerned Ca2+ channels that are receptor-operated by norepinephrine (NE) and mediate hyper-reactivity of vas deferens smooth muscle from rats with streptozotocin (STZ)-induced diabetes, and the mediatory responses of these channels, such as tension development, Ca2+ uptake and phosphatidylinositol (PI) turnover. Phosphatidylinositols 289-309 arginine vasopressin Rattus norvegicus 116-119 19651096-0 1988 Bradykinin and vasopressin both stimulate phosphoinositide turnover in astrocytes in high serum- and low serum-containing media but have no effect on [(3)H]thymidine incorporation. Phosphatidylinositols 42-58 arginine vasopressin Rattus norvegicus 15-26 2537241-2 1989 Stimulation of the cells with arginine vasopressin (AVP) (1 microM) for 2 min caused a significant increase in labelled phosphatidic acid and a significant fall in radioactivity in phosphatidylinositol and phosphatidylinositol 4-monophosphate + phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositols 181-201 arginine vasopressin Rattus norvegicus 52-55 2542838-8 1989 We conclude that osmotic stress, but not acute hypovolemia, results in vasopressin-dependent activation of brainstem neurons by stimulating inositol phospholipid metabolism. Phosphatidylinositols 140-161 arginine vasopressin Rattus norvegicus 71-82 2969763-0 1988 Vasopressin stimulates inositol phospholipid metabolism in rat medulla oblongata in vivo. Phosphatidylinositols 23-44 arginine vasopressin Rattus norvegicus 0-11 2969763-1 1988 We have investigated whether microinjections of arginine-vasopressin (AVP) into the nucleus tractus solitarii (NTS) of rats results in the stimulation of inositol phospholipid metabolism, a biochemical event related to the activation of V1-type receptors. Phosphatidylinositols 154-175 arginine vasopressin Rattus norvegicus 57-68 2835449-0 1988 V1-type vasopressin receptors in rat brain septum: binding characteristics and effects on inositol phospholipid metabolism. Phosphatidylinositols 90-111 arginine vasopressin Rattus norvegicus 8-19 2835449-10 1988 The effects of these analogs on phosphoinositide hydrolysis is consistent with their potencies in displacing 3H-AVP from septal binding sites. Phosphatidylinositols 32-48 arginine vasopressin Rattus norvegicus 112-115 2835449-11 1988 These results indicate that vasopressin stimulates hydrolysis of inositol phospholipids in rat brain septum through an interaction with V1-type vasopressin receptors. Phosphatidylinositols 65-87 arginine vasopressin Rattus norvegicus 28-39 2835449-11 1988 These results indicate that vasopressin stimulates hydrolysis of inositol phospholipids in rat brain septum through an interaction with V1-type vasopressin receptors. Phosphatidylinositols 65-87 arginine vasopressin Rattus norvegicus 144-155 2963816-0 1988 Vasopressin induces V1 receptors to activate phosphatidylinositol- and phosphatidylcholine-specific phospholipase C and stimulates the release of arachidonic acid by at least two pathways in the smooth muscle cell line, A-10. Phosphatidylinositols 45-65 arginine vasopressin Rattus norvegicus 0-11 2826769-0 1988 High efficiency coupling of alpha-1 adrenergic receptors to inositol phospholipid metabolism revealed by denervation of rat vas deferens. Phosphatidylinositols 60-81 arginine vasopressin Rattus norvegicus 124-127 2537241-0 1989 Arginine vasopressin stimulates phosphoinositide turnover in an enriched rat Leydig cell preparation. Phosphatidylinositols 32-48 arginine vasopressin Rattus norvegicus 9-20 2537241-2 1989 Stimulation of the cells with arginine vasopressin (AVP) (1 microM) for 2 min caused a significant increase in labelled phosphatidic acid and a significant fall in radioactivity in phosphatidylinositol and phosphatidylinositol 4-monophosphate + phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositols 181-201 arginine vasopressin Rattus norvegicus 39-50 2855590-1 1988 We have previously shown that arginine vasopressin (AVP) stimulates the production of aldosterone in isolated superfused adrenal glomerulosa cells by a mechanism that involves an increased turnover of phosphoinositides. Phosphatidylinositols 201-218 arginine vasopressin Rattus norvegicus 39-50 3416185-0 1988 Vasopressin-stimulated turnover of phosphatidylinositol in the decentralised superior cervical ganglion of the rat. Phosphatidylinositols 35-55 arginine vasopressin Rattus norvegicus 0-11 3416185-1 1988 Vasopressin (AVP) receptors have been demonstrated in the superior cervical ganglion (SCG) linked to the turnover of phosphatidylinositol (PI). Phosphatidylinositols 117-137 arginine vasopressin Rattus norvegicus 0-11 3416185-1 1988 Vasopressin (AVP) receptors have been demonstrated in the superior cervical ganglion (SCG) linked to the turnover of phosphatidylinositol (PI). Phosphatidylinositols 117-137 arginine vasopressin Rattus norvegicus 13-16 2967914-1 1988 Specific vasopressin binding to WRK-1 rat mammary tumor cells was assessed and compared with vasopressin-induced alterations in phosphatidylinositol metabolism. Phosphatidylinositols 128-148 arginine vasopressin Rattus norvegicus 93-104 2967914-3 1988 The higher affinity site appeared to have V1a specificity and to correlate with vasopressin"s ability to stimulate phosphatidylinositol turnover in the cells. Phosphatidylinositols 115-135 arginine vasopressin Rattus norvegicus 80-91 2975069-7 1988 Unlabeled Antag also effectively antagonized vasopressin-stimulated phosphatidylinositol hydrolysis in septal tissue slices. Phosphatidylinositols 68-88 arginine vasopressin Rattus norvegicus 45-56 3112365-1 1987 We have previously reported that 8-arginine vasopressin (AVP) stimulates phosphatidylinositol turnover and Ca++ mobilization in rat aortic smooth muscle cells (A10). Phosphatidylinositols 73-93 arginine vasopressin Rattus norvegicus 44-55 3036589-8 1987 We suggest that the AVP-stimulated PA formation is an indication of phosphoinositide turnover. Phosphatidylinositols 68-84 arginine vasopressin Rattus norvegicus 20-23 19651096-2 1988 Cell division was arrested by transfer to low serum (0.1%)-containing medium for 24 h. Subsequently the neuropeptides bradykinin and vasopressin; previously shown to induce inositol phospholipid turnover, were added at 10 microM concentrations for a further 24 h, after which time the cultures were pulsed with [(3)H]thymidine to measure the rate of incorporation of the label due to receptor stimulation. Phosphatidylinositols 173-194 arginine vasopressin Rattus norvegicus 133-144 2985562-12 1985 These observations indicated that angiotensin II and [Arg]vasopressin interacted with independent receptors, both of which are linked to phosphoinositide breakdown and Ca2+ mobilization. Phosphatidylinositols 137-153 arginine vasopressin Rattus norvegicus 58-69 3561697-0 1987 Vasopressin activation of phosphatidylinositol metabolism in rat anterior pituitary in vitro and its modification by changes in the hypothalamo-pituitary-adrenal axis. Phosphatidylinositols 26-46 arginine vasopressin Rattus norvegicus 0-11 3561697-6 1987 Anterior pituitaries from vasopressin-deficient Brattleboro rats also show a phosphatidylinositol response to vasopressin. Phosphatidylinositols 77-97 arginine vasopressin Rattus norvegicus 26-37 3561697-6 1987 Anterior pituitaries from vasopressin-deficient Brattleboro rats also show a phosphatidylinositol response to vasopressin. Phosphatidylinositols 77-97 arginine vasopressin Rattus norvegicus 110-121 3561697-10 1987 These results confirm that the rat anterior pituitary contains functional vasopressin receptors capable of activating inositol phospholipid metabolism and that this biochemical response is modified by changes in the hypothalamo-pituitary-adrenal axis. Phosphatidylinositols 118-139 arginine vasopressin Rattus norvegicus 74-85 2947815-0 1987 L6 skeletal muscle cells have functional V1-vasopressin receptors coupled to stimulated inositol phospholipid metabolism. Phosphatidylinositols 88-109 arginine vasopressin Rattus norvegicus 44-55 2826210-0 1987 Vasopressin-induced turnover of phosphatidylinositol in the sensory nervous system of the rat. Phosphatidylinositols 32-52 arginine vasopressin Rattus norvegicus 0-11 2988926-0 1985 Pressor-type vasopressin receptors in the adrenal cortex: properties of binding, effects on phosphoinositide metabolism and aldosterone secretion. Phosphatidylinositols 92-108 arginine vasopressin Rattus norvegicus 13-24 2988926-3 1985 When added to dispersed rat adrenal glomerulosa cells, vasopressin (10(-8)-10(-6)M) stimulated the incorporation of 32P-phosphate into phosphatidylinositol, and the effect was blocked by the AVP receptor antagonist peptide d(CH2)5Tyr(Me)AVP. Phosphatidylinositols 135-155 arginine vasopressin Rattus norvegicus 55-66 2985562-0 1985 Increase in cytosolic calcium and phosphoinositide metabolism induced by angiotensin II and [Arg]vasopressin in vascular smooth muscle cells. Phosphatidylinositols 34-50 arginine vasopressin Rattus norvegicus 97-108 3011123-5 1986 It is suggested that activation of protein kinase C by phorbol esters or physiological stimuli (hormones that activate phosphoinositide turnover, such as vasopressin or angiotensin II) modulate the hepatocyte alpha 1-adrenergic responsiveness. Phosphatidylinositols 119-135 arginine vasopressin Rattus norvegicus 154-183 2938936-0 1986 Vasopressin stimulates phosphatidylinositol turnover and aldosterone synthesis in rat adrenal glomerulosa cells: comparison with angiotensin II. Phosphatidylinositols 23-43 arginine vasopressin Rattus norvegicus 0-11 2938936-1 1986 Vasopressin (VP) action was identified in rat adrenal glomerulosa cells measuring the VP stimulation of phosphatidylinositol breakdown to inositol-1-phosphate (IP). Phosphatidylinositols 104-124 arginine vasopressin Rattus norvegicus 0-11 2938936-1 1986 Vasopressin (VP) action was identified in rat adrenal glomerulosa cells measuring the VP stimulation of phosphatidylinositol breakdown to inositol-1-phosphate (IP). Phosphatidylinositols 104-124 arginine vasopressin Rattus norvegicus 13-15 2938936-1 1986 Vasopressin (VP) action was identified in rat adrenal glomerulosa cells measuring the VP stimulation of phosphatidylinositol breakdown to inositol-1-phosphate (IP). Phosphatidylinositols 104-124 arginine vasopressin Rattus norvegicus 86-88 3009431-10 1986 We propose that vasopressin and angiotensin II, which both mobilize calcium in hepatocytes via phosphatidylinositol turnover, can, by this same mechanism, activate a protein(s) which reduces further binding to their receptors. Phosphatidylinositols 95-115 arginine vasopressin Rattus norvegicus 16-46 3007742-0 1986 Comparison of the effects of muscarine and vasopressin on inositol phospholipid metabolism in the superior cervical ganglion of the rat. Phosphatidylinositols 58-79 arginine vasopressin Rattus norvegicus 43-54 3001231-0 1986 Arginine-vasopressin stimulates inositol phospholipid metabolism in rat hippocampus. Phosphatidylinositols 32-53 arginine vasopressin Rattus norvegicus 9-20 3001064-1 1986 We have previously characterized two distinct pools of phosphatidylinositol (PI) in the WRK-1 rat mammary tumor cell, one whose metabolism is enhanced in response to vasopressin and another which is insensitive to hormonal manipulation. Phosphatidylinositols 55-75 arginine vasopressin Rattus norvegicus 166-177 2998867-5 1985 The findings indicate that vasopressin is able to influence GTPase activity as well as accelerate phosphoinositide breakdown in rat hepatocytes. Phosphatidylinositols 98-114 arginine vasopressin Rattus norvegicus 27-38 6654910-1 1983 WRK-1 rat mammary tumor cells respond to vasopressin with an increase in the rate of phosphatidylinositol turnover. Phosphatidylinositols 85-105 arginine vasopressin Rattus norvegicus 41-52 6330070-0 1984 Subcellular site and mechanism of vasopressin-stimulated hydrolysis of phosphoinositides in rat hepatocytes. Phosphatidylinositols 71-88 arginine vasopressin Rattus norvegicus 34-45 6330070-1 1984 The intracellular site of vasopressin-induced phosphoinositide breakdown in rat hepatocytes was investigated. Phosphatidylinositols 46-62 arginine vasopressin Rattus norvegicus 26-37 6330070-4 1984 The level of 32P-labeled phosphatidylinositol in the plasma membrane decreased by 15% after 45 s of vasopressin treatment and then increased above control levels at later times while 32P-labeled phosphatidic acid levels in the plasma membrane gradually increased to 2-fold greater than control after 5 min of treatment. Phosphatidylinositols 25-45 arginine vasopressin Rattus norvegicus 100-111 6320911-5 1984 Phosphatidylinositol labeling was strongly stimulated by epinephrine, vasopressin and angiotensin II in cells from eu-, hyper- or hypothyroid rats. Phosphatidylinositols 0-20 arginine vasopressin Rattus norvegicus 70-81 6439189-2 1984 As early as 10s after addition of AVP (10(-6)M) a significant loss of radioactivity from phosphatidylinositol 4,5-bisphosphate but not from phosphatidylinositol 4-phosphate and phosphatidylinositol was observed in cells prelabelled with 32Pi. Phosphatidylinositols 89-109 arginine vasopressin Rattus norvegicus 34-37 6441046-4 1984 When the incorporation of [32P]phosphate into phospholipids was examined, phosphatidylinositol (PI) labeling due to vasopressin-stimulation remained rather unchanged up to 5 min but then rose gradually. Phosphatidylinositols 74-94 arginine vasopressin Rattus norvegicus 116-127 6315708-0 1983 Rapid changes in hepatocyte phosphoinositides induced by vasopressin. Phosphatidylinositols 28-45 arginine vasopressin Rattus norvegicus 57-68 6315708-1 1983 Vasopressin stimulated a 40% decrease in [32P]phosphatidylinositol 4,5-bisphosphate and a 15% decrease in [32P]phosphatidylinositol within 30 s of addition to hepatocytes prelabeled for 60 min with 32P. Phosphatidylinositols 46-66 arginine vasopressin Rattus norvegicus 0-11 6315708-2 1983 In hepatocytes prelabeled with [3H]inositol for 60 min, vasopressin produced 20% breakdown of phosphatidylinositol and 33% breakdown of phosphatidylinositol 4,5-bisphosphate within 30 s. There was a 40% increase in total phosphatidylinositol 4,5-bisphosphate within 30 s of vasopressin addition. Phosphatidylinositols 94-114 arginine vasopressin Rattus norvegicus 56-67 6315708-4 1983 In hepatocytes from rats labeled in vivo with [3H]inositol, vasopressin stimulated 10% loss of labeled phosphatidylinositol. Phosphatidylinositols 103-123 arginine vasopressin Rattus norvegicus 60-71 6315708-5 1983 Loss of [32P]phosphatidylinositol due to vasopressin was followed by reincorporation of label to levels greater than control while 32P reuptake into phosphatidylinositol 4,5-bisphosphate did not exceed control values. Phosphatidylinositols 13-33 arginine vasopressin Rattus norvegicus 41-52 6315708-9 1983 Vasopressin induces a rapid decrease of labeled phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate within 30 s. Phosphatidylinositols 48-68 arginine vasopressin Rattus norvegicus 0-11 6315016-0 1983 Influence of chronic ethanol treatment on alpha1-adrenergic and vasopressin receptor-stimulated phosphatidylinositol synthesis in isolated rat hepatocytes. Phosphatidylinositols 96-116 arginine vasopressin Rattus norvegicus 64-75 6315016-3 1983 However, vasopressin and alpha1-adrenergic stimulation of [32P]-incorporation into phosphatidylinositol of isolated hepatocytes from ethanol-treated rats was increased substantially compared to that of controls. Phosphatidylinositols 83-103 arginine vasopressin Rattus norvegicus 9-20 6302422-7 1983 In rat liver plasma membrane preparations, vasopressin increases phosphatidylinositol breakdown in the absence of Ca2+ or cytosol if deoxycholate is present. Phosphatidylinositols 65-85 arginine vasopressin Rattus norvegicus 43-54 7154849-7 1982 Phosphatidylinositol labeling was significantly increased by epinephrine, vasopressin and angiotensin II both in the absence or presence of calcium. Phosphatidylinositols 0-20 arginine vasopressin Rattus norvegicus 74-85 6814442-7 1982 In the hepatocytes prelabeled with [3H]arachidonic acid, stimulated degradation of phosphatidylinositol with the addition of vasopressin and resultant formation of phosphatidic acid were observed within 5 min. Phosphatidylinositols 83-103 arginine vasopressin Rattus norvegicus 125-136 6814442-8 1982 The transient accumulation of diacylglycerol, the product of phosphatidylinositol hydrolysis, also occurred within 5 min with vasopressin. Phosphatidylinositols 61-81 arginine vasopressin Rattus norvegicus 126-137 7084119-0 1982 Direct stimulation of phosphatidylinositol degradation by addition of vasopressin to purified rat liver plasma membranes. Phosphatidylinositols 22-42 arginine vasopressin Rattus norvegicus 70-81 7084119-3 1982 Vasopressin significantly enhanced degradation of phosphatidylinositol in the presence of deoxycholate (21% with deoxycholate alone versus 32% in the presence of vasopressin plus deoxycholate). Phosphatidylinositols 50-70 arginine vasopressin Rattus norvegicus 0-11 7084119-3 1982 Vasopressin significantly enhanced degradation of phosphatidylinositol in the presence of deoxycholate (21% with deoxycholate alone versus 32% in the presence of vasopressin plus deoxycholate). Phosphatidylinositols 50-70 arginine vasopressin Rattus norvegicus 162-173 7084119-5 1982 These results indicate that specific degradation of phosphatidylinositol can be seen after direct addition of vasopressin to a plasma membrane preparation. Phosphatidylinositols 52-72 arginine vasopressin Rattus norvegicus 110-121 7037762-2 1982 Using the vasopressin-sensitive rat mammary tumor cell line, WRK-1, we examined conditions under which vasopressin was able to stimulate turnover of prelabeled, radioactive phosphatidylinositol. Phosphatidylinositols 173-193 arginine vasopressin Rattus norvegicus 103-114 6766458-0 1980 Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells. Phosphatidylinositols 55-75 arginine vasopressin Rattus norvegicus 15-26 6272723-1 1981 Vasopressin stimulates the incorporation of [32P]Pi into phosphatidylinositol but not into other phospholipids in rat thoracic aorta strips. Phosphatidylinositols 57-77 arginine vasopressin Rattus norvegicus 0-11 6272723-2 1981 The relative abilities of three vasopressin analogues to stimulate phosphatidylinositol labelling in rat aorta are similar to their relative pressor potencies in vivo and to their relative potencies in stimulating the metabolism of rat hepatocytes, but very different from their relative antidiuretic potencies. Phosphatidylinositols 67-87 arginine vasopressin Rattus norvegicus 32-43 6272723-3 1981 The vasopressor antagonist [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid),8-arginine]vasopressin competitively inhibits [Arg8]vasopressin-stimulated phosphatidylinositol labelling in rat aorta with a pA2 of 8.1. Phosphatidylinositols 166-186 arginine vasopressin Rattus norvegicus 102-113 6272723-4 1981 It is concluded that the Ca2+-mobilizing vasopressin receptors (V1-receptors) of the rat aorta stimulate phosphatidylinositol metabolism, probably by enhancing phosphatidylinositol breakdown. Phosphatidylinositols 105-125 arginine vasopressin Rattus norvegicus 41-52 6272723-4 1981 It is concluded that the Ca2+-mobilizing vasopressin receptors (V1-receptors) of the rat aorta stimulate phosphatidylinositol metabolism, probably by enhancing phosphatidylinositol breakdown. Phosphatidylinositols 160-180 arginine vasopressin Rattus norvegicus 41-52 7030316-6 1981 Although the incorporation of [32P]Pi into hepatocyte lipids was decreased when cells were incubated in a Ca2+-free medium, vasopressin still provoked a substantial stimulation of phosphatidylinositol labelling under these conditions. Phosphatidylinositols 180-200 arginine vasopressin Rattus norvegicus 124-135 7030316-7 1981 Studies with the antagonist [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid),8-arginine]vasopressin indicated that the hepatic vasopressin receptors that control phosphatidylinositol metabolism are similar to those that mediate the vasopressor response in vivo. Phosphatidylinositols 177-197 arginine vasopressin Rattus norvegicus 103-114 7030316-7 1981 Studies with the antagonist [1-(beta-mercapto-beta, beta-cyclopentamethylenepropionic acid),8-arginine]vasopressin indicated that the hepatic vasopressin receptors that control phosphatidylinositol metabolism are similar to those that mediate the vasopressor response in vivo. Phosphatidylinositols 177-197 arginine vasopressin Rattus norvegicus 142-153 229824-9 1979 [1-Deaminocysteine,2-phenylalanine,7-(3,4-didehydroproline),8-arginine] vasopressin, a vasopressin analogue with enhanced antidiuretic potency, is relatively ineffective at stimulating phosphatidylinositol metabolism. Phosphatidylinositols 185-205 arginine vasopressin Rattus norvegicus 72-83 229824-10 1979 This suggests that the hepatic vasopressin receptors that stimulate phosphatidylinositol breakdown are different in their ligand selectivity from the antidiuretic vasopressin receptors that activate renal adenylate cyclase. Phosphatidylinositols 68-88 arginine vasopressin Rattus norvegicus 31-42 229824-16 1979 These results may be an indication that phosphatidylinositol breakdown is an integral reaction in the stimulus-response coupling sequence(s) that link(s) activation of alpha-adrenergic, vasopressin and angiotensin receptors to mobilization of Ca(2+) in the rat hepatocyte. Phosphatidylinositols 40-60 arginine vasopressin Rattus norvegicus 186-197 744314-0 1978 Stimulation of the breakdown and resynthesis of of phosphatidylinositol in rat hepatocytes by angiotensin, vasopressin and adrenaline. Phosphatidylinositols 51-71 arginine vasopressin Rattus norvegicus 107-118 7030316-0 1981 Phosphatidylinositol metabolism in rat hepatocytes stimulated by vasopressin. Phosphatidylinositols 0-20 arginine vasopressin Rattus norvegicus 65-76 7030316-1 1981 In isolated rat hepatocytes, vasopressin evoked a large increase in the incorporation of [32P]Pi into phosphatidylinositol, accompanied by smaller increases in the incorporation of [1-14C]oleate and [U-14C]glycerol. Phosphatidylinositols 102-122 arginine vasopressin Rattus norvegicus 29-40 7030316-3 1981 Vasopressin also promoted phosphatidylinositol breakdown in hepatocytes. Phosphatidylinositols 26-46 arginine vasopressin Rattus norvegicus 0-11 7030316-4 1981 Half-maximum effects on phosphatidylinositol breakdown and on phosphatidylinositol labelling occurred at about 5 nM-vasopressin, a concentration at which approximately half of the hepatic vasopressin receptors are occupied but which is much greater than is needed to produce half-maximal activation of glycogen phosphorylase. Phosphatidylinositols 24-44 arginine vasopressin Rattus norvegicus 116-127 7030316-4 1981 Half-maximum effects on phosphatidylinositol breakdown and on phosphatidylinositol labelling occurred at about 5 nM-vasopressin, a concentration at which approximately half of the hepatic vasopressin receptors are occupied but which is much greater than is needed to produce half-maximal activation of glycogen phosphorylase. Phosphatidylinositols 62-82 arginine vasopressin Rattus norvegicus 116-127 4369760-0 1974 Adrenergic stimulation of phosphatidylinositol labelling in rat vas deferens. Phosphatidylinositols 26-46 arginine vasopressin Rattus norvegicus 64-67 4476172-0 1974 Noradrenaline stimulation of phosphatidylinositol breakdown in rat vas deferens. Phosphatidylinositols 29-49 arginine vasopressin Rattus norvegicus 67-70 17507604-0 2007 Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway. Phosphatidylinositols 129-145 arginine vasopressin Rattus norvegicus 0-11