PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23273569-7 2013 INPPL1 belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family, a family of signal-modulating enzymes that govern a plethora of cellular functions by regulating the levels of specific phosphoinositides. Phosphatidylinositols 193-210 inositol polyphosphate phosphatase like 1 Homo sapiens 0-6 34314064-8 2021 Together, our data show that the PHR domain acts as an allosteric module regulating the catalytic activity of SHIP2 in response to specific phosphoinositide levels in the cell membrane. Phosphatidylinositols 140-156 inositol polyphosphate phosphatase like 1 Homo sapiens 110-115 34021368-1 2022 SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) plays an essential role in regulating phosphatidylinositol level in human cell, and is recruited to many phosphotyrosine (pY)-dependent signal transduction pathways by the SH2 domain. Phosphatidylinositols 93-113 inositol polyphosphate phosphatase like 1 Homo sapiens 0-46 34021368-1 2022 SH2 domain-containing inositol 5-phosphatase 2 (SHIP2) plays an essential role in regulating phosphatidylinositol level in human cell, and is recruited to many phosphotyrosine (pY)-dependent signal transduction pathways by the SH2 domain. Phosphatidylinositols 93-113 inositol polyphosphate phosphatase like 1 Homo sapiens 48-53 24704254-3 2014 We determined the crystal structures of human SHIP2, OCRL, and INPP5B, the latter in complex with phosphoinositide substrate analogs, which revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer. Phosphatidylinositols 98-114 inositol polyphosphate phosphatase like 1 Homo sapiens 46-51 23762820-3 2013 These proteins interfere with different steps in insulin-signaling: ENPP1/PC-1 and the phosphatases PTP1B and PTPRF/LAR inhibit the insulin receptor activation; INPPL1/SHIP-2 hydrolyzes PI3-kinase products, hampering the phosphoinositide-mediated downstream signaling; and TRIB3 binds the serine-threonine kinase Akt, reducing its phosphorylation levels. Phosphatidylinositols 221-237 inositol polyphosphate phosphatase like 1 Homo sapiens 161-167 23762820-3 2013 These proteins interfere with different steps in insulin-signaling: ENPP1/PC-1 and the phosphatases PTP1B and PTPRF/LAR inhibit the insulin receptor activation; INPPL1/SHIP-2 hydrolyzes PI3-kinase products, hampering the phosphoinositide-mediated downstream signaling; and TRIB3 binds the serine-threonine kinase Akt, reducing its phosphorylation levels. Phosphatidylinositols 221-237 inositol polyphosphate phosphatase like 1 Homo sapiens 168-174 34314064-0 2021 A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2. Phosphatidylinositols 15-31 inositol polyphosphate phosphatase like 1 Homo sapiens 77-82 28247964-4 2017 Knockdown of SHIP2, a phosphatidylinositol 3,4,5-trisphosphatase (PIP3 ) 5-phosphatase that generates PI(3,4)P2 , in MDA-MB-231 breast cancer cells, induced the development of focal adhesions and cell spreading, leading to the suppression of invasion. Phosphatidylinositols 22-42 inositol polyphosphate phosphatase like 1 Homo sapiens 13-18 28409542-7 2017 The lack of a PI 5-phosphatase Src homology 2 domain-containing inositol-5-phosphatase (SHIP)1 or SHIP2 impaired the FcgammaRIIb-accelerated clearance of PIs. Phosphatidylinositols 154-157 inositol polyphosphate phosphatase like 1 Homo sapiens 98-103 26826186-1 2016 Phosphoinositides, particularly phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], are recognized by SHIP2 (also known as INPPL1) a member of the inositol polyphosphate 5-phosphatase family. Phosphatidylinositols 0-17 inositol polyphosphate phosphatase like 1 Homo sapiens 162-167 26826186-1 2016 Phosphoinositides, particularly phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], are recognized by SHIP2 (also known as INPPL1) a member of the inositol polyphosphate 5-phosphatase family. Phosphatidylinositols 0-17 inositol polyphosphate phosphatase like 1 Homo sapiens 183-189 24133597-1 2013 SH2-containing inositol 5"-phosphatase 2 (SHIP2) is a vital regulator of phosphoinositide pools in metabolic pathways and is considered to downregulate phosphatidylinositol 3"-kinase signaling, which underlies the development of several kinds of human cancers. Phosphatidylinositols 73-89 inositol polyphosphate phosphatase like 1 Homo sapiens 0-40 24133597-1 2013 SH2-containing inositol 5"-phosphatase 2 (SHIP2) is a vital regulator of phosphoinositide pools in metabolic pathways and is considered to downregulate phosphatidylinositol 3"-kinase signaling, which underlies the development of several kinds of human cancers. Phosphatidylinositols 73-89 inositol polyphosphate phosphatase like 1 Homo sapiens 42-47 20679431-6 2010 Because SHIP2 is a negative regulator of insulin signaling, our findings suggest the importance of the phosphoinositide metabolism at CCPs in the regulation of insulin signal output. Phosphatidylinositols 103-119 inositol polyphosphate phosphatase like 1 Homo sapiens 8-13 22330088-2 2012 SHIP2 (SH2 (Src homology 2)-domain-containing inositol-phosphatase-2) plays a critical role in phosphoinositide signaling, cleaving the 5-phosphate from phosphatidylinositol 3,4,5-trisphosphate. Phosphatidylinositols 95-111 inositol polyphosphate phosphatase like 1 Homo sapiens 0-5 19825976-7 2010 These data highlight a novel biological role of the PP2A(T130) holoenzyme in EGF signaling through interaction with EGFR and the phosphatidylinositol (3,4,5)-trisphosphate 5-phosphatase SHIP2. Phosphatidylinositols 129-149 inositol polyphosphate phosphatase like 1 Homo sapiens 186-191 18486448-1 2008 SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is an ubiquitously expressed phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase which contains various motifs susceptible to mediate protein-protein interaction. Phosphatidylinositols 91-111 inositol polyphosphate phosphatase like 1 Homo sapiens 0-5 18486448-1 2008 SHIP2 (SH2-containing inositol polyphosphate 5-phosphatase 2) is an ubiquitously expressed phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P(3)) 5-phosphatase which contains various motifs susceptible to mediate protein-protein interaction. Phosphatidylinositols 91-111 inositol polyphosphate phosphatase like 1 Homo sapiens 7-60 15486046-1 2005 The Src homology 2-containing 5" inositolphosphatases (SHIP and SHIP2) dephosphorylate 3"-phosphorylated PtdIns on the 5" position, decreasing intracellular levels of PtdIns 3,4,5-P3. Phosphatidylinositols 105-111 inositol polyphosphate phosphatase like 1 Homo sapiens 64-69 16824732-0 2006 The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity. Phosphatidylinositols 41-61 inositol polyphosphate phosphatase like 1 Homo sapiens 35-40 15735664-9 2005 Furthermore, treatment with 10 microM of phosphatidylinositol 3 (PI3) kinase inhibitor, LY294002, abrogates HGF-induced cell scattering of SHIP-2-overexpressing cells but not parental HEK293 cells, suggesting that a balance between PI3 kinase and SHIP is important for cell motility. Phosphatidylinositols 41-61 inositol polyphosphate phosphatase like 1 Homo sapiens 139-145 14502564-9 2003 Lack of SHIP2 tyrosine phosphorylation may account for the insulin-specific inositol phospholipid pattern of accumulation in preadipocytes. Phosphatidylinositols 76-97 inositol polyphosphate phosphatase like 1 Homo sapiens 8-13 15316017-7 2004 Kinetic analysis with four phosphatidylinositol lipids bearing a 5-phosphate and 54 water-soluble inositol phosphates reveals that SP-synaptojanin and SHIP2 possess much broader substrate specificity than previously appreciated. Phosphatidylinositols 27-47 inositol polyphosphate phosphatase like 1 Homo sapiens 151-156 10194451-0 1999 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. Phosphatidylinositols 23-43 inositol polyphosphate phosphatase like 1 Homo sapiens 79-84