PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9523559-3 1998 Prolonged incubation of cells with PACAP failed to down-regulate the density and affinity of membrane binding sites and caused opposite changes in messenger systems: PACAP-stimulated cyclic AMP accumulation was attenuated in a time- and dose-dependent fashion (t(1/2) = 6.7 h and IC50 = 0.1 nM), whereas phosphoinositide turnover was overstimulated. Phosphatidylinositols 304-320 adenylate cyclase activating polypeptide 1 Mus musculus 166-171 32028278-4 2021 These postsynaptic actions were abolished by inhibitors of the PAC1 receptor, TRPC channels, phospholipase C, phosphatidylinositol-3-kinase and protein kinase C. Estradiol augmented the PACAP-induced inward current, depolarization and increased firing, which was abrogated by estrogen receptor (ER) antagonists. Phosphatidylinositols 110-130 adenylate cyclase activating polypeptide 1 Mus musculus 186-191