PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9284170-8 1997 GPI anchors of CD16 on neutrophils from controls and patients were both partially resistant to phosphatidylinositol-specific phospholipase C. The presence of promyelocytes in peripheral blood, low expression of CD16, and low chemotactic response of neutrophils suggest that patients with EOP have an abnormal maturation system in myeloid lineage cells in the bone marrow, which may be associated with the onset and course of EOP. Phosphatidylinositols 95-115 Fc gamma receptor IIIa Homo sapiens 15-19 9064320-5 1996 This, associated with increased enzymatic activity, also occurs upon stimulation of the transmembrane isoform of CD16 (Fc gamma RIIIA) in NK cells and in a T cell line expressing transfected Fc gamma RIIIA alpha ligand-binding chain in association with zeta, but not upon stimulation of the glycosil-phosphatidylinositol-anchored Fc gamma RIIIB on PMN. Phosphatidylinositols 300-320 Fc gamma receptor IIIa Homo sapiens 113-117 9064320-5 1996 This, associated with increased enzymatic activity, also occurs upon stimulation of the transmembrane isoform of CD16 (Fc gamma RIIIA) in NK cells and in a T cell line expressing transfected Fc gamma RIIIA alpha ligand-binding chain in association with zeta, but not upon stimulation of the glycosil-phosphatidylinositol-anchored Fc gamma RIIIB on PMN. Phosphatidylinositols 300-320 Fc gamma receptor IIIa Homo sapiens 119-133 9064320-5 1996 This, associated with increased enzymatic activity, also occurs upon stimulation of the transmembrane isoform of CD16 (Fc gamma RIIIA) in NK cells and in a T cell line expressing transfected Fc gamma RIIIA alpha ligand-binding chain in association with zeta, but not upon stimulation of the glycosil-phosphatidylinositol-anchored Fc gamma RIIIB on PMN. Phosphatidylinositols 300-320 Fc gamma receptor IIIa Homo sapiens 191-205 7694676-5 1993 Fc gamma RIII (CD16, phosphatidylinositol-linked) expression, slightly increased immediately (30 minutes) postinjection, was found to be strongly decreased on the newly formed population. Phosphatidylinositols 21-41 Fc gamma receptor IIIa Homo sapiens 0-13 7643012-3 1995 Treatment of neutrophils with phosphatidylinositol-specific phospholipase C effectively removed the phosphatidylinositol-linked surface molecules CD14 and CD16, yet did not reduce O2- production in response to C1q. Phosphatidylinositols 30-50 Fc gamma receptor IIIa Homo sapiens 155-159 8394282-5 1993 Both the treatment with phosphatidyl-inositol-specific phospholipase C (PI-PLC) and the restriction enzyme digestion of Fc gamma RIII cDNA showed that the Fc gamma RIII on EoL-1 cells was a phosphatidylinositol-linked form. Phosphatidylinositols 24-45 Fc gamma receptor IIIa Homo sapiens 155-168 7692930-6 1993 CD16, induced on the defective PNH PMN during the administration of G-CSF, was phosphatidylinositol-specific phospholipase C (PIPLC)-sensitive, implying that it had GPI-linkage to the membranes. Phosphatidylinositols 79-99 Fc gamma receptor IIIa Homo sapiens 0-4 8394282-5 1993 Both the treatment with phosphatidyl-inositol-specific phospholipase C (PI-PLC) and the restriction enzyme digestion of Fc gamma RIII cDNA showed that the Fc gamma RIII on EoL-1 cells was a phosphatidylinositol-linked form. Phosphatidylinositols 190-210 Fc gamma receptor IIIa Homo sapiens 120-133 8394282-5 1993 Both the treatment with phosphatidyl-inositol-specific phospholipase C (PI-PLC) and the restriction enzyme digestion of Fc gamma RIII cDNA showed that the Fc gamma RIII on EoL-1 cells was a phosphatidylinositol-linked form. Phosphatidylinositols 190-210 Fc gamma receptor IIIa Homo sapiens 155-168 8394282-8 1993 The EoL-1 cell line appears to be a useful in vitro model for the expression and function of the phosphatidylinositol-linked form of Fc gamma RIII on eosinophils. Phosphatidylinositols 97-117 Fc gamma receptor IIIa Homo sapiens 133-146 1846387-8 1991 In contrast, removal of most of Fc gamma RIII by phosphatidylinositol-specific phospholipase C did not significantly alter degranulation in response to IC. Phosphatidylinositols 49-69 Fc gamma receptor IIIa Homo sapiens 32-45 1431142-1 1992 Human polymorphonuclear neutrophils (PMN) express the low affinity receptors for the Fc domain of IgG (Fc gamma R), Fc gamma RII (CD32), and the glycosyl phosphatidylinositol-linked isoform of Fc gamma RIII (Fc gamma RIIIB, CD16) on their cell surface. Phosphatidylinositols 154-174 Fc gamma receptor IIIa Homo sapiens 193-206 1431142-1 1992 Human polymorphonuclear neutrophils (PMN) express the low affinity receptors for the Fc domain of IgG (Fc gamma R), Fc gamma RII (CD32), and the glycosyl phosphatidylinositol-linked isoform of Fc gamma RIII (Fc gamma RIIIB, CD16) on their cell surface. Phosphatidylinositols 154-174 Fc gamma receptor IIIa Homo sapiens 224-228 1384901-2 1992 Flow cytometric analysis of phosphatidylinositol (PI) anchored membrane proteins prior to BMT showed a markedly reduced expression of monocyte CD14 and neutrophil CD16 molecules. Phosphatidylinositols 28-48 Fc gamma receptor IIIa Homo sapiens 163-167 1311348-11 1992 Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor. Phosphatidylinositols 51-71 Fc gamma receptor IIIa Homo sapiens 105-111 1531473-0 1992 Induction of phosphatidylinositol-glycan-linked Fc gamma RIII in human monocytic THP-1 cells by transforming growth factor-beta 1 and retinoic acid. Phosphatidylinositols 13-33 Fc gamma receptor IIIa Homo sapiens 48-61 1654955-2 1991 Two forms of FcRIII have recently been characterized; a phosphatidylinositol linked form is found on neutrophils, whereas a transmembrane form of the molecule is found on a subset of peripheral blood lymphocytes. Phosphatidylinositols 56-76 Fc gamma receptor IIIa Homo sapiens 13-19 1654955-5 1991 We found FcRIII expressed by AM has a molecular mass of 50 to 60 kD on sodium dodecyl sulfate polyacrylamide gel electrophoresis and migrates as a single band with a molecular mass of 35 kD after digestion with endoglycosidase F. Macrophage FcRIII was resistant to cleavage by phosphatidylinositol-specific phospholipase C. These results demonstrate that FcRIII expressed by AM is a transmembrane glycoprotein similar to the molecule found on peripheral blood lymphocytes. Phosphatidylinositols 277-297 Fc gamma receptor IIIa Homo sapiens 9-15 1650262-6 1991 Finally, tiazofurin was found to induce expression of a phosphatidylinositol-specific phospholipase C-sensitive Fc gamma-receptor III (FcRIII) on HL60 cells, a feature consistent with neutrophilic, but not monocytic, differentiation. Phosphatidylinositols 56-76 Fc gamma receptor IIIa Homo sapiens 112-133 1650262-6 1991 Finally, tiazofurin was found to induce expression of a phosphatidylinositol-specific phospholipase C-sensitive Fc gamma-receptor III (FcRIII) on HL60 cells, a feature consistent with neutrophilic, but not monocytic, differentiation. Phosphatidylinositols 56-76 Fc gamma receptor IIIa Homo sapiens 135-141 1532472-9 1992 Similarly, a reduction in the expression of Fc gamma RIII by treatment with phosphatidyl-inositol specific phospholipase C reduced PMN recognition of IgG-sensitized cells. Phosphatidylinositols 76-97 Fc gamma receptor IIIa Homo sapiens 44-57 1347707-0 1992 Absolute requirement of CD11/CD18 adhesion molecules, FcRII and the phosphatidylinositol-linked FcRIII for monoclonal antibody-mediated neutrophil antihuman tumor cytotoxicity. Phosphatidylinositols 68-88 Fc gamma receptor IIIa Homo sapiens 96-102 1371474-1 1992 Triggering of the Fc gamma RIII (CD16) on natural killer (NK) cells by monoclonal antibodies or antibody-coated target cells stimulates a rapid phospholipase C (PLC)-mediated hydrolysis of inositol phospholipids and results in subsequent delivery of the lytic hit. Phosphatidylinositols 189-211 Fc gamma receptor IIIa Homo sapiens 18-31 1371474-1 1992 Triggering of the Fc gamma RIII (CD16) on natural killer (NK) cells by monoclonal antibodies or antibody-coated target cells stimulates a rapid phospholipase C (PLC)-mediated hydrolysis of inositol phospholipids and results in subsequent delivery of the lytic hit. Phosphatidylinositols 189-211 Fc gamma receptor IIIa Homo sapiens 33-37 1531473-6 1992 These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA. Phosphatidylinositols 53-73 Fc gamma receptor IIIa Homo sapiens 88-101 1531473-6 1992 These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA. Phosphatidylinositols 53-73 Fc gamma receptor IIIa Homo sapiens 103-116 1703295-8 1991 Previous data have indicated that the NK-cell Fc gamma RIII is coupled to inositol phospholipid hydrolysis. Phosphatidylinositols 74-95 Fc gamma receptor IIIa Homo sapiens 46-59 1846387-9 1991 We conclude that degranulation elicited by IC results from ligation of both Fc gamma RII and phosphatidylinositol-specific phospholipase C-insensitive Fc gamma RIII. Phosphatidylinositols 93-113 Fc gamma receptor IIIa Homo sapiens 151-164 2526846-2 1989 A low affinity receptor for IgG immune complexes, Fc gamma RIII(CD16), is expressed on human NK cells as an integral membrane glycoprotein anchored through a transmembrane peptide; on polymorphonuclear neutrophils (PMN) the receptor is anchored through a phosphatidylinositol (PI) linkage. Phosphatidylinositols 255-275 Fc gamma receptor IIIa Homo sapiens 50-63 1693531-2 1990 While Fc gamma RIII is reported to be a phosphatidylinositol (PI)-linked, rather than peptide-linked, protein on neutrophils and NK cells, its membrane linkage in macrophages has not been studied. Phosphatidylinositols 40-60 Fc gamma receptor IIIa Homo sapiens 6-19 2166753-6 1990 The neutrophil expresses the phosphatidylinositol-linked form of FcRIII, encoded by the gene FcRIII-1. Phosphatidylinositols 29-49 Fc gamma receptor IIIa Homo sapiens 65-71 2166753-6 1990 The neutrophil expresses the phosphatidylinositol-linked form of FcRIII, encoded by the gene FcRIII-1. Phosphatidylinositols 29-49 Fc gamma receptor IIIa Homo sapiens 93-99 2139103-5 1990 However, Fc gamma RIII on neutrophils, a molecule linked to the membrane by a phosphatidylinositol-glycan moiety, although binding anti-Fc gamma RIII-coated erythrocytes vigorously was incapable of mounting a phagocytic response. Phosphatidylinositols 78-98 Fc gamma receptor IIIa Homo sapiens 9-22 2531919-2 1989 Two similar genes, CD16-I and CD16-II, encode membrane glycoproteins that are anchored by phosphatidylinositol (PI)-glycan and transmembrane polypeptides, respectively. Phosphatidylinositols 90-110 Fc gamma receptor IIIa Homo sapiens 19-23 2531919-2 1989 Two similar genes, CD16-I and CD16-II, encode membrane glycoproteins that are anchored by phosphatidylinositol (PI)-glycan and transmembrane polypeptides, respectively. Phosphatidylinositols 90-110 Fc gamma receptor IIIa Homo sapiens 30-34 2545784-6 1989 That is, K/NK lymphocyte Fc gamma RIII was resistant to phosphatidylinositol-specific phospholipase C and surface expression of Fc gamma RIII was not affected on K/NK lymphocytes from patients with paroxysmal nocturnal hemoglobinuria, a disorder of hemopoietic stem cells resulting in deficient expression of glycan-phosphatidylinositol-anchored proteins. Phosphatidylinositols 56-76 Fc gamma receptor IIIa Homo sapiens 25-38 2545784-6 1989 That is, K/NK lymphocyte Fc gamma RIII was resistant to phosphatidylinositol-specific phospholipase C and surface expression of Fc gamma RIII was not affected on K/NK lymphocytes from patients with paroxysmal nocturnal hemoglobinuria, a disorder of hemopoietic stem cells resulting in deficient expression of glycan-phosphatidylinositol-anchored proteins. Phosphatidylinositols 316-336 Fc gamma receptor IIIa Homo sapiens 25-38 2526846-2 1989 A low affinity receptor for IgG immune complexes, Fc gamma RIII(CD16), is expressed on human NK cells as an integral membrane glycoprotein anchored through a transmembrane peptide; on polymorphonuclear neutrophils (PMN) the receptor is anchored through a phosphatidylinositol (PI) linkage. Phosphatidylinositols 255-275 Fc gamma receptor IIIa Homo sapiens 64-68 2525780-6 1989 Treatment of neutrophils with phosphatidylinositol-specific phospholipase C resulted in the release of a large percentage of the CD16 molecules from the cell surface. Phosphatidylinositols 30-50 Fc gamma receptor IIIa Homo sapiens 129-133 2525780-8 1989 These data demonstrate that both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms of the CD16 molecule exist and that they are differentially expressed on neutrophils and natural killer cells. Phosphatidylinositols 58-78 Fc gamma receptor IIIa Homo sapiens 108-112 2536067-0 1989 Fc gamma R(CD16) interaction with ligand induces Ca2+ mobilization and phosphoinositide turnover in human natural killer cells. Phosphatidylinositols 71-87 Fc gamma receptor IIIa Homo sapiens 0-15 2525100-2 1989 The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-specific phospholipase C (PIPLC). Phosphatidylinositols 110-130 Fc gamma receptor IIIa Homo sapiens 4-8 2521732-2 1989 This cDNA (pGP5) encodes a 46-kDa phosphatidylinositol-linked cell surface protein with CD16 determinants and affinity for human IgG. Phosphatidylinositols 34-54 Fc gamma receptor IIIa Homo sapiens 88-92 2967437-3 1988 We show that FcRIII is a phosphatidyl inositol (PI)-anchored protein in neutrophils. Phosphatidylinositols 25-46 Fc gamma receptor IIIa Homo sapiens 13-19 2846696-5 1988 Ligation of the FcR (CD16) with the mAb 3G8 also triggered phosphoinositide turnover. Phosphatidylinositols 59-75 Fc gamma receptor IIIa Homo sapiens 21-25 11449354-6 2001 Such functional effect correlates with a perturbation of the phosphoinositide (PI) metabolism by means of a shc-mediated negative regulation of inositol 1,4,5 triphosphate (IP3) generation and intracellular calcium flux upon CD16 ligation. Phosphatidylinositols 61-77 Fc gamma receptor IIIa Homo sapiens 225-229 10397167-1 1999 CD16 (Fc gamma R type III), a low affinity IgG Fc receptor, is found in two forms, a transmembrane Fc gamma RIIIa expressed by NK cells and monocytes and a phosphatidylinositol-linked Fc gamma RIIIb present on neutrophils. Phosphatidylinositols 156-176 Fc gamma receptor IIIa Homo sapiens 0-4 9725258-3 1998 After digestion with phosphatidylinositol-specific phospholipase C, surface CD16 on both neutrophils and eosinophils decreased substantially, suggesting that eosinophil CD16 is a glycosyl-phosphatidylinositol-linked isoform. Phosphatidylinositols 21-41 Fc gamma receptor IIIa Homo sapiens 76-80 9725258-3 1998 After digestion with phosphatidylinositol-specific phospholipase C, surface CD16 on both neutrophils and eosinophils decreased substantially, suggesting that eosinophil CD16 is a glycosyl-phosphatidylinositol-linked isoform. Phosphatidylinositols 21-41 Fc gamma receptor IIIa Homo sapiens 169-173 9692878-1 1998 CD16 (FcgammaR type III) is a low-affinity IgG Fc receptor (R) that exists in two isoforms, a transmembrane FcgammaRIIIa expressed by NK cells and monocytes, and a phosphatidylinositol-linked FcgammaRIIIb expressed by neutrophils. Phosphatidylinositols 164-184 Fc gamma receptor IIIa Homo sapiens 0-4 9701036-7 1998 Hydrolysis of inositol phospholipids was measured following incubation with K562 target cells and/or CD16 mAb for different times. Phosphatidylinositols 14-36 Fc gamma receptor IIIa Homo sapiens 101-105