PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14751540-7 2004 BK-stimulated responses were attenuated by inhibitors of selective B2 receptor (Hoe 140), phosphatidylinositol (PI)-PLC (U73122), an intracellular Ca2+chelator (BAPTA/AM), PKC (GF109203X), tyrosine kinase (genistein), and MEK1/2 (PD98059). Phosphatidylinositols 90-110 kininogen 1 Homo sapiens 0-2 11139431-10 2000 In the cell lines SW-480 and H-69 both BK and Hoe 140 but not FR 173657 stimulated phosphatidylinositol hydrolysis. Phosphatidylinositols 83-103 kininogen 1 Homo sapiens 39-41 10408151-6 1999 Bradykinin increases the influx of Ca2+ and the turnover of phosphoinositide through the stimulation of bradykinin B2 receptor. Phosphatidylinositols 60-76 kininogen 1 Homo sapiens 0-10 10323587-5 1999 This study examined the effects of differentiating SH-SY5Y cells on muscarinic- and bradykinin-receptor-mediated phosphoinositide and Ca2+ signalling. Phosphatidylinositols 113-129 kininogen 1 Homo sapiens 84-94 10408151-6 1999 Bradykinin increases the influx of Ca2+ and the turnover of phosphoinositide through the stimulation of bradykinin B2 receptor. Phosphatidylinositols 60-76 kininogen 1 Homo sapiens 104-114 9208130-16 1997 This rank order of potency of agonist BK-related peptides, coupled with the antagonism of the BK-induced [3H]-IPs by the specific B2-receptor antagonists, strongly suggests that a B2-receptor subtype is involved in mediating functional phosphoinositide (PI) responses in the CEPI-17-CL4 and P-CEPI cells. Phosphatidylinositols 236-252 kininogen 1 Homo sapiens 38-40 9374730-9 1997 We also found that TNF-alpha significantly enhanced increases in phosphoinositide (PI) accumulation induced by bradykinin. Phosphatidylinositols 65-81 kininogen 1 Homo sapiens 111-121 9712847-2 1998 We report here that depletion of cellular cholesterol leads to the inhibition of epidermal growth factor- and bradykinin-stimulated PtdIns turnover in A431 cells. Phosphatidylinositols 132-138 kininogen 1 Homo sapiens 110-120 9761428-3 1998 The medium change slightly augmented the bradykinin-induced increase in intracellular free Ca2+ concentration and phosphoinositide hydrolysis with a different time course from that for prostaglandin E2 synthesis. Phosphatidylinositols 114-130 kininogen 1 Homo sapiens 41-51 9224807-4 1997 FR190997 markedly stimulated phosphatidylinositol hydrolysis in Chinese hamster ovary cells permanently expressing the human bradykinin B2 receptor. Phosphatidylinositols 29-49 kininogen 1 Homo sapiens 125-135 9224807-5 1997 The response of phosphatidylinositol hydrolysis was antagonized by the B2 receptor selective antagonist Hoe 140 (D-Arg-[hydroxyproline3,beta-thienylalanine4,D-Tic7,++ +Oic8]bradykinin). Phosphatidylinositols 16-36 kininogen 1 Homo sapiens 173-183 8914860-11 1996 Stimulation of phosphatidylinositol turnover and calcium mobilization were also induced by 10 nM bradykinin; these effects were influenced neither by the previous administration of the NK1 receptor agonist nor by the three antagonists tested. Phosphatidylinositols 15-35 kininogen 1 Homo sapiens 97-107 9068370-0 1996 Pharmacological characterization of bradykinin receptors coupled to phosphoinositide turnover in SV40-immortalized human trabecular meshwork cells. Phosphatidylinositols 68-84 kininogen 1 Homo sapiens 36-46 9068370-2 1996 Phosphoinositide (PI) turnover studies were conducted using [3H]myo-inositol-labeled HTM3 cells and anion exchange chromatography to quantify [3H]inositol phosphates generated in response to bradykinin (BK) and various BK analogs. Phosphatidylinositols 0-16 kininogen 1 Homo sapiens 191-201 8613709-0 1996 Bradykinin stimulates phosphoinositide turnover and phospholipase C but not phospholipase D and NADPH oxidase in human neutrophils. Phosphatidylinositols 22-38 kininogen 1 Homo sapiens 0-10 7626288-7 1995 By contrast, bradykinin, which evoked comparable increases in cytosolic calcium and phosphoinositide turnover, did not stimulate airway smooth muscle cell growth. Phosphatidylinositols 84-100 kininogen 1 Homo sapiens 13-23 8833191-1 1996 Cultured astrocytes express bradykinin (BK) receptors, which are coupled to phospholipase C (PLC) through G-protein to mediate phosphoinositide (PI) hydrolysis. Phosphatidylinositols 127-143 kininogen 1 Homo sapiens 28-38 8833191-1 1996 Cultured astrocytes express bradykinin (BK) receptors, which are coupled to phospholipase C (PLC) through G-protein to mediate phosphoinositide (PI) hydrolysis. Phosphatidylinositols 127-143 kininogen 1 Homo sapiens 40-42 7623773-0 1995 Role of protein kinase C subtypes alpha and delta in the regulation of bradykinin-stimulated phosphoinositide breakdown in astrocytes. Phosphatidylinositols 93-109 kininogen 1 Homo sapiens 71-81 7623773-1 1995 Cultured astrocytes express bradykinin (BK) receptors coupled to phospholipase C (PLC)-mediated phosphoinositide (PI) hydrolysis. Phosphatidylinositols 96-112 kininogen 1 Homo sapiens 28-38 7741756-4 1995 In human umbilical artery smooth muscle cells, histamine (EC50 16 microM), bradykinin (EC50 4.5 nM), 5-HT (EC50 0.7 microM) and carbachol (EC50 21 microM) produced substantial effects (> 20% of the response to 1 mM histamine) on inositol phospholipid hydrolysis while ATP (1 mM) and thrombin (1 U/mL) were much less effective. Phosphatidylinositols 232-253 kininogen 1 Homo sapiens 75-85 8176221-5 1994 Thus, BK can induce AA release via the hydrolysis of phosphatidylinositols by a phospholipase C (PLC). Phosphatidylinositols 53-74 kininogen 1 Homo sapiens 6-8 8263514-0 1994 Decreased myo-inositol uptake is associated with reduced bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol content in cultured neuroblastoma cells exposed to L-fucose. Phosphatidylinositols 79-99 kininogen 1 Homo sapiens 57-67 8156826-11 1994 Muscarinic agonists, histamine and bradykinin, but not adrenergic, serotonergic agonists or prostaglandins, increased phosphoinositide turnover. Phosphatidylinositols 118-134 kininogen 1 Homo sapiens 35-45 8132619-6 1994 These results provide the first evidence that Y2 receptors negatively couple to AII- or BK-induced phosphoinositide turnover leading to Ca2+ mobilization through pertussis toxin-sensitive GTP-binding protein(s). Phosphatidylinositols 99-115 kininogen 1 Homo sapiens 88-90 8177372-0 1994 Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells. Phosphatidylinositols 96-116 kininogen 1 Homo sapiens 74-84 8177372-5 1994 Chronic exposure of neuroblastoma cells to media containing 30 mM glucose, galactose, or mannose caused a significant decrease in Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated 32P incorporation into phosphatidylinositol compared to cells cultured in medium containing 30 mM fructose. Phosphatidylinositols 241-261 kininogen 1 Homo sapiens 196-206 8177372-8 1994 myo-Inositol metabolism and content and bradykinin-stimulated phosphatidylinositol synthesis were also maintained when media containing 30 mM glucose, galactose, or mannose was supplemented with 250 microM myo-inositol. Phosphatidylinositols 62-82 kininogen 1 Homo sapiens 40-50 8263514-3 1994 In these studies, L-fucose supplementation of culture medium was used to assess the effect of decreased myo-inositol metabolism and content on bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol production. Phosphatidylinositols 165-185 kininogen 1 Homo sapiens 143-153 8263514-8 1994 Bradykinin stimulated diacylglycerol production in neuroblastoma cells by increasing the hydrolysis of both phosphoinositides and phosphatidylcholine. Phosphatidylinositols 108-125 kininogen 1 Homo sapiens 0-10 7689642-1 1993 Bradykinin- and substance P (SP)-stimulated second messenger studies in isolated subsets of neuroglia showed bradykinin-stimulated synthesis of phosphoinositides (PI) in type-1 astrocytes and oligodendrocytes. Phosphatidylinositols 144-161 kininogen 1 Homo sapiens 0-10 7689642-1 1993 Bradykinin- and substance P (SP)-stimulated second messenger studies in isolated subsets of neuroglia showed bradykinin-stimulated synthesis of phosphoinositides (PI) in type-1 astrocytes and oligodendrocytes. Phosphatidylinositols 144-161 kininogen 1 Homo sapiens 109-119 7686736-3 1993 The bradykinin receptor-mediated activation of phospholipase C (PLC) resulted in an extensive and rapid stimulation of phosphoinositide metabolism. Phosphatidylinositols 119-135 kininogen 1 Homo sapiens 4-14 1282721-1 1992 The effect of bradykinin (BK) on the intracellular free calcium activity [Ca2+]i and phosphoinositide (PI) turnover was investigated in human glomerular epithelial cells (GEC) in culture. Phosphatidylinositols 85-101 kininogen 1 Homo sapiens 14-24 8419539-6 1993 The peptide bradykinin, determined to be coupled to phosphatidylinositol hydrolysis and internal Ca2+ mobilization in chromaffin cells, exhibited a behavior similar to that of P2y agonists in adenosine transport inhibition (39%). Phosphatidylinositols 52-72 kininogen 1 Homo sapiens 12-22 1282721-1 1992 The effect of bradykinin (BK) on the intracellular free calcium activity [Ca2+]i and phosphoinositide (PI) turnover was investigated in human glomerular epithelial cells (GEC) in culture. Phosphatidylinositols 85-101 kininogen 1 Homo sapiens 26-28 1591276-4 1992 Bradykinin stimulated the intracellular accumulation of total inositol phosphates suggesting that its effects were mediated by stimulation of phosphoinositide metabolism. Phosphatidylinositols 142-158 kininogen 1 Homo sapiens 0-10 1330138-8 1992 These results suggest that in osteoblastic cells the mechanism of action of bradykinin involves stimulation of the phosphoinositide metabolism and increases in cytosolic calcium levels through activation of B2 receptors. Phosphatidylinositols 115-131 kininogen 1 Homo sapiens 76-86 2163209-3 1990 Bradykinin increased cellular DAG at concentrations similar to those that increase inositol phosphates, suggesting that bradykinin stimulates phosphatidylinositol hydrolysis, as observed in other systems. Phosphatidylinositols 142-162 kininogen 1 Homo sapiens 0-10 1309839-0 1992 Human decidua is a target tissue for bradykinin and kallikrein: phosphoinositide hydrolysis accompanies arachidonic acid release in uterine decidua cells in vitro. Phosphatidylinositols 64-80 kininogen 1 Homo sapiens 37-47 1309839-4 1992 Bradykinin (100 nmol/L) stimulated a rapid release of arachidonic acid (within 2 min) associated with an increase in inositol trisphosphate which was detectable after 20 s. Protein kinase C activation by phorbol ester enhanced arachidonic acid release in response to both bradykinin and the Ca++ ionophore A23187 but inhibited bradykinin-stimulated phosphoinositide hydrolysis. Phosphatidylinositols 349-365 kininogen 1 Homo sapiens 0-10 2037585-1 1991 I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA). Phosphatidylinositols 45-65 kininogen 1 Homo sapiens 161-171 2037585-1 1991 I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. Stimulation of human fibroblasts with bradykinin (BK) results in the generation of diacylglycerol (DG) and phosphatidic acid (PA). Phosphatidylinositols 45-65 kininogen 1 Homo sapiens 173-175 2037585-7 1991 Short pretreatment of the cells with phorbol 12-myristate 13-acetate (PMA) abolished the BK-induced breakdown of phosphoinositides, but did not affect the second-phase DGc level. Phosphatidylinositols 113-130 kininogen 1 Homo sapiens 89-91 1851210-1 1991 Long-term ethanol exposure is known to inhibit bradykinin-stimulated phosphoinositide hydrolysis in cultures of neuroblastoma x glioma 108-15 cells. Phosphatidylinositols 69-85 kininogen 1 Homo sapiens 47-57 2081544-1 1990 Bradykinin (BK) and platelet-derived growth factor (PDGF) act as mitogens and stimulate phosphatidylinositol (PI) turnover in human fibroblasts. Phosphatidylinositols 88-108 kininogen 1 Homo sapiens 0-10 2174449-0 1990 Bradykinin induces phosphoinositide turnover, 1,2-diglyceride formation, and growth in cultured adult human keratinocytes. Phosphatidylinositols 19-35 kininogen 1 Homo sapiens 0-10 1309239-0 1992 The epithelial phenotype of human neuroblastoma cells express bradykinin, endothelin, and angiotensin II receptors that stimulate phosphoinositide hydrolysis. Phosphatidylinositols 130-146 kininogen 1 Homo sapiens 62-72 1309239-5 1992 The effects of the three peptides--bradykinin, endothelin, and angiotensin II--on phosphoinositide hydrolysis in SH-EP cells were additive, a result suggesting that the three kinds of receptors may activate distinct transducer proteins and/or phospholipase C subtypes. Phosphatidylinositols 82-98 kininogen 1 Homo sapiens 35-45 1770982-9 1991 The precise molecular basis and pathophysiological significance of the enhanced bradykinin-induced phosphoinositide cascade in fibroblasts from aged donors remains to be determined. Phosphatidylinositols 99-115 kininogen 1 Homo sapiens 80-90 2163209-3 1990 Bradykinin increased cellular DAG at concentrations similar to those that increase inositol phosphates, suggesting that bradykinin stimulates phosphatidylinositol hydrolysis, as observed in other systems. Phosphatidylinositols 142-162 kininogen 1 Homo sapiens 120-130 2163209-10 1990 These results suggest that isoproterenol and bradykinin generate DAG from the following different lipid sources: bradykinin stimulates phosphatidylinositol hydrolysis to produce DAG; isoproterenol stimulates an increase in DAG from unknown sources. Phosphatidylinositols 135-155 kininogen 1 Homo sapiens 45-55 2163209-10 1990 These results suggest that isoproterenol and bradykinin generate DAG from the following different lipid sources: bradykinin stimulates phosphatidylinositol hydrolysis to produce DAG; isoproterenol stimulates an increase in DAG from unknown sources. Phosphatidylinositols 135-155 kininogen 1 Homo sapiens 113-123 2765565-2 1989 Addition of either cerebroside sulfate (CS) or phosphatidylinositol (PI), solubilized with the nonionic surfactant C12E8, to BK or its analogue [Gly6]-BK enhances the relative fluorescence intensity of peptide emission at 288 nm. Phosphatidylinositols 47-67 kininogen 1 Homo sapiens 151-153 2557246-0 1989 Histamine and bradykinin stimulate the phosphoinositide turnover in human umbilical vein endothelial cells via different G-proteins. Phosphatidylinositols 39-55 kininogen 1 Homo sapiens 14-24 2506191-11 1989 They also confirm that the Ca2+-phosphatidylinositol cascade is present in these cells and suggest that this cascade is modulated by ATP, TRH, and bradykinin. Phosphatidylinositols 32-52 kininogen 1 Homo sapiens 147-157 2898111-6 1988 These studies suggest the presence of B2-bradykinin receptors on the human embryonic pituitary tumour cell-line which appear to be coupled to the phosphatidyl inositol turnover signal transduction mechanism. Phosphatidylinositols 146-167 kininogen 1 Homo sapiens 41-51 2538844-0 1989 Bradykinin and bradykinin antagonists effects on endothelial cell phosphoinositide metabolism; implications for septic shock. Phosphatidylinositols 66-82 kininogen 1 Homo sapiens 0-10 2538844-0 1989 Bradykinin and bradykinin antagonists effects on endothelial cell phosphoinositide metabolism; implications for septic shock. Phosphatidylinositols 66-82 kininogen 1 Homo sapiens 15-25 2629164-10 1989 The dose-dependence of morphological changes was compared and contrasted to the dose-dependent effect of phorbol esters on bradykinin-stimulated phosphoinositide turnover. Phosphatidylinositols 145-161 kininogen 1 Homo sapiens 123-133 3263854-4 1988 These findings suggest that bradykinin stimulates phosphoinositide hydrolysis by phospholipase C in human fibroblasts via IAP-insensitive pathway, and that PSS fibroblasts appear to be defective in the pathway. Phosphatidylinositols 50-66 kininogen 1 Homo sapiens 28-38 2853304-6 1988 When cells were pulsed with 32Pi for 60 min and stimulated by veratridine plus scorpion venom for an additional 30 min, uptake of 32Pi into phosphatidylinositol was reduced; stimulating cells with bradykinin, a receptor agonist which activates the inositol cycle, promoted a 3.8 fold increase. Phosphatidylinositols 140-160 kininogen 1 Homo sapiens 197-207 2538467-1 1989 We compared the time courses of bradykinin-induced turnover of phosphoinositides and the appearance of unesterified arachidonic acid (uAA) and eicosanoids. Phosphatidylinositols 63-80 kininogen 1 Homo sapiens 32-42 3562319-6 1986 CD reveals that BK also interacts with acidic lipids which bear a net electrical charge (e.g., cerebroside sulfate and phosphatidyl inositol) but not with lipids bearing no net charge (e.g., cerebroside and phosphatidyl choline). Phosphatidylinositols 119-140 kininogen 1 Homo sapiens 16-18 3024076-0 1986 Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors. Phosphatidylinositols 0-20 kininogen 1 Homo sapiens 68-78 2833432-4 1988 The results of the study indicate that stimulation of 1-14C-AA-prelabelled PMNs with BK liberates AA mainly from phosphatidylinositol, while A23187 causes release of AA from phosphatidylcholine, phosphatidylethanolamine, and possibly phosphatidylserine. Phosphatidylinositols 113-133 kininogen 1 Homo sapiens 85-87 2820797-5 1987 Substances known to activate protein kinase C such as phorbol 12-myristate 13-acetate, or to stimulate phosphoinositide turnover such as thrombin and bradykinin are also effective in raising fructose 2,6-bisphosphate. Phosphatidylinositols 103-119 kininogen 1 Homo sapiens 150-160 6302691-5 1983 Bradykinin caused a release of arachidonic acid from methylated phospholipids (phosphatidylcholine) and phosphatidylinositol. Phosphatidylinositols 104-124 kininogen 1 Homo sapiens 0-10