PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26715839-7 2015 Activation of cisplatin-induced autophagic flux was increased by using chloroquine (CQ), which can accumulate LC3B-II protein and increase punctate distribution of LC3B localization. Chloroquine 71-82 microtubule associated protein 1 light chain 3 beta Homo sapiens 110-114 28903368-3 2017 Functional autophagy was demonstrated in CC cell lines (LoVo; HT-29) showing a dose-dependent increase of the autophagy markers LC3B, p62 and autophagic vesciles upon increasing concentrations of the autophagy inhibitor chloroquine, which was demonstrated by immunoblotting, immunofluorescence and electron microscopy. Chloroquine 220-231 microtubule associated protein 1 light chain 3 beta Homo sapiens 128-132 27109915-5 2016 When treated with radiation alone, human esophageal carcinoma xenografts showed increased LC3B and p-LKB1 expression, which was decreased by the autophagy inhibitor chloroquine. Chloroquine 165-176 microtubule associated protein 1 light chain 3 beta Homo sapiens 90-94 27250034-5 2016 In EAC cell lines, an increase in LC3B and p62 was observed with increasing concentrations of the autophagy inhibitor chloroquine, which indicates functional basal autophagy. Chloroquine 118-129 microtubule associated protein 1 light chain 3 beta Homo sapiens 34-38 26715839-7 2015 Activation of cisplatin-induced autophagic flux was increased by using chloroquine (CQ), which can accumulate LC3B-II protein and increase punctate distribution of LC3B localization. Chloroquine 71-82 microtubule associated protein 1 light chain 3 beta Homo sapiens 164-168 26715839-7 2015 Activation of cisplatin-induced autophagic flux was increased by using chloroquine (CQ), which can accumulate LC3B-II protein and increase punctate distribution of LC3B localization. Chloroquine 84-86 microtubule associated protein 1 light chain 3 beta Homo sapiens 110-114 26715839-7 2015 Activation of cisplatin-induced autophagic flux was increased by using chloroquine (CQ), which can accumulate LC3B-II protein and increase punctate distribution of LC3B localization. Chloroquine 84-86 microtubule associated protein 1 light chain 3 beta Homo sapiens 164-168 26715839-9 2015 Compared to cisplatin treatment alone, the combination of cisplatin and CQ decreased p-AMPK and increased p-mTOR protein expressions, in addition, the AMPK inhibitor Compound C plus cisplatin downregulated p-AMPK and upregulated p-mTOR as well as depressed LC3B cleavage. Chloroquine 72-74 microtubule associated protein 1 light chain 3 beta Homo sapiens 257-261 23847175-4 2014 LC3B showed an increase with CQ treatment although this was different to LysoTracker signals in terms of dose and time. Chloroquine 29-31 microtubule associated protein 1 light chain 3 beta Homo sapiens 0-4 25128814-4 2014 Use of the autophagy inhibitors chloroquine and bafilomycin A1, or RNA interference of ATG7, suggested that these increases in LC3B and SQSTM1 levels were in part attributed to altered autophagic flux. Chloroquine 32-43 microtubule associated protein 1 light chain 3 beta Homo sapiens 127-131 23847175-6 2014 CQ also induced apoptosis in cell lines, which was blocked by pan-caspase inhibitor z-VAD resulting in a reduction in cells undergoing apoptosis and a subsequent upregulation of autophagic markers LC3B and lysosomal dye signals. Chloroquine 0-2 microtubule associated protein 1 light chain 3 beta Homo sapiens 197-201 34917923-5 2022 Moreover, although chloroquine and ivermectin effectively inhibited the expression of LC3B in the nucleus, chloroquine specifically maintained the performance of LC3B in cytoplasm, thereby contributing to the differentiation of ciliated cells and subsequent improvement in the beating functions of the cilia, whereas ivermectin only facilitated differentiation of goblet cells. Chloroquine 19-30 microtubule associated protein 1 light chain 3 beta Homo sapiens 86-90 23939040-7 2013 The piperine-induced autophagic flux was further confirmed by assaying LC3-II accumulation and LC3B puncta formation in the presence of chloroquine, a well-known autophagy inhibitor. Chloroquine 136-147 microtubule associated protein 1 light chain 3 beta Homo sapiens 95-99 24085292-6 2013 Treatment with lysosomal inhibitors (ammonium chloride or chloroquine) or inhibitors of cathepsins (Z-FF-FMK or Z-FA-FMK) or knock-down of LC3B expression by siRNAs suppressed PI-induced IkappaBalpha degradation. Chloroquine 58-69 microtubule associated protein 1 light chain 3 beta Homo sapiens 139-143 34917923-5 2022 Moreover, although chloroquine and ivermectin effectively inhibited the expression of LC3B in the nucleus, chloroquine specifically maintained the performance of LC3B in cytoplasm, thereby contributing to the differentiation of ciliated cells and subsequent improvement in the beating functions of the cilia, whereas ivermectin only facilitated differentiation of goblet cells. Chloroquine 107-118 microtubule associated protein 1 light chain 3 beta Homo sapiens 162-166 34146643-4 2021 And chloroquine treatment increased LC3B levels in ILK-knockdown GES-1 cells. Chloroquine 4-15 microtubule associated protein 1 light chain 3 beta Homo sapiens 36-40 34440609-6 2021 The increased level of LC3B-II induced by CB-2 was neither eliminated when autophagy initiation was suppressed by wortmannin nor further increased when autophagosome degradation was inhibited by chloroquine (CQ). Chloroquine 195-206 microtubule associated protein 1 light chain 3 beta Homo sapiens 23-27 34440609-6 2021 The increased level of LC3B-II induced by CB-2 was neither eliminated when autophagy initiation was suppressed by wortmannin nor further increased when autophagosome degradation was inhibited by chloroquine (CQ). Chloroquine 208-210 microtubule associated protein 1 light chain 3 beta Homo sapiens 23-27 32033497-13 2020 Combined treatment with Tenovin-6 and autophagy inhibitor chloroquine increased the cytotoxic effect by inducing microtubule-associated protein 1 light chain 3B (LC3B)-II accumulation, and by enhancing apoptosis and cell-cycle arrest. Chloroquine 58-69 microtubule associated protein 1 light chain 3 beta Homo sapiens 162-166 35551547-6 2022 Lowest cell proliferation was achieved with the concomitant use of genomic DNA, HGFR inhibitor, and chloroquine, when the proliferation stimulating effect of STAT3 overexpression could be outweighed by the inhibitory effect of LC3B, indicating the putative involvement of HGFR-mTOR-ULK1 molecular cascade in HGFR inhibitor-mediated autophagy. Chloroquine 100-111 microtubule associated protein 1 light chain 3 beta Homo sapiens 227-231 32414129-5 2020 Treatment of chloroquine retards the degradation of AHR and triggers physical interaction between AHR and LC3B. Chloroquine 13-24 microtubule associated protein 1 light chain 3 beta Homo sapiens 106-110 32414129-6 2020 Knockdown of LC3B suppresses the chloroquine-mediated increase of AHR. Chloroquine 33-44 microtubule associated protein 1 light chain 3 beta Homo sapiens 13-17 34996966-3 2022 Here we scrutinize this approach and show that bafilomycin A1 (BafA) but not chloroquine is suitable for flux quantification due to the stimulating effect of chloroquine on non-canonical LC3B-lipidation. Chloroquine 158-169 microtubule associated protein 1 light chain 3 beta Homo sapiens 187-191 34032339-7 2021 CQ inhibited the degradation of mitophagosomes in vitrified oocytes, manifested as decreased mitochondria-lysosomes colocalization, increased fluorescence fraction of VDAC1 overlapping LC3B, increased LC3B-II/I protein expression ratio, and p62 accumulation. Chloroquine 0-2 microtubule associated protein 1 light chain 3 beta Homo sapiens 185-189 30788651-6 2019 LC3B was up-regulated by combined treatment of zVAD with chloroquine which also revealed that DNA damage was reduced in live cells but enhanced in dead cells indicating the role of autophagy in maintaining cell health. Chloroquine 57-68 microtubule associated protein 1 light chain 3 beta Homo sapiens 0-4 31024806-9 2019 The LC3B-II/I ratio was significantly reduced by 3-MA treatment and increased by CQ treatment. Chloroquine 81-83 microtubule associated protein 1 light chain 3 beta Homo sapiens 4-8