PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31559456-0	2019	Epidermal growth factor receptor/heme oxygenase-1 axis is involved in chemoresistance to cisplatin and pirarubicin in HepG2 cell lines and hepatoblastoma specimens.	pirarubicin	103-114	heme oxygenase 1	Homo sapiens	33-49	
31559456-11	2019	CONCLUSION: The cytotoxic effects of CDDP and THP were both enhanced under HO-1 knockdown conditions as well as under conditions that inhibit the activation pathway of HO-1 by EGFR inhibitors.	pirarubicin	46-49	heme oxygenase 1	Homo sapiens	75-79	
31559456-11	2019	CONCLUSION: The cytotoxic effects of CDDP and THP were both enhanced under HO-1 knockdown conditions as well as under conditions that inhibit the activation pathway of HO-1 by EGFR inhibitors.	pirarubicin	46-49	heme oxygenase 1	Homo sapiens	168-172	
31559456-1	2019	PURPOSE: To investigate the possibility that the antioxidant stress protein Heme oxygenase-1 (HO-1) is involved in the acquisition of chemoresistance in cisplatin and pirarubicin (CITA) therapy.	pirarubicin	167-178	heme oxygenase 1	Homo sapiens	76-92	
31559456-1	2019	PURPOSE: To investigate the possibility that the antioxidant stress protein Heme oxygenase-1 (HO-1) is involved in the acquisition of chemoresistance in cisplatin and pirarubicin (CITA) therapy.	pirarubicin	167-178	heme oxygenase 1	Homo sapiens	94-98	
31559456-6	2019	RESULTS: HO-1 expression in HepG2 cells was increased by the treatment of cisplatin (CDDP) and pirarubicin (THP) dose-dependently.	pirarubicin	95-106	heme oxygenase 1	Homo sapiens	9-13	
31559456-6	2019	RESULTS: HO-1 expression in HepG2 cells was increased by the treatment of cisplatin (CDDP) and pirarubicin (THP) dose-dependently.	pirarubicin	108-111	heme oxygenase 1	Homo sapiens	9-13	
31559456-7	2019	In HO-1 knockdown HepG2 cells, the HO-1 was not expressed and the percentage of trypan blue-positive cells (dead cells) was significantly increased after treatment of CDDP and THP.	pirarubicin	176-179	heme oxygenase 1	Homo sapiens	3-7	
24927633-10	2014	Moreover, HO-1 expression/induction also related to the chemosensitivity of colon cells; HO inhibitor zinc protoporphyrin significantly increased cytotoxicities of THP (i.e., 2.6 - 5.3 folds compared to cells without zinc protoporphyrin treatment).	pirarubicin	164-167	heme oxygenase 1	Homo sapiens	10-14