PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34935899-0	2022	Down-regulating GRP78 reverses pirarubicin resistance of triple negative breast cancer by miR-495-3p mimics and involves the p-AKT/mTOR pathway.	pirarubicin	31-42	AKT serine/threonine kinase 1	Homo sapiens	127-130	
34935899-13	2022	Therefore, the mechanism of pirarubicin resistance might involve the miR-495-3p/GRP78/Akt axis, which would provide a possible strategy for treating TNBC.	pirarubicin	28-39	AKT serine/threonine kinase 1	Homo sapiens	86-89	
33065796-12	2020	In addition, compared with the control group, the THP group had significantly higher LC3 protein expression, a significantly higher LC3-II/LC3-I ratio (P<0.05), and significantly lower p-PI3K, p-Akt, and p-mTOR (P<0.05).	pirarubicin	50-53	AKT serine/threonine kinase 1	Homo sapiens	195-198	
31649535-0	2019	Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth.	pirarubicin	19-30	AKT serine/threonine kinase 1	Homo sapiens	39-42	
31649535-2	2019	In this study, we found that pirarubicin (THP), one important chemotherapeutic drug for treating bladder cancer intravesically, dramatically elevated phosphorylations of both Akt and Erk1/2 in addition to inducing DNA damage.	pirarubicin	29-40	AKT serine/threonine kinase 1	Homo sapiens	175-178	
31138757-0	2019	Low concentration of rutin treatment might alleviate the cardiotoxicity effect of pirarubicin on cardiomyocytes via activation of PI3K/AKT/mTOR signaling pathway.	pirarubicin	82-93	AKT serine/threonine kinase 1	Homo sapiens	135-138