PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15350632-0 2004 The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells. pirarubicin 138-149 ATP binding cassette subfamily C member 1 Homo sapiens 76-117 9443942-8 1998 Two anthracyclines, the doxorubicin derivative pirarubicin and 2"-bromo-4"-epi-DNR seemed to have a slightly higher Ka value for Pgp than for MRP. pirarubicin 47-58 ATP binding cassette subfamily C member 1 Homo sapiens 142-145 12897808-0 2003 Functional study of intracellular P-gp- and MRP1-mediated pumping of free cytosolic pirarubicin into acidic organelles in intrinsic resistant SiHa cells. pirarubicin 84-95 ATP binding cassette subfamily C member 1 Homo sapiens 44-48 12897808-1 2003 We sought to determine the efficiency of the intracellular functional P-gp- and MRP1-mediated pumping of THP into acidic organelles in SiHa cells and etoposide-resistant SiHa/VP16 cells. pirarubicin 105-108 ATP binding cassette subfamily C member 1 Homo sapiens 80-84 12897808-3 2003 The functional studies of both intracellular functional P-gp- and MRP1-mediated pumping were performed by using THP in a conventional spectrofluorometer, and they demonstrated that SiHa and SiHa/VP16 cells are good models to illustrate the functional role of intracellular P-gp and MRP1 in the transport of free cytosolic drug into acidic organelles. pirarubicin 112-115 ATP binding cassette subfamily C member 1 Homo sapiens 66-70 10729360-8 2000 We now examined the effect of PAK-104P on Pgp-and MRP1-mediated efflux of three anthracyclines, daunorubicin, pirarubicin, hydroxydoxorubicin and of calcein acetoxymethyl ester and calcein. pirarubicin 110-121 ATP binding cassette subfamily C member 1 Homo sapiens 50-54 10729360-11 2000 PAK-104P also non-competitively inhibits the MRP(1)-mediated efflux of daunorubicin, pirarubicin, hydroxyrubicin, calcein acetoxymethyl ester and calcein. pirarubicin 85-96 ATP binding cassette subfamily C member 1 Homo sapiens 45-50