PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15009100-2 2004 In contrast to a previous report, we found that anthralin induced time- and concentration-dependent phosphorylation of epidermal growth factor receptor in primary human keratinocytes. Anthralin 48-57 epidermal growth factor receptor Homo sapiens 119-151 15009100-5 2004 Second, there is a correlation between a time-dependent increase in anthralin-induced epidermal growth factor receptor phosphorylation and H(2)O(2) generation. Anthralin 68-77 epidermal growth factor receptor Homo sapiens 86-118 15009100-6 2004 Third, the structurally different antioxidants n-propyl gallate and N-acetylcysteine inhibited epidermal growth factor receptor phosphorylation induced by anthralin. Anthralin 155-164 epidermal growth factor receptor Homo sapiens 95-127 15009100-8 2004 The epidermal growth factor receptor-specific tyrosine kinase inhibitor PD153035 abrogated anthralin-induced epidermal growth factor receptor phosphorylation and activation of extracellular-regulated kinase 1/2. Anthralin 91-100 epidermal growth factor receptor Homo sapiens 4-36 15009100-8 2004 The epidermal growth factor receptor-specific tyrosine kinase inhibitor PD153035 abrogated anthralin-induced epidermal growth factor receptor phosphorylation and activation of extracellular-regulated kinase 1/2. Anthralin 91-100 epidermal growth factor receptor Homo sapiens 109-141 15009100-10 2004 Our data identify anthralin-induced reactive oxygen species and, more specifically, H(2)O(2) as an important upstream mediator required for ligand-independent epidermal growth factor receptor phosphorylation and downstream signaling. Anthralin 18-27 epidermal growth factor receptor Homo sapiens 159-191