PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12093468-10 2002 The action of tolbutamide on beta-cells may be an example of desensitization caused by a lack of releasable insulin since the signaling mechanisms are nearly unchanged, whereas the action of phentolamine, an imidazoline, induces a strong desensitization without reducing insulin content or secretory granules, apparently by abolishing Ca2+ influx. Phentolamine 191-203 insulin Homo sapiens 271-278 3936737-1 1985 Interactions between naloxone, phentolamine and lysine acetylsalicylate upon glucose induced insulin release. Phentolamine 31-43 insulin Homo sapiens 93-100 8820989-0 1996 Phentolamine precludes inhibitory effect of the K+ channel opener pinacidil on insulin release. Phentolamine 0-12 insulin Homo sapiens 79-86 8820989-5 1996 We found, that phentolamine precludes the effect of pinacidil on glucose induced insulin release in healthy man. Phentolamine 15-27 insulin Homo sapiens 81-88 3525048-6 1986 Phentolamine but not atropine or propranolol resulted in a greater insulin response compared to saline (3247 +/- 762 vs 1348 +/- 388 microU/ml/120 min, P less than 0.01). Phentolamine 0-12 insulin Homo sapiens 67-74 8405704-9 1993 With hypoxemia and phentolamine blockade, the insulin response was enhanced with a 10-fold increase above baseline. Phentolamine 19-31 insulin Homo sapiens 46-53 3936737-5 1985 In diabetics, acute insulin responses to glucose were significantly increased by all the agents tested (naloxone, phentolamine and lysine acetylsalicylate), but only the cyclooxygenase inhibitor significantly augmented second phase insulin secretion and glucose disappearance rates. Phentolamine 114-126 insulin Homo sapiens 20-27 7041931-2 1982 In comparison with the control group of patients, phentolamine was associated with a significant increase in plasma insulin concentration after 30 and 60 min of surgery. Phentolamine 50-62 insulin Homo sapiens 116-123 3542627-2 1986 When the response of insulin secretion to glucose administration during clonidine therapy was compared with that after 12 days of wash-out for clonidine in this patient (who was then receiving phentolamine mesylate), there was a marked suppression of insulin secretion to stimulation by intravenous glucose during oral clonidine therapy. Phentolamine 193-214 insulin Homo sapiens 251-258 6753532-0 1982 Effect of phentolamine on insulin levels and insulin responsiveness in endotoxicosis. Phentolamine 10-22 insulin Homo sapiens 26-33 422303-2 1979 The intravenous infusion of alpha-adrenergic blocking agents tolazoline or phentolamine supressed plasma cortisol and GH response to insulin-induced hypoglycemia. Phentolamine 75-87 insulin Homo sapiens 133-140 230455-5 1979 Phentolamine effectively abolished the fall in plasma insulin concentration during exercise in 2 adrenalectomized patients. Phentolamine 0-12 insulin Homo sapiens 54-61 6997131-10 1980 The rise induced by adrenergic beta-receptor stimulation with epinephrine plus phentolamine was equivalent to the rise from 40 +/- 11 to 280 +/- 48 pM caused by an insulin-induced fall in serum glucose of about 50% and that induced by isoproterenol infusion, which caused a fourfold rise from 69 +/- 3 to 271 +/- 84 pM. Phentolamine 79-91 insulin Homo sapiens 164-171 219013-2 1979 No noteworthy differences were observed, except that the characteristic rebound of insulin upon discontinuation of SRIF was significantly lower with phentolamine (P less than 0.01). Phentolamine 149-161 insulin Homo sapiens 83-90 709896-3 1978 Insulin secretion was significantly higher (P less than 0.025) 30 and 60 min after an injection of glucagon in the glucagon-phentolamine test. Phentolamine 124-136 insulin Homo sapiens 0-7 596218-3 1977 At rest phentolamine increased the plasma concentrations of both insulin and norepinephrine. Phentolamine 8-20 insulin Homo sapiens 65-72 844018-3 1977 Alternatively, epinephrine withdrawal following removal of the tumour under phentolamine infusion may have induced increased insulin production and hence potentiated the development of hypoglycemia. Phentolamine 76-88 insulin Homo sapiens 125-132 4937445-0 1971 Effect of phentolamine upon insulin secretion during exercise. Phentolamine 10-22 insulin Homo sapiens 28-35 12072-7 1976 Both theophylline and phentolamine modify and increase the glibenclamide-induced insulin release pattern. Phentolamine 22-34 insulin Homo sapiens 81-88 1249209-2 1976 The diabetics had a significantly (P less than 0.01) greater increase in circulating insulin 1 h after an intravenous phentolamine infusion than did the normal subjects. Phentolamine 118-130 insulin Homo sapiens 85-92 4766993-0 1973 Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion. Phentolamine 65-77 insulin Homo sapiens 12-19 4766993-0 1973 Increase of insulin concentration in maturity-onset diabetics by phentolamine (Regitine) infusion. Phentolamine 79-87 insulin Homo sapiens 12-19 4928263-5 1971 Alpha adrenergic blockade by the intravenous infusion of phenotolamine significantly suppressed plasma HGH responses to insulin-induced hypoglycemia and to arginine infusion, and enhanced plasma insulin response to arginine infusion. Phentolamine 57-70 insulin Homo sapiens 120-127 4928263-5 1971 Alpha adrenergic blockade by the intravenous infusion of phenotolamine significantly suppressed plasma HGH responses to insulin-induced hypoglycemia and to arginine infusion, and enhanced plasma insulin response to arginine infusion. Phentolamine 57-70 insulin Homo sapiens 195-202 402275-0 1977 The influence of phentolamine, an adrenergic blocking agent, on insulin secretion during surgery. Phentolamine 17-29 insulin Homo sapiens 64-71 402275-7 1977 In another group which was given the glucose load during infusion of Ringer"s lactate and phentolamine, plasma levels of insulin also increased significantly after the glucose load and remained elevated during surgery. Phentolamine 90-102 insulin Homo sapiens 121-128 402275-9 1977 From these results it is suggested that suppression of insulin secretion by surgical stress is inhibited by the alpha blocking agent phentolamine. Phentolamine 133-145 insulin Homo sapiens 55-62 1248452-3 1976 When glucose was given during phentolamine administration, insulin levels rose more in the epinephrine-treated animals than in the hypoxic animals, despite similar blood glucose levels. Phentolamine 30-42 insulin Homo sapiens 59-66 5792915-1 1969 alpha-Adrenergic blockade with phentolamine significantly enhances the insulin response to arginine. Phentolamine 31-43 insulin Homo sapiens 71-78