PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19414504-1 2009 A base excision repair enzyme, NTH1, has activity that is capable of removing oxidized pyrimidines, such as thymine glycol (Tg), from DNA. thymine glycol 108-122 nth like DNA glycosylase 1 Homo sapiens 31-35 19414504-1 2009 A base excision repair enzyme, NTH1, has activity that is capable of removing oxidized pyrimidines, such as thymine glycol (Tg), from DNA. thymine glycol 124-126 nth like DNA glycosylase 1 Homo sapiens 31-35 14734554-3 2004 hNTH1 and hNEIL1 but not hNEIL2 excised the two stereoisomers of thymine glycol (5R-Tg and 5S-Tg), but their isomer specificity was markedly different: the relative activity for 5R-Tg:5S-Tg was 13:1 for hNTH1 and 1.5:1 for hNEIL1. thymine glycol 65-79 nth like DNA glycosylase 1 Homo sapiens 0-5 16446124-0 2006 Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerization. thymine glycol 10-24 nth like DNA glycosylase 1 Homo sapiens 28-33 16111924-4 2006 Interestingly, cells deficient in hNTH1, the DNA glycosylase that repairs a major lethal single free radical damage, thymine glycol, were more radiosensitive but at the same time fewer DSBs were formed post-irradiation. thymine glycol 117-131 nth like DNA glycosylase 1 Homo sapiens 34-39 15358233-2 2004 Human NTH1 is a bifunctional enzyme with DNA glycosylase and AP lyase activities and removes Tg as the first step of base excision repair (BER). thymine glycol 93-95 nth like DNA glycosylase 1 Homo sapiens 6-10 17150535-3 2004 hNTH1 and hNEIL1 recognized a similar spectra of bases lesions, but the preference of damage including the stereoisomers of thymine glycol was significantly different between hNTH1 and hNEIL1. thymine glycol 124-138 nth like DNA glycosylase 1 Homo sapiens 0-5 17150535-3 2004 hNTH1 and hNEIL1 recognized a similar spectra of bases lesions, but the preference of damage including the stereoisomers of thymine glycol was significantly different between hNTH1 and hNEIL1. thymine glycol 124-138 nth like DNA glycosylase 1 Homo sapiens 175-180 12401779-1 2002 In mammalian cells, thymine glycols and other oxidized pyrimidines such as 5,6-dihydrouracil are removed from DNA by the NTH1 protein, a bifunctional DNA-N-glycosylase. thymine glycol 20-35 nth like DNA glycosylase 1 Homo sapiens 121-125 14522981-1 2003 Human endonuclease III (hNTH1), a DNA glycosylase with associated abasic lyase activity, repairs various mutagenic and toxic-oxidized DNA lesions, including thymine glycol. thymine glycol 157-171 nth like DNA glycosylase 1 Homo sapiens 24-29 12519758-6 2003 When Tg is opposite guanine (Tg:G), the two activities are of the same specific activity as the AP lyase activity of hNTH1 against Tg:A (Ocampo, M. T. A., Chaung, W., Marenstein, D. R., Chan, M. K., Altamirano, A., Basu, A. K., Boorstein, R. J., Cunningham, R. P., and Teebor, G. W. (2002) Mol. thymine glycol 5-7 nth like DNA glycosylase 1 Homo sapiens 117-122 12200441-1 2002 Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylase, Escherichia coli Nth (endonuclease III), or its mammalian homologue NTH1. thymine glycol 0-14 nth like DNA glycosylase 1 Homo sapiens 188-192 28709015-5 2017 The DNA glycosylase NTHL1 in these extracts was able to excise Tg from both naked DNA and sites in nucleosomes that earlier studies had shown to be sterically accessible. thymine glycol 63-65 nth like DNA glycosylase 1 Homo sapiens 20-25 11287425-3 2001 Using duplex 2"-deoxyribose oligonucleotides containing an abasic (AP) site, a thymine glycol, or a 5-hydroxyuracil residue as substrates, we found the AP lyase activity of hNth1 was 7 times slower than its DNA glycosylase activity, similar to results reported for murine and human 8-oxoguanine-DNA glycosylase, which are also members of the endonuclease III family. thymine glycol 79-93 nth like DNA glycosylase 1 Homo sapiens 173-178 12140329-9 2002 The specific activities of hNTH1 for cleavage of oligonucleotides containing 5-foU and thymine glycol were 0.011 and 0.045 nM/min/ng protein, respectively. thymine glycol 87-101 nth like DNA glycosylase 1 Homo sapiens 27-32 9890904-9 1999 5-Hydroxycytosine, thymine glycol, 5-hydroxy-6-hydrothymine, 5,6-dihydroxycytosine, and 5-hydroxyuracil were substrates of hNTH1 protein among 17 lesions found in DNA substrates. thymine glycol 19-33 nth like DNA glycosylase 1 Homo sapiens 123-128 29610152-1 2018 Endonuclease III-like protein 1 (NTH1) is a DNA glycosylase required for the repair of oxidized bases, such as thymine glycol, within the base excision repair pathway. thymine glycol 111-125 nth like DNA glycosylase 1 Homo sapiens 0-31 29610152-1 2018 Endonuclease III-like protein 1 (NTH1) is a DNA glycosylase required for the repair of oxidized bases, such as thymine glycol, within the base excision repair pathway. thymine glycol 111-125 nth like DNA glycosylase 1 Homo sapiens 33-37 23940330-4 2013 One of these, n(th) endonuclease III-like (NTH1), removes oxidized pyrimidines from DNA, including thymine glycol. thymine glycol 99-113 nth like DNA glycosylase 1 Homo sapiens 43-47 22639086-1 2012 Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III. thymine glycol 0-14 nth like DNA glycosylase 1 Homo sapiens 140-144 22639086-1 2012 Thymine glycol (Tg), one of the oxidized bases formed in DNA by reactive oxygen species, is repaired by the DNA glycosylases such as NEIL1, NTH1 and Endo III. thymine glycol 16-18 nth like DNA glycosylase 1 Homo sapiens 140-144