PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29303021-4	2018	The effect of AZ on rat AIA was evaluated by secondary hind paw swelling, arthritis index, TNF-alpha and IL-1beta serum levels and histological examination of ankle joint.	Acetazolamide	14-16	interleukin 1 beta	Rattus norvegicus	105-113	
29303021-7	2018	RESULTS: AZ treatment could inhibit secondary hind paw swelling and arthritis index, reduce serum levels of TNF-alpha and IL-1beta, and ameliorate pathological changes of ankle joint in AIA rats.	Acetazolamide	9-11	interleukin 1 beta	Rattus norvegicus	122-130	
27104804-13	2016	This study found that ACZ could decrease the content of pro-inflammatory cytokines, such as MCP-1, IL-1beta, TNF-alpha and IFN-gamma in rat lungs, and, the lung injury in the HA+ACZ group reduced.	Acetazolamide	22-25	interleukin 1 beta	Rattus norvegicus	99-107	
30067070-0	2018	Acetazolamide protects rat articular chondrocytes from IL-1beta-induced apoptosis by inhibiting the activation of NF-kappaB signal pathway.	Acetazolamide	0-13	interleukin 1 beta	Rattus norvegicus	55-63	
30067070-4	2018	Here, we investigated the antiapoptotic effect of AZ on interleukin-1beta (IL-1beta)-induced apoptosis, a classic in vitro model of chondrocyte apoptosis.	Acetazolamide	50-52	interleukin 1 beta	Rattus norvegicus	56-73	
30067070-4	2018	Here, we investigated the antiapoptotic effect of AZ on interleukin-1beta (IL-1beta)-induced apoptosis, a classic in vitro model of chondrocyte apoptosis.	Acetazolamide	50-52	interleukin 1 beta	Rattus norvegicus	75-83	
30067070-5	2018	AZ treatment could inhibit IL-1beta-induced apoptosis, evidenced by increasing cell viability, relieving apoptotic nuclear morphology, decreasing apoptosis rates, and restoring mitochondrial membrane potential.	Acetazolamide	0-2	interleukin 1 beta	Rattus norvegicus	27-35	
30067070-7	2018	In conclusion, our findings indicated that AZ could effectively attenuate IL-1beta-induced chondrocyte apoptosis mediated by regulating the protein levels of apoptosis-related genes and inhibiting the activation of NF-kappaB signal pathway, suggesting that AZ might be of potential clinical interest in RA treatment.	Acetazolamide	43-45	interleukin 1 beta	Rattus norvegicus	74-82