PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32680925-1	2021	99mTc-PHC-102 is a 99mTc-labeled derivative of acetazolamide, a high-affinity small organic ligand of Carbonic Anhydrase IX (CAIX).	Acetazolamide	47-60	carbonic anhydrase 9	Mus musculus	102-123	
34201814-4	2021	In this work, we co-administrated acetazolamide, a carbonic anhydrase isoform IX (CAIX) inhibitor which was reported to increase chemotherapy efficacy in various cancer types, to the cisplatin/fendiline approach in SKNBE2 xenografts in NOD-SCID mice with the aim of identifying a novel and more effective treatment.	Acetazolamide	34-47	carbonic anhydrase 9	Mus musculus	51-80	
34201814-4	2021	In this work, we co-administrated acetazolamide, a carbonic anhydrase isoform IX (CAIX) inhibitor which was reported to increase chemotherapy efficacy in various cancer types, to the cisplatin/fendiline approach in SKNBE2 xenografts in NOD-SCID mice with the aim of identifying a novel and more effective treatment.	Acetazolamide	34-47	carbonic anhydrase 9	Mus musculus	82-86	
32680925-1	2021	99mTc-PHC-102 is a 99mTc-labeled derivative of acetazolamide, a high-affinity small organic ligand of Carbonic Anhydrase IX (CAIX).	Acetazolamide	47-60	carbonic anhydrase 9	Mus musculus	125-129	
23226406-3	2012	We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker of tumor hypoxia based on a near-infrared (NIR) fluorescent derivative of the CA IX inhibitor acetazolamide (AZ).	Acetazolamide	193-206	carbonic anhydrase 9	Mus musculus	81-86	
30511819-3	2019	This work fabricates acetazolamide (ACE)-loaded pH-responsive nanoparticles (ACE-NPs), which are quickly disintegrated in an acidic solution (pH 6.8), resulting in a quick release of ACE from these NPs to inhibit the expression of CA IX, thus up-regulating the pHe value.	Acetazolamide	21-34	carbonic anhydrase 9	Mus musculus	231-236	
30511819-3	2019	This work fabricates acetazolamide (ACE)-loaded pH-responsive nanoparticles (ACE-NPs), which are quickly disintegrated in an acidic solution (pH 6.8), resulting in a quick release of ACE from these NPs to inhibit the expression of CA IX, thus up-regulating the pHe value.	Acetazolamide	36-39	carbonic anhydrase 9	Mus musculus	231-236	
30511819-3	2019	This work fabricates acetazolamide (ACE)-loaded pH-responsive nanoparticles (ACE-NPs), which are quickly disintegrated in an acidic solution (pH 6.8), resulting in a quick release of ACE from these NPs to inhibit the expression of CA IX, thus up-regulating the pHe value.	Acetazolamide	77-80	carbonic anhydrase 9	Mus musculus	231-236	
27153561-6	2016	Targeting the hypoxic tumor compartment by knockdown of carbonic anhydrase IX (CAIX) using short hairpin RNA or by chemical inhibition of CAIX with acetazolamide potentiates the anti-cancer activity of rapamycin.	Acetazolamide	148-161	carbonic anhydrase 9	Mus musculus	138-142	
30746618-9	2019	Further analysis showed that introducing an additional stress by treating the orally active CA-IX inhibitor (acetazolamide) can synergistically increase the efficacy of 3-BP in vivo, which was confirmed using a mouse model.	Acetazolamide	109-122	carbonic anhydrase 9	Mus musculus	92-97	
30179778-5	2018	Copper-free "click" chemistry was utilized for conjugating SMA-TPGS with Acetazolamide (ATZ, a CA IX-specific targeting ligand).	Acetazolamide	73-86	carbonic anhydrase 9	Mus musculus	95-100	
30179778-5	2018	Copper-free "click" chemistry was utilized for conjugating SMA-TPGS with Acetazolamide (ATZ, a CA IX-specific targeting ligand).	Acetazolamide	88-91	carbonic anhydrase 9	Mus musculus	95-100	
26912427-2	2016	We have previously described a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tumor-associated isoform IX (CAIX), which can transport highly potent cytotoxic drugs into CAIX-expressing solid tumors.	Acetazolamide	37-50	carbonic anhydrase 9	Mus musculus	147-151	
26912427-2	2016	We have previously described a novel acetazolamide derivative, a carbonic anhydrase ligand with high affinity for the tumor-associated isoform IX (CAIX), which can transport highly potent cytotoxic drugs into CAIX-expressing solid tumors.	Acetazolamide	37-50	carbonic anhydrase 9	Mus musculus	209-213	
23226406-3	2012	We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker of tumor hypoxia based on a near-infrared (NIR) fluorescent derivative of the CA IX inhibitor acetazolamide (AZ).	Acetazolamide	193-206	carbonic anhydrase 9	Mus musculus	177-182	
23226406-3	2012	We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker of tumor hypoxia based on a near-infrared (NIR) fluorescent derivative of the CA IX inhibitor acetazolamide (AZ).	Acetazolamide	208-210	carbonic anhydrase 9	Mus musculus	81-86	
23226406-3	2012	We have developed a quantitative in vivo optical imaging method for detection of CA IX as a marker of tumor hypoxia based on a near-infrared (NIR) fluorescent derivative of the CA IX inhibitor acetazolamide (AZ).	Acetazolamide	208-210	carbonic anhydrase 9	Mus musculus	177-182