PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
1474164-0	1992	Elucidating the relationship between acetazolamide plasma protein binding and renal clearance using an albumin infusion.	Acetazolamide	37-50	albumin	Homo sapiens	103-110	
1474164-2	1992	In a hypoalbuminemic patient receiving acetazolamide, albumin infusion (50 g) increased acetazolamide plasma protein binding towards normal as the serum albumin concentration rose (r = 0.91, P < .001).	Acetazolamide	39-52	albumin	Homo sapiens	54-61	
1474164-2	1992	In a hypoalbuminemic patient receiving acetazolamide, albumin infusion (50 g) increased acetazolamide plasma protein binding towards normal as the serum albumin concentration rose (r = 0.91, P < .001).	Acetazolamide	88-101	albumin	Homo sapiens	54-61	
1474164-3	1992	The ratio of acetazolamide renal plasma clearance to creatinine clearance decreased as serum albumin levels increased (r = 0.78, P < .05) and the unbound drug fraction fell (r = 0.88, P < .01), but clearance ratios based on unbound plasma acetazolamide levels did not change.	Acetazolamide	13-26	albumin	Homo sapiens	93-100	
1474164-4	1992	Albumin infusion resulted in a nonparallel decline over time between plasma and unbound plasma acetazolamide concentrations.	Acetazolamide	95-108	albumin	Homo sapiens	0-7	
1474164-5	1992	These data demonstrate that, over the range of observed serum albumin concentrations, acetazolamide renal plasma clearance is sensitive to changes in plasma protein binding.	Acetazolamide	86-99	albumin	Homo sapiens	62-69